성능중심의 건축재료설계시스템 구축에 관한 기초적 연구

윤상미(Yoon Sang-Mi),노태임(Roh Tae-Im),김상헌(Kim Sang-Heon),지석원(Ji Suk-Won),최수경(Choi Soo-Kyung),서치호(Seo Chee-Ho) 대한건축학회 2008 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.28 No.1(구조계)

Since the study on building performance was started by Building Research Station in 1930s, the results of the study has been reported from many parts of the world and Building construction codes and standardhas been revised as performance based in advanced nations and as well in Korea various performance certification systems are in operation. In this study, the constituent elements of performance design system were established by acquiring the problem of the performance certification system being in operation in Korea. With this result, a performance design system was suggested as optimum material and method selection stage using building classification system, acquirement of required function, required performance, suggestion of evaluation index by feedback of verification method and evaluation index

인체 노로바이러스의 한국분리주 Hu/NLV/Gunpo/2006/KO의 분자생물학적 특성

정아용,윤상임,지영미,강윤성,이영민,Jeong, Ah-Yong,Yun, Sang-Im,Jee, Young-Mee,Kang, Yoon-Sung,Lee, Young-Min 한국미생물학회 2009 미생물학회지 Vol.45 No.2

노로바이러스는 급성 위장염을 일으키는 Caliciviridae 과(family)에 속하는 바이러스로 유전자형이 매우 다양하다. 본 연구에서는 노로바이러스 국내분리주의 게놈 RNA로부터 3개의 open reading frame (ORF) 모두의 염기서열을 분석하고, 유전학적 계통분석을 통하여 분자생물학적 특성을 분석하였다. 본 연구에 사용된 노로바이러스(Hu/NLV/Gunpo/2006/KO)는 바이러스성 식중독, 장염 증세를 보이는 2세 여아 가검물로부터 분리되었다. 역전사반응과 PCR 증폭을 통해서 바이러스의 게놈 RNA를 3개의 중첩되는 cDNA 단편으로 합성하였으며, 합성된 cDNA를 염기서열 분석에 직접 사용하였다. 시퀀싱 결과 Hu/NLV/Gunpo/2006/KO는 3개의 ORF (ORF1, 5,100 bp; ORF2, 1,647 bp; ORF3, 765 bp)로 구성되어 있음을 알 수 있었다. 35개의 노로바이러스 국외 분리주와 비교한 결과, ORF1은 ORF2 또는 ORF3에 비해서 상대적으로 염기의 변이율이 낮았으며, 특히 ORF2와 ORF3의 C-말단 부위에서 높은 변이율을 관찰하였다. 유전학적 계통도를 분석한 결과, Hu/NLV/Gunpo/2006/KO는 genogroup II 에 속하며, Saitama U1, Gifu'96, Mc37, Vietnam 026과 같은 클러스터를 형성하는 것을 알 수 있었다. 본 연구를 통하여 노로바이러스 Hu/NLV/Gunpo/2006/KO의 3개의 ORF 염기서열을 모두 밝힘으로써, 앞으로 노로바이러스의 검출법 개발과 유전학적 상관관계뿐 아니라, 유전자의 기능 분석과 관련된 기초연구에 중요한 기초자료를 제공할 수 있을 것으로 기대한다. Norovirus (NV) with a variety of genotypes, a member of the family Caliciviridae, causes acute nonbacterial gastroenteritis in humans. We determined the nucleotide sequence of three open reading frames (ORFs) of a NV Korean strain and characterized the genetic relationship with others. The Korean strain designated Hu/NLV/Gunpo/2006/KO was isolated from the stool specimen of a 2-year-old female suffering from gastroenteritis. By performing reverse transcription and PCR amplification, three overlapping cDNAs were synthesized and used for direct sequencing. We found that like other NVs, this strain contains three ORFs: ORF1, 5,100 bp; ORF2, 1,647 bp; ORF3, 765 bp. Of 35 NVs, ORF1 had a level of genetic diversity lower than ORF2 and ORF3, of which the C-termini of the ORF2 and ORF3 showed a relatively high degree of genetic diversity. Phylogenetic analyses indicated that the Korean strain belonged to genogroup II, with Saitama U1, Gifu'96, Mc37, and Vietnam 026 being formed a single genetic cluster. The nucleotide sequence information of three ORFs of a NV Korean isolate will be useful not only for the development of a diagnostic tool and understanding of genetic relationship, but also provide important basic information for the functional analysis of their gene products.

