기억성 경도인지장애 및 알츠하이머 치매 환자에서 해마, 편도체, 뇌들보, 내후각 피질과 혈중 지질, 호모시스테인, 엽산 농도와의 연관성

이상준,김태형,허량,최승은,이봉주,김경미,이정구,김홍대,문치웅,김영훈,Lee, Sang Jun,Kim, Tae Hyung,Huh, Lyang,Choi, Seung Eun,Lee, Bong Ju,Kim, Gyung Mee,Lee, Jung Goo,Kim, Hong Dae,Mun, Chi Woong,Kim, Young Hoon 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Objectives In this study, the authors evaluated the correlation between levels of serum lipid, homocysteine, and folate with volumes of hippocampus, amygdala, corpus callosum, and in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD) type. Methods The study recruited patients who visited the dementia clinic of Haeundae Paik Hospital in Korea between March 2010 and June 2014. Among those, patients who had taken the neurocognitive test, brain magnetic resonance imaing, tests for serum lipid, homocysteine, folate, and apolipoprotein E (APOE) genotyping and diagnosed with aMCI or AD were included for analysis. Bilateral hippocampus, entorhinal cortex, amygdala and corpus callosum were selected for region of interest (ROI). The cross-sectional relationships between serum lipid, homocysteine, folate and ROI were assessed by partial correlation analysis and multiple linear regression analysis. Results In patients with aMCI, old age (> 80) and APOE ${\varepsilon}4$ carrier were associated with AD [odds ration (OR) : 12.80 ; 95% confidence interval (CI) : 2.25-72.98 and OR : 4.48 ; 95% CI : 1.58-12.67, respectively]. In patients with aMCI or AD, volumes and thickness of ROI were inversely correlated with levels of serum lipid and homocysteine. In multiple linear regression analyses, higher total cholesterol level was related to lower left, right hippocampus volume and left amygdala volume ; higher low-density lipoprotein cholesterol was related to lower right entorhinal cortex thickness ; higher homocysteine level was related to lower corpus callosum volume. Conclusions Higher serum lipid and homocysteine levels are associated with decreased volume of hippocampus, amygdala, corpus callosum and entorhinal cortex thickness in patients with aMCI or AD. These findings suggest that serum lipid and homocysteine levels are associated with AD as a modifiable risk factor.

과학기술위성3호 소형영상분광기 발사모델 환경시험 결과

이상준,김정현,이준호,이치원,장태성,강경인,Lee, Sang-Jun,Kim, Jung-Hyun,Lee, Jun-Ho,Lee, Chi-Won,Jang, Tae-Sung,Kang, Kyung-In 한국광학회 2011 한국광학회지 Vol.22 No.4

과학기술위성3호 부탑재체인 소형영상분광기 COMIS(Compact Imaging Spectrometer)는 400 - 1050 nm의 관측 대역에서 분광 관측을 수행하는 영상 분광기이다. COMIS는 2012년 고도 700 km의 원 궤도에서 발사 된 후 27 m의 공간분해능과 2 - 15 nm의 파장 분해능을 갖도록 설계되었다. 본 논문에서는 COMIS 비행 모델의 환경시험 수행결과를 기술한다. 발사 환경인 진동 가진에 의한 영상분광기의 광학적, 구조적인 변화 여부와 우주환경인 열.진공 상태에서의 기능 시험을 수행하여 안정성 및 신뢰성을 검증 받았다. 우주공간에서의 환경으로 일컬어지는 고진공($10^{-5}$ torr이하)과 $-30^{\circ}C{\sim}35^{\circ}C$의 고온 및 저온의 열적 변화 상태를 모사하는 시험에서 정상적인 기능을 보였고, 10 grms의 랜덤 진동 가진 전.후의 고유 진동수는 1% 이내의 변화량을 보였다. 환경시험 전 후로 영상분광기의 변조전달함수(MTF, Modulation Transfer Function) 측정을 하여 광학 성능이 유지됨을 확인하였다. 환경시험을 마친 영상분광기는 현재 과학기술위성3호 본체와의 조립을 진행 중에 있으며 2012년 발사 예정에 있다. A compact imaging spectrometer (COMIS) was developed for a microsatellite STSAT-3. The satellite is now rescheduled to be launched into a low sun-synchronous Earth orbit (~700 km) by the end of 2012. Its main operational goal is the imaging of the Earth's surface and atmosphere with ground sampling distance of 27 m and 2 - 15 nm spectral resolution over visible and near infrared spectrum (0.4 - 1.05 ${\mu}m$). A flight model of COMIS was developed following an engineering model that had successfully demonstrated hyperspectral imaging capability and structural rigidity. In this paper we report the environmental test results of the flight model. The mechanical stiffness of the model was confirmed by a small shift of the natural frequency i.e., < 1% over 10 gRMS random vibration test. Electrical functions of the model were also tested without showing any anomalies during and after vacuum thermal cycling test with < $10^{-5}$ torr and $-30^{\circ}C\;-\;35^{\circ}C$. The imaging capability of the model, represented by a modulation transfer function (MTF) value at the Nyquist frequency, was also kept unvaried after all those environmental tests.

