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조형권(Hyoung Kwon Cho),함인혜(In Hye Ham),황완균(Wan Kyunn Whang) 대한약학회 1999 약학회지 Vol.43 No.3
From the water fraction of the MeOH extract, three compounds, 1,3,4,5-terrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate) (chlorogenic acid), quercetin 3-O-beta-D-galactopyranoside (hyperoside), and 1(R)-hydroxy-3,4-seco-lup-4(23),20(30)-dien-3,11alpha-olactone-1apha-L-rhamnopyranosyl(1->4)-beta-D-glucopyranosyl(1->6)-beta-L-glucopyranosyl ester (chiisanoside) were isolated and their strutures determinated by 1H-NMR, 13C-NMR, IR, and FAB-Nass. Chlorogenic acid and Chiisanoside had been quantitated by HPLC from eight Acanthopanax species per 10g A. koreanum 19.82, 4.17mg, A. nambunensis 65.00, 1.86mg, A chiisanense 67.19, 4.72mg, A. albeofructus 69.58, 4.96mg, A. chungbunensis 31.96, 6.73mg, A. pedunclus 13.95, 1.52mg, A. senticosus 27.19, 8.17mg, A. sessiliflorum 7.49, 5.88mg.
식방풍(植防風, Peucedani Radix)의 품질표준화에 관한 연구
이승재,김호현,조형권,이광섭,강인호,함인혜,황완균,Lee, Seung-Jae,Kim, Ho-Hyun,Cho, Hyoung-Kwon,Lee, Kwang-Sup,Kang, In-Ho,Ham, In-Hye,Whang, Wan-Kyunn 한국생약학회 2001 생약학회지 Vol.32 No.4
The Radix of Peucedanum japonicum (Umbelliferae) has been used for dispelling wind-damp, headache, chills and wind cold. In order to evaluate to quality of it, the method for the quantitative determination of peujaponiside $(peucedanol\;7-O-{\beta}-D-apiofuranosyl(1{\rightarrow}6)-{\beta}-D-glucopyranoside)$ as standard compound has been developed. Peujaponiside is a major compound of Peucedani Radix. It was analyzed by HPLC using the solvent system of 15% $CH_3CN$. The amount of peujaponiside from Peucedani Radix are in the range 0.14% (n=20).
하재석,송재준,조형권,이승구,Ha Jae-Seok,Song Jae-Jun,Cho Hyoung-Kwon,Lee Seung-Goo 한국미생물·생명공학회 2006 한국미생물·생명공학회지 Vol.34 No.2
천연 단백질인 실크를 가수분해하여, 건강기능성 식품 등에 다양하게 활용될 수 있는 가용성 실크 펩타이드를 생산하는 효소공학적 연구를 수행하였다. 효소는 Bacillus, Aspergillus, 파파야, 파인애플 등으로부터 유래하는 10종의 프로티아제를 사용하였으며,가수분해 효율을 높이기 위하여 생 실크를 $CaCl_2$- 에탄올 공용액에 녹인 가용화된 실크를 제조하였고, 이를 상온 중성의 조건에서 50시간 동안 투석하여 효소반응을 위한 기질로 사용하였다. 효소반응은 37, pH 7.0에서 수행하였으며, 파인애플 유래 프로티아제인 Bromelain과 Bacillus유래 효소인 Alcalase가 실크의 가수분해에 적합한 것으로 확인되었다. 특히 파인애플 유래의 Bromelain은 가수분해 도중 불용성 침전물의 형성으로 인한 생산 수율의 감소가 가장 적어 가용성 실크 펩타이드의 제조에 적합하였고, 분자량 분포에 있어서도 보다 다양한 것으로 확인되었다. Enzymatic hydrolysis of silk fibers were investigated for the preparation of soluble silk peptides by ten food-grade proteases from Bacillus, Aspergilius, and plant sources. Silk fibers were dissolved for 1 hr in a 2:1 cosolvent (50% $CaCl_2$: ethanol) by heating at $90^{\circ}C$. The silk solution was filtered to remove Impurity particles and desalted for 50 hours by a dialysis process to remove the used cosolvent. When the silk hydrolysis was performed at $45^{\circ}C$ for 2 hours, most proteases from Bacillus and Aspergillus generated large amounts of insoluble aggregates. On the contrary, proteases from plant sources produced much less aggregates during prolonged incubations and also exhibited high hydrolysis activities. In regards of the solubility and broad molecular sizes of produced silk peptides, Bromelain was finally selected and applied for the enzymatic hydrolysis of silk fibers.
