Benzyl Viologen을 이용한 전기 변색소자에 있어서 ITO(Indium Tin Oxide)투명전극의 특성

김성훈,윤지영,Kim, Sung Hoon,Yoon, Ji Young 대한화학회 1997 대한화학회지 Vol.41 No.11

Benzyl viologen의 전기 변색특성을 조사했다. 인가전압 2.6 V에서는 강한 전기변색 응답성을 나타내지만 반복 내구성이 뛰어나지 못하다. 이러한 현상은 전기 변색소자의 투명 유리전극인 ITO막이 전장하에서 손상을 입기 때문이라는 것을 알 수 있었다. 전압인가 전후의 ITO막의 면저항, XRD, SEM 결과로 부터 ITO막이 마모됨이 입증되었다. Benzyl viologen was synthesized and the electrochromic properties was examined. At an applied voltage of 2.6 V the electrocoloration was appeared but electrooptical response abruptly decreased after a certain period of time. It was a cause that the quality of the ITO film was degraded, e.g. the conductivity of the ITO film reduced from the original value. The ITO surfaces under some different conditions were observed by XRD and SEM.

철분투여가 흰쥐의 간장 , 비장 및 근육조직내 지질함량에 미치는 영향

김성훈,허인수,박항균,모기철,김영홍 ( Sung Hoon Kim,Rhin Sou Huh,Hang Kyun Park,Ki Choul Mo,Young Hong Kim ) 한국축산학회 1985 한국축산학회지 Vol.27 No.11

The purposes of the present studies were to clarify the effect of iron on the contents of the total free fatty acids, free unsaturated fatty acids, phospholipids, and unsaturated fatty acids in phospholipids in the liver, spleen, and muscle tissues of rats. Twenty rats were devided into 4 groups each consisting of 5 rats. A group was fed a control diet, B group was fed the same control diet and administered 3m1 of 1.5%Fe(OH)3 by intramuscular injection per week, C group was fed the control diet containing 2.5%Fe(OH)₃, and D group was fed the control diet supplemented with 5% of Fe(OH)3 for 60 days. The results obtained were summarized as follows: 1. Mean total free fatty acid concentrations is the liver, spleen and muscle tissues of A, B, C and D groups were 5.496, 5.570, 3.626㎎/g, 6.910, 5.938, 3.632㎎/g, 5.806, 5.076, 4.108㎎/g, and 7.462, 6.020, 4.330㎎/g, respectively. 2. Mean free unsaturated fatty acid concentrations in liver, spleen and muscle tissues of A, B, C and D groups were 2.202, 2,612, 1.860 ㎎/g, 2.676, 2.180, 1.936 ㎎/g, 2.418, 1.922, 1.894 ㎎/g, and 2.786, 1.950, 1.988 ㎎/g, respectively. 3. Mean phospholipid concentrations in liver, spleen and muscle tissues of A, B, C and D groups were 33.60, 30.56, 15.62 ㎎/g, 24.70, 29.32, 13.82 ㎎/g, 26.30, 29.16, 14.46 ㎎/g, and 24.54, 27.20, 13,24 ㎎/g, respectively. 4. Mean unsaturated fatty acid concentrations in phospholipids in liver, spleen and muscle tissues of A, B, C and D groups were 1.704, 1.364, 0.746 ㎎/g, 1.594, 1.316, 0.738 ㎎/g, 1.61, 1.32, 0.726 ㎎/g, and 1.188, 1.280, 0.648 ㎎/g, respectively.

