청폐사간탕(淸肺瀉肝湯)이 급성기 중풍환자의 동맥경직도 및 맥압에 미치는 영향

박영민,홍진우,신원준,정동원,김석민,배형섭,김영석,문상관,정우상,조기호,Park, Young-Min,Hong, Jin-Woo,Shin, Won-Jun,Jeong, Dong-Won,Kim, Seok-Min,Bae, Hyung-Sup,Kim, Young-Suk,Moon, Sang-Kwan,Jung, Woo-Sang,Cho, Ki-Hoo 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.2

Objectives : Arterial stiffness and pulse pressure are related to cardiovascular and cerebrovascular survival and longevity. This study is aimed at examining the effects of Chungpyesagan-tang on arterial stiffness and Pulse pressure in acute stroke Patients. Methods: The subject of this study was acute strike Patients within 1 week after ictus, with Cardio-ankle vascular index(CAVI) higher than 9.0. They were divided into two groups: A treatment group (n=44) and a control group(n=46). For two weeks, Chungpyesagan-tang was given to the former, other herbal medicines to the latter. used for stroke patients for the control group for 2 weeks. At the end of first and second week, CAVI, pulse Pressure, National Institute of Health stroke scale(NIHSS), Modified Barthel Index(MBI) were measured. Serum lipid Profile, aspartate transaminase(AST), alanine transaminase(ALT). blood urea nitrogen(BUN), creatinine were also measured at the end of the study. Results : After 2 weeks, CAVI and Pulse Pressure in Chungpyesagan-tane group were significantly tower than those in the control group(P<0.05). NIHSS and MBI were improved in both groups. But there was no significant difference between the treatment group and the control group in terms of the NIHSS and MBI. Conclusions : We suggest Chungpyesagan-tanghas desirable effects on arterial stiffness and Pulse Pressure of acute stroke patients. It can improve morbidity and mortality of patients on the basis of influencing vascular stiffness and increased pulse pressure.

琴仙, 사회적 관계망과 정체성 찾기

박영민(Park, Young-min) 동양한문학회(구 부산한문학회) 2010 동양한문학연구 Vol.30 No.-

본 연구는 19세기 전반기의 황해도 해주 기생 琴仙의 한시를 통해 童妓가 자신을 둘러싼 사회적 관계망 속에서 어떻게 自我를 찾아 壯妓로 성장하여가는가를 밝혀보고자 한다. 금선은 황해주 해주에서 1800년에 태어나 13세 즈음부터 본격적으로 妓役을 수행한 기생이다. 금선의 한시는 필사본인 󰡔淸吟󰡕이라는 시권 속에 수록되어 있다. 금선은 한시를 통해 童妓에서 壯妓로 성장하는 기생의 成長談을 기생의 목소리로 직접 생생하게 들려준다. 현재까지 기생이 동기에서 장기로 성장하는 과정을 집중적으로 세밀하게 관찰할 수 있는 자료는 찾아보기 어려웠다. 금선의 한시에 대한 연구는 기생 작가, 여성 한시 작가의 새로운 발굴이라는 측면에서도 매우 중요한 의의가 있다. 그런데 학계에는 아직까지 금선의 한시에 대한 연구나 보고가 전혀 없는 실정이다. 금선의 성장담에서 가장 중요한 대상은 ‘客’이다. 실제, 기생의 일상은 관아에서의 妓役, 기방에서의 妓業이라는 공적, 사적 노동 현장에서 불특정 다수 남성들과의 교유로 이루어진다. 그런데 시집을 남긴 기생 가운데 자신이 상대하는 불특정 다수의 ‘객’을 호명하고 그들을 대상화하는 예는 거의 없었다. 반면 기생이 기역, 기방에서 ‘객’과 함께 하는 모습은 주로 남성들이 한시에서 묘사하였다. 그런데 남성 시인들이 묘사하는 기생의 모습은 남성들의 시선에 비친, 남성들이 보고자 하는 기생의 모습일 뿐이다. 그런데 금선은 자신의 일상에서 가장 핵심적인 사건이 불특정 다수 남성들 즉 ‘객’과의 교류임을 밝히고 한시에서 이 사건을 전면적으로 표현하였다. 금선은 노동의 주체로서 객체인 ‘客’을 향해 기역과 기업의 현장에 참여하는 자신이 무슨 일을 하고 있는지, 무엇을 원하는지를 분명하게 설명하고 보여준다. 금선과 객 사이에는 기생의 정체성이란 무엇인가에 대한 생각의 차이가 크게 존재한다. 금선은 때로는 객을 설득하고 때로는 저항하며 객과의 소통을 지향한다. 기생이 찾아가는 정체성의 끝에는 절개가 있었다. This paper focused on the widening our understanding of women literature in the 19th century. I introduced new documents, Keumsunsi(琴仙詩) and new woman writer, Keumsun(琴仙). She has not yet get known in women literature history. She was the important woman writer with Uncho(雲楚) in the late 19th century. This work is basically based on the understanding of her life and poems. Especially I paid attention to her social identity and daily thinking. And I emphasized that Keumsunsi was writen when Keumsun was very young. At that time Keumsun was 13 years old. I have characterized her daily life and thanking as a little gisaeng(童妓). I believe that analyzing the life and poems of Keumsun can contribute to understand the history of women literature in late Chosun dynasty. Especially she has acted as a little gisaeng in Haejoo in the early 19th century. I hope that this paper can contribute to understand the life and culture of gisaeng.

