주요 식품영양소의 수요분석

최지현,이계임 ( Ji Hyeon Choi & Kyei Im Lee ) 한국농업경제학회 1997 農業經濟硏究 Vol.38 No.1

Baicalein protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis through inhibition of reactive oxygen species production and CHOP induction

최지현,A Young Choi,Hana Yoon,최원재,윤경식,하주헌,Eui-Ju Yeo,강인숙 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.12

Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection and anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and cerebral ischemia, we investigated the effects of baicalein on apoptotic death of HT22 mouse hippocampal neuronal cells induced by thapsigargin (TG) and brefeldin A (BFA), two representative ER stress inducers. Apoptosis,reactive oxygen species (ROS) production, and mitochondrial membrane potential (MMP) were measured by flow cytometry. Expression level and phosphorylation status of ER stress-associated proteins and activation and cleavage of apoptosis-associated proteins were analyzed by Western blot. Baicalein reduced TG- and BFA-induced apoptosis of HT22 cells and activation and cleavage of apoptosis-associated proteins, such as caspase-12 and -3 and poly(ADP-ribose)polymerase. Baicalein also reduced the TG- and BFA-induced expression of ER stress-associated proteins,including C/EBP homologous protein (CHOP)and glucose-regulated protein 78, the cleavage of X-box binding protein-1 and activating transcription factor 6α, and the phosphorylation of eukaryotic initiation factor-2α and mitogen-activated protein kinases,such as p38, JNK, and ERK. Knock-down of CHOP expression by siRNA transfection and specific inhibitors of p38 (SB203580), JNK (SP600125), and ERK (PD98059) as well as anti-oxidant (N-acetylcysteine)reduced TG- or BFA-induced cell death. Baicalein also reduced TG- and BFA-induced ROS accumulation and MMP reduction. Taken together, these results suggest that baicalein could protect HT22 neuronal cells against ER stress-induced apoptosis by reducing CHOP induction as well as ROS accumulation and mitochondrial damage.

다면적 인성검사 II 재구성판으로 살펴본 주요우울장애 자살 시도자의 심리적 특성

최지현,박은희,Choi, Ji-Hyun,Park, Eun-Hee 한국정신신체의학회 2021 정신신체의학 Vol.29 No.1

연구목적 본 연구는 MMPI-2-RF를 통해 주요우울장애 환자군 중 자살 시도자들의 심리적 특성을 확인하고자 하였다. 방 법 본 연구는 한림대학교 성심병원 정신건강의학과를 방문한 입원 및 외래 환자 중 한국판 K-MINI-Plus 5.0을 통해 DSM-IV의 주요우울장애 진단적 준거를 충족시키는 자 107명을 대상으로 하였다. 이들을 C-SSRS를 사용하여 자살 시도군(n=43)과 비시도군(n=64)으로 분류하였고 ANOVA를 통해 두 집단 간 MMPI-2-RF 척도 점수에서의 차이를 조사하였다. 더불어 우울 증상의 심각도와 공존질환의 이환 여부가 자살 시도 여부에 영향을 주었을 가능성을 고려해 이를 공변인으로 하여 추가적으로 ANCOVA 분석을 수행하였다. 결 과 본 연구에서 자살 시도군이 비시도군에 비해 효능감 결여(NFC), 대인관계 수동성(IPP), 자살/죽음 사고(SUI) 척도에서 유의하게 높은 점수를 나타냈다(p<0.05). 다만 자살/죽음 사고(SUI) 척도의 경우 우울 증상과 공존질환의 이환 여부를 통제한 이후에는 두 집단 간 차이에서 통계적으로 유의한 경향성을 보여주었다(p<0.10). 결 론 본 연구의 결과를 통해 MMPI-2-RF가 중등도 이상의 증상 심각도를 지닌 주요우울장애 집단에서 실제 자살 시도로 이행될 위험이 있는 환자를 심리적 특성을 확인하는데 유용한 도구임을 확인하였다. 이러한 결과를 토대로 본 연구의 한계와 향후 연구 방향에 대해 논의하였다. Objectives : This study was conducted to investigate differences in psychological characteristics between major depressive disorder (MDD) patients with and without suicide attempt using MMPI-2-RF. Methods : Subjects were 107 MDD patients who had visited the department of psychiatry of hallym university hospital and met the DSM-IV diagnostic criteria of MDD by the korean version of MINI-Plus 5.0.0. The patients were divided into suicidal attempters (n=43) and non-suicidal attempters (n=64) using C-SSRS. The one-way ANOVA was used to compare MMPI-2-RF scale scores between two groups. Additionally, ANCOVA was conducted considering the severity of depressive symptom and comorbidity as covariate. Results : Our results showed that Suicide/Death Ideation (SUI), Inefficacy (NFC) and Interpersonal Passivity (IPP) scales were significantly higher in the MDD patients with suicidal attempt compared to MDD patients without suicidal attempt (p<0.05). However, after controlling for the severity of depressive symptom and comorbidity, SUI scale showed a significant tendency (p<0.10). Conclusions : The result suggests that MMPI-2-RF scales could be a useful tool for identifying patients transitioning to actual suicidal attempts in the moderate or severe major depressive disorder group. Limitations of this study and directions for further research are also discussed.