PVA/탄소나노튜브 복합수용액의 유변학적 특성과 전기방사특성에 관한 연구

김성훈,왕샤오,이상철,민병길,Kim, Seoung-Hoon,Wang, Xiao,Lee, Sang-Cheol,Min, Byung-Gil 한국섬유공학회 2006 한국섬유공학회지 Vol.43 No.5

Aqueous solutions of poly(vinyl alcohol)(PVA) containing single-walled carbon nanotube (SWNT) and multi-walled carbon nanotube (MWNT) were prepared by using surfactants and sonication. It was found that the solution viscosities are significantly dependent on types and amount of surfactant and nanotubes. Sodium dodecylbenzene suifonate (NaDDBS) was most effective in dispersing SWNT in water by showing that highest viscosity of PVA/SWNT aqueous solution. The viscosity of PVA/CNT aqueous solution increased with increasing of sonication time implying the exfoliation of CNT However, the viscosity decreased at the additional sonication due to breaking of nanotubes in length. PVA/SWNT aqueous solution showed much higher viscosity than PVA/MWNT solution due to the increase of specific surface area and entanglement by exfoliation of SWNT rope to the individual nanotube. The PVA/SWNT solution exhibited good spinnability in electrospinning.

발효 , 세포배양 , 생물공정 잔나비 걸상 버섯 자실체 및 균사체의 생리활성 탐색

김성훈,이주노,김선희,오세종,안상욱,이진하,박영식,정을권,이현용 ( Sung Hoon Kim,Ju No Lee,Sun Hee Kim,Se Jong Oh,Sang Wook An,Jin Ha Lee,Young Shik Park,Eul Kwon Chung,Hyeon Yong Lee ) 한국미생물생명공학회 1998 한국미생물·생명공학회지 Vol.26 No.4

Reactions of Thianthrene Cation Radical Perchlorate with N-Arylbenzene- and N-Aryl-p-toluenesulfonamides. Synthesis of 5-(p-N-Arylbenzenesulfonamidephenyl)- and 5-(p-N-Aryl-p-toluenesulfonamidophenyl)thianthrenium Perchlorate

김성훈,김경태,Sung Hoon Kim,Kyongtae Kim Korean Chemical Society 1981 대한화학회지 Vol.25 No.6

티안트렌 양이온 자유라디칼 과염소산염은 p-톨루엔술포아니리드, 벤젠술폰아니리드, N-(2-메틸페닐)벤젠술폰아미드, N-페닐-p-톨루엔술폰아닐리드와 같은 N-아릴술폰아미드와 반응하여 각각 5-(p-N-p-톨루엔술폰아미도페닐)티안트렌이움 과염소산염(1a), 5-(p-N-벤젠술폰아미도페닐)티안트렌이움 과연소산염(1b), 5-(4-N-벤젠술폰아미도-3-메틸페닐)티안트렌이움 과염소산염(1c), 5-(p-N-페닐-N-p-톨루엔술폰아미도페닐)티안트렌이움 과염소산염(1d)을 준다. 한편 1d는 티안트렌 양이온 자유라디칼과 다시 반응하여 이과염소산염(1e)을 생성한다. 1a∼1e의 구조는 아세트아니리드와의 반응생성물인 5-(p-아세트아미도페닐)티안트렌이움 과염소산염과 매우 비슷하다. 그러나 두 반응의 양 관계에서 상이한 점은 술폰아미드와의 반응이 단일 메카니즘으로 진행되지 않음을 암시한다. Thianthrene cation radical perchlorate reacts with N-arylsulfonamides such as p-toluenesulfonanilide, benzenesulfonanilide, N-(2-methylphenyl)benzenesulfonamide, and N-phenyl-p-toluenesulfonanilide to give 5-(p-N-p-toluenesulfonamidophenyl)-(1a), 5-(p-N-benzenesulfonamidophenyl)-(1b), 5-(4-N-benzenesulfonamido-3-methylphenyl)-(1c), and 5-(p-N-phenyl-N-p-toluenesulfonamidophenyl thianthrenium perchlorate (1d), respectively. In the meantime, 1d reacts further with thiathrene cation ratical to form diperchlorate(1e). The structure of 1a~1e is very similar to 5-(p-acetamidophenyl) thianthrenium perchlorate which has been obtained from the reaction with acetanilide. However, the discrepancy in the stoichiometry between two reactions indicates that the reaction with sulfonamide appears not to proceed with a single mechanism.

