기관골 신생증 1예

오영상,이은우,정종혁,문승원,김수현,김동한,양혁승,박정환,박경옥,강성수,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Tracheobronchopathia osteoplastica is a rare disorder of unknown cause characterized by the projection of numerous bony or cartilaginous submucosal nodules into the tracheobronchial lumen with sparing of the posterior membranous portion of tracheobronchial tree. In the past, most of the cases were diagnosed as secondary finding at autopsy. Nowaday, the key component of the evaluation is flexible fiberoptic laryngoscopy and bronchoscopy, which typically demonstrates irregular spicules of subrnucosal bone and cartilage projecting into the tracheobronchial lumen and causing various degrees of airway obstruction. A 45 years old man was visited Sunchon St. Carollo hospital due to discomfort on throat. We saw several nodules just below vocal cord via laryngoscope. The computed tomography revealed multiple small calcified nqdules on trachea and both main bronchi. Pathologic finding of bronchoscopic biopsy showed abnormal proliferation of bony and cartilagious nodules in the tracheal submucosa. These fingdings were consistent with tracheobronchopathia osteoplastica. We report here on a case of tracheobronchopathia osteoplastica with review of literature.

생체용 Ti₁-x-Zrx합금의 기계적 성질과 내부식성

정종현,백승남,노학,고영무 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.1

While titanium and its alloys has been well studied for a long time, new interest in these materials and their properties has arisen in recent years with respect to their application as biomedical metallic materials. For practical purposes, the following performances are essential for biomaterials. (1) low specific gravity (2) high corrosion resistance (3) good biostability and biocompatibility (4) sufficient mechanical properties (5) non-toxicity To develop biomedical implant materials having all the properties mentioned above, new titanium-zirconium alloys were prepared in this study. Mechanical properties and corrosion resistance were then investigated for as-cast and as-homogeneized Ti₁_x-Zrx alloys in order to reveal their possible use for biomaterials. From the experiments, the following results are obtained: 1. No martensite structure are observed in the specimens made of pure Ti and Zr. In contrast them, Ti-Zr alloys containing 18wt%Zr, 24wt%Zr and 48wt%Zr show a kind of martensite structure regardless heat treatment. 2. Fineness of structures for as-cast-alloys seems to vary with alloy composition. Ti-Zr alloy containing 48wt%Zr shows the finest microstructure. 3. Hardness of Ti-Zr alloys shows continuous change through the system and the alloys containing 48 to 60wt%Zr indicate higher hardness compared with those of pure Ti and other alloys. It is well known that hardness is usually changed with substitutional atoms, and effect of solute atom on hardness is greatest with an equi-atomic composition. The greatest hardness which was obtained in Ti-Zr alloys containing 48 to 60wt%Zr is therefore reasonable. Also, enhanced hardness can be explained on elastic interaction between dislocation and substitutional solute atoms in crystal structure and on fineness of structure. 4. Pure Ti and Zr alloys containing 6wt%Zr, 12wt%Zr, 18wt%Zr, 36wt%Zr show better corrosion resistance compared with those of pure Zr, stainless steel(SUS 316L) and the Ti-Zr alloy containing 48wt%Zr. 5. Comparing hardness, microstructure and corrosion of Ti₁_x-Zrx alloys, no large differences between as-cast and as-homogenized alloys are seen.

지진하중에 대한 다경간 교량의 비탄성 변위응답 평가

송종걸,남왕현,정영화 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

To evaluate inelastic seismic reponses of multi-span bridge structures, the capacity spectrum method(CSM) incorporating the equivalent single-degree-of freedom(ESDOF) method is presented. Application of the CSM incorporating the ESDOF method is illustrated by example analysis for symmetric and asymmetric bridge structures. To investigate an accuracy of the CSM, the maximum displacements estimated by the CSM are compared to those by inelastic time history analysis for several artificial earthquakes. The results show that the CSM provided conservative estimates of the maximum displacements for the symmetric and asymmetric bridge structures, and the trend of conservative estimates of the asymmetric bridge structures was significantly larger than that of the symmetric bridge structure.

횡하중 분포와 등가단자유도 방법의 영향을 고려한 다경간 교량의 내진성능 평가

송종걸,남왕현,정영화 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B

To evaluate inelastic seismic responses of multi-span-bridge, the equivalent single-degree-of-freedom (ESDOF) methods and the lateral load distributions are applied to the capacity spectrum spectrum method(CSM). From the pushover analysis results using the four ESDOF methods and the six types lateral load distributions, the ESDOF method more than lateral load distribution is found to have an important influence upon the pushover analysis. The effects of the higher mode on the bridge seismic behaviors are also increased as the number of pier increase. Therefore, it can be concluded that lateral load distributions and ESDOF methods for reflection of higher mode effects should be considered in the seismic analysis of the bridge structural.