소아 급성 위장관염의 중증도 평가를 위한 기존 중증도 점수척도들의 비교

최지현,정태웅,김성준,정주영,김민성,한승범,강진한,김상용,임정우,김황민,박재홍,조대선,마상혁,정혜숙,천두성,고대균,김종현,Choi, Jee-Hyun,Jung, Tae Woong,Kim, Seong Joon,Chung, Ju-Young,Kim, Min-Sung,Han, Seung Beom,Kang, Jin-Han,Kim, Sang Yong,Rhim, Jung 대한소아감염학회 2014 Pediatric Infection and Vaccine Vol.21 No.1

목적: 급성 위장관염으로 입원한 소아 환자들의 중증도를 여러 척도로 평가하여 각 척도간의 차이를 비교하고, 원인 바이러스가 밝혀진 예를 따로 분류하여 원인 병원체에 따른 임상양상 및 중증도의 차이를 알아보고자 하였다. 방법: 전향적으로 전국 8개 지역 9개 의료기관의 소아청소년과에 급성 위장관염으로 진단받아 입원한 5세 미만의 환자를 대상으로 Vesikari 척도, Clark 척도, 수정 Flores 척도로 중증도를 평가하였다. 연구군으로부터 수집된 분변 검체로 로타바이러스, 장 아데노바이러스는 효소면역법으로, 노로바이러스, 아스트로바이러스, 사포바이러스는 RT-PCR 방법으로 검출하였다. 결과: 최종 연구 대상군은 총 214례로 남녀비는 1.58:1이고, 연령층은 6개월 미만이 35명(16.4%), 6-23개월이 105명(49.1%), 24-59개월이 74명(34.5%)이었다. Vesikari 척도와 Clark 척도간 일치율은 0.521 (P<0.001)이고, '중증'인 경우가 Vesikari 척도는 60.7%, Clark 척도는 2.3%로 Clark 척도가 '중증' 평가에 더욱 엄격하였다. 결론: 급성 위장관염의 중증도를 평가하는 각 척도들간에는 차이가 있었다. 각 연구자들의 결과를 객관적으로 비교하기 위해서는 척도를 하나로 통일하거나 각 척도들의 평가기준을 모두 조사하여 각 척도의 중증도를 동시에 얻는 것이 필요하다. Purpose: This study aimed to evaluate the disease severity of children suffering from gastroenteritis using different scales. The results are compared and subsequently classified on the basis of the type of virus causing the disease in order to investigate the differences in clinical characteristics and disease severity according to pathogen. Method: This study was conducted prospectively with patients under 5 years of age diagnosed with acute gastroenteritis and hospitalized at 9 medical institutions in 8 regions across the Republic of Korea. Disease severity was evaluated using the Vesikari Scale, the Clark Scale, and the modified Flores Scale. Fecal samples collected from patients were used to detect rotavirus and enteric adenovirus by enzyme immunoassay, and for RT-PCR of norovirus, astrovirus, and sapovirus. Results: There were a total of 214 patients with a male : female ratio of 1.58 : 1, of which 35 were under the age of 6 months (16.4%), 105 were aged 6-23 months (49.1%), and 74 were aged 24-59 months (34.5%). The rate of concordance between the Vesikari and Clark Scales was 0.521 (P<0.001) and, in severe cases, the Vesikari Scale was 60.7% and Clark Scale was 2.3%, indicating that the Clark Scale was stricter in the evaluation of severe cases. Conclusions: In children with gastroenteritis, there were differences in disease severity based on the scale used. Therefore, to achieve consistent results among researchers, either only a single scale or a measure of all scales should be used to determine disease severity.

