Fontan Procedure이후 심장혈관계의 혈류역학적 특성에 관한 수치적 연구

고형종,김경훈,심은보 金烏工科大學校 1998 論文集 Vol.19 No.-

The aim of this study is to develop a computational model representative of the circulation in patients with a uni-ventricular heart sugically palliated by a total atrio-pulmonary connection. A model of the cardiovascular system is built using standard Iumped components such as resistance, voltage source, check valve and capacitor. We assume that there is only an atrium in the right heart part of the model after the Fontan procedure. In this study, baroreceptor reflex and cardiopulmonary reflex control model are implemented to explain the autoregulation of cardiovasculasr system. Another important aspect of the model is to utilize a beat-to-beat approach in sensing pressure deviations, in transferring these to autonomous nerve system, and in regulating the control variables such as heart rate, heart contractility, peripheral resistance, and venous tone. To verify the present code. we have computed the LBNP(Lower Body Negative Pressure)simulation and compared its results with the existing experimental data. The hemodynamic changes after the Fontan procedure are simulated and compared with the existion clinical data. After Fontan procedure, heart rate, CVP(Central venous pressure) and diastolic pressure increase whereas pulse pressure and systolic pressure go down. Increased CVP, induced by the removal of right ventricle, makes the heart rate go up via baroreceptor reflex control. The effects of known hazardous exposures after Fontan procedure are also investigated. We assume increased peripheral resistance to simulate the situation of exposure to cold. In this case increased arterial pressure induces the decrease of heart rate. which results in decrease of cardiac output. On the other hand, exposure to heat increases heart rate and cardiac output. Hemorrhage in cardiovascular system results in increase of ABP(Arterial Blood Pressure) and decrease of heart rate and cardiac output.

성남시 지역주민의 정신질환에 대한 태도 연구

고영,신수경,황태연,이충순,박연수,김인숙,황은숙,정원재 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.1

多樣한 黃芩藥鍼製劑의 安全性 및 效能에 關한 硏究

김호경,마진열,전원경,윤수영,강은정,주혜정,고병섭 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

In order to detect the safety and effect of various aqua-acupunctures from Scutellariae Radix, the modifications of boiling, filtration and dilution were employed for the manufacture of aqua-acupunctures. We injected 0.2cc of aqua-acupunctures into Joksamri(足三里) of rat, repeatedly. we compared subacute toxicity of them with saline group, distilled water(D.W.) group, acupuncture group and control group. The results were summarized as follows: 1. The groups were all healthy and alive, and there was no special abnormality in physical condition and autopsy. And there were not any toxic symptoms in repeating application of aqua-acupunctures to the rat, including changes of body weight, organ weight, haematological examination and serum biochemical test. 2. There was slight change of body weight in acupuncture group : We could see significance after 3 days (p<0.05) and after 7 days (p<0.001) in body weight loss. After 9 days, all tested groups were suppressed in body weight increment. 3. Result of organ weight: In Palking aqua-acupuncture(D-2 group), saline group and acupuncture group there were some statistical significance. Especially, acupuncture group revealed significant result in liver and spleen than aqua-acupunctures. From this result, we could suggest that the efficacy of acupuncture was preceded herbal medicine. 4. In serum biochemical test, we examined glucose(GLU), triglyceride(TG) and cholesterol(CHOL). In comparison with control group, the diluted 10 times of hwanggum aqua-acupuncture (× 10 group) was recognized significant decrease of glucose, but the diluted 100 times of Hwanggum aqua-acupuncture (× 100 group), D-2 group, saline group were confirmed significant increment. There was not any meaningful change of CHOL in all of tested group, excepting the acupuncture group was exhibited statistically significant decrease(p<0.05). In TG level all tested group except complex injection of standard compound (CPA group) and HG, there were significant value in statistically. The diluted solution was more significant decrease than Hwanggaum aqua-acupuncture(HG). The mutual relationship of components of aqua-acupuncture tended to decrease level of TG, regardless of its concentration. In acupuncture group, we gained some interesting result in meaningful decrease in TG. 5. Haematological examination showed significant increment of gramulocytes(GR) in all tested groups except Hwanggum aqua-acupuncture. And the diluted solutions of HG expressed very high increment of them(p<0.001). The GR and Mean Corpuscular Volume(MCV) of acupuncture group showed statistical significance.

