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말레인산 암로디핀 정 5 mg과 베실산 암로디핀 정 5 mg의 약동학 특성 및 안전성 비교
최희연,김재우,임형석,조상헌,김종률,최상민,정진아,임종래,배균섭,Choi, Hee-Youn,Kim, Jae-Woo,Lim, Hyeong-Seok,Cho, Sang-Heon,Ghim, Jong-Lyul,Choe, Sang-Min,Jung, Jin-Ah,Lim, Jong-Lae,Bae, Kyun-Seop 대한임상약리학회 2012 臨床藥理學會誌 Vol.20 No.1
Background: Amlodipine is a third-generation dihydropyridine calcium channel blocker for treating hypertension. Though marketed primarily as a besylate salt, there have been some efforts to find other comparable salts. Among them, maleate is the salt that has been considered favorable for many drugs. The aim of this study was to compare the pharmacokinetics, as well as safety and tolerability of amlodipine maleate with amlodipine besylate. Methods: This study was open, randomized, two-period crossover design investigated in twelve healthy male volunteers over a 144 h period after administrating two forms of amlodipine 5 mg, respectively. Each period was separated with 2 weeks. Plasma concentrations of amlodipine were determined by liquid chromatography-tandem mass spectrometry. Safety profiles were assessed by vital signs, physical examinations, electrocardiograms, laboratory testing and adverse events monitoring. Results: All subjects were completed this study. Geometric mean ratios (GMRs) of amlodipine maleate/amlodipine besylate of $C_{max}$ and $AUC_{last}$ for amlodipine were 0.92 (90% confidence interval, 0.81 ~ 1.05) and 1.05 (0.96 ~ 1.16), respectively. No serious adverse events were reported, and no clinically relevant changes were observed in safety profiles during this trial. Conclusion: Pharmacokinetics, tolerability and the safety were comparable between amlodipine maleate and amlodipine besylate in healthy individuals.
최희연,이수영,서호석,정종현,임원정 대한정신약물학회 2013 대한정신약물학회지 Vol.24 No.3
Clinicians are faced with major challenges when treating women with psychiatric disorders who are contemplating pregnancy or are pregnant. Recent data suggest that pregnancy has no protective effect on the course of psychiatric disorders and that discontinuation of psychotropic drugs is associated with a significant risk of relapse. This article reviews the major clinical dilemmas in managing women with psychiatric disorders who plan to conceive. Before pregnancy, clinical considerations for the interventions such as family planning, parental education and supporting, and antenatal care are important to reduce the risk of pregnancy complications. To treatment decision, clinicians should discuss with the woman the absolute and relative risks associated with not treated mental disorder and psychotropic drugs. Non-pharmacological treatment should be considered also. Treatment strategies, for each of the women with psychiatric disorders who plan to conceive are discussed. 정신질환이 있는 여성이 임신을 계획할 때 임상의는 환자의 증상과 기능에 대해 철저히 평가해서 질환으로 인해 발생할 수 있는 위험성과, 약물치료가 줄 수 있는 위험성을 비교해서 궁극적으로는 임산부와 태아에게 가장 이득이 되는 결정을 해야 한다. 이와 더불어 전반적인 산전관리와 교육이 중요하며 비약물학적 치료도 적극적으로 고려한다. 임산부의정신약물치료에 대해서 대규모 연구나 분석으로 약물의 안전성에 대한 시도가 되고 있지만, 아직까지는 약물과 특정한주요기형발생 간의 연관성은 일관적이지 않으므로, 임상의는 각 환자의 특성과 약물치료의 위험-이득에 근거해서 임신 전부터 포괄적인 치료 전략을 세우도록 한다.