스월유동장에 있어서 연소속도에 미치는 난류특성의 영향에 관한 연구

이상준,이종태,이성열,Lee, Sang Jun,Lee, Jong-Tai,Lee, Song-Yol 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.1

Flow velocity was measured by, use of hot wire anemometer. Turbulence intensity was in proportion to mean flow velocity regardless of swirl velocity. And integral length scale has proportional relation with swirl velocity regardless of measurement position. Turbulent burning speed during flame propagation which was determined by flame photograph and gas pressure of combustion chamber was increased with the lapse of time from spark and was decreased a little at later combustion period. Because of combustion promotion effect, turbulent burning speed was increased according to increase of turbulence intensity. Burning speed ratio i.e. ratio of turbulent burning speed ($S_BT$) to laminar burning speed ($S_BL$) was found out by use of turbulence intensity u' and integral length scale $l_x$ , $\delta_L$ is width of preheat zone in laminar flame.

생체 인식 시스템을 위한 심전도 개인인식 알고리즘 개발

이상준,김진권,이영범,이명호,Lee, Sang-Joon,Kim, Jin-Kwon,Lee, Young-Bum,Lee, Myoung-Ho 대한의용생체공학회 2010 의공학회지 Vol.31 No.5

This paper is about the personal identification algorithm using an ECG that has been studied by a few researchers recently. Previously published algorithm can be classified as two methods. One is the method that analyzes ECG features and the other is the morphological analysis of ECG. The main characteristic of proposed algorithm uses together two methods. The algorithm consists of training and testing procedures. In training procedure, the features of all recognition objects' ECG were extracted and the PCA was performed for morphological analysis of ECG. In testing procedure, 6 candidate ECG's were chosen by morphological analysis and then the analysis of features among candidate ECG's was performed for final recognition. We choose 18 ECG files from MIT-BIH Normal Sinus Rhythm Database for estimating algorithm performance. The algorithm extracts 100 heartbeats from each ECG file, and use 40 heartbeats for training and 60 heartbeats for testing. The proposed algorithm shows clearly superior performance in all ECG data, amounting to 90.96% heartbeat recognition rate and 100% ECG recognition rate.

스월유동장의 화염전파에 미치는 난류특성의 영향에 관한 연구

이상준,이종태,이성열,Lee, Sang-Jun,Lee, Jong-Tae,Lee, Seong-Yeol 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.10

Flow velocity was measured using a hot wire anemometer. Turbulence intensity was in proportion to mean flow velocity regardless of swirl velocity. And integral length scale has proportional relation with swirl velocity regardless of measurement position. Flame speed calculated by radius of visualized flame was increased and then decreased according to lapse of time from spark. Maximum flame speed was increased according to increase of turbulence intensity. Burning speed and flame transport effect increased with increase of swirl velocity, but ratio of burning speed to flame speed decreased with increased of swirl velocity. Mass fraction burned versus volume fraction burned was increased in proportion to the increase of turbulence intensity, caused by increase of combustion promotion effect according to increase of turbulence intensity and scale.