분쟁해결을 위한 대체적 수단으로서 ITLOS 권고적 의견 절차 활용 - SRFC 권고적 의견 사건(사건번호 21)을 중심으로 -

최지현,Choi, Jee-hyun 한국해양과학기술원 2022 Ocean and Polar Research Vol.44 No.2

SRFC (Sub-Regional Fisheries Commission) requested to the ITLOS (International Tribunal for the Law of the Sea) an advisory opinion relating to the IUU (Illegl, Unreported, and Unregulated) fishing (Case No-21 of the ITLOS). Since, in the UNCLOS, there is no article authorizing the jurisdiction of the ITLOS full court's Advisory opinion, so various scholarly opinion wad divided. But ITLOS delivered its Advisory opinion confirming its jurisdictional competence over the Advisory proceedings with its legal opinion about the IUU issues. It opens new possibility of the alternative dispute settlement mechanism of the ITLOS through the advisory procedures. In reality, there has been a view that ICJ (International Court of Justice) could take the part of a kind of dispute settlement through its Advisory procedures. But the advisory procedures of the ITLOS, with no definite clause in UNCLOS about the advisory procedures, which provides more allowances for the function of advisory opinion as the alternative dispute settlement mechanism. ITLOS accepted the requests of the advisory opinion by the State parties through international organization or themselves directly. And the advisory opinion of the ITLOS aims the interpretation and application into the special issues-specially IUU fishing in Case No. 21 of the ITLOS-. Those factors could enable more enhanced role of the ITLOS as an alternative dispute settlement mechanism. But those possibility has contain risk of excessive and unlimited advisory role of the ITLOS. So it is important to focus on the restriction on the role of the State parties in the request of the advisory opinion to the ITLOS. In this regard it is meaningful that the ITLOS has suggested a kind of legal standing in the advisory procedures in that only coastal States could request the Advisory opinion about the IUU in their EEZ. Furthermore the discretionary power of the ITLOS in the Article 138 of the Rules of the Tribunal could curtail the abuse of the Advisory opinion initiated by the States parties of the UNCLOS. Under this framework, Advisory opinion could broaden more alternative option to the disputes between State parties of the UNCLOS in that after being delivered detailed interpretation of the UNCLOS about the specific issues, States parties could devote themselves to searching for flexible solution for the disputes between State parties. It could obtain legal explanation about the dispute under the Article 297 and Article 298 by detouring the jurisdiction limits through advisory procedures.

평균기온과 식생의 영향을 고려한 격자기반 일 지표토양온도 예측 모형 개발

최지현 ( Chi Hyun Choi ),최대규 ( Dae Gyu Choi ),최현일 ( Hyun Il Choi ),김경헌 ( Kyung Hyun Kim ),김상단 ( Sang Dan Kim ) 한국물환경학회 2012 한국물환경학회지 Vol.28 No.1

Land surface temperature in ecohydrology is a variable that links surface structure to soil processes and yet its spatial prediction across landscapes with variable surface structure is poorly understood. And there are an insufficient number of soil temperature monitoring stations. In this study, a grid-based land surface temperature prediction model is proposed. Target sites are Andong and Namgang dam region. The proposed model is run in the following way. At first, geo-referenced site specific air temperatures are estimated using a kriging technique from data collected from 60 point weather stations. Then surface soil temperature is computed from the estimated geo-referenced site-specific air temperature and normalized difference vegetation index. After the model is calibrated with data collected from observed remote-sensed soil temperature, a soil temperature map is prepared based on the predictions of the model for each geo-referenced site. The daily and monthly simulated soil temperature shows that the proposed model is useful for reproducing observed soil temperature. Soil temperatures at 30 and 50 cm of soil depth are also well simulated.

