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만성정신분열병에서 Diazepam의 항정신병 효과에 대한 예비적 연구
최휘영,이택중,김용식,이정균 대한신경정신의학회 1985 신경정신의학 Vol.24 No.1
The purpose of this study was to test the antipsychotic effect of diazepam. Twenty-five hospitalized chronic schizophrenic patients who had been resistant to standard neuroleptic treatment were included. The patients were subdivided into two groups and the study was run double-bline, cross-over, with twc successive periods of three weeks each. Thus all patients were received once diazepam (30〜90mg/day) and once placebo alternatively. The effect of diazepam was assessed weekly by the Brief Psychiatric Rating Scale (BPRS) and the Clinical Global Impression Scale (CGI). Diazepam showed no difference from placebo in antipsychotic effect during total six weeks, that is, two successive periods of three weeks, but there were significant antipsychotic effect of diazepam, during first three weeks. This result seems to be due to the carry-over effect of diazepam during second three weeks for placebo medication and due to the masking of antipsychotic effect by the side effects of diazepam. So further longterm clinical studies are needed. In addition, there were no significant differences in sex, age, duration of illness, maintenance daily dosage of diazepam, neuroleptic dosage and duration of neuroleptic medication over chlorpromazine 600mg equivalent between the patients who did respond to diazepam and who did not. Eight patients dropped out mainly because of the side effects. Seventeen patients completed this study and ten of them showed the side effects during the maintenance periods of diazepam.
Ras 단백질 Cysteine Carboxyl Methyltransferase의 특성에 관한 연구
崔暉英,朴光淑,朴吉洪,柳總根 고려대학교 의과대학 1993 고려대 의대 잡지 Vol.30 No.1
To understand the mechanism by which ras oncoprotein exhibits its physiological guanine nucleotide triphosphatase (GTPase) activity and pathological influence such as carcinogenesis, in depth knowledge on posttranslational processing is underscored. In the context, we focus on the biological role of enzymatic carboxyl methylation of C-terminal cysteine in ras family protein. Characterization of ras-protein cysteine carboxyl methyltransferase is the current objectives. Membrane extracts from bovine brain catalyze the transfer of methyl groups from S-adenosyl-L-methionine (AdoMet) to N-acetyl-S-farnesyl-L-cystein (AFC). It was determined by counting the radioactivity from[^(14)C] methyl AFC, the product of the methylation reaction as the α-carboxylmethyl ester derivative of AFC. According to subcellular cell fractionation, significant AFC is 11.1 μM, for AdoMet 3.8 μM and S-adenosyl-L-homocysteine (AdoHcy) was a competitive inhibitor with respect to AdoMet with an apparant Ki=1.8 μM. The change of methyl transferase activity following development of rat brain was analyzed and the highest specific activity was found 38 days after birth. respect to AdoMet with an apparant Ki=1:8 μM The change of methyl transferase activity following development of rat brain was analyzed and the highest specific activity was found 38 days after birth. Our results suggest that cystein carboxyl methyltransferase is distinct entity from protein methylase-Ⅱ (PM-Ⅱ) and associated with membrane in bovine brain conforming to previous reports.
최휘영,왕순,이수용,김후남,Choi, Hwee-Young,Wang, Soon,Lee, Soo-Yong,Kim, Hoo-Nam 한국호스피스완화의료학회 2000 한국호스피스.완화의료학회지 Vol.3 No.2
The authors reported a case of terminal pediatric cancer patient. The patient was ten-year-old girl, and she was diagnosed as osteosarcoma with multiple metastasis to lung and bones. She was markedly depressed and had severe bone and chest pain. The patient was treated with hypnotherapy once or twice a week for two months. There was marked improvement in pain control and emotional reactions, and the hospice team could establish good rapport with her. Hypnotherapy would be one of the effective treatment modalities in assisting patients.
최휘영,이왕준,유명순,장진구,홍민하,김현수,이수영 대한불안의학회 2022 대한불안의학회지 Vol.18 No.2
Objective : Hospital workers’ mental health has deteriorated because of the ongoing COVID-19 pandem- ic. The purpose of this study was to investigate the impact of the prolonged COVID-19 pandemic on the men- tal health of hospital workers and its determinants. Methods : Two surveys were conducted among employees working in a hospital that received COVID-19 patients from the early phase of the pandemic in South Korea. Data on demographics, perceived threat, work- place evaluation, resilience, and mental health status were collected using the Korean General Health Ques- tionnaire-20 in the initial phase (February 2020) and during the third wave of COVID-19 (December 2020) for 467 and 545 workers, respectively. The mental health of hospital workers in the two phases was compared, and the risk and protective factors during the third wave were investigated. Results : The proportion of patients in the psychiatric high-risk group increased from 2.8% in the initial phase to 11.4% during the third wave. The perceived threat, workplace evaluation, and resilience of respon- dents deteriorated. Risk factors for mental health during the third wave included the perceived threat items of job stress, loss of control, and considering resignation. Protective factors included presence of children, work- place satisfaction, and hardiness in resilience. Conclusion : Hospital workers’ mental health deteriorated as the pandemic progressed. General stress and tension such as job stress, loss of control, considering resignation rather than COVID-19-specific stress had negative effects on mental health of hospital workers. Therefore, care for work stress itself can be helpful to maintain the mental health of hospital workers. Also, governance to improve workplace satisfaction or hardi- ness in resilience can be a potential protective factor for hospital workers’ mental health during the prolonged pandemic. (Anxiety and Mood 2022;18(2):80-91)
만성정신분열병에서 Diazepam의 향정신병 효과에 대한 예비적 연구
최휘영,이택중,김용식,이정균 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1
The purpose of this study was to test the antipsychotic effect of diazepam. Twenty-five hospitalized chronic schizophrenic patients who had been resistant to standard neuroleptic treatment were included. The patients were subdivided into two groups and the study was run double-bline, cross-over, with two successive periods of three weeks each. Thus all patients were received once diazepam (30∼90㎎/day) and once placebo alternatively. The effect of diazepam was assessed weekly by the Brief Psychiatric Rating Scale(BPRS) and the Clinical Global Impression Scale(CGI). Diazepam showed no difference from placebo in antipsychotic effect during total six weeks, that is, two successive periods of three weeks, but there were significant antipsychotic effect of diazepam, during first three weeks. This result seems to be due to the carry-over effect of diazepam during second three weeks for placebo medication and due to the masking of antipsychotic effect by the side effects of diazepam. So further long-term clinical studies are needed. In addition, there were no significant differences in sex, age, duration of illness, maintenance daily dosage of diazepam, neuroleptic dosage and duration of neuroleptic medication over chlorpromazine 600㎎ equivalent between the patients who did respond to diazepam and who did not. Eight patients dropped out mainly because of the side effects. Seventeen patients completed this study and ten of them showed the side effects during the maintenance periods of diazepam.