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      • KCI등재

        대식세포의 oxLDL 생성에 미치는 강활속단탕의 영향

        고성규,정용수,선승호,Ko Seong-Gyu,Jeong Yong-Su,Sun Seung-Ho 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.2

        Objective : As a link in chain of research to confirm the oriental medical prescription which has the anti-atherosclerosis effects, this research evaluated the effects on the macrophage-related factors by using KanghwalSokdantang(KS). Methods : In order to perform this research, we have evaluated the effects on the oxLDL formation from the macrophages, the nitric oxide formation, and the oxidation of macrophages. Thus, with this evaluation, we have investigated the applicapability on the artherosclerosis. Results : KanghwalSokdantang has showed a noticeable reduction of protein oxidation in the process of oxLDL formation, has remarkably restrained phospholipid peroxidation, an index to estimated the phospholipid oxidation and reduction that are formed in the process of macrophage's oxLDL formation, and has increased the nitrite concentration noticeably in the LDL-dealing macrophages. By increasing the survival rate of macrophages, KanghwalSokdantang has restrained the cellular damages. KanghwalSokdantang is ineffective on the LDH outflow from damaged cells. $1{\mu}g/ml$ KanghwalSokdantang sample has increased acid phosphatase activity remarkably. Conclusion : KanghwalSokdantang has the possibility to be used in the prevention and treatment of atherosclerosis, which is formed by the oxLDL formation of macrophages.

      • KCI등재후보
      • KCI등재

        비주얼 씽킹을 활용한‘우리 몸의 구조와 기능’수업이 초등학생의 자기주도학습, 창의적 문제해결력 및 과학적 태도에 미치는 효과

        고성규,홍승호 한국생물교육학회 2021 생물교육 Vol.49 No.4

        This study developed a ‘structure and function of our body’ program using visual thinking and applied it to analyze the effect on elementary school students’ self- directed learning skills, creative problem solving ability and scientific attitude. The results of the program using visual thinking to sixth-grade students are as follows. First, the ‘structure and function of our body’ program using visual thinking is effective in improving the sixth graders’ self- directed learning skills. In the sub-elements, the experimental group was significantly improved in intrinsic motivation, openness, and autonomy. We inferred that the intrinsic motivation has increased because they worked on learning in an acceptable atmosphere by organizing the contents the topic through drawing activities. In the process of sharing each other's drawing outcomes, they acknowledged each other's opinions and openly accepted others' opinions. And autonomy was improved in the process of learners planning and organizing their own learning. Second, there was no significant difference in understanding, diffusion, criticism, and motivation in the sub-elements, although it had a significant impact on improving the total score of their creative problem solving ability. Third, the program had a significant impact on improving scientific attitude. Cooperation increased in the process of communicating and discussing what they organized on their own. Therefore, the program using visual thinking learning strategies demonstrates that the approach might be effective in improving elementary school students' self-directed learning skills, creative problem solving ability, and scientific attitude.

      • KCI등재

        허혈경계부의 감소를 보인 뇌졸중 환자에 대한 증례보고

        고성규,Ko, Seong-Gyu 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.2

        I have treated one ischemic stroke patient in acute stage with Seonghyangjeonggi-san, and observed remarkable reduction of the size ischemic portion in brain CT, notable improved motor power of patient. So I report this case of stroke patint. The ischemic penumbra, simply stated, is the part of the brain that is sandwiched brain regions committed to die and those that receive enough blood to communicate. Therefore, it is ischemic brain tissue that has just enough to communicte and function. The life expectancy of the penumbrais short. Although the penumbra is an elegant concept, in practice, it has been a difficult one to exploit. Up to now, a lot of research worker have tried to develop the method to make a accurate diagnosis. and then we know that PET and Xenon CT is available for the diagnosis for the ischemic penumbra. But those are not perfect to diagnose of penumbra. The case in my case report was confirmed as ischemic penumbra with CT. I know that CT is not prefect to diagnose penumbra, but I just want to raise the interest in penumbra of oriental medicine researcher and my report will be benificial to the penumbra researcher.

      • KCI등재

        뇌졸중환자의 연하장애에 관한 임상적 연구 (1)

        고성규,Ko, Seong-Gyu 대한한방내과학회 1997 大韓韓方內科學會誌 Vol.18 No.1

        Dysphagia generally has a good prognosis after stroke involving cerebral hemisphere or braibstem, but it could have serious consquence with dehydration leading to haemoconcentration, renal failure and aspiration leading to pneumonia. This preliminary report was written for main report. The main report will be written to give an objective guide post of management and treatment in stroke patient with dysphagia. The objective guide posts were follows as, 1. Close examination for relationship between dysphagia in stroke patients and other neurological deficits 2. Influence on the prognosis of dysphagia in stroke patients by the grade of dysphagia at admission time. 3. The realtionship between the site and size of brain damage and the grade and prognosis of dysphagia 4. The frequency and prognosis of dysphagia in stroke patients according to sex and age. 5. The rate and speed of recovery with dysphagia after stroke. 6. Frequency and process of complications, aspiration pneumonia, weight loss, sore, in stroke patient group with dysphagia.