은교산과 Ciprofloxacin의 병용투여가 Streptococcus pneumoniae 호흡기감염에 미치는 영향

이상준,전귀옥,송광규,최해윤,김종대,Lee, Sang-Jun,Jeon, Kwi-Ok,Song, Kwang-Kyu,Choi, Hae-Yun,Kim, Jong-Dae 대한동의생리학회 2005 동의생리병리학회지 Vol.19 No.3

In order to evaluate the in vivo synergic effect of Eunkyo-san which was a traditional poly-herbal formula has been used in the treatment of respiratory diseases in Korea, with quinolone antibiotics, ciprofloxacin (CPFX), the viable bacterial number and histopathological changes were monitored after experimental respiratory infection with S. pneumoniae ATCC 6303. The obtained results were as follows: In CPFX groups, the viable bacterial numbers were significantly decreased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In control group, severe infiltration of inflammatory cells, hemorrhage and hypertrophy of alveolar linings were demonstrated at microscopical levels. However, these abnormal histopathological changes were significantly decreased compared to that of control group in CPFX groups, and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. In CPFX groups, the LSA (luminal surface of alveoli $\%$) were significantly increased compared to that of control group and these were more dramatically decreased compared to that of single treatment with CPFX, respectively in concomitant treated groups with Eunkyo-san. According to these results, it is considered as the in vivo antibacterial activity of CPFX was dramatically increased by concomitant use of Eunkyo-san against S. pneumoniae ATCC 6303 infection of respiratory tract.

한강 상류와 중류지역에서 측정한 일반수질의 계절적 변화(1988. 8$\sim$1989. 9)

이상준,정규철,Lee, Sang-Jun,Chung, Kyou-Chull 대한예방의학회 1990 예방의학회지 Vol.23 No.1

This study was conducted to investigate of water qualities in the upper and middle reaches of the Han River. For this purpose, water was sampled at Kwangjin and 1st Han-River Bridges of the Han River in Seoul and analysed from August, 1988 to September, 1989. The results are summarized as follows : 1. Water quality at 1st Han-River Bridge was more polluted than that at Kwangjin Bridge. 2. Except biological oxygen demand (BOD), turbidity, suspended solid (SS), dissolved oxygen (DO), DO saturation (DOS), ammonia nitrogen ($NH_3-N$), nitrite nitrogen ($NO_2-N$) and chloride ion ($Cl^-$) at Kwangjin and 1st Han-River Bridges were lower as compared with the previous data before redevelopment of the Han River. 3. SS, DO and pH at Kwangjin and 1st Han-River Bridges could be classified to the 1st grade in environmental water quality standard. DOS at Kwangjin Bridge was over 100% and that at 1st Han-River Bridge was below 100% in the Han River. BOD at Kwangjin Bridge could be classified to End grade and that at 1st Han-River Bridge to 3rd grade in environmental water quality standard. 4. The higher the level of water was, the lower the levels of turbidity and SS, and $NH_3-N$ was decreased with increasing water level at 1st Han-River Bridge. DO was decreased as water temperature went up but DOS was increased with DO. BOD was positively correlated with nitrite-nitrogens. 5. Turbidity and SS at the both sites and Chloride ion ($Cl^-$) at Kwangjin Bridge were increased in July and August. And DO at the both sites and $NH_3-N$ at 1st Han-River Bridge were decreased in at July and August.