승강대 운동이 비만고등학생의 혈청 지질 및 아포지단백 대사에 미치는 영향

박철호,고봉민,박은경,우상헌,안민호 동아대학교 스포츠과학연구소 2000 스포츠科學硏究論文集 Vol.18 No.-

The purpose of this study was to investigate the effect of 12 wks before and after step test of obsese student in D high school in Pusan city, exercise group(7) performed 12 wks step test and control group(7), before and after subjects performed the maximal exercise thest on treadmile's 12 wks step test. Through the comparision and analysis of change serum lipids and apolipoprotein metabolism, the results of this study were as follows. 1.In 12 wks before and after step test at the rest time, exercise group was found to have a increase In TC(12.7%), TG(9.76%), LDL-C(13.8%) and to have a significant increase in HDL-C(11.3%), FFA(96.8%). 2.At the rest, the control group was found to have a little increase in TG(9.2%) and HDL-C(6.7%), and to have a significant increase in TC(9.2%), LDL-C(8.9%) and FFA(7.5%). 3.In 12 wks before and after step test at the maximal exercise, the exercise group was found to have a significant increase in TC(5.6%), HDL-C(20.2%) and FFA(54.3). 4.At the maximal exercise, were found to have a significant increase in TC(9.7%) and LDL-C(9.9%) in the control group. 5.In 12 wks before and after step test at the maximal exercise, the exercise group was found to have a significant increase in Apo A-I(8.0%). 6.Statistically, At the maximal exercise, were found to have a significant increase in Apo B(7.8%).

초등학생의 1000m 달리기-걷기 평가방법에 관한 연구

박철호,박은경,고봉민,우상헌,안민호,차유림 東亞大學校附設스포츠科學硏究所 2002 스포츠科學硏究論文集 Vol.20 No.-

This research aims to develop a new evuluation method of endurance for elementary school students. The norm of the event of 1,000m running-walking was examined and reviewed. As a result, a new highly-valid norm for the present 1,000m running-walking was made. Among the 5th and 6th graders, 2,144 pupils were chosen. The subjects were given 1,000m running-walking and step test. The new norm led to the following results: 1. The frequency distribution of PEI according to Cajori's 5-stage evaluation method turned out to be normal for both 5th and 6th graders. In conclusion, this new norm of 1,000m running-walking is believed to provide more valid and credible scores for elementary school students. The 1,000m running-walking records and the PEI will be used as the basic data for foretelling one's endurance.

장기간의 40분 달리기 운동이 비만학생의 혈청 지질 및 아포지단백 대사에 미치는 영향

박철호,권민호,고봉민,박은경,우상헌 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

The purpose of this study was to investigate the effect of 12 wks before and after running exercise of obsese student in D high school in Pusan city, exercise group(7) performed 12 wks running exercise and control group(7),before and after subjects performed the maximal exercise thest on treadmile's 12 wks running exercise. Through the comparision and analysis of change serum lipids and apoliporotein metabolism, the results of this study were as follows. 1. In 12 wks before and agter running exercise at the rest time,exercise group was found to have a great decrease in TC(8%),TG(29%),LDL-C(7%) and to have a significant in crease in HDL-C(20%),FFA(74%). 2. At the rest, the control group was found to have a little decrease in TG, HDL-C,LDL-C and to have little changes in TC and FFA. 3. In 12wks before and after running exercise at the maximal exercise, the exercise group was found to have a significant decrease in TC(18%),TG(23) and to have a significant in crease in HDL-C(20%),LDL-(25%),FFA(23%) and TG and HDL-C were found to have a significant change. 4. At the maximal exerxcise , were found to have little change in the control group. 5. Apo A-I in the exercise group was found not to have the change signicantly. but to have anincrease 5% at the rest time, 6% at the maximal exercise. And the control group was almost found not to have change. 6. Statically, Apo B in the exercise group was found not to have a signficant change, but to have the increase 12%at the maximal exercise and the control group was found not to have a change.

비만학생들의 운동후 회복시 초과 산소소비량 및 지속시간에 관한 연구

박철호,권민호,고봉민,박은경,우상헌 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

The purpose of this study was to examine the effect of two different intensity of continuous exercise on magnitude of excess post-exercise oxygen consumption(EPOC), energy consumption following a 20min treadmill exercise. The subjects of this study were eight super-obesity in middle school students who were above 13 years old. subjects participated in two different exercise intensity to measure respiratory gas, blood lactate concentration and eardrum temperature. The results of this study were as follows: 1. The Energy consumption of the high intensity (80% VO₂ max) exercise group (264.68 35.60cal) was greater than that of the low intensity (50%) exercise group(172.01 20.39 Cal)(p<.001). 2. The EPOC of the high intensity exercise group (22.36+ 6.82Cal ) was greater than that of the low intensity exercise group(15.39+5.27 Cal)(p<.001). 3. The EPOC duration of th high intensity exercise group(28.36=3.56min) was longer than that of the low intensity exercise group(17.23+1.25min)(p<.001) 4. The blood lactate concentration, respiratory exchange ratio and temperature of the high intensity exercise group were greater than those of the low intensity exercise group(p<.05,p<.01). EPOC and duration were increase with 80%VO₂max, 80% VO₂max as intensity exercise got higher this also showed that it had something to do with lactate concentration in blood and increase of body temperature in the conclusion. We considered that there was a difference in using methods of energy, as there was a similar difference in RER. We though this following with oxygen consumption after exercise, we could clarify that high intensity exercise was better than lower intensity exercise in sametime for those who are obese especially adolescents to maintain their weights on the aspect of effect.

