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장기돈,조강수,이주용,박성윤,강동혁,이형호 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.5
Purpose: To evaluate predictors of the success rate for one session of shock wave lithotripsy (SWL), focusing on the relationships between pretreatment hydronephrosis grade and one-session SWL success rates. Materials and Methods: The medical records of 1824 consecutive patients who underwent an initial session of SWL for treatment of urinary stones between 2005 and 2013 were reviewed. After exclusion, 700 patients with a single, 4–20 mm diameter radiopaquecalculus were included in the study. Results: The mean maximal stone length (MSL) and skin-to-stone distance were 9.2±3.9 and 110.8±18.9 mm, respectively. The average values for mean stone density (MSD) and stone heterogeneity index (SHI) were 707.0±272.1 and 244.9±110.1, respectively. One-session success rates were 68.4, 75.0, 75.1, 54.0, and 10.5% in patients with hydronephrosis grade 0, 1, 2, 3, and 4, respectively. Patients were classified into success or failure groups based on SWL outcome. Multivariate logistic regression analyses revealed that MSL [odds ratio (OR) 0.888, 95% confidence intervals (CI): 0.841–0.934, p<0.001], MSD (OR 0.996, 95% CI: 0.995–0.997, p< 0.001), SHI (OR 1.007, 95% CI: 1.005–1.010, p<0.001), and pretreatment hydronephrosis grade (OR 0.601, 95% CI: 0.368–0.988, p= 0.043) were significantly associated with one-session success. Conclusion: Pretreatment grades 3 or 4 hydronephrosis were associated with failure of SWL in patients with a single ureteral stone. In the presence of severe hydronephrosis, especially hydronephrosis grade 4; physicians should proceed cautiously in choosingand offering SWL as the primary treatment for ureteral stone.
납에 노출된 흰쥐에서 Chlorella 섭취가 혈청내 지방성분 및 효소활성에 미치는 영향
김성조,백승화,이주돈,김운성,문광현,임효빈,허종욱,정성윤 한국식품영양학회 2001 韓國食品營養學會誌 Vol.14 No.2
This study was performed to investigate the influence of Chlorella which effected the change of Pb contents, enzyme activity and lipid compounds on the rats fed the beverage involved Pb and the different contented Chlorella added-diets for 18weeks. The rat's weight of 200ppm Pb group was decreased 6.04% and the cause of that was Pb intake. But the rat's weight of Chlorella added-diets+200ppm Pb group was increased 4.02%(p<0.01). When feeding the different(0%, 2%, 5%, 10%) Chlorella added-diets with the Pb contented beverage to the rats, we could know that the Pb contents accumulated on tissue were decreased to 20.70(0%), 12.88(2%), 14.83 (5%) and 19.56(10%), compared with the quantity of Pb taken in. Total-cholesterol, triglyceride, glucose content and AST, ALT, ALP, LDH enzyme activity in serum were the highest on 200ppm Pb group and those were decreased by the order of different (2%∼5%>10%) Chlorella contents +200ppmPb group. A significance was recognized on the level of 1%. Therefore, when rats were exposed to Pb, it was thought that the amount of Chlorella intake was adequate on content 2∼5% for reducing the lead toxicity.
Tumor enucleation for the treatment of T1 renal tumors: A systematic review and meta-analysis
정현철,강태욱,이주용,황의창,박홍준,황준일,장기돈,김영환,정재흥 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.2
Purpose: To evaluate the clinical efficacy and safety of tumor enucleation (TE) compared with partial nephrectomy (PN) for T1 renal cell carcinoma. Materials and Methods: According to protocol, we searched multiple data sources for published and unpublished randomized controlled trials and nonrandomized studies (NRSs) in any language. We performed systematic review and meta-analysis according to the Cochrane Handbook for Systematic Reviews of Interventions and rated the certainty of the evidence (CoE) using the GRADE framework. Results: We are uncertain about the effects of TE on perioperative (mean difference [MD] 3.38, 95% CI 1.52 to 5.23; I2=68%; 4 NRSs; 942 participants; very low CoE) and long-term (MD 2.31, 95% CI -1.40 to 6.01; I2=57%; 4 NRSs; 542 participants; very low CoE) residual renal function. TE may result in little to no difference in short-term residual renal function (MD 1.04, 95% CI 0.25 to 1.83; I2=0%; 2 NRSs; 256 participants; low CoE). We are uncertain about the effects of TE on cancer-specific mortality (risk ratio [RR] 0.90, 95% CI: 0.11 to 7.28; I2=0%; 2 NRSs; 551 participants; very low CoE) and major adverse events (RR 0.48, 95% CI: 0.30 to 0.79; I2=0%; 10 NRS; 2,360 participants; very low CoE). Conclusions: While TE appears to have similar effects on short term postoperative residual renal function, there were uncertainties on mortality and major adverse events. However, we need rigorous RCTs to elucidate the effects of TE as the evidence stems mostly from NRSs.