만성 신부전에서 캄슘 장 흡수율에 미치는 1a Hydroxycholecalciferol 의 효과

성기양(Ki Yang Sung),윤상임(Sang Im Yoon),이강욱(Gang Wook Lee),신영태(Young Tai Shin),노흥규(Heung Kyu Ro) 대한내과학회 1992 대한내과학회지 Vol.43 No.5

Background: Renal osteodystrophy is a major problem in patients with CRF, especially in dialyzed patient. Deficiency of Vitamin D has a important role in the mechanism of renal osterodystrophy. Method: To investigate the effects of 1a (OH) K4 on the calcium metabolism in patients with chronic renal failure, the concentration of serum clcium, phosphorus, parathyroid hormone, the amounts of 24 hours urinary calcium, phosphorus and the rates of intestinal calcium absorption using radioactive 45Ca. 45Ca were measured before administration of la (OH) D3, 1 and 2 weeks after the administration of 1a (OH) D3, 1μg/day in 15 patients with chronic renal failure. The same parameters were measured in 13 healthy controls without medication. Results: 1) The intestinal absorption rate of 45Ca reached at the peak level between 60 and 120 minutes after oral intake of 5μCi of the 45Ca in both patients and controls. 2) The basal intestinal 45Ca absorption rate of the patients were lower than that of the controls (p<0.05) and intestinal 45Ca absorption rates were increased gradually with 1a (OH) D3, administration, especially in patients with low basal serum calcium concentration (< 8 mg/dl). 3) Serum calcium concentration were increased significantly in patients after medication (p<0.05), but serum phophorus, urine calcium and urine phosphorus were not changed. 4) Basal iPTH levels of the patients were markedly higher than controls and decreased significantly within 2 weeks in patient with administration of 1a (OH) D3, Conclusion: 1 a (OH) D3 administration in chronic renal failure is effective to maintain serum calcium level and to prevent renal osteodystrophy through increased intestinal calcium absorption and decreased PTH secretion.

실시간 한반도 지진위험지도 생성 방법

오혜주(Oh Hye ju),임지은(Im Ji eun),이예림(Lee Ye lim),윤상후(Yoon Sang hoo) 한국방재학회 2018 한국방재학회논문집 Vol.18 No.1

2016년 경주에서 발생한 규모 5.8의 지진으로 인해 지진에 대한 우려가 증가하고 있다. 따라서 지진 재해에 대한 대응방안 마련이 필요한 시점이다. 본 연구는 기상청 웹으로부터 지진자료를 크롤링하여 지진위험을 시각화하였다. 자료는 1980년부터 2016년까지 한반도에서 발생한 규모 2.0 이상의 지진이며 총 1,411건이다. 수집된 자료로부터 지진위험지도를 생성하기 위해 150×150 격자를 생성하여 지진 위험성을 나타내었다. 추가적으로 지진발생추세를 알아보기 위해 2000년 전후의 지진 위험성을 평가하였다. 그 결과 지진위험지도는 경주, 평안북도, 황해지역이 지진의 위험성이 높은 것으로 나타났으며 2000년 이후 한반도의 지진발생이 북서지역이나 황해, 동해에서 남한 내륙으로 이동했음을 확인할 수 있었다. The 5.8 magnitude earthquake in 2016 raises concerns about earthquakes. Therefore, it’s necessary to prepare countermeasures against earthquake disaster. This study visualizes the earthquake risk by crawling earthquake data from the Korea Meteorological Administration web. The data are 1,411 earthquakes with a magnitude of 2.0 or more on the Korean Peninsula from 1980 to 2016. 150×150 grid was generated from the data to generate an earthquake hazard map, which indicated an earthquake hazard. In addition, the seismic risk before and after 2000 was evaluated to see the trend of earthquake occurrence. As the results, southeast region, northwest region and the yellow sea are at high risk of earthquakes. And we could find that the trend of earthquake occurrence since 2000 has changed from northwest region, yellow sea, east sea to north inland.

군 복무 중 취득한 자격증의 취업효과에 대한 연구

박창호(Chang-Ho Park),송재근(Jae-Geun Song),이임주(Im-Joo Lee),임무열(Moo-Yeol Lim),윤상은(Sang-Eun Yoon),배종환(Jong-Hwan Bae),김승현(Seung-Hyun Kim) 충남대학교 경영경제연구소 2016 경영경제연구 Vol.38 No.2

