Moire 영상을 이용한 근골격계 질환의 한의학적 진단에 관한 연구

이은경,유승현,이수경,강성호,한종민,정명수,천은주,송용선,이기남,Lee Eun-Kyoung,Yu Seung-Hyun,Lee Su-Kyung,Kang Sung-Ho,Han Jong-Min,Chong Myong-Soo,Chun Eun-Joo,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2000 대한예방한의학회지 Vol.4 No.2

This research has conducted studies on an Oriental medicine-based method of diagnosing of occupational musculoskeletal system diseases. This researcher has searched through existing relevant medical literature. Also, this researcher has worked on a moire topography using moire topography. In this course, this researcher has reached the following conclusion in relation to the possibility of using a moire topography as a diagnosing device of musculoskeletal system diseases under Oriental medicine . 1 The Western medicine outlines its criteria of screening occupational musculoskeletal system diseases as follows A. The occupational musculoskeletal diseases must clearly include one or more of the subjective symptoms characterized by pain, hypoesthesia dysaesthesia, anaesthesia. etc . B, There should be clinically admitted objective observations and diagnosis outlining that the disease concerned shows symptoms such as tenderness, induration. and edema that can appear with occupational musculoskeletal system diseases. dyscinesia should be admitted with the disease concerned, or there should be observations and diagnosis outlining that abnormality exists in electric muscular or nervous diagnosis and examination . C. It should be admitted that prior to the occurrence of symptoms or observations and diagnosis on musculoskeletal system-related diseases, a patient has been engaged in works with conditions requiring improper work posture or work movement. That is, this is an approach whereby they see abnormality in the musculoskeletal system come from material and structural defect, and adjust and control abnormality in the musculoskeletal system and secreta . 2. The Oriental medicines sees that a patient develops the pain of occupational musculoskeletal diseases as he cannot properly activate the flow of his life force and blood thus not only causing formation of lumps in the body and blocking the flow of life force and blood in some parts of the body. Hence, The Oriental medicine focuses on resolving the cause of weakening the flow of life force and blood, instead of taking material approach of correcting structural abnormality Furthermore , Oriental medicine sees that when muscle tension builds up, this presses blood vessels and nerves passing by, triggering circulation dyscrasia and neurological reaction and thus leading to lesion. Thus, instead of taking skeletal or neurophysiological approach. it seeks to fundamentally resolve the cause of the flow of the life force and blood in muscles not being activated. As a result Oriental medicine attributes the main cause of musculoskeletal system diseases to muscle tension and its build-up that stem from an individual's long formed chronicle habit and work environment. This approach considers not only the social structure aspect including companies owners and work environment that the existing methods have looked at, but also individual workers' responsibility and their environmental factors. Hence, this is a step forward method. 3 The diagnosis of musculoskeletal diseases under Oriental medicine is characterized by the fact that an Oriental medicine doctor uses not only photos taken by himself, but also various detection devices to gather information and pass comprehensive judgment on it. Thus, it is the core of diagnosis under Oriental medicine to develop diagnosing devices matching the characteristics of information to be induced and to interpret information so induced from the views of Oriental medicine. Diagnosis using diagnosing devices values the whole state of a patient and formal abnormality alike, and the whole balance and muscular state of a patient serves as the basis of diagnosis. Hence, this method, instead of depending on the information gathered from devices under Western medicine, requires devices that provide information on the whole state of a patient in addition to the local abnormality information that X-ray. CT, etc., can offer. This method sees muscle as the central par

우즈베키스탄 한방병원에서 진행한 한의약 비만관리 프로그램의 효과

이은경,정명수,유영진,권동현,이준석,장보형,윤진원,박유리,박해모,이선동,고성규,Lee, Eun-Kyoung,Chong, Myongsoo,Ryu, Young Jin,Kwon, Donghyun,Lee, Joonseok,Jang, Bo-Hyoung,Yun, Jin Won,Park, Yu Lee,Park, Haemo,Lee, Sundong,Ko, Seong-Gyu 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.2

