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엉겅퀴 뿌리 물 추출물의 류마티스 관절염 동물 모델에 대한 개선 효과
노종현(Jong Hyun Nho),이현주(Hyeun Joo Lee),이에나(E Na Lee),우경완(Kyeong Wan Woo),장지훈(Ji Hun Jang),김선라(Sun Ra Kim),조현우(Hyun Woo Cho),노세응(Se Eung Noh),정호경(Ho Kyung Jung) 한국약용작물학회 2020 한국약용작물학회지 Vol.28 No.6
Background: The roots of Cirsium japonicum var. ussuriense (RCJ) have been used as traditional medicine in Korea for hematuria and hematemesis. These extracts exert anti-oxidative and anti-inflammatory effects by scavenging for free radical and regulating the inflammatory response. However, the effect of RCJ on rheumatoid arthritis (RA) has not been elucidated. Thus, we evaluated the water extract of RCJ (WRCJ) using type II collagen-induced RA models. Methods and Results: RA was induced by immunization with type II collagen. All experimental materials were orally administered daily for three weeks. The positive control group was administered with 0.2 ㎎/㎏ methotrexate (n = 7), while the experimental group was administered with WRCJ (100 or 500 ㎎/㎏, n = 7). Serum levels of TNF-alpha, Interleukin 6 (IL-6), and type II collagen IgG (CII) were measured using ELISA. Administration of 500 ㎎/㎏ WRCJ decreased the levels of TNF-alpha, IL-6, and CII. Moreover, WRCJ treatment diminished swelling of hind legs and infiltration of inflammatory cells in RA models’ synovial membrane. Conclusions: These results indicate that WRCJ could improve RA, reduce inflammatory indicators and synovial inflammation. However, further experiments are required to determine how WRCJ can influence the signal transduction pathway in RA.
Network Analysis을 이용한 류마티스관절염 활액 대식세포에서 유전자 발현 연구
지종대 ( Jong Dae Ji ),김태환 ( Tae Hwan Kim ),이빛나라 ( Bit Na Ra Lee ),최성재 ( Sung Jae Choi ),이영호 ( Young Ho Lee ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 2011 대한류마티스학회지 Vol.18 No.2
Objective. We wanted to investigate the mechanisms that could account for the pathogenesis of rheumatoid arthritis, so we examined the different expressions of the genes in rheumatoid arthritis (RA) synovial fluid macrophages as compared with that of normal peripheral blood (PB) monocyte-derived macrophages using microarray and bioinformatic analysis. Methods. We examined the expression of genes by using a gene expression oligonucleotide microarray. The differences of the gene expressions between the RA synovial macrophages and the normal PB monocytes-derived macrophages were analyzed using bioinformatic tools, including cytoscape and its plugin. Results. In this study, we found that 899 genes (464 genes up-regulated and 435 genes down-regulated) were differentially expressed between the two groups. Among the 899 genes, 552 genes were included for gene ontology analysis and network analysis. Based on biological process ontology, they were categorised mainly into immune response processes, responses to stimulus and signaling and regulation of biological processes. In addition to the genes related with STAT1 and AP-1 signaling, we found that the genes involved in the antigen processing and the cell cycle are abundantly expressed in RA synovial macrophages, suggesting that these genes may play an important role in the pathogenesis of RA. Conclusion. Our study suggest that this approach using integration of the gene expression profile with the protein interaction data may help to find several important pathogenic mechanisms in RA.
방사선 조사 마우스에서 소장움세포의 Apoptosis 발생에 미치는 생약의 효과
김성호,안미라,나승렬,이종환,김재하,조성기,장종식,신동호 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1
Apoptosis의 유발을 억제하는 한약제를 파악하여 apoptosis와 관련된 정상적 또는 질병에 대한 연구에 자료를 제공하고자 방사선에 의해 유도된 apoptosis를 지표로 한의학적 처방에서 많이 사용되는 대표적 한약제(24종)의 효과를 검증하였다. 용안육, 산조인, 원지, 인삼, 복령, 목향, 천궁, 백작약, 승마, 시호 및 눈꽃동충하초 투여군에서 apoptosis는 감소되었으며, 이들 생약제는 apoptosis와 관련된 질병의 예방 및 치료에 적용할 수 있을 것이다. 추 후 이들 생약의 작용 기전에 대한 연구가 요구된다. This study was performed to determine the effect of several herbs on radiation-induced apoptosis in jejunal crypt cells. Longyanrou(Euphoris longana), Suanzaoren(Zizyphus vulgaris), Yuanzhi(Polygala tenuifolia), Rensan(Panax ginseng), Fuling(Poria cocos), Muxiang(Saussurea lappa), Chuanxiong(Cnidium officinale), Baishaoyao(Paeonia lactifolia), Shengma(Cimicifuga heracleifolia), Chaihu(Bupleurum falcatum) and Dongchongxiacao(Paecilomyces japonica) reduced the frequency of radiation-induced apoptosis(p<0.05). Although the mechanisms of this effect remain to be elucidated, these results indicated that Longyanrou, Suanzaoren, Yuanzhi, Rensan, Fuling, Muxiang, Chuanxiong, Baishaoyao, Shengma, Chaihu and Dongchongxiacao might be useful inhibitors of apoptosis, especially since these are relative nontoxic natural products.
