구개결 언어에 대한 Screening test와 설문조사의 비교분석

임재석,권종진,장현석,박영준,최철민,전상호,장수정 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

Purpose : This study was carried out to evaluate the abnormalites of the speeches of the cleft patients and compare the results of the speech evaluations of a speech pathologist with those of parents. Materials and Methods: Eleven cleft patients' parents were questioned about their children's speech and then the speeches of the cleft patients were evaluated by a speech pathologist and their results were compared with those of parents. Results : Nasal emission was noted in twenty percent of patients, with thirty percent demonstrating hypernasality and all demonstrating no hyponasality and aspirate. And twenty percent of patients show hoarseness. There was no statistically significant difference in the sensitivities to nasal emission between the speech pathologist and parents (p>0.05). However the speech pathologist is more sensitive to hypernasality than parents(p<0.05).

갑상선기능저하증에 기인한 내인성 급사 1예 보고

이정규,전지현,김민정,이규재,김한겸,조현득,채양석 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2

Although it is known that hypothyroidism can cause cardiac dysfunction, it is very hard to find a case report on sudden death due to hypothyroidism. There are only two reported cases on mediline; one is about a 15-year-old girl who died suddenly of Hashimoto's thyroiditis and the other is about a 31-year-old man who also died suddenly of hypothyroidism associated with chronic lymphocytic thyroiditis. Recently we found a young woman who unexpectedly died while she was sleeping. She was diagnosed as hypothyroidism when she went to hospital about a month before she died. At autopsy there were roughly four abnormal findings; Hashimoto's thyroiditis, mild chronic active hepatitis, diverticulosis and accessory spleen. Trace of chlorpheniramine was detected in gastric remains and blood alcohol level was 0.37 percent. To our knowledge, this is the first case reporting sudden and unexpected natural death associated with hypothyroidism in Korea.

한국산 배의 Polyphenol 화합물군이 쥐의 면역기능에 미치는 영향

최희진,한호석,박정혜,배종호,우희섭,안봉전,배만종,김현구,최청 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.4

This study was conducted to investigate immunofunctional activity of the polyphenol fractions isolated from Korean pear. In the experimental of Rosette forming cell, the results showed that all the polyphenol fractions enhance the cell count compared with the control group. Especially polyphenol fraction II and III showed highly significant effect on Rosette forming cell, and allergy inhibition. After antigen challenge, histamine content of blood of the polyphenol groups was lowered to near the normal group.