      • KCI등재후보

        한의과대학의 예방(사회)의학 관련 교과목의 교육과정 및 표준화방안

        고성규,신용철,Ko, Seong-Gyu,Shin, Yong-Cheol 대한예방한의학회 2008 대한예방한의학회지 Vol.12 No.2

        The rapid change of the health and medical environment and the globalization of medicine has driven doctors to converge and analyse of new and up-to-date medical information and decide to what to make decision for diagnosis and treatments in clinical practice. Medical environment goes with the changes with social environment such as rapid increase of aging population, changes of disease pattern, formation of new area of experts except doctors, government intervention for the medical system, medical insurance of the charges of medical treatment, a increased desire for human rights. These trends should be adopted rapidly to the education system for the students of medical school. The learning objectives of the preventive medicine was developed in 1995 and underwent necessary revision of the contents to create the first revision in 2006. However, the required educational contents of health promotion and disease prevention have been changed by the new trends of medical education such as PBL and integrated curriculum and the 2006 revision does not satisfy these needs. We formed a task force which surveyed all the Western and Traditional Korean medical colleges to describe the state of preventive medicine education in Korea, analyzed the changing education demand according to the change of health environment and quantitatively measured the validity and usefulness of each learning objective in the previous curriculum. With these results, for the good education for preventive medicine, each Traditional Korean medicine schools need more preventive medicine faculties and teaching assistants and opening of some required subjects such as Yangsaeng and Qigong. And future studies of the learning process and ongoing development of teaching materials according to the new learning objectives should be undertaken with persistence in order to ensure the progress of preventive medicine education.

      • KCI등재

        승마체험자의 여가제약이 제약-협상과 행동의도에 미치는 영향 연구

        고성규,김미영,이충기 한국호텔관광학회 2019 호텔관광연구 Vol.21 No.4

        The purpose of this study is to investigate the relationships among leisure constraint, constraintnegotiation and behavioral intention using structural equation modeling in the context of horse riding participants. To this end onsite surveys were conducted for those who experienced horse riding in Seoul, Gyeonggi-do, Daegu, Gyeongsangbuk-do, and Jeju. 700 questionnaires were distributed to horse riding participants, but 490 questionnaires were finally used for empirical analysis. In this study leisure constraints of horse riding participants were classified into intrapersonal, interpersonal, and structural constraints. Constraint-negotiation consisted of companion, exploration, and systemicity. The results of this study reveal that all three leisure constraints factors of horse riding participants had positive impacts on three constraint-negotiation factors positively. All three constraint-negotiation factors were also found to positively influence behavioral intention of horse riding. In particular, all three constraint-negotiation factors played important mediating roles between three leisure constraints factors and behavioral intention. The findings of this study suggest that leisure constraint-negotiation factors play an important role in predicting behavioral intention of horse riding via leisure constraints. Theoretical and practical implications were provided in conclusion section. 본 연구의 목적은 승마체험자를 대상으로 여가제약과 제약-협상 및 행동의도 간의 영향관계를 구조 방정식 모델을 이용하여 분석하고자 한다. 이를 위하여 서울, 경기도, 대구, 경상북도, 제주도에서 승마체험자를대상으로 현장조사를 실시하였다. 승마체험자를 대상으로 700부의 설문지가 배포되었으며, 최종 490부를실증분석에 이용하였다. 본 연구에서는 승마체험자의 여가제약 요인을 내재적(intrapersonal), 대인적(interpersonal), 구조적(structural)으로 분류하였으며, 제약-협상 요인은 동반성(companion), 탐색성(exploration), 체계성(systemicity)으로 분류하였다. 분석결과 승마체험의 3가지 제약(내재적, 대인적, 구조적)은 모두 승마체험 제약협상에 긍정적인 영향을 미치는 것으로 나타났으며, 승마체험 제약협상의 3가지요인(동반성, 탐색성, 체계성)은 모두 행동의도에 긍정적인 영향을 미치는 것으로 나타났다. 또한, 승마체험제약협상의 3가지 요인(동반성, 탐색성, 체계성)은 승마체험의 3가지 제약(내재적, 대인적, 구조적)과 행동의도 간의 관계에서 매개역할을 수행하는 것으로 나타났다. 이러한 연구결과는 승마체험에 있어서 제약-협상 요인이 여가제약으로부터 승마체험 행동의도를 예측하는데 중요한 역할을 한다는 사실을 시사해준다. 결론에서는 본 연구의 분석결과를 토대로 학술적, 실무적 시사점을 제시하였다.

