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이수현(李守賢),이동엽(李東燁) 서울대학교 교육연구소 2013 아시아교육연구 Vol.14 No.2
본 연구는 외국에서 개발된 학업소진척도(MBI-SS)의 국내 타당화를 목적으로 수행되었다. 이를 위해 의과대학 재학생들(4개 학년, 총 382명)을 대상으로 학업소진 설문지를 실시하고 신뢰도 및 타당도를 확인하였다. 탐색적 요인분석 결과 3개의 하위요인(정서적 고갈, 무능력감, 냉소성), 총 14문항(정서적 고갈 5문항, 무능력감 5문항, 냉소성 4문항)이 적절한 것으로 나타났다. 이 같은 요인구조 모델이 적합한지 확인하기 위해 확인적 요인분석을 실시한 결과 3요인 모형이 적절함을 확인할 수 있었다. 또한 각각의 하위요인이 적절한 신뢰도를 지니는 것으로 나타났다. 마지막으로 학업소진 척도는 우울과 정적상관을, 학업효능감과는 부적상관을 갖는 것으로 나타나 적절한 타당도를 지니고 있음이 확인되었다. 이러한 분석 결과를 바탕으로 본 연구의 의의와 제한점을 논의하였다. The MBI-SS (Maslach Burnout Inventory-Student Survey) Scales were validated using 382 medical students who were attending a university in Seoul. Exploratory factor analysis yielded 3 factors with 14 items (5 items in exhaustion, 5 items in inefficacy, and 4 items in cynicism). After EFA, the hypothesized model was verified by confirmatory factor analysis, and the model was found in the good fit. Each factor also produced adequate internal consistency. Finally, it was found that factor-derived scale scores were related to scores on a measure of CES-D (The Center for Epidemiologic Studies-Depression) Scale, negatively related to academic efficacy. Significances and implications of the study were discussed.
이수현(李守賢),김동민(金東敏) 서울대학교 교육연구소 2011 아시아교육연구 Vol.12 No.2
본 연구는 수퍼비전 작업동맹 척도(WAI-T)의 요인구조를 탐색할 목적으로 수행되었다. 이를 위해 수퍼비전을 받고 있는 상담 수련생 245명(남 26명, 여 219명)을 대상으로 수퍼비전 작업동맹 척도를 실시하고 확인적 요인분석과 탐색적 요인분석을 통해 요인구조를 검토하였다. 확인적 요인분석을 실시한 결과 1요인 모형, 2요인 모형, 3요인 모형 모두 적합하지 않은 것으로 나타났다. 다음으로 새로운 요인추출 가능성을 탐색하기 위해 탐색적 요인분석을 실시하였다. 그 결과 2 요인이 추출되었다. 요인 1은 긍정진술문 문항으로 구성되어 있었고, 요인 2는 부정 진술문 문항(역채점 문항)으로 구성되어 있었다. 각 요인에는 원래 목표, 과제, 정서적 유대로 분류되었던 문항들이 골고루 포함된 것으로 나타났다. 이 같은 결과는 수퍼비전 경험이 많은 참여자만을 대상으로 했을 때도 동일하게 나타났다. 또한 부정 진술문 문항으로 구성된 요인 2는 요인 1과 그 의미상 같은 구인을 측정하는 것으로 판단되지만 전체 WAI-T의 구인 타당도와 신뢰도에는 부정적인 영향을 미치고 있는 것으로 나타났다. 이러한 분석 결과를 바탕으로 WAI-T의 활용에 대한 시사점을 논의하였다. The purpose of this study was to examine the factor structure of supervisory Working Alliance Inventory-Trainee(WAI-T). WAI-T was administered to 245 trainees who were currently engaged in clinical supervision. Then, a confirmatory factor analysis was conducted to find the best model among the three models(one factor model, two factor model, three factor model). However, none of these models showed acceptable values on the fitness indices. To examine the possibility of other factor structure, an exploratory factor analysis was conducted. In this analysis, two factors were extracted. Regardless of the original item classifications, the items loaded on Factor 1 were all positively stated. All the negatively stated items were loaded on Factor 2. Factor 1 showed higher correlations with the Counselor Activity Self-efficacy sub-scales than both Factor 2 and full WAI-T. The results of the analysis suggested that at least some of the Factor 2 items were problematic, in that they were interfering with construct validity and internal consistency. Overall, this study suggests that at least Korean trainee may not judges supervisory relationship on the basis of goal, task, and emotional bond as suggested by Bordin(1983).
이수현,전성우,김헌성 대한내분비학회 2022 Endocrinology and metabolism Vol.37 No.2
Drug repositioning is a strategy for identifying new applications of an existing drug that has been previously proven to be safe. Based on several examples of drug repositioning, we aimed to determine the methodologies and relevant steps associated with drugrepositioning that should be pursued in the future. Reports on drug repositioning, retrieved from PubMed from January 2011 to December 2020, were classified based on an analysis of the methodology and reviewed by experts. Among various drug repositioningmethods, the network-based approach was the most common (38.0%, 186/490 cases), followed by machine learning/deep learningbased (34.3%, 168/490 cases), text mining-based (7.1%, 35/490 cases), semantic-based (5.3%, 26/490 cases), and others (15.3%,75/490 cases). Although drug repositioning offers several advantages, its implementation is curtailed by the need for prior, conclusive clinical proof. This approach requires the construction of various databases, and a deep understanding of the process underlyingrepositioning is quintessential. An in-depth understanding of drug repositioning could reduce the time, cost, and risks inherent to early drug development, providing reliable scientific evidence. Furthermore, regarding patient safety, drug repurposing might allow thediscovery of new relationships between drugs and diseases.
이수현 ( Soo Hyun Lee ),노미령 ( Mi Ryung Roh ),정기양 ( Kee Yang Chung ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.5
Squamous cell carcinoma (SCC) of the nail bed is rare, and it usually mimics a variety of diseases. Thus, a true diagnosis of subungual SCC may be delayed for years. The appearance of a subungual tumor at presentation is often non-diagnostic, and exploratory nail-plate removal with biopsy is recommended. We have experienced four patients with subungual SCC, and they were treated by Mohs micrographic surgery (MMS). In an average follow-up of 13.5 months, there was no recurrence in all cases. However, in one case, amputation was performed due to local periosteal invasion. In cases of subungual SCC without bone involvement, particular virtue of MMS over amputation is that it permits the preservation of both function and cosmesis of the nail unit. Since the maintenance of function is of the utmost priority, MMS can be considered the most appropriate technique, as it enables us to maximize the preservation of normal anatomy of the finger. (Korean J Dermatol 2012;50(5):425∼431)