횡하중 분포와 등가단자유도 방법의 영향을 고려한 다경간 교량의 내진성능 평가

송종걸,남왕현,정영화 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.A

To evaluate inelastic seismic responses of multi-span-bridge, the equivalent single-degree-of-freedom (ESDOF) methods and the lateral load distributions are applied to the capacity spectrum method(CSM). From the pushover analysis results using the four ESDOF methods and the six types lateral load distributions, the ESDOF method more than lateral load distribution is found to have an important influence upon the pushover analysis. The effects of the higher mode on the bridge seismic behaviors are also increased as the number of pier increase. Therefore, it can be concluded that lateral load distributions and ESDOF methods for reflection of higher mode effects should be considered in the seismic analysis of the bridge structural.

사람 비만세포주에서 Clozapine과 Fluoxetine에 의한 케모카인 및 케모카인 수용체의 상이한 발현

유영민,김종우,조정제,임강현 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : It has been suggested that the immune system has a role in the pathophsiology of neuropsychiatric diseases. There are some reports that clozapine and fluoxetine affect on cytokine networks. Recently, it has been known that chemokines have chemotactic effect, and modulate a number of biological responses including the process of inflammation and the maintenance of CNS homeostasis. In the present study, we investigated the effect of clozapine or fluoxetine on the expression of chemokines and their receptors. Methods : Human mast cells(HMC-1) was incubated with phorbol myristate acetate(PMA, 100ng/㎖) and calcium ionophore A23187(350ng/㎖) for 3 hours. Colzapine(10^-7M) or fluoxetine(10^-7M) were pretreated for 1 hour. RT-PCR was performed for the detection of expression of various chemokines and chemokine receptors. Results : after treatment of clozapine, the expression of MCP-1, MIP-1β, CCR3,CXCR2, CXCR3 and CXCR4 were lower than the PMA/Ca ionophore-treated group, while the expression of MIP-1α, RANTES and IL-8 were not changed. However, fluoxetine was not affected the changes of expression of various chemokines and chemokine receptors. Conclusion : This result indicates that clozapine may affect on the expression of chemokines and chemokine receptors. Therefore, this study could, in part, provide the important basic data on the explanation of side effects of clozapine, such as fever and pancreatitis.

크롬(Ⅵ)의 체내 흡수와 소실속도에 관한 연구

김현영,이성배,임철홍,이권섭,정용현,이종성,한정희,전윤석,황호순,이용묵 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The CrO3 mostly used in plating. metal surface disposal, leather, cosmetic manufacturing, as an experiment material by repeatedly inhaling and exposure the male S.D. rats at a 0.00, 0.2., 0.50, 1.25 mg/㎡ concentration(particle size: 0.5-0.5 aerosol)6hours a day, 5day a week in 13weeks comparing with 2weeks, 8weeks of recovery group about the noxiousness of the experiment animal and the reduce scale of the CrO3 in the internal organ especially in blook and respiratory organ with the period of convalescent and clearance. The experiment results which we received are as follows. 1. In blood the RBC, HGB and HCT experiment, rats with 0.20, 0.50 mg/㎡ concentration showed that there were some decreases but not dependent. The kidneys absolute weight compared with control group was reduced intentionally(p〈0.05) and the lungs absolute weight compared with control group showed intentional increase(p〉0.05). 2. After the exposure of the experiment material, the whole blook, l\blood plasma and red blood cell in blood by (x): the period of convalescent, per (y); the decreasing of Cr concentration, was y=66.51 e -0.057x, y=67.2 e-0.101x, y=70.01 e-0.030 in 0.50 mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life (day)was estimated 12.0, 6086, 23.0 each. 3, After the exposure of the experiment material, the experiment animals lung, liver and kidneys by(x); the period of convalescent, per (y); the decreasing of Cr conentration, was y=1808 e-0.00493x, y=12.02e-0.0297x, y=67.61 e-0.0292x in 0.50mg/㎡ exposure concentration by calculating the clearance coefficient of correlation, and the half life(day)was estimated 140.6, 23.3, 23.7, each, and including lung, liver with all of the experiment internal organs, the Cr clearance decreased as the exposure concentration increased.

비만과 정상체중 여고생의 영양섭취 비교 연구

조현숙,김세종,최승욱,백영호 釜山大學校 附設 體育科學硏究所 2005 體育科學硏究所 論文集 Vol.21 No.2

The purpose of this study was to compare the obese and the normal weight girls in high school on the level of the recommended dietary allowances for the Koreans based on total energy intake, the ratio of 3nutrients intake, micro-nutrients intake, daily dietary intake and the ratio of 4nutrients intake by animality and vegetability. The results of this study are as follows:...............

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

횡하중 분배방법을 이용한 교량구조물의 비탄성 변위응답 평가

송종걸,남왕현,정영화 江原大學校 産業技術硏究所 2005 産業技術硏究 Vol.25 No.A

In order to evaluate seismic performance of multi-degree-of-freedom bridge structure, moderate lateral load distribution methods using the pushover analysis were developed by many researchers. One of important variables to improve an accuracy of pushover analysis is lateral load distribution. In this study, pushover analyses were performed using the five types of lateral load distribution and seismic performances were evaluated by capacity spectrum method (CSM). To verify an accuracy of suggested lateral load distribution, the maximum displacement estimates by the CSM were compared to those by inelastic time history analysis.