혈청내 유리지방산의 비색정량법

김성훈,박항균,모기철,허린수,Kim Sung Hoon,Park Hang Kyun,Mo Ki Choul,Huh Rhin Sou 대한수의사회 1983 대한수의사회지 Vol.19 No.1

The present paper describes a simple colorimetric determination method of serum or plasma free fatty acids in various animal for those who are in the laboratories unequiped with high-cost newer analysing equipments and for those clinicians with low-cost a

A Case of End-Stage Renal Disease with Joubert Syndrome due to CEP290 Mutation

김성훈,이상택,성문우,김만진,이준화,Kim, Sung Hoon,Lee, Sang Taek,Seong, Moon-Woo,Kim, Man Jin,Lee, Jun Hwa The Korea Society of Inherited Metabolic Disease 2020 대한유전성대사질환학회지 Vol.20 No.1

쥬버트 증후군(JS, Joubert syndrome)은 대부분 상염색체 열성으로 유전되는 유전성 대사질환으로 임상증상은 신생아 시기부터 발현된다. 저자들은 신생아기부터 특징적인 임상 증상이 순차적으로 발현되어 임상적으로 JS를 의심하였으나 특징적인 뇌 MRI 소견인 molar tooth sign (MTS)이 늦게 나타난 후 전장엑솜분석(WES, whole exome sequencing)으로 확진 된, 말기 신부전을 동반한 JS 1례를 경험하였기에 보고하고자 한다. 14세 남자 환자는 출생 직후 반복적인 무호흡과 과호흡으로 치료받은 병력이 있으며, 생후 8개월때부터 전반적 발달 지연과 관련되어 처음 병원을 방문하여 기본적인 발달 지연에 관한 검사를 시행하였으나 특이 소견 없었고, 이후 15개월 때 근육생검을 포함한 여러 검사를 통해 사립체(mitochondrial) 질환으로 진단 되었었다. 이후 물리 치료만 하며 관찰 하던 중 안구진탕과 망막질환이 확인되었다. 생후 7세 8개월에는 처음 발작이 있었으며, 말기 신부전이 있어 8세부터 혈액투석을 시작한 후, 혈액 투석 직후 수차례 발작이 있었으나 전해질 불균형으로 인한 발작으로 진단하여 항뇌전증 약물 치료는 하지 않았다. 9세 4개월 때 고혈압으로 인한 뇌출혈로 치료 받았으며, 이때 시행한 뇌 CT상 MTS가 처음 의심되었다. 13세 10개월에 시행한 뇌 MRI 검사상 MTS가 명확히 확인되었고, 전장엑솜 분석으로 JS의 CEP290 mutation (c.6012-12T>A)이 확인되었다. 환자는 신생아기부터 발현된 특징적인 임상 소견과 말기 신부전 상태, 뇌 CT 또는 MRI소견, 그리고 전장엑솜분석 검사로 JS로 확진하였다. JS는 임상 양상이 다양할 뿐만 아니라 진단에 중요한 MTS 소견이 초기에 보이지 않더라도, 임상적으로 의심된다면 확진을 위해서 전장엑솜분석을 시행하는 것이 필요하다. Joubert syndrome (JS) is a rare genetic disorder that is characterized by ataxia, hypotonia, developmental delay, respiratory abnormalities such as apnea-hyperpnea, and abnormal eye movements. The pathognomonic diagnostic finding is the "molar tooth sign" (MTS) on brain magnetic resonance imaging (MRI), described as cerebellar vermis hypoplasia or dysplasia, thick and horizontally oriented superior cerebellar peduncles, and an abnormally deep interpeduncular fossa. JS is characterized by genetic heterogeneity: pathogenic variants in over 30 genes have been identified to date. The CEP290 protein, which is on chromosome 12q21.3, is most frequently mutated in patients with JS, especially with renal involvement. Here, we report a case of JS in a 14-year-old male patient with end-stage renal disease. To the best of our knowledge, this is the first Korean report of a patient with JS due to CEP290 mutation (c.6012-12T> A) whose diagnosis was confirmed after repetitive MRI. We suggest consultation with an experienced neuro-radiologist and follow-up MRI studies to detect a "hidden" MTS if clinical findings suggest a diagnosis of JS. Furthermore, even in the absence of an MTS, whole exome sequencing should be considered.