우울 증상을 수반한 만성 정신분열병 입원환자에서의 Paroxetine 효과 : 이중맹검 위약대조 연구

한평주,백영석,오상우,전현태,김지영 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

연구목적: 우울 증상이 있는 만성 정신분열병 환자를 대상으로 항정신병약물과 항우울제인 paroxetine 20mg을 병합 투여하여 우울 증상, 양성 증상, 음성 증상 및 일반적인 정신병리의 호전 여부를 밝히고자 하였다. 방법: DSM-IV 기준상 정신분열병으로 진단된 입원환자 중 우울 증상이 있는 49명을 대상으로 parox-etine과 위약을 이중맹검을 대조한 전향적 임상 연구로서 Hamilton Rating Scale for Depression (HRSD), Brief Psychiatric Rating Scale(BPRS), Positive and Negative Syndrome Scale (PANSS), Extrapyramidal Symptom Rating Scale(ESRS), UKU side effect rating scale(UKU), Clinical Global Impression(CGI)을 기저선과 1주, 2주, 4주, 6주의 시점에서 다섯 번 반복 측정하여 비교 검토하였다. 결과: 36명의 환자가 6주간의 실험을 마쳤다. Paroxetine군과 위약군을 비교해볼 때 HRSD 총점은 양군에서 의미있게 감소되어(p<.01) 우울 증상이 호전되었으나, 두 군간에 통계적으로 의미있는 차이는 없었다. 시간경과에 따라 항우울 효과는 paroxetine 군에서는 2주, 위약군에서는 4주 후부터 관찰되었다. 그리고 paroxetine군과 위약군 모두 PANSS 총점(p<.01)과 CGI 점수(p<.05)가 감소되어 전반적인 정신병리의 감소와 전체적인 임상적 호전을 보였으나, 두 군에서 양성 증상, 음성 증상, 일반적인 정신병리 그리고 약물 부작용은 유의미한 차이가 없었다. Paroxetine군에서 반응군고 비반응군으로 나누어 비교했을 때, 반응군이 비반응군보다 HRSD의 총점(p<.01)과 우울한 기분, 자살, 정신적 불안, 죄채감의 세부 항목에서 유의한 호전을 보였고(p</01),일과 활동, 초기 불면증, 건강염려증의 세부 항목이 호전되어(p<.05) 현저한 우울 증상의 호전을 보였다. 또한 반응군이 비반응군보다 BPRS 총점(p</01)과 PANSS의 일반적인 정신병리 점수(p<.05)가 낮게 나와, 일반 정신병리의 호전을 보였다. 결론: Paroxetine군과 위약군 모두에서 우울 증상의 감소가 있었지만, paroxetine군에서 항우울 효과가 빠르게 나타났다. 두 군간에 양성 증상, 음성 증상, 일반적인 정신병리와 부작용에 대한 차이는 없었다. Paroxetine군에서 반응군은 비반응군보다 우을 증상과 일반적인 정신병리에서 유의한 호전을 보였다. 즉 우울한 기분, 자살, 정신적 불안, 죄책감, 일과 활동, 초기 불면증, 건강염려증이 심한 정신분열병 환자에게 우울 증상을 회복시키는데 paroxetine 20mg의 병용 투여가 효과가 있었다. Objectives: This double-blind placebo-controlled study was conducted to demonstrate the improvement of depressive, positive and negative symptoms, and general psychopatholgy in depressed chronic schizophrenic inpatients with adjunctive paroxetine 20mg therapy in the morning. Methods: Forty nine chronic schizophrenic inpatients with depressive symptoms were randomly received adjunctive paroxetine of placebo for 6 week study period. Therapeutic effect and side dffects were evaluated by means of the Hamiltom Rating Scale for Depression(HRSD),The Brief Psychiatric Rating Scale(BPRS), the Positive and Negative Syndrome Scale(PANSS), the Extrapyramidal Symptom Rating Scale(ESRS), the UKU side effect rating scale(UKU), and the Clinical Global Impression(CGI) at baseline, first, second, forth, and sixth week of treatment in a controlled double-blind design. Results: 18 patients completed six weeks of paroxetine therapy, and 18 patients placebo therapy. 1) Comparison between paroxetine and placebo groups: (1) HRSD total scores in both groups were significantly decreased(p<.01) but there was no statistically significant difference between 2 groups. This study showed that significant effect in paroxetine group appeared at 2nd week of treatment(p<.01), while in placebo group at 4th week of treatment(p<.01). (2) PANSS, BPRS< CGI, ESRS, and UKU : In both groups, PANSS total scores and CGI scores were significantly decreased respectively(p<.01, p<.05) and thus indicated th im-provement of global psychopathology and entire effects. There were no significant differences between 2 groups in positive, negative symptoms, general psychopathology, and drug side effects. 2) Comparison between responding and nonresponding groups in paroxetine adjunctive therapy : (1) Compared with nonresponding group, responding group had significant decrease in HRSD total score(p<.01), in HRSD subitems such as depressed mood, suicide, psychic anxiety, and feelings of guilt(p<.01), and in other subitems such as work and activity, early insomnia, and hypochondriasis(p<.05). (2) Compared with nonresponding group, responding group had significantly decrease in BPRS total score(p<.01) and in general subscale of PANSS(p<.05). Conclusion: The results suggest that both paroxetine and placebo groups were improved in depressive symptoms, but paroxetine group had more rapid improvement than placebo group. There were no significant differences in positive symptoms, negative symptoms, general psychopathology, and drug side effects between two groups. Compared with nonresponding group in paroxetine adjunctive therapy, responding group had significant improvement in depressive symptoms and general psychopathology.

n-CdS_(0.46)Se_(0.54)/p-Cu_92-x)S_(0.46)Se_(0.54) 이종접합 태양전지의 제작과 그 특성에 관한 연구

유상하,최승평,이상열,홍광준,서상석,김혜숙,전승룡,윤은희,문종대,신영진,정태수,신현길,김택성,유기수 全北大學校 基礎科學硏究所 1994 基礎科學 Vol.16 No.-