동일 인물 검증을 위한 딥러닝 기반 삼중 항 네트워크 모델

이지영(Ji-Young Lee),김지호(Ji-Ho Kim),최회련(Hoeryeon Choi),이홍철(Hong-Chul Lee) 한국컴퓨터정보학회 2021 한국컴퓨터정보학회 학술발표논문집 Vol.29 No.2

액상-환원법으로 초미세 Cu 분말 제조 시 반응 조건의 영향

박영민,진형호,김상렬,박홍채,윤석영,Park Young Min,Jin Hyeong Ho,Kim Sang Ryeol,Park Hong Chae,Yoon Seog Young 한국재료학회 2004 한국재료학회지 Vol.14 No.11

Ultra-fine Copper particles for a conductive paste in electric-electronic field were prepared using wet-reduction process with hydrazine hydrate ($N_{2}H_4{\cdot}H_{2}O$) as a reductor. The effect of reaction conditions such as the amount of dispersion ($Na_{4}O_{7}P_2{\cdot}10H_{2}O$) and reductor ($N_{2}H_4{\cdot}H_{2}O$) on the particle size and shape for the prepared Cu powders was investigated. The quantity of dispersion and reductor varied from 0 to 0.0025 M and from 5 to 40 ml at a reaction temperature of $70^{\circ}C$, respectively. The particle size, shape, and structure for the obtained Cu particles were characterized by means of XRD, SEM, TEM, EDS and TGA. The aggregation of Cu particles was reduced with relatively increasing of the amount of dispersion at fixed other reaction conditions. The smaller Cu particle with size of approximately 300nm was obtained from 0.032 M $CuSO_4$ with adding of 0.0025 M $Na_{4}O7P_2{\cdot}10H_{2}O$ and 40ml $N_{2}H_4{\cdot}H_{2}O$ at a reaction temperature of $70^{\circ}C$.

Lactobacillus pentosus 발효에 의한 담쟁이덩굴 줄기 추출물의 항산화 및 세포보호 효과

박소현 ( So Hyun Park ),성준섭 ( Joon Seob Seong ),이건수 ( Keon Soo Lee ),박영민 ( Young Min Park ),현송화 ( Song Hua Xuan ),차미연 ( Mi Yeon Cha ),강희철 ( Hee Cheol Kang ),박수남 ( Soo Nam Park ) 대한화장품학회 2017 대한화장품학회지 Vol.43 No.3

