중소기업의 육성과 자금문제

박희남 中央大學校經營大學 1964 經營論集 Vol.19 No.-

Clinical Significance of Additional Ablation of Atrial Premature Beats after Catheter Ablation for Atrial Fibrillation

박희남,김인수,양필성,김태훈,박준범,박진규,엄재선,정보영,이문형 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.1

Purpose: The clinical significance of post-procedural atrial premature beats immediately after catheter ablation for atrial fibrillation(AF) has not been clearly determined. We hypothesized that the provocation of immediate recurrence of atrial premature beats (IRAPB) and additional ablation improves the clinical outcome of AF ablation. Materials and Methods: We enrolled 200 patients with AF (76.5% males; 57.4±11.1 years old; 64.3% paroxysmal AF) who underwentcatheter ablation. Post-procedure IRAPB was defined as frequent atrial premature beats (≥6/min) under isoproterenol infusion(5 μg/min), monitored for 10 min after internal cardioversion, and we ablated mappable IRAPBs. Post-procedural IRAPB provocations were conducted in 100 patients. We compared the patients who showed IRAPB with those who did not. We also compared the IRAPB provocation group with 100 age-, sex-, and AF-type–matched patients who completed ablation without provocation (No-Test group). Results: 1) Among the post-procedural IRAPB provocation group, 33% showed IRAPB and required additional ablation with a longer procedure time (p=0.001) than those without IRAPB, without increasing the complication rate. 2) During 18.0±6.6 months of follow-up, the patients who showed IRAPB had a worse clinical recurrence rate than those who did not (27.3% vs. 9.0%; p=0.016), in spite of additional IRAPB ablation. 3) However, the clinical recurrence rate was significantly lower in the IRAPB provocation group (15.0%) than in the No-Test group (28.0%; p=0.025) without lengthening of the procedure time or raising complication rate. Conclusion: The presence of post-procedural IRAPB was associated with a higher recurrence rate after AF ablation. However, IRAPB provocation and additional ablation might facilitate a better clinical outcome. A further prospective randomized study is warranted.

우리나라 임금 체계의 현황과 문제점

박희남 中央大學校經營大學 1967 經營論集 Vol.24 No.-

한정된 샘플 수량으로 효과적인 저장신뢰도 예측을 위한 샘플링 시점 수와 샘플 수량 결정 방법 실험

박희남,장중순,박상철 한국경영과학회 2016 한국경영과학회 학술대회논문집 Vol.2016 No.4

This paper provides simulation-based results of effect analysis of estimation reliability about sample size and sampling periods when limited total sample quantity. Analysis accuracy of estimation reliability with sum of squared errors. Assumed true reliability according to the weibull distribution. Look for sum of squared errors value using a parameter estimation method using quantal response data. Finally confirm the scenario with smallest squared errors value.

사례에 의한 우리나라 노사관계의 문제점

박희남 中央大學校經營大學 1966 經營論集 Vol.22 No.-

The Interrelationship between Reading Strategies and L2 Learners’ Proficiency

박희남 한국중앙영어영문학회 2008 영어영문학연구 Vol.50 No.2

Previous research has shown that L2 learners differing in their degree of proficiency may employ different modes of processing while reading. The research questions are the following: (1) Is there any relationship between ESL learners’ reading strategies at each proficiency level and their reading comprehension ability? (2) Is there any difference in reading strategies used by low and high proficiency L2 learners? The subjects who participated in this study consisted of sixty-one ESL students. In order to divide students into higher and lower proficiency levels, the researcher used the Test of Adolescent and Adult Language (TOAL). For the purpose of identifying a subject’s ‘reading strategies’ items, the researcher used the Reading Strategy Questionnaire (RSQ) (Carrell, 1989; Pritchard, 1990; Rusciolelli, 1995). The results show that top-down reading strategies were preferred more by all students than bottom-up reading strategies when they read in an L2.

合評會

박희남 한국일본문화학회 2006 日本文化學報 Vol.0 No.29

적출 돼지 우심실에서 K[ATP] 통로 개방제가 심실빈맥 유발 및 활동전위기간 상환현상에 미치는 영향

박희남,황교승,이상칠,김병수,이수진,심완주,노영무,김영훈 대한심장학회 2004 Korean Circulation Journal Vol.34 No.3

