5.4 運動의 性格에 관하여

차현영 德成女子大學校 人文科學大學 史學科 1989 史浪 Vol.4 No.-

입체그림과 의문사를 이용한 중재가 언어발달지체유아의 기능적 어휘표현에 미치는 효과

차현영(Hyeon-Yeong Cha),이효진(Hyo-Jin Lee),정한진(Hanjin Jeong),서경희(Kyoung-Hee Sehr) 한국의료정보교육협회 2019 보건의료생명과학논문지 Vol.7 No.2

본 연구의 목적은 언어발달지체 유아를 대상으로 한 입체그림과 의문사를 이용한 활동이 기능적 어휘 표현에 미치는 효과를 알아보는 데 있다. 연구대상은 언어발달이 1년 이상 지체된 만 3세 남자아동으로 선정하였다. 본 연구의 설계는 A-B-A, 단일대상연구로 진행되었다. 사전평가는 40분의 놀이상황에서 아동의 산출 어휘를 기록하여 표현 어휘 빈도수를 측정하였으며, 사후평가는 사전평가와 동일하게 진행되었다. 입체그림과 의문사 무엇, 누구, 어디 질문을 통하여 아동이 표현할 수 있는 기회를 제공하여 중재를 진행하였다. 중재결과, 입체그림과 의문사를 이용한 중재가 언어발달지체 유아의 기능적 어휘 표현에 긍정적인 영향을 주는 것으로 나타났다. The purpose of this study is to find out the effects of activities using stereoscopic drawings and interrogative words on functional vocabulary of Child with Language Delay. The Subject was selected as a 3-year-old boy whose language development was delayed for more than a year. The design of this study was conducted as A-B-A, single subject research. The pre-assessment measured the frequency of the expression vocabulary by recording the children's vocabulary in a 40-minute play situation. The post-assessment was carried out in the same way as the pre-assessment. The arbitration was carried out stereoscopic drawings and a question of 'what, who, where', children were presented with an chance to express. The results showed that Intervention using stereoscopic pictures and interrogative words have a positive effect on the functional vocabulary expression of Child with Language Delay.

미용사의 이직요인 분석

차우정 ( Woo-jeong Cha ),오별 ( Byul Oh ),이옥현 ( Ok-hyun Lee ),김선혜 ( Sun-hye Kim ),김유정 ( Yoo-jung Kim ),신현영 ( Hyun-young Shin ),진용미 ( Yong-mi Jin ) 한국미용예술경영학회 2013 미용예술경영연구 Vol.7 No.2

This study, the factors in the hairdresser's turnover from various angles in several previous studies by analyzing the importance of turnover relief system is aimed to refocus. For the purposes of this study related to turnover leading papers, journal articles related to Internet search and were used as research data. Specific details of the study and Turnover Study on cosmetology, cosmetology Study on the turnover, turnover of hairdressers in previous studies analyzing the factors affecting, and the results are as follows. Wage and relationships that have the greatest impact on the turnover showed that the work environment and job content, promotion was also affecting turnover. With these results in turnover for the five factors that affect the current status of the understanding and exploring the best improvement was found to be urgent. The turnover rate relief and long-service hair salon hairdresser in the new talent recruitment and training is expected to decrease in the cost of job details about the elements, yet comprehensive follow-up studies are expected to be true.

머신러닝 기반 스마트폰 어플리케이션 멀웨어 감지에 관한 연구

차채연(Chaeyeon Cha),여현영(Hyeonyeong Yeo),심서영(Seoyoung Sim),홍수민(Sumin Hong),박형곤(Hyunggon Park) 한국통신학회 2022 한국통신학회 학술대회논문집 Vol.2022 No.2

본 논문은 스마트폰 어플리케이션이 실행될 때 요구하는 피쳐 데이터를 통해 머신러닝 기반 어플리케이션 멀웨어 여부를 감지하는 모델에 있어 학습에 사용된 데이터의 수와 사용된 머신러닝 알고리즘에 따른 모델의 분류 성능을 분석하였다. 학습에 사용된 데이터의 수와 사용한 알고리즘에 따라 모델의 분류 성능이 달라지는 점을 실제 데이터를 통하여 확인하였다.

혈액투석 환자의 우울 증상과 염증반응 및 심혈관 질환 위험 인자의 연관성

현영율 ( Young Youl Hyun ),김선철 ( Sun Chul Kim ),오세원 ( Se Won Oh ),차진주 ( Jin Joo Cha ),김혜원 ( Hye Won Kim ),이재원 ( Jae Won Lee ),최윤석 ( Yoon Seok Choi ),최혜민 ( Hye Min Choi ),부창수 ( Chang Su Boo ),고강지 ( Gang J 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.4

