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인체 폐암세포주에서 다약제내성유전자 표현과 Buthionine Sulfoximine 투여가 Cisplatin 및 Adriamycin 의 세포독성도에 미치는 영향
천선희(Seon Hee Cheon),유내춘(Nae Chun Yoo),김주항(Joo Hang Kim),김성규(Sung Kyu Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.5
Objectives: Cisplatin and adriamycin have been proven to be the most effective drugs for lung cancer, However, repeated courses of chemotherapy frequently result in a decreased therapeutic response because of the emergence of an acquired drug-resistance. Recently it has been demonstrated that the resistance to cisplatin, adriamycin or alkylating agents may be due to elevated intracellular glutathione levels in human and rodent tumor cell lines. This study was aimed to investigate any relationship between intracellular glutathione levels and sensitivity to cisplatin and adriamycin, and whether cytotoxicity to cisplatin and adriamycin could be in- creased with buthionine sulfoximine. Methods: We used human SCLC cell line, NCI-H209, and three human NSCLC cell lines, NCI-H727, NCI- H810 and NCI-H1299. The multidrug resistance gene expression was investigated by RNA slot blot analysis. The intracellular glutathione levels was examined before and after administration of buthionine sulfoximine. Drug sensitivity assays were performed using a modified MTT method. Results: 1) The resistance to adriamycin and cisplatin in human lung cancer ce11 lines was closely related to MDR1 expression level rather than that of intracellular glutathione level. Cisplatin resistance seemed to be related to the glutathione level above some concentrations. 2) 5-Fluorouracil resistance seemed not to be related to MDR1 expression or glutathione level. 3) Buthionine sulfoximine was not effective on adriamycin and cisplatin cytotoxicity in MDR1 positive cells, but effective in MDR1 negative cells. Conclusion: It is suggested that buthionine sulfoximine is an effective supplement to adriamycin and cisplatin in MDR1 negative cells. And its effectiveness in human lung cancer patients needs a further clinical studies.
고주파열치료(Radiofrequency Ablation) 후 발생한 합병증 증례 개복하 고주파열치료 후 발생한 발열, 혈소판 감소증 및 간기능 저하
이재길 ( Jae Gil Lee ),김석모 ( Suk Mo Kim ),김경식 ( Kyung Sik Kim ),원종윤 ( Jong Yoon Won ),유내춘 ( Nae Chun Yoo ),윤동섭 ( Dong Sup Yoon ),최진섭 ( Jin Sub Choi ),이우정 ( Woo Jung Lee ),김병로 ( Byong Ro Kim ) 대한간암학회 2005 대한간암학회지 Vol.5 No.-
위암에서 Collagen-4 및 Type-4 Collagenase의 발현과 예후인자로서 임상적 응용
노성훈(Sung Hoon Noh),이종인(Chong In Lee),정현철(Hyun Cheol Chung),박준오(Joon Oh Park),조재용(Jae Yong Cho),라선영(Sun Young Ra),유내춘(Nae Chun Yoo),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),민진식(Jin Sik Min),김병수(Byung Soo K 대한소화기학회 1996 대한소화기학회지 Vol.28 No.1
N/A Background/Aims: In Korea, gastric cancer is the commonest cancer and the leading cause of cancer-related death. Though the most effective treatment for gastric cancer is radical resection, there are many patients with gastric cancer inoperable at the time of diagnosis. Collagen-IV, one of the major intrinsic components of the basement membrane, has cell adhesion function and it is known to be associated with tumor invasion or penetration. Type- IV collagenase, a metallo- proteinase purified from highly metastatic tumor cells, has been implicated in the process of invasion of epithelial and endothelial basement membranes in several steps of tumor invasion and metastasis. Methods: We retrospectively reviewed the clinical records of SO patients with histologically proven gastric cancer who had been treated in Yonsei University Medical Center and Yonsei Cancer Center between June l985 and June 1990. We perfonned immunohistochemical staining of surgically resected specimens of stomach cancers to investigate the expression rate and clinical relevance of collagen-lV and type-IV collagenase as prognostic niarkers. Results: Collagen- IV expression rate was 50% in 40 gastric cancers and type-IV collagenas expression rate was 76% in 50 gastric cancers. Six cases(30%) recurred in 20 collagen-IV