은유에 대한 분석적 고찰

이상준,Lee, Sang-Jun 한국외국어대학교 외국어교육연구소 1989 외국어교육연구 Vol.- No.5

레일레이 페이딩 채널을 고려한 듀얼 홉 디코딩 후 전달 중계 시스템에서 부분 중계 노드 선택 기법의 정확한 비트 오차율 분석

이상준,이인호,Lee, Sangjun,Lee, In-Ho 한국정보통신학회 2014 한국정보통신학회논문지 Vol.18 No.1

듀얼 홉 시스템에서 기존의 두 홉에 대한 채널 정보를 이용하여 가장 좋은 성능을 나타내는 중계 노드 선택 기법은 채널 피드백을 위한 자원의 소모가 크다. 본 논문에서는 듀얼 홉 디코딩 후 전달 중계 시스템에서 첫 번째 홉에 대한 채널 정보만을 필요로 하는 부분 중계 노드 선택 기법을 이용하여 정확한 평균 비트 오차율을 분석한다. 이 때, 독립적인 레일레이 페이딩 채널을 가정하여 M-ary QAM에 대한 정확한 비트 오차율의 표현식을 유도한다. 또한, 수치적 결과를 통해 두 홉에 대한 채널 정보를 이용하여 가장 좋은 성능을 나타내는 중계 노드 선택 기법과 부분 중계 노드 선택 기법에 대한 성능을 비교한다. 여기서, 중계 노드의 수와 첫 번째 홉과 두 번째 홉 간 평균 채널 전력비를 다양하게 가정하여 평균 비트 오차율을 분석한다. The conventional best relay selection based on all the channel information for the first and second hops in dual-hop systems has a large consumption of resources for channel feedback. In this paper, we analyze the average bit error rate for partial relay selection based on the channel information only for the first hop in dual-hop decode-and-forward relaying systems, where we assume independent Rayleigh fading channels. In particular, we provide an exact and closed-form expression for the average bit error rate of M-ary QAM. Also, through numerical investigation, the performance of the partial relay selection is compared with the performance of the best relay selection, and the performance is evaluated for different numbers of relays and various average channel power ratios for the first and second hops.

극한 프로그래밍의 사용성 향상 방안

이상준,배석찬,Lee, Sang-Jun,Bae, Seok-Chan 한국정보처리학회 2004 정보처리학회논문지D Vol.11 No.3

극한 프로그래밍은 빠르게 변화되는 사업 환경에 기민하게 대응하는 애자일 소프트웨어 개발 방법론 중에서 가장 대표적인 방법론이다. 소프트웨어 산업이 성숙됨에 따라 소프트웨어 품질 요소 중 사용성이 점차 강조되고 있으나, 극한 프로그래밍에서의 사용성을 확보하기 위한 노력이 부족하다. 본 논문에서는 극한 프로그래밍에 부족한 3가지 사항을 보강한다. 사용자 인터페이스 설계자의 역할을 정의 및 제시하구 사용성 평가 방법 도입 방안 제시하고, 개발 프로세스 및 산출물을 제안한다. 제안 방안의 타당성 분석을 위해 4가지 방법을 사용하였다. 첫째, 소프트웨어 개발 생명주기 지원 여부 분석, 둘째, CMM 핵심 프로세스 영역 만족도 분석, 셋째, CMM 규정 실무 만족도 향상 분석, 넷째, 녹차 쇼핑들을 개발하는 사례를 분석하였다. 녹차 쇼핑몰은 사용성 평가 방법의 도입으로 예측된 실행시간이 23%, 학습용이성이 21% 향상되었다. 또한, 휴리스틱 평가 점수가 18글 설문지 평가 점수는 16% 향상되었다. Extreme programming is the most representative methodology among agile software development methodologies that is agile in business environment which change fast. As software industry is matured, usability of software quality characteristics is emphasized gradually, but effort to obtain usability in extreme programming is insufficient. In this paper, three things lacked in extreme programming are reinforced. First, roles of user interface expert are defined. Second, usability testing method to extreme programming are introduced. Third, development process and products are proposed. The proposed plan is validated by four methods, which analyze supporting software development life cycle, analyze satisfaction of CMM key process areas, analyze satisfaction of CMM practices, and analyze development of green tea shopping mail. Green tea shopping mall is improved 23% in the estimated running time, 21% in the learnability. Also, usability is improved 18% in the heuristic evaluation and 16% in the questionnaire method.