      • KCI등재

        뇌졸중(腦卒中) 전조증상(前兆症狀)으로서의 현훈(眩暈)에 대한 설문조사분석(設問調査分析)

        고성규,용형순,Ko, Sung-Gyu,Yong, Hyung-Soon 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.1

        Objective : This study has been made to analysis of clinical type of vertigo prodromic Cerebral Vascular Disease in stroke patients who admitted to sangji oriental hospital department of circulatoty internal medicine in the period from July. 1999 to October 1999. Methods : A Questionaire was done after explanationin details to patients and agreement of patients. The inquire was done as follows. Sex and age, risk factor of stroke, type of stroke, existence of vertigo last three years before stroke attack, the beginning age of vertigo and period of prevalence, frequency, continuance time of vertigo, predilection season and time, factor of causing vertigo, accompanying symptoms of vertigo, severity of vertigo. Result and Conclusion : The existence of Rotation sense(Rotation group and non-Rotation group) and the type of Stroke is no difference significantly but the Rotation vertigo group and non-Rotation vertigo group is difference significantly in distribution. The sixties in age of vertigo attack, previous vertigo before 3 year Stroke attack, irregular in predilection season of vertigo, have a high frequency significantly in distribution and previous period of vertigo has no significantly difference in distribution. One or two per a month in frequency of vertigo, below 5 minute in continuance time of vertigo, irregular in predilection time of vertigo, stand up and sit down in causing vertigo position have a high frequency significantly in distribution.

      • KCI등재

        인공신경망을 활용한 동착강도 예측

        고성규,최창호,신휴성 한국지반공학회 2011 한국지반공학회논문집 Vol.27 No.11

        Adfreeze bond strength is a primary design parameter, which determines bearing capacity of pile foundation in frozen ground. It is reported that adfreeze bond strength is influenced by various affecting factors like freezing temperature, confining pressure, characteristics of pile surface, soil type, etc. However, several limited researches have been performed to obtain adfreeze bond strength, for past studies considered only few affecting factors such as freezing temperature and type of pile structures. Therefore, there exists a limitation of estimating the design parameter of pile foundation with various factors in frozen ground. In this study, artificial neural network algorithm was involved to predict adfreeze bond strength with various affecting factors. From past five studies, 137 data for various experimental conditions were collected. It was divided by 100 training data and 37 testing data in random manner. Based on the analysis result, it was found that it is necessary to consider various affecting factors for the prediction of adfreeze bond strength and the prediction with artificial neural network algorithm provides enough reliability. In addition, the result of parametric study showed that temperature and pile type are primary affecting factors for adfreeze bond strength. And it was also shown that vertical stress influences only certain temperature zone, and various soil types and loading speeds might cause the change of evolution trend for adfreeze bond strength. 동착강도는 동토지반 말뚝기초 설계시 지지력을 결정하는 주요 설계정수이다. 동착강도는 동결온도, 구속응력, 말뚝표면 특성, 토사종류 등 다양한 인자들에 의해 동시다발적인 영향을 받는 것으로 보고되고 있다. 하지만 동착강도에 대한 연구는 소수의 인자들만 반영할 수 있는 실험연구를 중심으로 수행되어온 경향이 있으며, 설계정수로서 동착강도를 산정하기 위한 방법들은 동결온도, 말뚝재료 등의 주요 인자들만을 고려할 수 있는 한계가 있어 왔다. 본 연구는 인공신경망 이론을 동착강도 산정에 활용함으로서 다양한 영향인자 조건에서 동착강도를 예측할 수 있는 방안을 모색하기 위한 목적으로 수행되었다. 인공신경망 학습을 위하여 총 5종류의 연구사례로부터 137개의 자료를 수집하였으며, 그 중 100개를 학습자료로, 37개를 실증자료로 구분하였다. 연구결과 단계적 인공신경망 학습을 통하여 동착강도 산정 시 다양한 영향인자를 다차원적으로 고려하여 예측하는 방법이 병행되어야 할 필요성을 확인하였으며, 5개 영향인자를 동시에 고려하여 동착강도를 예측할 수 있는 신뢰성 높은 학습결과를 도출 및 검증하였다. 또한, 매개변수 연구결과 동착강도는 동결온도와 말뚝재료의 변화에 가장 민감하게 반응하는 것으로 나타났고 수직응력에 의한 영향은 일부 온도구간에서만 뚜렷하게 나타나며 토사종류와 재하속도의 변화에 따라 동착강도가 증가하는 경향이 변화하는 특성을 나타내었다.

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