서일원,류춘선,이주돈,이영환,변광의 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2
Biogenic amines can be formed and degraded either as the result of endogenous amino acid decarboxylase activity in raw materials or by the growth of decarboxylase-positive microorgannisms under conditions favorable to enzyme activity. Three biogenic amines(Tryptamine, Histamine, Tyramine) were intensively investigated by the HPLC during Kimchi fermentation at 5℃. The patterns of microfloral changes in lactic acid bacterial group, Leuconostoc, Streptococcus and Lactobacillus, were similar to the typical low-temperature fermentation. The population of microbial growth were high after 10 days and gradually decreased. The levels of Tyramine were lowered(10mg/kg) during this mid-periods(8∼16 days) but very high in initial-(15mg/kg) and final-periods (30mg/kg), in which the total acidity ranged between 0.2∼0.35% and 0.4∼0.6%, while the acidity in mid-periods revealed 0.35∼0.4% beginning the initial ripening period. Leuconostoc was highly increased in number in mid-period but slightly declined as the acidity increased, whereas Streptococcus was highly distributed in initial-period and Lactobacillus in final-period. The levels of Tryptamine and Histamine were relatively low throughout the whole fermentation period, but the profile of Tryptamine level was very similar to the case of Tyramine. Histamine was maintained at a certain level after mid-period of fermentation.
한국인의 상용 식품중 무기질함량과 분석방법 비교연구 : 1. 나트륨 1. Sodium
문현경,정해랑,송범호,이주돈,김희재,황성희 한국식품위생안전성학회 1991 한국식품위생안전성학회지 Vol.6 No.3
In order to observe the Na contents, Korean common foods, especially processed foods were analyzed by Atomic Absorption Spectrophotometer. 1. The Na contents of instant noodle (ramen) was 400-900 mg/100 g and Na contents of their soup powder was 10000-16000 mg/100 g. 2. The Na contents of corns snd beans was very low but their processed foods, corn flake and soybean milk, had relatively high Ns contents. 3. The Na contents of meats was 40-60 mg/100 g but the Na contents of meats products was 700-900 mg/ 100 g. 4. The Na contents of flavoring salt was 12000-38000 mg/100 g, those of soybean products was 3000-6000 mg/100 g, and that of seasoning MSG was 8000-17000 mg/100 g. 5. There was no statistical difference between the results of wet ash method and dry ash method in the Na contents of all food groups.
결명자 첨가식이가 흰쥐의 체내 카드뮴 축적에 미치는 영향
김성조,백승화,허종욱,김운성,이주돈,강경원,박성혜,한종현,정성윤,이승현 동아시아식생활학회 2002 동아시아식생활학회지 Vol.12 No.6
The purpose of this study is to investigate the effect of raw Cassia tora 1., powder added-diets on reducing cadmium accumulatin in rats. The experimental animals were Sprague-Dawley family(♂. 4 weeks) which was classified into normal group ('N, compared group CS, Cd-added group C1 and groups C2, C3, C4 in which 0.5, 1.0 and 1.5% of the Cassia tora L. powder are added. respectively. The growth rate and food efficiency ratio, and the amounts of accumulated cadmium in rats for 8 weeks were measured and analyzed.<br/> The results are as follows;<br/> 1. The rates of weight gain decreased in the order of C3>C2>C4>Cn>Cs>C1 groups. and C1 group to which only cadmium water had been fed was the lowest among them. The correlation between groups C1 and C3 was significantly different at the 1% level.<br/> 2. Food efficiency ratio(FER) decreased in the order of C3>C2>Cs>Cn>C4>C1. and the FERs of C3, C2, Cs, Cn and C4 are greater than that of C1 by 22.87, 19.89, 18.54, 14.20 and 13.17% respectively.<br/> 3. As for the Cassia tora L. powder-added groups, the amounts of cadimum accumulated in organs and tissues, that is, the brain, heart, spleen, liver, lungs, testicles, kindey, femoral muscale and leg bones were 0.45±0.04 to 0.83±0.04, 1.68±0.02 to 2.16±0.02, 3.26±0.05 to 4.62±0.27, 37.82±0.09 to 47.71±0.73, 1.07±0.10 to 1.66±0.04, 1.04±0.06 to 1.24±0.08, 36.79±0.20 to 39.61±0.53, 0.87±0.02 to 1.00±0.02 and 0.65±0.17 to 1.27±0.06 ㎍/g respectively.<br/> 4. The accumulated Cd content for C4 was the lowest among Cassia tora L. powder-added groups. When the results for C4 are compared with those for C1, it is observed that each cadmium content accumulated in the brain, heart, spleen, liver, lungs, testicles, kidney, femoral muscle and leg bones is dropped by 49.03, 22.56, 36.02, 35.75, 41.75, 36.20, 37.00, 22.77 and 56.67%, respectively, On the other hand, the accumulated Cd contest increased in the order of brain < leg bones < femoral muscle > testicles < lungs < heart < spleen < kidney < liver.<br/> 5. The average Cd accumulation rate in organs and tissues relative to the total Cd intake was 7.14% for C1, while they are 4.91, 4.81 and 4.50% for Cassia tora L. powder-added groups C2, C3 and C4, respectively.<br/> 6. The Cd content accumulated in the hair for C1 was the highest, and those for Cassia tora L. powder-added groups gradually increased until 6 weeks and decreased after that. 7. The Cd content accumulated in the feces for C4 was the highest, and those for the groups other than C3 and C4 gradually decreased until 6 weeks and increased after that.