인플루언서의 경제적 이해관계를 표시하지 않은 광고 규제에 대한 고찰

최지현(Choi, Jihyun) 중앙법학회 2021 中央法學 Vol.23 No.1

이 글은 SNS상 인플루언서의 경제적 이해관계를 표시하지 않은 부당광고에 대한 규제, 특히 규제 필요성에 관하여 심층적으로 분석한 글이다. 먼저 SNS상 인플루언서의 경제적 이해관계를 표시하지 않은 부당광고와 관련하여 관련 법령 및 행정규칙을 살피고, 표시광고법상 부당광고 요건에 관하여 검토하였다. 다음으로 SNS상 인플루언서의 경제적 이해관계를 표시하지 않은 부당광고에 대한 규제에 관하여 논하였다. 이와 관련하여 인플루언서가 관련 법률인 표시광고법상 사업자에 해당하는지 여부에 관하여 해석론적 관점에서 검토하였다. 그리고 인플루언서의 경제적 이해관계를 표시하지 않은 부당광고에 대한 규제 필요성과 관련하여, 광고에 대한 규제 필요성, SNS상 게시되는 광고에 대한 규제 필요성, SNS에서 인플루언서가 하는 광고에 대한 규제 필요성으로 단계를 거쳐 검토하였다. 이후 SNS상 인플루언서의 경제적 이해관계를 표시하지 않은 부당광고에 대한 규제 수단에는 무엇이 있는지 논하였다. 표시광고법상 규제수단을 전부 적용할 수 있으나, 인플루언서 마케팅은 신산업분야이므로 엄격한 규제를 하는 것이 적절하지 않을 수 있어, 다른 비권력적 수단도 고려해야 할 것이다. 최근 추천보증심사지침이 다시 개정되어 시행되었지만 개정된 내용에 관해서도 비판이 있다. SNS상 게시물에 경제적 이해관계 표시를 어떻게 할지를 결정하는 것은 쉽지 않은 문제이므로 추천보증심사지침이 개정에 개정을 거듭하더라도 업계에서는 불만이 있을 수밖에 없을 것이다. 온라인·모바일 매체는 빠르게 변화하며 새로운 것을 계속해서 만들어내고 있고, 2020년 코로나19 사태를 맞이하여 온라인·모바일 매체의 사용량은 폭증하여 변화속도가 가속화되고 있다. 이러한 변화속도에 맞추어 온라인 플랫폼, SNS, 인플루언서, 1인 미디어에 관한 연구는 법학분야에서도 지속적으로 관심을 가지고 연구를 해 나아가야 할 분야라고 생각한다. This article provides an in-depth analysis of regulations on “influencer advertising”, particularly the need for regulations on advertisements that do not disclose the financial interests of the advertising influencers on social network services (SNS). First, relevant laws and administrative rules were examined in the context of unfair advertisements by influencers on SNS that do not disclose their financial interests. Next, the legal elements of what constitutes unfair advertising under the Act on Fair Labeling and Advertising were reviewed. This article then proceeds to discuss the ways, in which regulations may potentially apply to unfair advertisements that do not disclose the financial interests of the influencers on SNS. In this context, this article reviews whether influencers on SNS constitute a class of advertisers under the Act on Fair Labeling and Advertising, and makes an interpretive determination as to whether the Act should apply to them. Next, this article makes the case for regulations on unfair advertisements on SNS that do not disclose the influencers’ financial interests by examining the necessity of regulations on advertisements in general, advertisements on SNS, and advertisements on SNS by influencers, focusing on the likelihood of confusion by consumers. Finally, this article discusses what regulatory enforcement tools are available against unfair advertisements that do not properly disclose the financial interests of influencers on SNS. Online and mobile media are rapidly changing and continuing to create new things, and the use of online and mobile media has surged in the wake of the COVID-19 pandemic in 2020, accelerating the pace of change. In line with this pace of change, I believe that research on online platforms, SNS, influencers, and one person media is an area that needs to be continuously studied with interest in the field of law.

국내 S-OJT 연구 동향 분석

최지현 ( Choi¸ Jeehyun ),조대연 ( Cho¸ Daeyeon ) 한국인력개발학회 2020 HRD연구 Vol.22 No.4

본 연구의 목적은 시스템 접근으로서의 S-OJT(예: 투입, 과정, 산출 등)와 전통적인 내용분석 틀(연구시기, 연구대상, 연구방법 등)을 활용하여 국내 S-OJT 연구동향을 분석하는 것이다. 이를 위해 국내에서 S-OJT 연구가 시작된 1998년부터 2019년까지의 국내 학술지 및 석·박사 학위논문 중 ‘S-OJT’, ‘체계적 현장훈련’, ‘구조화된 현장훈련’을 주제로 한 총 27편의 논문을 연구의 대상으로 하였다. 분석결과, 첫째, S-OJT 시스템을 기준으로, 연구내용은 산출영역(13편, 48.1%)과 투입영역(12편, 44.4%)이 가장 많았다. 둘째, 연구대상은 기업조직(23편, 85.2%)과 훈련생(18편, 66.7%)이 가장 많았고, 4기(2010~2014) 동안 가장 다양한 연구대상으로 활발한 연구가 수행되었다. 셋째, 연구결과인 S-OJT의 효과성은 내적 효과성(12편)이 외적 효과성(4편)에 비해 많았다. 넷째, 연구방법은 양적연구(19편, 70.4%)가 가장 많았다. 이러한 분석결과를 바탕으로 몇가지 시사점을 제시하였다. The purpose of this study is to analyze domestic S-OJT research trends by applying S-OJT as a system(e.g., input, process, output, etc.) and traditional content analysis frame(research period, research target, research method, etc.). To this end, a total 27 studies including articles and dissertations under the theme of 'S-OJT', 'systematic on the job training', and 'structured on the job training' were targeted from 1998 to 2019, when S-OJT's research began in Korea. As a result of the research analysis, first, the contents of research were most in the output area 13(48.1%), input areas 12(44.4%). Second, 23 studies (85.2%) were conducted on corporate organizations and 18 studies (66.7%) were conducted on trainees were the most. And during the fourth period (2010-2014), active studies were carried out with the most diverse research targets of study. Third, the effectiveness of S-OJT, the result of the study, was much more in the Internal-effects (12) than the external-effects (4). Fourth, quantitative research (19, 70.4%) was carried out the most in the research method. Based on these analysis results, several implications were presented.