이상호,이미라,우종윤 大韓小兒齒科學會 1990 大韓小兒齒科學會誌 Vol.17 No.2
Temporamandibular disorders have symptoms such as pain, muscular tenderness, clicking noise in the TMJ and restriction of mandibular movement. The diversity of problems and causes of pain among patients is so great that there is no particular method of treatment which can be applied without differentiation to a large group of patient. Temporamandibular disorder in children and adolescents have been studied since the beginning of the 1970s. A report of child who had been treated with occlusal splint due to TMJ disorder was presented.
멀티미디어 서버를 위한 슬롯 어드레싱 및 재참조 시간 기반 버퍼링 시스템 설계에 관한 연구
양종운,나인호 군산대학교 정보통신기술연구소 2000 情報通信技術硏究論文集 Vol.4 No.-
This paper is present how to maximize the buffer utilization in fixed amounts of buffer space and disk bandwidth. And, how to use concurrent streams in the multimedia server system to increasing data block's reusing rates. First, buffer sharing scheme that allows multiples to share buffers. Our analysis and preliminary simulation results indicate that buffer sharing could lead to as much as 50% reduction in total buffer space requirements. Second, we use buffer replacements scheme to data sharing, which is data blocks of reading from disk and reuse the data blocks to increasing disk bandwidth. Also, reduce the waiting time when users are request the any video stream in the stored in the multimedia server systems to satisfying real-time constraints and using fixed resource(i.e., buffer space, disk bandwidth and network bandwidth) Finally, we propose the schemes for reduce I/O bandwidth and maximizing the buffer utilizations in multimedia server systems.
최병재,이제호,장미라,이종갑 大韓小兒齒科學會 1997 大韓小兒齒科學會誌 Vol.24 No.3
Ankylosis is defined as a fusion of alveolar bone with dentin and/or cementum and may occur at any time during or following active eruption. Ankylosed teeth maintain existing occlusal levels while adjacent teeth continue to erupt via deposition of alveolar bone. This may result in th clinical apperarance of depression or submergence of ankylosed teeth below the occlusal plane. It is found more frequently in children of late mixed dentition and in mandibular primary molars. The problems arising from ankylosed teeth, due to their submerged positions, are elongation of the antagonist, tipping of the adjacent teeth, loss of arch length, food impaction and subsequent destruction of periodontal tissue, disturbance of succedaneous tooth eruption. The author observed several cases fo ankylosed primary molars and properly managed. Following results were obtained. 1. Severe infraoccluded ankylosis results in loss of arch length and undesirable effect on eruption path of succedaneous tooth, therefore early diagnosis and management are important. 2. The teeth without problems may be examined periodically and restored in order to maintain the normal occlusal function.
정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구
이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2
Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.
Effects of salmon DNA fraction in vitro and in a monosodium iodoacetate
Ho Jong Ra,Mi Young Oh,Hee Ju Kim,Seung Yong Lee,Dae Woon Eom,Suk Kyu Lee,Su-Nam Kim,Kyu Sung Chung,Hyuk Jai Jang 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.2
PRF001 is a fragmented DNA polymer extracted from the testes of salmon. The purpose of this study was to assess the anti-inflammatory effect of PRF001 in itro as well as the protective effect of PRF001 intake against arthritis in a rat model. In vitro, cell survival and inflammatory markers after H2O2 treatment to induce cell damage were investigated in CHON-001 cells treated with different concentrations of PRF001. In vivo, osteoarthritis was induced by intra-articular injection of monosodium iodoacetate (MIA) into the knee joints of rats. After consumption of PRF001(10, 50, or 100 mg/kg) for 4 weeks, inflammatory mediators and cytokines in articular cartilage were investigated. In vitro, the levels of inflammatory markers, IL-1β, TNF-α, COX-2, iNOS, and PGE2, were significantly suppressed by PRF001 treatment. In vivo, the inflammatory mediators and cytokines, IL-1β, p- Erk1/2, NF-kB, TNF-α, COX-2, and PGE2, as well as MMP3 and MMP7, which have catabolic activity in chondrocytes, were decreased in the MIA-induced osteoarthritic rats following intake of PRF001. Histological analysis revealed that PRF001 had a protective effect on the articular cartilage. Altogether, these results demonstrated that the anti-inflammatory property of PRF001 contributes to its protective effects in osteoarthritis through deregulating IL-1β, TNF-α, and subsequent signals, such as p-Erk1/2, NF-κB, COX-2, PGE2, and MMPs.