승화방법에 의해 CdS_0.46Se_0.54 단결정을 성장하여 결정구조를 조사하고, Van der Pauw 방법으로 Hall effect를 측정하여 carrier density의 온도 의존성과 mobility의 온도 의존성을 조사하였다. 성장된 CdS_0.46Se_0.54 단결정을 치환반응하여 n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 이종접합 태양전지를 제작하였다. Spectral response, 전류-전압특성 및 전력변환 효율을 조사하여 그 결과로부터 개방전압은 0.48V, 단락 전류 밀도는 21mA/㎠, fill factor와 전력변환효율은 각각 0.75와 9.5%를 얻었다. CdS_0.46Se_0.54 single crystal was grown by a sublimation method. The crystal structure and the temperature dependence of carrier density and mobility of CdS_0.46Se_0.54 single crystal were studied. Heterojunction solar cells on n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 were fabricated by the substitution reaction. The spectral response, the J-U characteristics and the conversion efficiency of the n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells were studied. The open-cricuit voltage, short-circuit density, fill factor and conversion efficiency of n-CdS_0.46Se_0.54/p-Cu_2-xS_0.46Se_0.54 heterojunction solar cells under 80mW/㎠ illumination were found to be 0.48V, 21mA/㎠, 0.75 and 9.5%, respectively.

유기용제 취급근로자들의 요중대사물질과 말초임파구 자매염색분체교환 발현빈도에 관한 조사연구

김돈균,황인경,류철인,이수일,정갑열,이용환,이충렬,현원일,김석봉,전용덕 大韓産業醫學會 1990 대한직업환경의학회지 Vol.2 No.1

저자들은 유기용제 취급여성근로자 90명을 대상으로 1988년 7월부터 1989년 8월까지 말초혈액임파구에서의 자매염색분체교환의 발현빈도를 조사하고 이들의 업종, 근속연수, 요중마뇨산 농도등이 자매염색분체교환의 발현빈도에 미치는 영향을 조사하였으며 그 결과를 요약하면 다음과 같다. 1. 유기용제 취급근로자들의 말초혈액임파구에서의 자매염색분체교환의 발현빈도는 대조군에 비하여 유의하게 증가되었다. 2. 말초혈액임파구에서의 자매염색분체교환의 발현빈도가 가장 높은 업종은 프라스틱제품 제조업이었다. 3. 근속연수가 말초혈액임파구에서의 자매염색분체교환의 발현빈도에 미치는 영향은 현저하지 않았다. 4. 요중마뇨산농도와 말초혈액임파구에서의 자매염색분체교환의 발현빈도간에는 유의한 상관관계가 있었다. In order to know the possibility of utilizing the sister chromatid exchanges as an index which could evaluate the effect of organic solvents on the health in industrial workers, the authors studied the effects of the inductivity of sister chromatid exchanges in peripheral lymphocytes from 90 female workers expoxed to organic solvents and 20 non-exposed female workers. The results obtained were as follows : 1. The frequency of sister chromatid exchanges in peripheral lymphocytes from 90 female workers exposed to organic solvents was significantly increased in comparison with 20 control subject. 2. The frequency of sister chromatid exchanges was significantly increased in the workers who were employed in the manufacture of plastic materials than the other manufactures. 3. There were no significant differences in the frequency of sister chromatid exchanges by carriers of the exposed workers.

Comparison of the in vivo and in vitro dermal absorption rate of Spinosad

Ji-Hyun Bang(Ji-Hyun Bang),Hyun-Ok Ku(Hyun-Ok Ku),Byung-Suk Jeon(Byung-Suk Jeon),Hyobi Kim(Hyobi Kim),Kwang-Jick Lee(Kwang-Jick Lee),Yong-Sang Kim(Yong-Sang Kim),Hee Yi(Hee Yi) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-

Prediction of skin penetration of Bifenthrin using in vitro micro-pig skin model

Ji-Hyun Bang(Ji-Hyun Bang),Hyun-Ok Ku(Hyun-Ok Ku),Byung-Suk Jeon(Byung-Suk Jeon),Hyobi Kim(Hyobi Kim),Kwang-Jick Lee(Kwang-Jick Lee),Yong-Sang Kim(Yong-Sang Kim),Hee Yi(Hee Yi) 한국예방수의학회 2019 한국예방수의학회 학술대회자료집 Vol.2018 No.-