Objective : As part of the Korean Medicine Official Development Assistance(ODA) and Public Health Project, we implemented a obesity management program(OMP) using Korean medicine in Uzbekistan and its follow-up study was conducted to evaluate the effectiveness of the program. Method : We recruited the participants of whose Body Mass Index(BMI) were over $25kg/m^2$ and who agreed to participate in the program at the South Korea-Uzbekistan Friendship Korean Medical Hospital in Uzbekistan. The program consisted of auricular acupuncture, functional food, and education program on diet and exercise. It was provided once a week during 7-week period. Anthropometric measurements and blood test measuring total cholesterol, triglyceride, and glucose were performed at the baseline, the end of the program, and 10-month follow-up. At the end of the program and the follow-up, survey on satisfaction and self-evaluation of the effectiveness of the program was additionally conducted. Results : 43 out of 78 participants completed the program and were included in the analysis. The analysis of the main outcomes showed that there were significant decreases in anthropometric measurements such as body weight, waist circumference, body mass index (BMI) and body fat content as well as blood test including triglycerides, total cholesterol and blood glucose levels. In the follow-up study, 24 subjects participated and 19 subjects (79.1%) reported that they succeeded in weight control. Furthermore, many participants reported that they maintained healthy lifestyles like healthy diet and regular exercise. The satisfaction with the program was also relatively high, and the education program was selected as the most motivating intervention for weight control. The outcomes such as body weight, BMI, body fat content, and blood glucose level were maintained to be at the decreased level; however, waist circumference, total cholesterol and triglycerides levels either returned back to the baseline level or were elevated to the level higher than the baseline. Conclusion : This study suggests that the OMP using Korean medicine may contribute to weight control of obese population in Uzbekistan. It is meaningful in that the study shows the possibility of implementing health promotion programs using Korean medicine in other countries with different cultures. In the future, more efforts to evaluate the effectiveness of the programs using rigorous methodologies and utilize the effective programs in ODA project will be needed.

산업보건에의 한의학적 참여방안에 관한 연구

이은경,정명수,천은주,김삼태,강성호,이수경,한종민,김성천,유택수,정재열,송용선,이기남,Lee E.K.,Chong M.S.,Chun E.J.,Kim S.T.,Kang S.H.,Lee S.K.,Han J.M.,Kim S.C.,Yu T.S.,Jeung J.Y.,Song Y.S.,Lee K.N. 대한예방한의학회 1999 대한예방한의학회지 Vol.3 No.2

Oriental Medical Service established foundation that Oriental medical clinic can take part in industrial health service by being specified industrial calamity medical treatment organ, but research which develope program that Oriental Medical Service approach on the occupational disease and industrial health only dealt in the Western Medical System was insufficient. So we studied on theoretical foundation and basic bearing about .program of oriental medical health examination in the workplace, it is based on explanation and assessment reformed by western medicine. We reached the conclusion as follows, 1. We must reconsider the concept that mind of Oriental medicine is preventive medicine, and assess positively result of social medicine. 2. Importance of industrial health is being enlarged in the category of health care. 3. Western medical health in including industrial health have faced much problems at this time, we can search by alternative proposal grafting on Oriental Medicine. 4. Oriental medical participation in the industrial health have various benefits at side satisfaction of workers, effect of prevention, efficiency of cost, and increasing rate of medical treatment and return to workplace of workers with industrial calamity. 5. We must consider Oriental Medical Health Examination as one way of health management program of workers, not as formality. 6. The advantage of Oriental Medical Health Examination can increase ability of individual health management in preventive medicine and the production in workers' health management.

외배엽 이형성증 어린이의 구강 회복: 증례보고

이은경,김지연,김신,정태성,Lee, Eungyung,Kim, Jiyeon,Kim, Shin,Jeong, Taesung 대한장애인치과학회 2017 International Journal of Disability and Oral Healt Vol.13 No.1

본 증례에서와 같이 외배엽 이형성증 환자에서는 획일화된 치료 방법은 없다. 술자 입장에서는 기능적 또는 형태적으로 완벽한 장치가 아니라 할지라도, 외배엽 이형성증의 무치악 환아에게는 심미적 요구가 만족됨으로써 자존감을 드높일 수 있는 치료가 될 수 있다. 특히 외배엽 이형성증 환아는 어린 나이에 의치 장착을 시작하기 때문에 환자의 나이와 구강상태, 심미적인 요구 수준, 저작 방법 등 여러가지를 고려한 개별적 맞춤화 과정을 통해 치료방법을 찾는 것이 중요하다. 또한 환자의 성장에 맞춰 장치를 교환해주며 타 과와의 활발한 교류로 최선의 치료를 해주는 것이 추천되며, 술자와 환자 및 환자 보호자간의 충분한 대화를 통해 치료 방법을 신중하게 결정하는 것이 좋다. Ectodermal Dysplasia is a genetic disorder caused by the abnormal development of two or more structures derived from the ectodermal layer. As an aspect in dentistry, ectodermal dysplasia is characterized by hypodontia, conical or peg-shaped teeth, reduced salivary secretion and decreased vertical dimension. These unfavorable oral conditions make children to have difficulties with mastication, esthetics, and even in social activities. This case report presents an alternative oral rehabilitation treatment of a 4-year-old boy with ectodermal dysplasia. A removable space maintainer with artificial teeth in maxillary arch was delivered according to the initial treatment plan. However, the child failed to adapt the appliance because of his masticatory habit. Then a fixed-type space maintainer was delivered on the patient's esthetic demand and it restored function, esthetics and self-esteem of the patient. The treatment described here suggests that individually customized considerations are essential for the oral rehabilitation of a patient with ectodermal dysplasia.