호흡과 감응: 읽기에 관한 신체론적 이해

최지현 ( Ji Hyun Choi ) 한국독서학회 2016 독서연구 Vol.0 No.38

이 논의의 목적은 읽기 행위가 갖는 본래적 의미를 되살리기 위한 일환으로 읽기의 신체성 개념을 검토하려는 데 있다. 읽기 행위란, 의미를 구성하는 기호적 실천으로서, 그 행위가 행위 주체로서 독자의 실재성을 드러내며, 행위로서 읽기의 실천성을 포착하고, 행위의 지향처로서 필자의 현전성을 확인할 수 있어야 하며, 따라서 이를 위해 필요한 개념적 요구를 충족해야한다. 곧, 읽기 행위는 물리적이며, 주도적이고, 감각적인 과정으로 규정되어야 한다. 논의의 배경에는 근본적으로는 읽기의 소통 불가능성이라는 문제상황이 자리 잡고 있다. 언어에 대한 객관주의적 설명이 야기한 이 문제상황은 이후 구성주의와 의사소통이론에 의해 해소되는 듯 보였지만, 독서교육의 장에서이 입장들이 읽기 과정에 대한 합리주의적 설명을 시도하면서 다시금 근본문제에 부닥치게 되었다. 의미 구성 과정으로서의 읽기에 주목하면서 독자의 읽기 행위가 갖는 능동성을 부각하였음에도 불구하고, 구성주의적 읽기교육 이론은 이 행위를 정신적 과정으로 제한해 둠으로써 의미의 구성이갖는 실천적, 주체 구성적 의미를 놓치고 다시금 선험적이고 객관주의적인읽기로 후퇴하고 있다. 또한 읽기의 대화적 속성에 주목함으로써 읽기행위가 갖는 실천적 의의를 부각하였음에도 불구하고, 의사소통적 읽기 교육이론은 이 과정을 정보 처리적 과정처럼 묘사함으로써 의미의 기원이 다시필자에게로 회귀되는 문제를 안게 되었다. 이 글에서는 읽기 행위의 신체성 개념을 통해 읽기의 소통 불가능한 문제상황을 해소할 단서를 얻고자 하였다. 음독이든, 혹은 묵독이든 간에 읽기과정에서 호흡이 갖는 의미 실현의 중요한 작용들을 살피고, 읽기 과정에서 ‘감응’이 갖는 상호 이해의 가능성을 검토하였다. The purpose of this study is to inquire the concept of corporality of reading to rehabilitate the primary significance of reading acts. As the semiotic practices the reading acts should reveal the spontaneousness of a reader as an initiative actor, the practicability of reading as physical acting, and the presence of a writer as an perceptible object. That is, reading acts should be defined as initiative, physical, and perceptible process. The background of this discussion basically is holding a problematic situation of incommunicability in reading. We have assessed that this problematic situation was resolved by the constructivism and communication theory, although it had caused by objectivistic explaining for the language. However, while these approaches have attempted to rationalistic explanation of the reading process in reading education, the issue of incommunicability is emerging and going back to the original problem. I tried to find a clue to solve this problem through the concept of ‘corporality’ in reading acts. To this end, I reviewed the important roles of realizing significance of ‘respiration’ in reading process and discussed the possibility of ‘inspiration’ for mutual understanding.

농어업 부가가치의 새로운 창출을 위한 식품산업의 중장기 발전전략(5/5차연도)

최지현(Ji-Hyeon Choi),김병률(Byeong-Ryul Kim),김성우(Seong-Woo Kim),이동소(Dong-So Lee),김윤진(Yun-Jin Kim),차원규(Won-Kyu Cha),박재홍,강혜정,안동환 한국농촌경제연구원 2013 한국농촌경제연구원 기본연구보고서 Vol.- No.-