목적: 우울증 환자에서 염증 반응의 증가가 관찰되며, 심혈관계 합병증이 증가한다는 것이 알려져 있다. 또한 만성신부전 환자의 주된 사망 원인은 심혈관계 합병증이며, 우울 증상은 만성신부전 환자에서 흔히 관찰되는 증상이다. 이 연구의 목적은 유지 혈액투석을 받고 있는 만성신부전 환자에서 우울 증상과 다양한 염증 표지자 및 심혈관계 합병증의 위험 요소들과의 연관 관계를 밝히는 것이다. 방법: 고려대학교 안암 병원에서 유지 혈액투석을 받고 있는 53명의 환자들을 대상으로 연구하였다. Beck 우울증 척도(BDI)가 11 이상인 환자들을 우울 증상군으로, 10 이하인 환자들을 대조군으로 정의하였다. 의무기록을 통해 각 군의 환자들의 특성과 검사소견을 수집하였으며, 각 환자군에서 혈중 IL-10, TNF-α 농도를 측정하고, IL-10 과 TNF-α 프로모터 영역의 유전형 변이를 분석하였다. 결과: TNF-α, CRP 및 ferritin의 농도는 우울 증상군에서 유의하게 높았으며 (p=0.001, 0.04, 0.02), IL-10의 농도는 우울 증상군에서 낮게 관찰되었다 (p=0.05). 좌심실 비대의 빈도는 대조군에 비해 우울 증상군에서 높았다 (44% vs 9%, p=0.01). 프로모터 영역의 유전형 변이 분석에선, IL-10을 더 많이 생산하는 것으로 알려진 GG 유전형 변이가 대조군에 비해 우울 증상군에서 더 적게 관찰되었다 (8% vs 35.7%, p=0.039). 결론: 우울 증상을 보이는 혈액투석 환자에서 염증 반응의 증가 및 좌심실비대, 좌심실 구혈률 감소 등 심혈관계 질환 위험 인자의 증가가 관찰되며, 향후 이들 간의 인과 관계를 밝히기 위한 후향적 연구가 필요할 것으로 생각된다. Purpose: Depression is associated with increased inflammation and cardiovascular disease. And in patients with end stage renal disease (ESRD), depression is a common problem and cardiovascular disease is the main cause of death. The aim of this study is to investigate the association of depression with various inflammatory markers and with some cardiovascular risk factors in ESRD patients on hemodialysis. Methods: 53 patients with ESRD on maintenance hemodialysis were divided into depressive symptom (BDI≥11) group and control (BDI<11) group by the 21-items Becks depression inventory (BDI). We collected patients characteristics and laboratory measurements by medical records. And then, we measured the levels of IL-10 and TNF-αaand analyzed the genotype of IL-10 and TNF-αapromoter area. Results: The levels of TNF-α, CRP and ferritin were significantly higher in depressive symptom group (p=0.001, 0.04, 0.02) and IL-10 concentration tended to be lower in depressive symptom group (p= 0.05). The prevalence of left ventricular hypertrophy was higher in depressive symptom group than in the control group (44% vs 9%, p=0.01). GG genotype known as high IL-10 producer was less common in depressive symptom group than in control group (8% vs 36%, p=0.039). Conclusion: Increased inflammation, high left ventricular hypertrophy prevalence and low ejection fraction were observed in depressive hemodialysis patients. Further prospective study is needed to clarify the role of depression in the development of inflammation and cardiovascular disease in ESRD patients.

Anti-cancer Effect of Luminacin, a Marine Microbial Extract, in Head and Neck Squamous Cell Carcinoma Progression via Autophagic Cell Death

신유섭,차현영,이복순,강성운,황혜숙,권학철,김철호,최은창 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2

Purpose The purpose of this study is to determine whether luminacin, a marine microbial extract from the Streptomyces species, has anti-tumor effects on head and neck squamous cell carcinoma (HNSCC) cell lines via autophagic cell death. Materials and Methods Inhibition of cell survival and increased cell death was measured using cell viability, colony forming, and apoptosis assays. Migration and invasion abilities of head and cancer cells were evaluated using wound healing, scattering, and invasion assays. Changes in the signal pathway related to autophagic cell death were investigated. Drug toxicity of luminacin was examined in in vitro HaCaT cells and an in vivo zebrafish model. Results Luminacin showed potent cytotoxicity in HNSCC cells in cell viability, colony forming, and fluorescence-activated cell sorting analysis. In vitro migration and invasion of HNSCC cells were attenuated by luminacin treatment. Combined with Beclin-1 and LC3B, Luminacin induced autophagic cell death in head and neck cancer cells. In addition, in a zebrafish model and human keratinocyte cell line used for toxicity testing, luminacin treatment with a cytotoxic concentration to HNSCC cells did not cause toxicity. Conclusion Taken together, these results demonstrate that luminacin induces the inhibition of growth and cancer progression via autophagic cell death in HNSCC cell lines, indicating a possible alternative chemotherapeutic approach for treatment of HNSCC.

Therapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis

김명덕,김성수,차현영,장승훈,장다영,김욱환,서해영,이재호 생화학분자생물학회 2014 Experimental and molecular medicine Vol.46 No.-

Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to be beneficial for the treatment of liver fibrosis. Here, we investigated the use of genetically engineered MSCs that overexpress hepatocyte growth factor (HGF) as a means to improve their therapeutic effect in liver fibrosis. Liver fibrosis was induced by intraperitoneal injection of dimethylnitrosamine. HGF-secreting MSCs (MSCs/HGF) were prepared by transducing MSCs with an adenovirus carrying HGF-encoding cDNA. MSCsor MSCs/HGF were injected directly into the spleen of fibrotic rats. Tissue fibrosis was assessed by histological analysis 12 days after stem cell injection. Although treatment with MSCs reduced fibrosis, treatment with MSCs/HGF produced a more significant reduction and was associated with elevated HGF levels in the portal vein. Collagen levels in the liver extract were decreased after MSC/HGF therapy, suggesting recovery from fibrosis. Furthermore, liver function was improved in animalsreceiving MSCs/HGF, indicating that MSC/HGF therapy resulted not only in reduction of liver fibrosis but also in improvement of hepatocyte function. Assessment of cell and biochemical parameters revealed that mRNA levels of the fibrogenic cytokines PDGF-bb and TGF-b1 were significantly decreased after MSC/HGF therapy. Subsequent to the decrease in collagen, expression of matrix metalloprotease-9 (MMP-9), MMP-13, MMP-14 and urokinase-type plasminogen activator was augmented following MSC/HGF, whereas tissue inhibitor of metalloprotease-1 (TIMP-1) expression was reduced. In conclusion, therapy with MSCs/HGF resulted in an improved therapeutic effect compared with MSCs alone, probably because of the anti-fibrotic activity of HGF. Thus, MSC/HGF represents a promising approach toward a cell therapy for liver fibrosis.

Elevated MRGPRX2 Levels Related to Disease Severity in Patients With Chronic Spontaneous Urticaria

Cao Thi Bich Tra,차현영,양은미,예영민 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.3

Mas-related G-protein coupled receptor-X2 (MRGPRX2), a receptor on mast cells, basophils, and eosinophils associated with immunoglobulin E (IgE)-independent degranulation, has been reported to be highly expressed on cutaneous mast cells in patients with severe chronic spontaneous urticaria (CSU). We sought to investigate whether MRGPRX2 levels in the sera from CSU patients differ from those in healthy control subjects and to evaluate the clinical utility of MRGPRX2 levels in CSU patients. Severe CSU was defined as urticaria activity score over 7 days (UAS7) ≥ 28. Serum samples from 116 (73 severe and 43 non-severe) CSU patients and 50 healthy subjects were screened for MRGPRX2 using enzyme-linked immunosorbent assay. Serum MRGPRX2 levels were significantly higher in patients with severe CSU (median [interquartile range], 16.5 [10.8–24.8]) than in healthy controls (11.7 [6.5–21.2], P = 0.036) and in non-severe CSU patients (8.7 [4.5–18.8], P = 0.002), although they did not differ between healthy subjects and non-severe CSU patients. Serum MRGPRX2 levels in CSU patients showed positive correlations with UAS7 and specific IgE against Dermatophagoides farinae in CSU subjects, whereas no correlations were observed for age, sex, urticaria duration, atopy, combined angioedema, autologous serum skin test positivity, or total IgE levels. Logistic regression analysis identified serum MRGPRX2 ≥ 12 ng/mL (odds ratio, 6.421; P = 0.002) as an independent risk factor for severe CSU, along with increased serum total IgE levels, peripheral basophil percentage, and angioedema. In conclusion, we suggest that serum MRGPRX2 could help indicate severe CSU.

미용서비스 종사자의 웰니스가 주관적 행복감에 미치는 영향

김유정 ( Yoo-jung Kim ),오별 ( Byul Oh ),이옥현 ( Ok-hyun Lee ),차우정 ( Woo-jeong Cha ),김선혜 ( Sun-hye Kim ),신현영 ( Hyun-young Shin ),진용미 ( Yong-mi Jin ) 한국미용예술경영학회 2013 미용예술경영연구 Vol.7 No.1

The purpose of this study is to encourage right recognition and to suggest efficient methods that provide willingness and energy to life. To this end, the study empirically explored with workers in beauty service on how wellness affects subjective happiness. The study results are as follows. First, From demographical characteristic of subjects, unmarried women in their twenties and thirties who are current students or graduated from college or university were most. Second, From working form of subjects, workers with these conditions were most-daily working time of 8 hours to less than 10, over one year to less than three years career in franchise beauty salon, and designer with career over three years. Third, From influences of wellness on subjective happiness, in the achievement factor compared to others and positive satisfaction factor, there was negative relationship in internal attribution factor. In negative anxiety factor and helpless factor on aging, there were negative relationship in positive emotion factor, self-development and taking medicine instruction factor. In satisfaction factor in old age, there were negative relationship in control of food, service for society, and negative emotion factor but there was partially positive factor among wellness factors. In conclusion, it is suggested that for efficient management of human resources and service in high quality in beauty industry, wellness program considering physical fatigue, mental stress, and lack of leisure life for workers in beauty service is improved.