자격증이 취업에 미치는 영향에 대해서는 많은 연구가 있었지만 군 복무 중 취득한 자격증이 취업에 도움이 되는지에 대해서는 알려진 것이 거의 없다. 만약, 군 복무 중 취득한 자격증이 사회에서 필요로 하는 자격증이 된다면 군 복무기간도 인적자본을 축적하는 좋은 기회로 작용할 것이다. 본 연구는 한국직업능력개발원의 한국교육고용패널(Korean Education & Employment Panel: KEEP) 자료를 이용하여 군 복무 중 취득한 자격증이 제대 후 취업에 도움이 되는지를 탐색하였다. 연구 결과, 군 복무 중 취득한 자격증은 전반적으로 첫 일자리 취업 소요기간에 영향을 미치지 못했으나 일부 자격증은 취업소요기간 단축효과가 있었고, 임금도 다소 상승하는 것으로 나타났다. 하지만 일자리 형태 결정에 미치는 영향은 거의 없는 것으로 확인되었다. Although there exist many studies about the effects of licenses on employment, little is known about the effects of licenses acquired during military service on employment. If the licenses acquired during military service is helpful in the labor market, it will help unemployed youth find a job after graduation from university. Using the Korea Education & Employment Panel (KEEP) data published by the Institute for Vocational Education and Training, we examine whether licenses acquired during military service can have a significant effect on employment, the type of jobs, and wages. Our results indicate that young people with licenses acquired during military service have a shorter period to find a first job and have greater wages in the first job. However, the licenses obtained in military services do not have a significant effect on the type of a first job.

크론병 치료 가이드라인 개정판

박재준 ( Jae Jun Park ),양석균 ( Suk-kyun Yang ),예병덕 ( Byong Duk Ye ),김정욱 ( Jong Wook Kim ),박동일 ( Dong Il Park ),윤혁 ( Hyuk Yoon ),임종필 ( Jong Pil Im ),이강문 ( Kang Moon Lee ),윤상남 ( Sang Nam Yoon ),이희영 ( Heeyou 대한소화기학회 2017 대한소화기학회지 Vol.69 No.1

Crohn`s disease (CD) is a chronic, progressive, and disabling inflammatory bowel disease (IBD) with an uncertain etiopathogenesis. CD can involve any site of the gastrointestinal tract from the mouth to the anus, and is associated with serious complications, such as bowel strictures, perforations, and fistula formation. The incidence and prevalence rates of CD in Korea are still lower compared with those in Western countries, but they have been rapidly increasing during the recent decades. Although there are no definitive curative modalities for CD, various medical and surgical therapies have been applied for the treatment of this disease. Concerning CD management, there have been substantial discrepancies among clinicians according to their personal experience and preference. To suggest recommendable approaches to the diverse problems of CD and to minimize the variations in treatment among physicians, guidelines for the management of CD were first published in 2012 by the IBD Study Group of the Korean Association for the Study of the Intestinal Diseases. These are the revised guidelines based on updated evidence, accumulated since 2012. These guidelines were developed by using mainly adaptation methods, and encompass induction and maintenance treatment of CD, treatment based on disease location, treatment of CD complications, including stricture and fistula, surgical treatment, and prevention of postoperative recurrence. These are the second Korean guidelines for the management of CD and will be continuously revised as new evidence is collected. (Korean J Gastroenterol 2017;69:29-54)

당뇨병환자에서 게이트심장혈액풀신티그라피를 이용한 심기능 평가

윤상임,송치운,이진홍,안미애,성기양,송민호,이강욱,신영태,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Major cardiovascular complications of diabetes are coronary atherosclerosis, diabetic dilated cardiomyopathy, autonomic neuropathy and those are major causes of morbidity and mortality in diabetic patients. Gated blood pool heart scan is noninvasive and useful method for evaluation of functional status of heart in diabetics. We evaluated 52 patients with diabetes and divided 3 groups. Group 1 were 11 patients without proteinuria or with proteinuria less than 550mng during 24 hours. Group 2 were 9 patients with proteinuria more than 550mg during 24 hours and group 3 were 32 patients with endstage renal diasese due to diabetes. We performed 99mTc-HSA cardiac gated blood pool scan and used left ventricular ejection fraction(LVEF), peak ejection rate(PEF) to indices of LV systolic function and peak filling rate(PER) to index of LV diastolic function. The results were follows : 1) LVEF, PER were significantly lower in diabetics with ESRD than diabetics without ESRD, but there were no significant difference between normal controls and diabetics without ESRD 2) PFR was significantly lower in diabetics than normal controls, but there were no significant differences in diabetics with or without nephropathy. 3) There were negative correlation between PER, PFR and duration of diabetes. On the basis of results, PFR is a LV functional index of GBPS which can disclose early change of LV dysfunction in patients with diabetes.