집단 약동학 모형에 대한 통계학적 고찰

이은경,Lee, Eun-Kyung 한국통계학회 2010 응용통계연구 Vol.23 No.3

약동학 모형은 약동학 모수들의 복잡한 비선형형태의 함수로 복잡한 미분방정식의 형태로 나타나기도 한다. 집단 약동학은 약동학 모형에서 약동학 모수들의 개인 간 차이를 나타내기 위해 이를 랜덤효과로 가정하므로 비선형 혼합 효과 모형이 된다. 본 논문에서는 임상약리학에서 약동학적 특징을 설명하기 위해 사용하는 집단 약동학 모형에 대한 통계학적 고찰을 해 본다. 또한 실제 임상자료를 이용하여 집단 약동학 모형을 적용하여 분석해 봄으로써 통계적 의미를 살펴본다. The Pharmacokinetic model is a complex nonlinear model with pharmacokinetic parameters that is some-times represented by a complex form of differential equations. A population pharmacokinetic model adds individual variability using the random effects to the pharmacokinetic model. It amounts to the nonlinear mixed effect model. This paper, reviews the population pharmacokinetic model from a statistical viewpoint; in addition, a population pharmacokinetic model is also applied to the real clinical data along with a review of the statistical meaning of this model.

브라운다리 근사를 통한 확산모형의 우도 근사법

이은경,심송용,이윤동,Lee, Eun-kyung,Sim, Songyong,Lee, Yoon Dong 한국통계학회 2015 응용통계연구 Vol.28 No.5

확산모형은 입자의 운동현상과 금융자산의 미시적 가격변동을 설명하기 위하여 사용되는 수리적 모형이다. 확산모형의 추정방법에 관한 논의는 다양한 분야에서 이루어져 왔다. 통계학적 관점에서 우도적 방법에 기반한 확산모형의 추정방법을 개발하려는 시도가 계속되어 왔다. 이산시간 간격으로 관측된 자료를 이용하여 확산모형을 추정할 때 최대우도 추정법을 적용하기 위해서는 확산모형에 대한 전이확률 밀도함수를 구해야 한다. 본 연구에서는 확산모형의 전이확률밀도를 근사하기 위하여, 정규분포를 따르는 확률변수를 이용하여 브라운다리 확률과정에 대한 경로적분을 대체하는 방법을 제안하고, 그 수치적 성질을 다른 방법들과 비교한다. Diffusion is a mathematical tool to explain the fluctuation of financial assets and the movement of particles in a micro time scale. There are ongoing statistical trials to develop an estimation method for diffusion models based on likelihood. When we estimate diffusion models by applying the maximum likelihood estimation method on data observed at discrete time points, we need to know the transition density of the diffusion. In order to approximate the transition densities of diffusion models, we suggests the method to approximate the path integral of the random process with normal random variables, and compare the numerical properties of the method with other approximation methods.

얼랑분포의 축차확률비검정과 관련된 적분 방정식의 해

이은경,나명환,이윤동,Lee Eun-Kyung,Na Myung Hwan,Lee Yoon-Dong 한국통계학회 2005 응용통계연구 Vol.18 No.1

본 연구에서는 얼랑(Erlang)분포의 규모모수에 대 한 축차확률비검정(SPRT)과 관련된 적분방정식의 정학한 해를 구하는 법을 살펴보기로 한다. 축차확률비검정에서 그 평균 표본 개수, 그리고 1종 오류 확률과 2종 오류 확률은 프레돔 형태의 적분 방정식으로 나타나게 된다. 이러한 적분 방정식은 보통 가우시안 쿼드러쳐(qudrature)를 이용하여 근사적으로 그 해를 구하는 것이 일반적이다. 얼랑분포의 경우 이러한 적분방정식의 해가 정확하게 구할 수 있음이 알려져 있다. 본 연구에서는 얼랑분포에서 그 해를 구하는 구체적 방법을 살펴보기로 한다. In this paper, we propose a method to evaluate the solutions of the renewal equations related to SPRT for Erlang distribution. In SPRT, the Average Sample Number(ASN) and type I or type II error probabilities are shown in Fredholm type integral equations. The integral equations are generally solved by the approximation method using Gaussian quadrature. For Erlang distribution, it has been known that the exact solutions of the equations exist. We propose the algorithm to solve the equations.