Background and objectives:It remains to be defined how K[ATP] Channel Opener facilitates to induce ventriculararrhythmias. The purposes of this study are to assess the effects of K[ARP] Channel Opener, PCO400, on the actionpotential duration (APD) and APD restitution (APDR) kinetics, and their relationship with induction of ventriculartachycardia (VT)/fibrillation (VF), pro-fibrillatory effects. Materials and Methods:We recorded transmembranepotentials (TMPs) by microelectrode technique to explore the effects of PCO400 in ninetecn isolated perfusedswine right ventricles. TMPs were recorded on the endoeardial side at the concentrations 0 μM, 1 μM, 2.5 μM, 5μM, 10 μM, and washed-out period (1 hour). Ventricular refractory periods were measured while scanning djastolewith premature ventricular beats during pacing at the cycle length of 600 ms at each concentration. The maximalslopes (Smax) of APDR were calculated with the data of S1S2 pacing and VF. Results:PCO400 reduced APD90(208±76 ms to 41±9 ms during S1, p<0.001, 111±32 ms to 54±28 ms during VF, p<0.001). While PCO400 tendedto increase Smax of APDR at the concentration of 1 μM (0.6 to 0.7 by S1S2, 2.3 to 3.0 during VF), it reducedSmax at higher concentrations (-0.01 by S1-S2, p<0.05;-1.1 during VF, p<0.01). The increment of PCO400concentration was associated with facilitated VT/VF induction (24.4% to 100%, p<0.001). Spontaneous VF inductionrate was the highest at 1 μM (38.5%) which resulted in the highest Smax. Conclustion:PCO400 shows pro-fibrillatoryeffect by APD reduction and dynamic changes of Smax, Smax is closely related to spontancous induction of VT/VF,and APD90 shortening below 70 ms is critical for the maintenance of VT/VF. (Korean Circulation J 2004;34(3):296-303) 배경 및 목적:K[ATP] 개방제가 어떤 기전으로 심실성 부정맥을 유발하는지에 관해서는 알려진 바가 적다. 본 연구의 목적은K[ATP] 개방제인 PCO400이 활동전위기간(APD)와 APD상판 역동학에 미치는 영향과 이외 심실빈맥/세동의 유발과의 연관성에 대하여 알고자 함이다.방 법:19마리의 적출관류 돼지 우심실에서 미세전극 기법으로 세포막 전위를 기록하였다. 세포막 전위는 심내막측에서 PCO400 농도 0 μM, 1μM, 2.5μM, 5 μM, 10μM과 세척 1시간 후 기록하였다. 심실불응기는 각각의농도에서 60 ms 조율하면서 기외수축 조율을 하여 측정하였다. APD 상환곡선의 최대 기울기(Smax)는 S1S2조율 및 심실세동 중에 기록된 활동전위로 계산하였다. 결 과: PCO400은 APD90을 감소시켰다(600 ms S1 조율: 208±76 ms에서 41±9 ms, p<0.001;심실세동 중: 111±32 ms에서 54±28 ms, p<0.001). PCO400은 1 μM의 농도에서는 Smax를 증가시켰지만(S1S2 조율: 0.6에서 0.7, 심실세동 중:2.3에서 3.0) 고농도에서는 오히려 감소시켰다(S1S2 조율:-0.01, p<0.05, 심실세 동 중:-1.1, p<0.01). PCO400의 농도의 증가는 심실빈 맥/세동 유발률의 증가와 관련 있었다(24.4%에서 100%, p<0.01). 자발적인 심실세동의 유발률은 1 μM(38.5%) 에서 가장 높았으며 이는 높은 Smax와 관련 있었다. 결 론: PCO400은 활동전위기간의 감소와 Smax의 역동적 변 화를 유도함으로 새동의 유발을 용이하게 하였다. Smax 는 자발적인 심실빈맥/세동의 유발과 연관이 있으며 APD90이 70 ms 이하로 감소하는 상황은 심실빈맥/세동 의 유지에 결정적인 역할을 하는 것으로 생각된다.

다전극 Basket 도자로 Mapping하여 전극도자 절제한 우측 중격 우회로에 의한 방실회귀성 빈맥 2례

박희남,김영훈,이현수,정성원,김진석,이상칠,심완주,노영무 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.11

Antifibrillatory and Proarrhythmic Effects of d,l-Sotalol Mediated by the Action Potential Duration Restitution Kinetics

박희남,김영훈,황교승,이수진,이현수,임홍의,노영무 대한심장학회 2005 Korean Circulation Journal Vol.35 No.4

Background and Objectives:The action potential duration (APD) restitution kinetics has been known to play a crucial role in the initiation and maintenance of ventricular tachycardia (VT)/fibrillation (VF). We hypothesized that "the anti-arrhythmic and proarrhythmic effects of d,l-sotalol are mediated by changing the APD restitution (APDR) kinetics". Materials and Methods:The purposes of this study were: 1) to assess the effects of d,lsotalol on the APDR kinetics, and 2) to correlate the anti-arrhythmic and proarrhythmic action using the APDR kinetics. We recorded the transmembrane potentials (TMPs), using the microelectrode technique, in seven isolated perfused swine right ventricles, at the baseline, and with 1, 5, 10 and 20 mg/L of d,l-sotalol, with a washout period of 1 hour. The ventricular effective refractory periods (VERP), APD at 90% repolarization (APD90), spontaneous defibrillation rate and VF inducibility were measured at each concentration. We plotted APDR curves of S1-S2 pacing against VF, and calculated the maximal slopes (Smax) of the APDR. Results:Sotalol (10 mg/L) prolonged the APD90 (p<0.001) by reducing the Smax of the APDR (by S1-S2 pacing, p<0.01 during VF, p<0.05). Accordingly, 41.7% of the VT/VF was terminated spontaneously, and VT/VF inducibility reduced from 91.1% at the baseline to 25% with 10 mg/L sotalol. A higher dose of sotalol (20mg/L) increased the Smax, despite continuous prolongation of the VERP and APD90, resulting in the increase in the VT/VF inducibility (36.4%). Conclusion:Sotalol produces its anti-fibrillatory effect by APD prolongation in parallel with a flattening of the Smax at therapeutic doses. However, a higher concentration of sotalol increased the Smax and VF inducibility in isolated swine ventricular tissue.