HaCaT 세포에서 자외선 B에 의해 유도되는 DNA 상해에 대한 국내 수종 자생 식물 에탄올 추출물의 저해효과
이석희,하세은,조형권,박종군,Lee, Seok Hee,Ha, Se Eun,Cho, Hyoung Kwon,Park, Jong Kun 한국식품영양학회 2014 韓國食品營養學會誌 Vol.27 No.5
In the present study, the effects of extracts from Korean plants on the DNA damage response in HaCaT cells exposed to ultraviolet B (UVB) were investigated. The activity of cells treated for 24 hr with ethanol extracts from Vaccinium spp. (VS), and Vitis vinifera L (VV) alone was similar to that of the non-treated control, but gradually decreased at concentrations above $200{\mu}g/mL$. However, when post-incubation of UVB-exposed cells was carried out for 24 hr in medium containing VS or VV extracts, the cell activity increased in a concentration-dependent manner compared with that in the normal growth medium. The cell viability of UVB-exposed cells also increased when post-incubated in medium containing VS or VV extracts, in a concentration-dependent manner. Nuclear fragmentation analysis showed that post-incubation with VS or VV extracts decreased the UVB-induced apoptosis by about 10 and 13%, respectively, of that in cells post-incubated in growth medium. After 24 hr of post-incubation in medium containing VS or VV extracts, the level of CPD and 8-OHdG decreased in time- and concentration-dependent manners. Overall these results suggest that VS and VV extracts assist the survival of UVB-exposed cells, in accordance with the respective decrease in the levels of UVB-induced DNA damage.
LMK02의 품질규격화와 $A{\beta}$ 올리고머에 의해 유도된 희주해마 H19-7세포주에 미치는 항치매효과
강형원,김상태,손형진,한평림,조형권,이영재,류영수,Kang, Hyung-Won,Kim, Sang-Tae,Son, Hyeong-Jin,Han, Pyeong-Leem,Cho, Hyoung-Kwon,Lee, Young-Jae,Lyu, Yeoung-Su 대한동의생리학회 2009 동의생리병리학회지 Vol.23 No.2
For standardization of LMK02 quality, Ginsenoside Rg3 of Red Ginseng and Decursin of Angelica gigas Nakai in the constituents of LMK02 were estimated as indicative components. From LMK02 water extract, has been used in vitro test for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with APP-related dementias and Alzheimer's disease (AD). $A{\beta}$ oligomer derived from proteolytic processing of the ${\beta}$-amyloid precursor protein (APP), including the amyloid-${\beta}$ peptide ($A{\beta}$), play a critical role in the pathogenesis of Alzheimer's dementia. We determined that oligomer amyloid-${\beta}$ ($A{\beta}$) have a profound attenuation in the increase in rat hippocampus H19-7 cells from. Experimental evidence indicates that LMK02 protects against neuronal damage from cells, but its cellular and molecular mechanisms remain unknown. Using a hippocampus cell line on $A{\beta}$ oligomer-induced neuronal cytotoxicity, we demonstrated that LMK02 inhibits formation of $A{\beta}$ oligomer, which are the behavior, and possibly causative, feature of AD. In the Red Ginseng, the average amounts of Ginsenoside Rg3 were $47.04{\mu}g/g$ and $42.3{\mu}g/g$, 90 % of its weight were set as a standard value. And, in the Angelica gigas Nakai, the average amounts of Decursin were 2.71 mg/g and 2.44mg/g, 90 % of its weight were also set as a standard value. The attenuated $A{\beta}$ oligomer in the presence of LMK02 was observed in the conditioned medium of this $A{\beta}$ oligomer-induced cells under in vitro. In the cells, LMK02 significantly activated antiapoptosis and decreased the production of ROS. These results suggest that neuronal damage in AD might be due to two factors: a direct $A{\beta}$ oligomer toxicity and multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of $A{\beta}$ oligomer, underlie the neuroprotective effects of LMK02 treatment.
장원환가감방(壯元丸加減方)인 LMK02가 아밀로이드 전구단백질(前驅蛋白質)으로 형질전환(形質轉換)된 초파리에 미치는 효과
김상태 ( Sang Tae Kim ),강형원 ( Hyung Won Kang ),한평림 ( Pyeong Leem Han ),조형권 ( Hyoung Kwon Cho ),김태헌 ( Tae Heon Kim ),류영수 ( Yeoung Su Lyu ),손형진 ( Hyeong Jin Son ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.2
Objective : Recent studies indicate that the deposition of beta-amyloid (Aβ) is related in the pathogenesis of Alzheimer`s disease (AD), but the underlying mechanism is still not clear. Method : To investigate the potential cellular functions of APP and LMK02, we use transgenic drosophila as a model was treated with either LMK02, and the effect in APP expression was determined by climbing assay. LMK02 have been shown to be neuroprotective in fly model systems. We asked whether dietary supplementation with LMK02 would influence behavior and AD-like pathology in a transgenic fly model. Result : LMK02 water extract have attenuated fly death in vivo. LMK02-treated fly increased percentage of flight ability more longly and survival ratio more than controls. APP-GRIM drosophila treated with LMK02 had significantly less accumulation of APP deposition in the eye and brain as compared to control drosophila. Conclusion : These results suggest that LMK02 prevent APP-induced neurotoxicity through attenuating flies death induced by APP, and may be useful as potential therapeutic agents for AD.