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간문맥종양혈전증을 동반한 간세포암종에서 반복적인 간동맥 내 항암약물주입요법의 효과
심명기,김도영,박준용,김자경,김성애,안상훈,전재윤,문영명,원종윤,이도연,한광협 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3
목적: 간문맥혈전증을 동반한 간세포암종은 그 예후가 매우 나쁘며, 치료하지 않는 경우 평균 생존기간은 2개월 정도이다. 이러한 경우 반복적인 간동맥 내 항암약물주입요법이 시도되고 있으나, 그 약제나 방법에 대해 아직 확립된 바가 없다. 본 저자 등은 간동맥혈전증을 동반한 간세포암종에서 반복적으로 간동맥 내 주입한 항암제와 각 군의 생존율을 비교하였다. 대상과 방법: 1999년 1월부터 2003년 12월까지 간문맥혈전증을 동반한 간세포암종으로 진단받은 103명의 환자를 대상으로 다음과 같이 2군으로 나누어 분석하였다. 즉, 제 1군(67명)은 CDDP (80 mg/m2, 2시간 1일 간)만을, 제 2군(36명)은 CDDP (60 mg/m2, 2시간 1일 간)과 5- FU (500 mg/m2, 5시간 3일 간)을 1개월마다 간동맥 내로 투여하였다. 치료 3개월에 치료 반응을 평가하고 각 군의 생존기간을 비교하였다. 결과: 초치료 3개월째에 반응을 평가할 수 있었던 66명(64.1%)의 환자에서 종양의 크기 또는 혈청 AFP의 감소에 따른 치료 반응을 종합하여 볼 때 완전관해는 2명(3.0%), 부분관해는 11명(16.7%), 안정병변은 18명(27.3%), 진행병변은 35명(53.0%)이었다. 치료군의 생존중앙값은 6개월이었으며 제1군은 5개월, 제2군은 8.5개월이었다(P>0.05). 치료의 부작용은 보존적 치료로 대부분 조절되었고, 간기능의 악화는 Ⅰ군에서 Ⅱ군보다 더 많았다(P<0.05). 결론: 간문맥혈전증을 동반한 간세포암종에서 CDDP을 포함한 반복적인 간동맥 내 항암약물주입요법은 일부에서 치료 효과가 있으며, 5-FU와의 병합요법을 시행할 경우 치료 효과를 높일 수 있을 것으로 기대된다. Background/Aims: The aim of this study is to elucidate the efficacy of repeated hepatic arterial infusion chemotherapy (HAIC) and different chemotherapeutic regimens for treating patients having advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). Methods: From Jan. 1999 and Dec. 2003, a total of 103 patients diagnosed as having HCC with PVTT, but without extrahepatic spreading, were enrolled in this study. They were stratified into two groups. Group I (67 patients) received intraarterial cisplatin (CDDP, 80 mg/m2 for 2 hours on Day 1), Group Ⅱ (36 patients) received intraarterial CDDP (60 mg/m2 for 2 hours on Day 2) and 5-fluorouracil (5-FU, 500 mg/m2 for 5 hours on Day 1-3). They were scheduled to receive at least three consecutive courses of the HAIC at 1 month intervals. Results: Among the 66 patients who completed the protocol, one (2.5%) and seven (17.5%) patients of group Ⅰ, and one (3.8%) and four (15.4%) of group Ⅱ, exhibited complete and partial responses, respectively. The median survival period of all the patients was 6 months. Group Ⅱ showed a tendency to improve the median survival compared to group Ⅰ (8.5 vs 5.0 months, respectively, P=0.45). The most common adverse reaction was nausea (58.2%). However, an elevation of the total bilirubin level was more frequent in Group Ⅰ than in Group Ⅱ (61.3% vs 20.7%, respectively, P<0.05). Conclusions: Repeated HAIC using CDDP achieved favorable results in a few patients with HCC with PVTT, and additional 5-FU may be useful.
천식 의심 환자에서 천식 치료에 의한 유도 객담 내 염증지표의 변화
심명기 ( Myoung Ki Sim ),최인선 ( Inseon S. Choi ),김우진 ( Woo Jin Kim ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.3
Background: Eosinophilic airway inflammation is characteristic for typical asthma, but neutrophilic inflammation has been found in severe asthmatics resistant to steroid therapy. This study aimed to evaluate responses to asthma treatment according to inflammatory cell types in sputum. Methods: For a cross-sectional study, 240 consecutive patients with suspected asthma who underwent a 4.5% saline-induced sputum test and a test for airway hyperresponsiveness to methacholine or for airway reversibility were enrolled. Of these patients, 23 who inhaled corticosteroids were entered to a follow-up sputum study. Results: The number of sputum eosinophils was significantly related to the forced expiratory volume in one second/ forced vital capacity (r=-0.180, P<0.05) and airway hyperresponsiveness (r=-0.222, P<0.01), and the number of neutrophils was significantly related to age (r=0.165, P<0.05) and forced expiratory volume in one second (r=-0.157, P< 0.05). Subjects with sputum eosinophilia (n=88, 20.5%) had received asthma treatment before the tests more often than those with neutrophilia (n=23, 4.3%) or mixed granulocytic nature (n=11, 0%) (P<0.05 for each). In the follow-up study, the number of eosinophils was significantly decreased in the eosinophilic subjects (P<0.05), and the Δinterferon- γ/interleukin-5 ratio was significantly related to Δeosinophils (r=0.933, P<0.001). There was an inverse relationship between the number of neutrophils and the increase in forced expiratory volume in one second (r=-0.459, P<0.05) or Δinterferon-γ (r=-0.842, P<0.01). Conclusion: The severity of asthma may depend on inflammatory cell types in sputum. Although inflammatory markers of sputum improve by asthma treatment, treatment responses differ according to cell types. Therefore, sputum examination may be useful for predicting therapeutic responses in asthmatics.
Successful Removal of a Screw Nail in the Jejunum Using Double-Balloon Enteroscopy
김동주,심명기,이상욱,이태희 대한소화기내시경학회 2015 Clinical Endoscopy Vol.48 No.5
The vast majority of foreign bodies (FBs) that enter the stomach pass through the gastrointestinal tract spontaneously. When the FB enters the small bowel—beyond the reach of conventional endoscopy—daily radiographs are needed to ensure its safe passage. However, endoscopic intervention is an appropriate management strategy for a sharp-pointed FB, because sharp FBs have a higher risk of intestinal perforation. We describe here a case in which a 1.5-cm, sharp-pointed screw nail in the proximal jejunum was removed successfully by double-balloon enteroscopy from a 19-year-old-male with autism. This case adds to the growing body of evidence demonstrating the value of therapeutic double-balloon enteroscopy in the field of FB ingestion.