단일항 안장점근사법에 의한 확산모형의 추정

이은경,이윤동,최영수,Lee, Eun-Kyung,Lee, Yoon-Dong,Choi, Young-Soo 한국통계학회 2010 Communications for statistical applications and me Vol.17 No.3

최근 확산모형의 추정을 위한 매우 다양한 방법론들이 제시되고 연구 되어 왔다. 본 연구에서는 제안된 확산모형의 추정 방법 중에서, 안장점근사법을 이용한 확산모형의 모수 추정방법에 대하여 살펴보게 되고, 가장 단순한 형태의 안장점근사법인 단일항 안장점근사법의 사용을 제안하게 된다. 단일항 안장점근사법은 오일러근사법과 마찬가지로 계산속도가 빠르고, 다양한 모형에 적용이 가능하면서도 최대우도추정량과 마찬가지로 성능이 우수한 특성을 갖고 있음을 살펴보게 된다. OU 확산모형을 대상으로 한 시뮬레이션 연구를 통하여 단일항 안장점근사를 이용한 추정량과 다른 추정량들과의 성질을 비교한다. Recently various methods were suggested and reviewed for estimating diffusion processes. Out of suggested estimation method, we mainly concerns on the estimation method using saddlepoint approximation method, and we suggest a term saddlepoint approximation(ASP) method which is the simplest saddlepoint approximation method. We will show that ASP method provides fast estimator as much as Euler approximation method(EAM) in computing, and the estimator also has good statistical properties comparable to the maximum likelihood estimator(MLE). By simulation study we compare the properties of ASP estimator with MLE and EAM, for Ornstein-Uhlenbeck diffusion processes.

확산모형 전이확률밀도의 급수근사법과 그 계수

이은경,최영수,이윤동,Lee, Eun-Kyung,Choi, Young-Soo,Lee, Yoon-Dong 한국통계학회 2010 응용통계연구 Vol.23 No.2

확산모형은 최근 금융현상의 연구 등에 자주 사용되는 모형이다. 본 연구에서는 확산모형의 추정에서 중요한 역할을 하는 전이확률밀도를 구하는 방법과 이를 급수전개 방식으로 근사하는 기존 연구들을 검토하여 보고, 급수전개법에서의 계수를 손쉽게 구할 수 있는 방법을 고려하게 된다. 급수전개법 계산과정에서 중요한 허밋다항식에 딘킨연산자를 반복적으로 적용하는 과정을 손쉽게 계산할 수 있는 알고리즘을 제안한다. Modelling financial phenomena with diffusion processes is frequently used technique. This study reviews the earlier researches on the approximation problem of transition densities of diffusion processes, which takes important roles in estimating diffusion processes, and consider the method to obtain the coefficients of series efficiently, in series approximation method of transition densities. We developed a new efficient algorithm to compute the coefficients which are represented by repeated Dynkin operator on Hermite polynomial.

집단 약동학 모형을 위한 모형 진단과 적합도 검정에 대한 고찰

이은경,Lee, Eun-Kyung 한국통계학회 2012 응용통계연구 Vol.25 No.1

집단 약동학 모형 추정의 결과는 환자에게 투약학 약물의 용량결정에 직접적 영향을 미치므로 추정 모형에 대한 타당도와 적합도의 검증이 중요하다. 본 논문에서는 다양한 집단 약동학 모형 적합도 검증을 위한 방법들을 비교, 분석하고 실제 임상자료를 이용하여 최적의 집단 약동학 모형을 찾고 이에 대하여 다양한 타당도, 적합도 검정을 실시하여 모형을 진단해 본다. The result of the analysis of a population pharmacokinetic model can directly influence the decision of the dose level applied to the targeted patients. Therefore the validation procedure of the final model is very important in this area. This paper reviews the validation methods of population pharmacokinetic models from a statistical viewpoint. In addition, the whole procedure of the analysis of population pharmacokinetics, from the base model to the final model (that includes various validation procedures for the final model) is tested with real clinical data.