The effect of captafol on the hematological value, erythrocyte membrane and plasma biochemical value in vitro

김성훈,황화선,차신우,한상섭,노정구,Kim, Sung-hoon,Hwang, Hwa-seon,Cha, Shin-woo,Han, Sang-seop,Roh, Jung-koo The Korean Society of Veterinary Science 1993 大韓獸醫學會誌 Vol.33 No.3

Captafol은 phthalimide계통의 항진균제로써 difolatan이란 상품명으로 개발되어 과일, 채소의 탄저병 및 원목 등의 곰팡이 구제에 널리 사용되고 있는 것으로 국내에서도 두번째로 많이 생산, 사용되는 품목이나 독성실험에 관한 보고는 거의 없는 상태이다. 이에 본 연구에서는 captafol 자체에 대한 독성기전의 일부를 확인하고자 동물체내에서 일어나는 여러가지 대사작용이 배제된 시험관내에서 실험을 수행하였다. 랫트 혈액을 후대정맥으로 부터 채혈하여 4개의 시험관에 $2.5m{\ell}$씩 분주한 후 captafol 농도가 $0.1{\times}10^{-4}M$, $1{\times}10^{-3}M$, $1{\times}10^{-2}M$이 되도록 한 ethanol용액 $25{\mu}{\ell}$씩 넣고 $CO_2$ incubator에서 2시간 동안 부드럽게 혼합하여 혈액학적 성상 및 적혈구 취약성 시험을 수행하였다. 또한 원심분리하여 얻어진 혈장에서 생화학적 성상 등을 조사한 결과 다음과 같은 성적을 얻었다. 1. 적혈구수 및 hematocrit치는 captafol 투여량에 비례적으로 유의한(p<0.05) 감소를 나타내었다. 2. 적혈구막 취약성 실험에서 $1{\times}10^{-3}M$ 및 $1{\times}10^{-2}M$ 농도에서 대조군에 비하여 유의한(p<0.01) 증가를 나타내었다. 3. 혈장내 potassium이온의 농도는 captafol의 투여량에 비례적으로 증가하였다. 4. Total bilirubin 및 creatine kinase가 대조군에 비하여 각각 증가 및 감소하였다. The effect of captafol on the hematological value, erythrocyte membrane and plasma biochemical value was investigated using blood of SPF Sprague-Dawley male rats in vitro. For the anticoagulations, we used 0.5mg of heparin per $10m{\ell}$ of blood from vena cava. Three con-centrations($0.1{\times}10^{-4}M$, $1{\times}10^{-3}M$ and $1{\times}10^{-2}M$) captafol in ethanol were added to the each $2.5m{\ell}$ blood so that the linal concentration of ethanol was 1%. The blood contained with each concentration of captafol was incubated at $37^{\circ}C$ C for 2 hours under 5% $CO_2$ gas The whole blood and plasma were examined for hematological vaJues, erythrocyte membrane damage and biochemical values, respectively. The results obtained were summarized as follows ; 1. The number of RBC in $1{\times}10^{-2}M$ group and the concentration of MCHC in $1{\times}10^{-3}M$ group were significantly (p<0.05) decreased and increased from that of control values, respectively. The percentage of Hct was significantly (p<0.05) decreased with dose-response. 2. Erythrocyte fragility rate of $1{\times}10^{-3}M$ and $1{\times}10^{-2}M$ group were significantly (p<0.01) increased from that control with dose response. 3. Potassium ion level of $1{\times}10^{-2}M$ was significantly (p<0.05) increased from that of control. 4. The concentration of total bilirubin in the $1{\times}10^{-3}M$ and $1{\times}10^{-2}M$ groups were significantly increased from that of control. The enzyme level of creatine kinase in $1{\times}10^{-2}M$ group was significanlty (p<0.05) decreased from control value.