본 연구에서는 담쟁이덩굴 줄기 70% 에탄올 추출물과 발효균주 Lactobacillus pentosus를 이용하여 발효시킨 담쟁이덩굴 줄기 발효추출물에 대하여 항산화 및 세포보호 효과를 측정하였다. 1,1-Diphenyl-2-picrylhydrazyl (DPPH)를 이용한 자유라디칼 소거 활성(FSC₅₀)은 담쟁이덩굴 줄기 추출물 및 발효추출물이 각각 42.3 및 34.5 μ g/mL로 발효 후의 라디칼 소거활성이 약 18.4% 더 높게 나타났다. Lumiol-의존성 화학발광법을 이용한 Fe³⁺-EDTA/H₂O₂계에서의 총 항산화능(OSC₅₀) 평가에서도 담쟁이덩굴 줄기 추출물과 발효추출물은 각각 2.6 및 2.5 μ g/mL로 발효 후가 약 4.2% 정도 더 높은 총 항산화능을 나타냈다. ¹O₂로 유도된 적혈구 세포손상에 있어서 추출물 및 발효추출물의 세포 보호 효과(τ₅₀)는 50 μ g/mL에서 각각 126.4 및 173.0 min을 나타내어 발효 후 세포 보호 효과가 약 34.0% 더 높게 나타났다. 발효추출물은 지용성 항산화제로 알려진 (+)-α-tocopherol (43.4 min)보다도 3.9배 높은 세포 보호 활성을 보여주었다. 사람 섬유아세포인 Hs68을 대상으로 elastase 저해 활성을 조사하였다. Elastase 저해 활성(IC₅₀)은 담쟁이덩굴 줄기 추출물과 발효추출물에서 각각 873.6 및 687.8 μ g/mL로 발효 후에 elastase 저해 활성이 약 21.3% 더 높은 것으로 나타났다. 이상의 결과들은 담쟁이덩굴 줄기 발효추출물이 항산화 작용과 더불어 주름개선 효과를 가지는 천연 화장품 소재로써 응용 가능성이 있음을 시사한다. In this study, the antioxidant activities, cellular protective effects, and inhibitory effects on elastase of non-fermented and fermented extracts of Parthenocissus tricuspidata (P. tricuspidata) stem using Lactobacillus pentosus were investigated. The free radical scavenging activities (FSC₅₀) of non-fermented and fermented extracts were 42.3 and 34.5 μg/mL, respectively, in which the activity after fermentation was approximately 18.4% higher. Reactive oxygen species (ROS) scavenging activities (OSC₅₀) in Fe³⁺-EDTA/H₂O₂ system of non-fermented and fermented extracts were 2.6 and 2.5 μg/mL, respectively. The activity after fermentation was approximately 4.2% higher. In the ¹O₂-induced cellular damage of erythrocytes, the cellular protective effects (τ₅₀) of non-fermented and fermented extracts were 126.4 and 173.0 min at 50 μg/mL, respectively. The activity after fermentation was approximately 34.0% higher. The effect of fermented extract was 3.9 times higher than (+)-α-tocopherol (τ₅₀ = 43.4 min), known as a lipophilic antioxidant at 50 μg/mL. The inhibitory effect of elastase was investigated to predict the anti-wrinkle efficacy using Hs68 human fibroblasts cells. The elastase inhibitory activities (IC₅₀) of non-fermented and fermented extracts were 873.6 and 687.8 μg/mL, respectively, and the activity after fermentation was approximately 21.3% higher. These results indicated that fermented extract of P. tricuspidata stem has potentials as natural cosmetic ingredients with antioxidant and anti-wrinkle effect.

공초점주사현미경에 의한 푹스각막이상증의 각막조직소견

박영민,최범석,이종수.Young Min Park. MD. Beom Seok Choi. MD. Jong Soo Lee. MD. PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.9

Purpose: To analyze the morphology and density of corneal tissue in patients with early stage Fuchs’ corneal endothelial dystrophy (FCED) by in vivo confocal microscopy (IVCM). Case summary: Each layer of the cornea in 2 patients with early-stage FCED was examined with IVCM (ConfoScan 4.0, NIDEK, Co. Ltd., albignasego, Italy). Cross-sectioned corneal images of the corneal epithelium, Bowman’s layer, stromal layer, Descemet’s membrane, and endothelium were evaluated. Corneal epithelium, Bowman’s layer, and anterior stroma of both patients showed no abnormalities. Case 1 was diagnosed as Stage 1 FCED, demonstrating typical changes including pleomorphism, polymegathism, and the presence of guttae in the corneal endothelial layer. Case 2 was diagnosed as Stage 2 FCED, showing several hyper-reflective whitish dots in the posterior stroma, hypo-reflective vertical strands in the stroma adjacent to Descemet’s membrane, and pleomorphism, polymegathism, and guttae in the corneal endothelial layer. Conclusions: IVCM is a non-invasive and effective tool to diagnose early-stage FCED.

