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Menadione에 의해 유발된 간독성에 미치는 홍삼사포닌의 영향
장봉준,배춘식,조용성,차용호,박창원,조대현,장경진,Jang, Bong-jun,Bae, Chun-sik,Cho, Yong-seong,Cha, Yong-ho,Park, Chang-won,Cho, Tae-hyun,Chang, Kyung-jin 대한수의학회 1997 大韓獸醫學會誌 Vol.37 No.3
It is known that 2-methyl-1,4-naphtoquinone(menadione, MD) induces hepatotoxicities both in vivo and in vitro. These toxic effects are believed to result from oxidative damages to hepatocytes by "active oxygen" species via one-electron reduction of the naphtoquinone. The ginsenoside(GS) is a complex mixture of individual ginsenosides which is known to produce a range of effects on the cardiovascular and central nervous systems. In particular, GS has an antioxidant effect. In this experiment we studied the effect of GS from red panax ginseng(red ginseng total saponin, RGTS) on free radical-induced liver injuries by MD. Administration of MD($150{\mu}M$) caused an increase in aspartate aminotransferase(AST) activities and lipid peroxidation, decrease in alkaline phosphatase(ALP) activities and total bilirubin levels in blood, caused depletion of GSH and changes of antioxidant enzyme(superoxide dismutase, catalase) activities are shown in liver tissue. Administration of RGTS restored the AST levels that increased by MD, but catalase showed no significant changes. RGTS also had an effect of restoring the GSH level and had some synergistic effects with SOD. These data suggest that RGTS may have some protective effects on liver injury which is related with the oxygen free radical.
장봉준,박채영,이장용,김성민,이종명,문수영,김정훈 한국막학회 2018 한국막학회 총회 및 학술발표회 Vol.2018 No.05
이산화탄소 분리막은 이산화탄소에 대한 선택성이 우수하면서도 투과성이 뛰어나야 그 성능을 제대로 발휘할 수 있는데, 대부분의 고분자 분리막들은 투과도 및 선택도에 있어 매우 뚜렷한 상충관계를 보이고 있으며, 이러한 상충관계를 극복할 수 있는 고투과성 및 고선택성을 갖는 분리막의 개발이 시급하다 할 수 있다. 근래 PEG (polyethylene glycol)가 이산화탄소에 대한 투과선택도가 뛰어난 것이 밝혀져 많은 연구가 진행되고 있으며, 본 연구는 이에 더해 내구성이 우수한 표면고착된 PEG 함유 고분자 복합막을 제조하여 이의 이산화탄소에 대한 분리에 대하여 발표한다.
자기장으로 구동되는 관내 구동용 생검마이크로로봇과 이의 제어방법 개발
장봉준(Bongjun Jang),남재광(Jaekwang Nam),이원서(Wonseo Lee),김종률(Jongyul Kim),장건희(Gunhee Jang) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12
We propose a novel biopsy micro-robot (BMR) and control method utilizing external precession magnetic field (EPMF). The BMR can generate helical motion to navigate in fluidic environments and selective needle releasing motion to take specimens by utilizing the EPMF. Since a field direction vector of the EPMF rotate along the axis with a precession angle (δ), the BMR composed of the multiple magnets can rotates with respect to the field axis to generate the helical motion. The needle releasing motion can be selectively generated by controlling the field direction of the EPMF. Finally, we fabricated a prototype of the BMR and constructed a magnetic navigation system (MNS) to generate the EPMF. Then, we conducted navigation experiments in complex tube and biopsy experiments with pseudo specimen made by agar to verify the BMR and its manipulation methods.