임플란트 주위염 치료시 치아회분말과 치과용 연석고의 혼합 매식의 골재생 효과
최희연,김학균,김수관,문성용,김상렬,박광범,김용민,임성철,김은석,이정훈,Choi, Hee-Yeon,Kim, Hak-Kyun,Kim, Su-Gwan,Moon, Seong-Yong,Kim, Sang-Yeol,Park, Kwang-Bum,Kim, Young-Min,Lim, Seong-Chul,Kim, Eun-Seok,Lee, Jeong-Hoon 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.2
The purpose of this study was to evaluate histomorphometrically a toothash - plaster of Paris mixture associated with collagen membrane ($Bio-Gide^{(R)}$), regarding new bone formation in the peri-implantitis defects in dogs. Three mandibular molars were removed from 1-year-old mongrel dogs. After 2 months of healing, 2 titanium implants with sandblasted with large grit and acid etched (SLA) surface were installed in each side of the mandible. Experimental peri-implantitis was induced with ligatures after successful osseointegration. Ligatures were removed after identification of bone defect beneath the level of 5th thread of fixture on radiographic image. The mucoperiosteal flaps were elevated and the contaminated fixtures were treated with chlorhexidine and saline. The bone defects were assigned to one of the following treatments: no guided bone regeneration (GBR) procedure (group 1), GBR with Bio-$Oss^{(R)}$ and Bio-$Gide^{(R)}$ (group 2), or GBR with toothash - plaster of Paris mixture (TPM) and Bio-$Gide^{(R)}$ (group 3). The dogs were sacrificed after 8 or 16 months. The mean percentages of new bone formation within the limits of the 5 most coronal threads were $17.83{\pm}10.69$ (8 weeks) and $20.13{\pm}13.65$ (16 weeks) in group 1, $34.25{\pm}13.32$ (8 weeks) and $36.33{\pm}14.21$ (16 weeks) in group 2, and $46.33{\pm}18.39$ (8 weeks) and $48.00{\pm}17.78$ (16 weeks) in group 3, respectively. The present study confirmed statistically considerable new bone formation within the threads in group 3 compared with group 1 at 8 and 16 weeks (P<0.05). Although, data analysis did not reveal significant differences between group 2 and 3, the latter showed better results during the period of 8 or 16 weeks. Our findings support the effectiveness of TPM as a GBR material in the treatment of peri-implantitis bone defect.
해면골 밀도변화에 따른 임플랜트 주위골의 3 차원 유한요소법적 응력분석
최희연,황영필,계기성 朝鮮大學校 口腔生物學硏究所 1997 Oral Biology Research (Oral Biol Res) Vol.21 No.1
The purpose of this study was to get the information about the evaluation and prognosis of the surrounding bone of the implant analyzing the stress and displacement pattern occurred at the vertical and inclined load. Three-dimensional finite element model was constructed in the mandible with the placement of one implant fixture. The composition of the finite element model was S type, that is, S- 100(sponge bone 100%), S-75(sponge bone 75%), S-50(sponge bone 50%), S-25(sponge bone 25%), and C type, that is, C-100(cortical bone 1.5㎜ + sponge bone 100%), C-75(cortical bone 1.5㎜ + sponge bone 75%). C-50(cortical bone 1.5㎜ + sponge bone 50%), C-25(cortical bone 1.5㎜ + sponge bone 25%). After the three-demensional finite element model was complected. The vertical load pralied and the inclined load of 30°to the long axis of the implant were applied with the 200N to the superstructure of implant, and then the stress and the displacement were analyzed by the soft ware ABAQUS and I-DEAS. The following results were obtained: 1. In the case of S type composed of the sponge bone, the stress value and stress pattern of the surrounding bone of the implant occurred similarly irrespective of the bone density change, and the less the bone density was, the greater the displacement was. 2. In the case of C-50 type composed of the cortical bone and sponge bone, the stress occurred predominantly at the cortical bone of the cervical area of the implant at the vertical and inclined load. 3. In the case of C-25 type composed of the cortical one and sponge bone, the stress occurred predominantly at the cortical bone of the cervical area of the implant and at the outer layer of the mandible at the vertical and inclined load. In conclusion, the sponge bone density acted the role of the important variable about the treatment planning and the prognosis of the implant, and the special measure for increasing the bone density must be considered when the sponge bone density is under the normal level clinically.
Clinical Features and Prognosis of Corneal Ulcers in Dogs with Chronic Kidney Disease
최희연,김세은,김태현,장재영,황선영,서강문 한국임상수의학회 2021 한국임상수의학회지 Vol.38 No.3
This study was designed to investigate the characteristics of corneal ulcers in dogs with chronic kidney disease (CKD). Medical records of dogs that had been diagnosed with corneal ulcers and chronic kidney disease at Haemaru Referral Animal Hospital between April 1, 2011 and March 31, 2016 were investigated. A control group was randomly selected during the same time period. This group included patients with corneal ulcers but no evidence of systemic disease. The mean healing time of superficial corneal ulcers in the CKD group was 21.0 ± 15.0 days. This was a significantly longer healing time than was observed in the control group (11.0 ± 6.6 days, p = 0.019). The incidence rates of uveitis and keratoconjunctivitis sicca in the CKD group were significantly higher than in the control group (p = 0.000 and p = 0.026, respectively). Additionally, non-healing ulcers had significantly elevated white blood cell counts, while those with healing ulcers had WBC counts within the normal range in CKD group (p = 0.000). This study revealed that corneal ulcers in CKD patients would be delayed epithelial healing process and accompanied by ocular disease which affected to corneal healing compared to non- CKD patients.