폐경기 여성에서의 Cyclofenil의 효능에 관한 연구 : 갱년기 장애 및 Ca 장흡수에 관하여

노흥규,윤상임,성기양,이경숙,이강욱 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

In postmenopausal syndrome, most common symptoms are those of vasomotor irritability such as hot flush and palpitation, irritable bladder symptoms and dyspareunia according to atrophy of urogenital epithelium, anxiety, nervousness, depression and insomnia. Approximately 40 percent of women in postmenopausal period develop symptoms serious enough to seek medical assistance. Among non-steroid agents, cyclofenil(4, 4' cyclohexidene methlyene diphenoacetate) is known to be a quite interesting substance according to the action at the level of the hypophyseal and hypothalamic centers by reducing the incretion of FSH and restoring normal endorphin, dopamine and norepinephrine activities, thus favorably affecting the whole postmenpausal neurovegutative symptomatology. In order to evaluate effect of cyclofenil on postmenopausal symptomatology and calcium metabolism, we examined 32 patients with postmenopausal syndrome before and after 200mg/day of oral cyclofenil treatment for 30-60 days. The results were as follows: 1. With 30 days of cyclofenil administration, subjective symptoms such as facial flush, palpitation, anxiety, nervousness and dyspareunia were improved significantly (p<0.001, p<0.001, p<0.01, p<0.005, respectively). But insomnia and depression were improved significantly after 60 days of cyclofenil administration (p<0.05, p<0.001, respectively). 2. Intestinal calcium absorption rate disclosed tendency of improvement without statistical significance 30 days after cyclofenil treatment. 3. Serum calcium and phosphorus level were not changed significantly before and after cyclofenil. 4. There was no definite evidence of side effects such as uterine bleeding due to cyclofenil. In conclusion, we thought that cycofenil is effective in management of postmenopausal syndrome but for the effect on calcium metabolism, further evaluation should be needed.

갑상선 질환 환자에서 골밀도와 혈청 Osteocalcin 농도의 분석

노흥규,송치운,윤상임,성기양,송민호 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

Spontaneous hyperthyroidism and that due to excessive administration of thyroid hormone result in osteopenia. However there has been no general agreement on the incidence of osteopenia in hyperthyroidism or the recovery of the mineral loss after treatment of hyperthyroidism or the recovery of the mineral loss after treatment of hyperthyroidism. We conducted a cross sectional study on the effect of hyperthyroidism and its treatment on vertebral bone mineral density using dual energy x-ray absorptiometry. We measured vertebral bone mineral density, serum Gla protein and serum intact PTH in 21 postmenopausal Graves' patients who maintained euthyroid state with antithyroid drug treatment and in 10 patients with nontoxic nodular goiter that received no suppressive thyroid hormone. Bone mineral densities of lumbar spine in patients with Graves' disease showed no significant decrease compared to patients with nontoxic nodular goiter. The level of serum Gla protein in patients with Graves' disease was significantly higher than that of patients with nodular nontoxic goiter and it was positvely correlated with serum T_3level. The level of serum intact PTH showed no significant difference between both groups of patients with Graves' disease and nodular nontoxic goiter. The serum levels of Gla protein were positively correlated with the values of serum PTH in all patients with Graves' disease and nodular nontoxic goiter. The bone mineral densities of the postmenopausal patients with Graves' disease following induction of euthyroid state with antithyroid drug treatment showed no significant decrease compared to controls.

갑상선 기능항진증 환자의 골밀도에 관한 연구 : 예보

노흥규,성기양,윤상임 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

A preliminary study to evaluate the effect of thyroid function on the bone mineral density(BMD) was done. BMD was measured at lumbar spine 2, 3, 4 (A-P view) in 10 euthyroid nodular goiter, 8 primary hypothyroidism and 20 hyperthyroidism patients, perimenopausal or postmenopausal periods. Serum calcium, phosphorus, thyroid hormone concentrations and other parameters were measured to analysis. The results were as follows. 1. The BMDs of euthyroidism, hypothyroidism, and hyperthyroidism were 0.85± 0.16gm/㎠ (M±SD), 0.83±0.29 and 0.79±0.16 respectively, without any significant difference, but the BMD of hyperthyroidism was lowest. 2. The BMD of postmenopause of all thyroid disease patients was significantly lower than that of perimenopause patients. 3. There was no significant relationship between BMD and serum calcium, phosphorus, T_3, T_4 or duration of treatment for thyroid disease. In conclusion, the BMD is affected mainly by the age and thyroid function, so attention to osteoporosis must be considered for the patients of thyroid disease in menopause.