평양 남정리 53호분 출토 토제칠기의 보존 및 제작기법 연구 : 토제칠이배, 토제칠반, 토제칠안

황현성,임수경,김희진,이태진,고민정,윤은영 국립중앙박물관 2013 고고학지 Vol.19 No.-

본고는 일제 강점기 조사 미등록 유물 정리사업의 일환으로 수행한 평양 남정리 53호분 출토 토제칠이배, 토제칠반, 토제칠안에 관한 연구이다. 남정리 출토 유물은 소지가 목심이 아닌 토제라는 것과 칠이배와 칠반을 얹은 칠안이 함께 출토되었다는 점에서 주목할 만하다. 토제칠이배 및 칠반 그리고 칠안의 보존처리를 통해 이들의 형태와 문양 등에 대해 알 수 있었다. 또한 칠기에 사용된 붉은색 안료의 성분을 분석하여 안료의 주성분이 진사(HgS)였음을 확인하였다. 이번 연구에서 기존에 잘 알려지지 않았던 한반도 내 위치한 낙랑의 토제칠기에 관해 살펴볼 수 있었으며 이러한 제작방법이 한나라 고유의 문화인지 아니면 재지세력이 한나라의 영향을 받아 현지화한 문화의 산물인지에 대해 생각해 볼 수 있는 기회라 생각된다. This research paper examines the lacquered pottery cup, plate and table unearthed from Tomb No. 53 at Namjeong-ri in Pyongyang, which were under conservation treatment as a part of the Project of Unregistered Artefacts Uncovered in the Japanese Colonial Era. It is very rare to have a lacquered pottery cup and plate, lying on a lacquered pottery table, as a set of grave goods. In particular, they are not wooden but pottery items. Through conservation treatment for lacquered pottery cup, plate and table, it was possible to find out their shapes and decoration patterns. The resulting analysis of the red pigment used indicates that cinnabar (HgS) is the main element. This research is significant because it examines lacquered pottery wares produced in Lelang, which has rarely been conducted. Further research will need to prove whether their production techniques were in the unique Chinese Han style or were produced by indigenous craftsmen who adopted the Chinese Han technique.

Calcium Channel Inhibitor, Verapamil, Inhibits the Voltage-Dependent K⁺ Channels in Rabbit Coronary Smooth Muscle Cells

Ko, Eun A,Park, Won Sun,Son, Youn Kyoung,Ko, Jae-Hong,Choi, Tae-Hoon,Jung, In Duk,Park, Yeong-Min,Hong, Da Hye,Kim, Nari,Han, Jin Pharmaceutical Society of Japan 2010 Biological & pharmaceutical bulletin Vol.33 No.1

<P>We investigated the effect of the phenylalkylamine Ca<SUP>2+</SUP> channel inhibitor verapamil on voltage-dependent K<SUP>+</SUP> (Kv) channels in rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Verapamil reduced the Kv current amplitude in a concentration-depenent manner. The apparent <I>K</I><SUB>d</SUB> value for Kv channel inhibition was 0.82 μ<SMALL>M</SMALL>. Although verapamil had no effect on the activation kinetics, it accelerated the decay rate of Kv channel inactivation. The rate constants of association and dissociation by verapamil were 2.20±0.02 μ<SMALL>M</SMALL><SUP>−1</SUP> s<SUP>−1</SUP>, and 1.79±0.26 s<SUP>−1</SUP>, respectively. The steady-state activation and inactivation curves were unaffected by verapamil. The application of train pulses increased the verapamil-induced Kv channel inhibition. Furthermore, verapamil increased the recovery time constant, suggesting that the inhibitory effect of this agent was use-dependent. The inhibitory effect of verapamil was not affected by intracellular and extracellular Ca<SUP>2+</SUP>-free conditions. Another Ca<SUP>2+</SUP> channel inhibitor, nifedipine (10 μ<SMALL>M</SMALL>) did not affect the Kv current, and did not alter the inhibitory effect of verapamil. Based on these results, we concluded that verapamil inhibited Kv current in a state-, time-, and use-dependent manner, independent of Ca<SUP>2+</SUP> channel inhibition.</P>

Development and Ultrastructure of Glandular Trichomes in Pelargonium x fragrans Mabel Grey (Geraniaceae)

( Kyoung Nam Ko ),( Kyoung Whan Lee ),( Sang Eun Lee ),( Eun Soo Kim ) 한국식물학회 2007 Journal of Plant Biology Vol.50 No.3