positivc cases and six cases(30/c) recurred in 20 collagen-IV negative cases(p=1.00000). Eleven cases(29%) recurred in 38 type-P' collagenase positive cases and four cases(33%) recurred in 12 type-IV collagenase negative cases(p=0.77255). In the collagen-IV positive and negative group, 5-ye.ar disease-free survival rate was 607c and 67%, respectively(p=0.6725), and 5-year overal] survival rate was 71% and 827o, respectively(p=0.3953). In the type-IV collagenase positive and negative group, 5-year disease-free survival rate was 63% and 60%, respectively(p=0.6407), and 5-year ovevall survival rate was 78% and 60%, respectively (p=0.3822). Conclusions: Collagen-IV and type-lV collagenase were found in gastric tissues. However, together with recurrence rate and survival rat:, expressions of collagen- IV and type-IV collagenase were not significantly correlated with T state, nodal status, TNM stage and histologic differentiation of gastric cancer. Further studies to define the biological role of collagen-IV and type-IV collagenase is required. (Korean J Gastroenlerol 1996;28:1 - 10)
우측 쇄골하 동맥과 흉벽을 침범한 침습성 Aspergillosis 1 예
윤용석(Yong Seok Yoon),정소영(So Young Chong),최병현(Byung Hyun Choi),김성철(Seong Cheol Kim),서형찬(Hyung Chan Suh),이석(Seok Lee),유내춘(Nae Chun Yoo),민유홍(Yoo Hong Min),한지숙(Jee Sook Hahn),고윤웅(Yun Woong Ko) 대한내과학회 1997 대한내과학회지 Vol.53 No.2
Invasive aspergillosis is an infection that occurs in immunocompromised patients. Its prevalence was increased in the last decade with progression of antineoplastic chemotherapy and immunosuppressive therapy after transplantation. Because it carries a high mortality and morbidity, early diagnosis and aggressive treatment are critical for successful management. In many patients, invasive aspergillosis remains confined to the lung although direct extension to pleural cavity or pericardium has been reported. However great vessel involvement is rare. Therefore we report a case of invasive aspergillosis involving right subclavian artery and chest wall in a patient after chemotherapy for acute lympoblastic leukemia.
간암세포주를 대상으로 한 체외 복합 항암제 감수성 검사
박인서(In Suh Park),정재복(Jae Bock Chung),김병수(Byung Soo Kim),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),유내춘(Nae Chun Yoo),조재용(Jae Yong Cho),최진혁(Jin Hyuk Choi),임호영(Ho Yeong Lim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2
N/A Primary hepatocellular carcinoma(HCC) is one of the most common malignancies in Korea due mainly to high incidence of chronic hepatitis B virus infection. Most of the HCC are inoperable even at first presentation. So chemotherapy could be one of the major therapeutic modalities, but HCC is seldom chemosensitive. This type of chemoresistance is explainesd by high level of expression of multidrug resistance(MDR) gene and p-glycoprotein. We initiated this study to establish the in vitro model of drug selection and combination for HCC. Three human HCC cell lines and five cytotoxic drugs were used. MTT assays for cytotoxicity test were performed with single chemotherapeutic agent and various two drug combinations. Slot blot analysis for measuring the expression levels or MDR1 RNA was performed and demon strated that 2 HCC lines show moderate to high degree of MDRI expression, The ranges of drug concetration which causes 50% inhibition of the cell lines(IC50) are in the clinically achievable concentrations for the 5-fluorouracil in two HCC lines, and adriamycin in one cell line. Two cell lines which showed positive MDRI exression were resistant to adriamycin. But all three cell lines were sensitive to etoposide irrespective of MDR1 expression. In thelinically achievable concentration ranges those we tested, singnificantly improved cytotoxic effects are demonstrated in combinations of etoposide plus cisplatin, and etoposide plus mitomycin-C out of 10 possible two drug combinations. These data indicate the need for in vivo trials with the combination chemotherapy of etoposide plus cisplatin or etoposide plus mitomycin-C for HCC.