중증도에 따른 아벨리노 각막이상증의 공초점주사현미경 소견

박영민,김호윤,이종수,Young Min Park,MD,Ho Yun Kim,MD,Jong Soo Lee,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.3

Purpose: In this study we analyzed and objectified the characteristics of the Avellino corneal dystrophy patients considering disease severity using in vivo confocal microscopy (IVCM). Methods: Each corneal layer of 36 eyes in 18 patients with Avellino corneal dystrophy was examined using IVCM (ConfoScan 4.0, NIDEK, Co. Ltd., Albignasego, Italy). Patients were classified into 3 groups based on disease severity (mild, moderate, or severe). Results: In the mild group, hyper-reflective granular deposits without dark shadows were observed in the anterior stroma. As the disease progressed, corneal deposits were also found at the posterior stroma and epithelium, and clusters of hyper-reflective corneal deposits resembling stromal opacity were noted. The range of corneal deposits measured using Z-scan optical pachymeter was 111.14 ± 30.95 um in the mild group, 157.47 ± 25.00 um in the moderate group, and 193.42 ± 52.23 um in the severe group (p < 0.05). Conclusions: The origin of the corneal deposits in Avellino corneal dystrophy may be related to corneal stromal cells and distributed from the corneal epithelial layer to the stromal layer. IVCM might be useful for the standardization of disease severity by digitalizing the range of deposits. J Korean Ophthalmol Soc 2014;55(3):361-367

구강위생 증진제용 솔비톨 제조에 미치는 말티톨 및 올리고당의 영향

박영민,조인식,백인섭,정인식 ( Young Min Park,In Shik Cho,In Sup Baik,In Sik Chung ) 한국산업식품공학회 1997 산업 식품공학 Vol.1 No.3

파란색 colored light가 운동 기능에 미치는 영향

박영민,박동근,김정식 ( Young Min Park,Dong Keun Park,Jeong Sik Kim ) 한국스포츠심리학회 1995 한국스포츠심리학회 학술발표논문집 Vol.- No.3

피부과 외래환자에서 아토피피부염의 상대 빈도와 임상적 특징 및 검사 소견에 관한 연구

박영민,박홍진,김태윤,김정원 ( Young Min Park,Hong Jin Park,Tae Yoon Kim,Chung Won Kim ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Background : Atopic dermatitis(AD) is a common disease, and population-based studies indicate that the frequency of AD has increased substantially during recent decades. However, there have been few studies on the hospital based relative frequency, and clinical and laborat,ory findings of AD in Korea. Objective : The presenl study was aimed to elucidate the relative frequency of AD on the outpatient base, and to investigate the clinical manifestations and immunological laboratory findings. Methods : Our study was designed by analysing outpatients with AD via physical examination, questionnaires and immunological investigations such as skin prick tests, Multi test CMI, and measurernent of eosinophil counts, total IgE, Derrnatophagoides pteronyssinus-specific IgE and eosinophil cationic protein(ECP). Results : The results were as follows : 1. The relat,ive frequen:y of AD on the hospital base in 1995-1996 was 8.6%. 2. The mean age of onset was 3.36 years. 57.3% of the patients had their onset of eczema by the age of 1 year, 65.5% by 2 years and 83% by 5 years. The most common site at the onset was the face followed by antecubital area, popliteal area, neck, and trunk. 3. The predilection site on physical examination were the face, neck, antecubit,al area, popliteal area and trunk in decreesing order. 4. Concomitant allergic rhinitis, keratoconjunctivitis and asthma were present in 2~3.4%, 14.1%, and 9.5% of patients with AD, respect.ively, whereas pure AD was present in 34.1%. 5. Family history of atopy was observed in 60.5% of AD patient.s. 6. The most frequent ninor fea~ture of AD was xerosis followed by perifollicular accentuation, allergic shiner, cheilitis, imitation allergy, palrnar hyperlinearity and molluscum cantagiosum. 7. Seasonal aggravation was found in 86.8% of patients with AD, especially in summer and winter, The rnost significant aggravating factors were wools followed by sweating, heating, dryness, excessive bat.hing and emotional stress. 8. Abnormal levels of .osinophils, total IgE and ECP were seen in 44.8%, 78.9% and 31.7% Of patients with AD, respec.ively. 9. Cell mediated immunty was decreased in 68.2% of patients with AD. 10. Positive reactivity( at least rnore than one alle~rgen) in the skin prick t,est was noted in 76% of pat,ients with AD and the most popular 8 allergens were D. pteronyssinus, D. farinae, cat fur, M4 mixed threshing dust., dog hair, mugwort pollen, H3 tree pollen and birch pollen. 11. The specific IgE aritibodies to D. pteronyssinus(>+1) were found in 72.3% of AD patients and correlated with the r esults of the skin prick test in 76%. Conclusion : The hospi al-based relative frequency of AD investigated in our study tends to be increased. As the clinica featu~res and laboratory findings of AD might be influenced by genetic, environrnental and psychological factors, the systernic evaluation of patients with AD will be needed (Kor J Dermatol 1997;35(1): 96-106)