대칭, 비대칭 Viologen 유도체의 전기변색특성

김성훈,배진석,황석환,권태선,도명기,박철,Kim, Sung Hoon,Bae, Jin Seok,Hwang, Seok Hwan,Gwon, Tae Sun,Do, Myung Ki,Park, Chul 대한화학회 1996 대한화학회지 Vol.40 No.11

Viologen 유도체를 합성하여 이들의 electrochromic(전기변색) 특성을 조사했다. 1, 1'-diethyl-4, 4'-bipiridinium dibromide(EV), 1, 1'-dipropyl-4, 4'-bipyridinium dibromide(PV), 1, 1'-dibuthyl-4, 4'-pyridinium dibromide(BV), 1-ethyl-1'-butyl-4, 4'-bipyridinium dibromide(EBV)를 대상으로 하여 propylene carbonate/methanol 용액내에서 전기변색성을 검토하였다. 또한 전장하에서 EV와 EBV의 cation radical은 dimer를 형성하는 것을 알 수 있었다. Several kind of viologen derivatives were synthesized and the electrochromic property of these compounds was examined by cyclovoltametric and chronoamperometric method, relating to the mechanisum of coloring reaction. The electrochromic properties of 1,1'-diethyl-4,4'-bipyridinium dibromide(EV), 1,1'-dipropyl-4,4'-bipyridinium dibromide(PV), 1,1'-dibuthyl-4,4'-bipyridinium dibromide(BV) and 1-ethyl-1'-butyl-4,4'-bipyridinium dibromide(EBV) are studied by using an propylenecarbonate/methanol solution with $Bu_4NBF_4$ as supporting electrolyte. A monomer-dimer equilibrium was proposed to explain the related observation that EV and EBV cation radical solutions are violet at an applied voltage of 1.7∼3.0V but become blue in open-circuit condition.

Squarylium, Croconium계 Polymethine 색소의 합성과 특성

김성훈,황석환,송한철,윤남식,Kim, Sung Hoon,Hwang, Seok Hwan,Song, Han Chul,Yoon, Nam Sik 대한화학회 1996 대한화학회지 Vol.40 No.12

기능성색소로 응용되는 몇몇 squarylium 및 croconium계 색소를 합성한 후 이들이 특성에 관해 조사했다. Squarylium 색소의 경우 5위치에 니트로기의 도입에 의하여 대폭 심색이동이 관찰되었으며 IR 및 solvatochromism 특성으로부터 중심 4고리의 1, 3 위치에 indoline환이 결합된 형태이며 기저상태가 극성인 구조를 취하고 있음을 알 수 있었다. 또한 다단계반응에 의해 비대칭 squaryliunm계 색소를 합성하였다. 중심에 5고리를 가지는 croconium계 색소를 합성하였으며 이들은 770-780nm에 ${\lambda}_{max}$을 나타냈다. 이들 색소의 구조와 흡수스펙트럼의 관계를 PPP-MO를 상용하여 해석한 결과 실측치와 좋은 상관관계를 나타냈다. The syntheses and absorption spectra of squarylium and croconium dyes were studied. IR data and negative solvatochromism revealed that squarylium dyes have symmetrical 1,3-bonded squarylium rings. A new class of unsymmetrical squarylium dyes and their precursor have also been synthesized. The λmax of croconium dyes undergoes a bathochromic shift of about 100 nm compared with corresponding squarylium dyes. This shift can he calculated by the Pariser-Parr-Pople molecular orbital method.