Synthesis and characterization of Pt-, Pd-, and Ru-promoted Ni–Ce_0.6Zr_0.4O₂ catalysts for efficient biodiesel production by deoxygenation of oleic acid

Jeon, Kyung-Won,Shim, Jae-Oh,Cho, Jae-Wan,Jang, Won-Jun,Na, Hyun-Suk,Kim, Hak-Min,Lee, Yeol-Lim,Jeon, Byong-Hun,Bae, Jong Wook,Roh, Hyun-Seog Elsevier 2019 Fuel Vol.236 No.-

<P><B>Abstract</B></P> <P>Herein, we prepared Pt-, Pd-, and Ru-promoted Ni–Ce<SUB>0.6</SUB>Zr<SUB>0.4</SUB>O<SUB>2</SUB> catalysts with improved oleic acid deoxygenation performance and investigated their physicochemical properties by N<SUB>2</SUB> adsorption-desorption, X-ray diffraction (XRD), NH<SUB>3</SUB> temperature-programmed desorption (NH<SUB>3</SUB>-TPD), and X-ray photoelectron spectroscopy (XPS). Among the above catalysts, the highest oleic acid conversion, C<SUB>9</SUB>–C<SUB>17</SUB> selectivity, and oxygen removal efficiency were observed for Pt/Ni–Ce<SUB>0.6</SUB>Zr<SUB>0.4</SUB>O<SUB>2</SUB>, which was mainly ascribed to its highest surface defect oxygen fraction and acidity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pt-, Pd-, and Ru-promoted Ni–Ce<SUB>0.6</SUB>Zr<SUB>0.4</SUB>O<SUB>2</SUB> catalysts (Me/Ni–CZO) were prepared. </LI> <LI> The above catalysts were used for oleic acid deoxygenation to produce biodiesel. </LI> <LI> Pt/Ni–CZO showed the best deoxygenation performance. </LI> <LI> Pt/Ni–CZO exhibited the highest surface defect oxygen fraction and acidity. </LI> </UL> </P>

Senescence is accelerated through donor cell specificity in cloned pigs.

Jeon, Hyun Yong,Jeong, Yeon Woo,Kim, Yeon Wook,Jeong, Yeon Ik,Hossein, Shamim M,Yang, Hyun,Hyun, Sang Hwan,Jeung, Eui-Bae,Hwang, Woo Suk D.A. Spandidos 2012 International journal of molecular medicine Vol.30 No.2

<P>Animals cloned by somatic cell nuclear transfer (SCNT) sometimes have abnormalities that result in large offspring syndrome or early death during gestation due to respiratory and metabolic defects. We cloned pigs using two sources of donor cells and observed phenotypic anomalies in three pigs cloned from one type of cell, s-pig fetal fibroblasts. These animals had many wrinkles on their faces and bodies and looked older than age-matched normal pigs. We performed the present study to examine whether the wrinkled phenotype in the cloned pigs was due to senescence, a genetic problem with donor specificity, or epigenetic problems with reprogramming. To address this issue, we investigated biomarkers of senescence, including telomere length and the expression of senescence-associated β-galactosidase (SA-β-gal), glyceraldehyde phosphate dehydrogenase (GAPDH) and β-actin. We also assessed the methylation status of euchromatic PRE-1 repetitive sequences and centromeric satellite DNA, and measured the mRNA levels of six imprinted genes, Copg2, Mest, Igf2R, GNAS, SNRPN and Ube3a. The telomeres of the wrinkled cloned pigs were much shorter than those of the normal cloned pigs and age-matched normal pigs. In the wrinkled cloned pigs, SA-β-gal activity was detected and GAPDH and β-actin were repressed. The mRNA levels of Mest, GNAS and Ube3a were reduced in the wrinkled cloned pigs, although there was no difference between the normal cloned pigs and normal controls. This gene expression analysis indicates that the wrinkled abnormality of our pigs originates from genetic abnormalities in the donor cells used for SCNT.</P>