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GST의 Sprague-Dawley Rat를 이용한 단회 경구투여 독성시험 및 4주 반복 경구투여 용량결정시험
한종민,홍지희,이혜영,정인철,진미림,김승형,박양춘,Han, Jong-Min,Hong, Jee-Hee,Lee, Hye-Yeong,Jung, In-Chul,Jin, Mi-Rim,Kim, Seong-Hyeong,Park, Yang-Chun 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.4
Objectives : This study aimed to evaluate the single oral dose toxicity and four weeks repeated dose determination of Gamisasangja-tang (GST) in male and female Sprague-Dawley rats. Methods : In the single oral toxicity study, rats were orally administered a single dose of 0 and 5,000 mg/kg GST. There were 5 rats in each group. After single administration, mortality, clinical signs, body weight changes and gross pathological finding were observed for 14 days. In the 4-weeks repeated oral dose determination study, rats were orally administered a single dose of 0, 1,250, 2,500 or 5,000 mg/kg GST. There were 5 rats in each group. Mortality, clinical signs, body weight changes, food consumption and gross pathological finding were observed for 28 days. Organ weight, clinical chemistry and hematology were tested after 28 days. Results : There was no mortality in either of the two studies. There were also no significant differences in clinical sign, body weight, organ weights, hematological or serum chemical parameters between the GST and control groups. Conclusions : The results obtained in this study suggest that the 50% lethal dose of GST is over 5,000 mg/kg, so this finding would be expected to provide scientific evidence for the safety of GST.
한종민,권소희,정해경,강홍구,송용선,이기남,Han Jong-Min,Kwon So-Hee,Jung Hae-Kyoung,Kang Hong-Gu,Song Yung-sun,Lee Ki-Nam 대한예방한의학회 2004 대한예방한의학회지 Vol.8 No.1
This study was conducted to evaluated the degree of job-related life style and stress of industrial workers to present fundamental materials of preventive oriental medicine. The medical examination with oriental medicine method was performed from October 14 to November 1, 2002 for the 474 industrial workers and general characters, life style and Psychosocial Well-being Index(PWI) were collected by using self-recording type questionnaire. The results were as follows; 1) All 474 of subjects were male, job type was distributed into technician, 37.8% of them, white collar worker, blue collar worker, research worker in an orderly fashion. 2) As a result of comparison between the job types in general characters, research worker group was the highest in education level, above 10 years group in employee duration and 1.5-2.99 million won group in monthly income was the largest group in all job type and the distribution was significantly different. 3) Analyzing the difference in life style according to the job type shows that significantly highest prevalence of drinking alcohol was found in blue collar workers, they drank alcohol 2-4 times a week and that workers did not smoke in all group of job type and the prevalence of exercise was significantly high in less than 1 time a week. 4) Analyzing the difference in the degree of stress according to the job type shows that blue collar worker group had the highest score in Factor 1, Factor 4 fields, technician group had the highest score in Factor 2 field and the differences were significant. Considering above results, the present study shows that there are difference in life style and stress according to the job type in industrial workers and that health management according to job type must be required to improve health condition and to prevent disease of industrial workers in the future.
병안목 달팽이류 두 종간 (Achatina fulica and Incilaria fruhstorferi)의 타액선에 관한 비교 연구
한종민,장남섭 한국패류학회 1996 The Korean Journal of Malacology Vol.12 No.2
Histochemical experiment was carry out respectively to confirm the properties of the salis (Achatina fulica and Incilaria fruhstorferi). SDS-PAGE was carried out to compare and invertigate the distribution aspects of protein patterns between the two species. Five types(A, B, F, H and I)of gland cells with four neutral mucopolysaccharide cells and one acid mucopolysaccharide cells and one acid mucopolysaccharide cell were observed in acinous of Achatina fulica, while six types were observed in acinous of Incilaria fruhstorferi: ond acid mucopolysaccharide cell(type-A) and four neutral mucopolysaccharide cells(type-B, C, D and F) and one cell that acid mucopolysaccharide is only mimbrane that surrounded granule(type-E). The results are follows:The thpe-A fland cell is commonly observed between the two species. The type-A gland cell in Achatina fulica possesses a nucleus with a developed heterdchromatin, and the cytoplasm was filled with round granules. The granules were surrounded with an uncertain boundary mimbrane and confirmed with neutral mucopolysaccharides, but is confirmed acid mucopolysaccharide in Incilaria fruhstorferi.The type-B gland cell is obwerved in the two species, too. The type-B gland cell in Achatina fulica was round shaped, and included an evenly alrge nucleus. The uncleoplasm included granules that were confirmed in the neutral mucopolysaccharides of the two species. The type-C and D gland cells exist only in Incilaria fruhstorferi, nucleoplasm was well developed heterochromatins. The type-E gland cell appears in the acinous surrounded the salivary gland of Incilaria fruhstorferi. Thdse granules appear irregular irregular shape and size and the cytoplasm is formed in alveolar. The type-F gland cells are commonly observed in the salivary glands of the two species. They are similar with the type-B gland cell, but the granular shape is comparatively small and irregular, and possess the neutral mucos granules. The type-H gland cells are mainly seen in only Achatina, and in nucleus is a well developed heterochromatin. The cytoplasm is filled with round small granules with acid mucopolysaccharide for alcianophilia observed. The type-I cell was small cell with an irregular shape and only observed in the gland cells of Achatina fulica. The heterochromatins were developed in the nucleus and the granules are not observed in cytoplasm.Secretory ducts of saliva are composed of the interlobular duct and interlobar secretory duct. In Achatina fulica the interlobular duct consists of a simple cuboidal epithelium, while the endothelium of intralobar secretory duct of Incilaria fruhstorferi consists of a simple squamous epithelium and in the cytoplasm is filled with granules(type-G secretory cell). A SDS-PAGE was carried out to confirm that the protein band pattern consist of salivary gland. In conclusions, five more bands in Achatina fulica and three bands in Incilaria fruhstorferi were confirmed in MW<29 kDa. one main band coincides comparatively with both and is between 29-45 kDa. There are four main bands in Achatina fulica and two main bands in Incilaria fruhstorferi between 45-66.5 kDa respectively. The bands in Achatina fulica seem more complex than in incilaria fruhstorferi.
血府逐瘀湯이 大動脈 平滑節 細胞에서 NO 生成에 미치는 影響
한종민,고창보,박창민,정명수,박길래,이기남 대한한의학회 2002 대한한의학회지 Vol.23 No.2
Effects of Hyeolbuchukeo-tang (Xiefuzhuyutang in chinese) on the NO Production in Aortic Vascular Smooth Muscle Cells
DYNAMIC BIFURCATION OF THE PERIODIC SWIFT-HOHENBERG EQUATION
한종민,Masoud Yari 대한수학회 2012 대한수학회보 Vol.49 No.5
In this paper we study the dynamic bifurcation of the Swift-Hohenberg equation on a periodic cell ${\Omega}=[-L,L]$. It is shown that the equations bifurcates from the trivial solution to an attractor $\mathcal{A}_{\lambda}$ when th control parameter λ crosses the critical value. In the odd periodic case $\mathcal{A}_{\lambda}$ is homeomorphic to $S^1$ and consists of eight singular points and thei connecting orbits. In the periodic case, $\mathcal{A}_{\lambda}$ is homeomorphic to $S^1$, an contains a torus and two circles which consist of singular points.