당뇨병성 미세혈관병증 환자에서 혈중 및 요중 Transforming Growth Factor-β-inducible Gene-h3의 농도

류성열,도주호,황준영,박근규,김성열,신동우,이동욱,이인규 계명대학교 의과학연구소 2001 계명의대학술지 Vol.20 No.1

Diabetic microangiopathy is a major contributing cause of mortality in patients with diabetes. Despite of conventional therapy to improve hyperglycemia and to control blood pressure, the incidence of diabetic nephropathy is reaching epidemic proportions world wide. Transforming growth factor-β (TGF-β) has been implicated in the pathogenesis of a number of kidney diseases characterized by glomerulosclerosis and tubulointerstitial fibrosis. TGF-β-inducible gene-h3(βig-h3) is a kind of recently identified TGF-β induced gene products. TGF-β is secreted in a latent form and requiring extracellular modification to become biologically active. In vitro, exposure of proximal tubular cells to high glucose concentrations leads to increased TGF-β1 and collagen expansion as it does in mesangial cells. Biologically active form of TGF-β plays a pathogenetic role in diabetic renal disease and βig-h3 may be a useful index of TGF-β1 bioactivity in the kidney. Level of beta2-microglobulin is useful as a parameter to detect the degree of tubular injury and alterations in tubular handling of proteins in patients with proreinuria and glomerular diseases. We measure blood and urine concentrations of TGF-β in diabetic microangiopathy patient. Since there is a substantial evidence for a cause and effect relatioship between upregulation of TGF-β and the progression of diabetic kidney disease, future studies will be needed to establish specific targets along these pathyways at which to intervene.

인정투쟁이론시각에서 본 SNS 사용자의 과의존 행동 결정요인 연구

류성열,박상철 한국지식정보기술학회 2017 한국지식정보기술학회 논문지 Vol.12 No.5

As the usage of SNS has considered as a normal modern behavior, there are downfalls alike behavioral addictions which related to excessive and compulsive behavior in SNS usage. In line with this situation, this study tends to examine the relationships among propensity for conspicuous consumption on SNS, conspicuous consumption on SNS and SNS overdependence. In this study, we attempted to undermine the determinants of users' overdependence toward SNS from the nature of human, we have also considered both propensity for conspicuous consumption on SNS and conspicuous consumption on SNS as major determinants. We developed the model with three research hypotheses and test it by using partial least squares approach after collecting 430 data from SNS users. According to our results, this study found that the propensity for conspicuous consumption on SNS affected both conspicuous consumption on SNS and SNS overdependence. We also found that the relationship between conspicuous consumption on SNS and SNS overdependence was positively significant. Based upon the empirical findings, this study has theoretical implications on explaining overdependence to SNS from the human nature. We also have practical implications for preparing some precaution policies to decrease overdependence on SNS.

Udenafil, a Phosphodiesterase 5 Inhibitor, Reduces Body Weight in High-Fat-Fed Mice

류성열,최윤정,박소영,김종연,김용대,김용운 대한남성과학회 2018 The World Journal of Men's Health Vol.36 No.1

Purpose: High-fat (HF) feeding induces hypothalamic leptin resistance via the activation of toll-like receptor 4 (TLR4). TLR4 deficiency confers resistance to diet-induced obesity. Udenafil, an anti-impotence drug, inhibits TLR4 in airway epithelial cells in vitro. In this study, we evaluated whether udenafil suppressed the hypothalamic expression of TLR4 and reduced body weight.Materials and Methods: The hypothalamic expression of TLR4, phosphodiesterase 5 (PDE5), nuclear factor-κB (NF-κB), and myeloid differentiation primary response gene 88 (Myd88) was analyzed by real-time polymerase chain reaction after treating mice for 2 days with udenafil (0, 12, 120, or 600 μg/d). Furthermore, the hypothalamic expression of TLR4, pro-opiomelanocortin (POMC), and neuropeptide Y (NPY) was analyzed after 9 days’ treatment with udenafil and/or leptin. We also measured body weight and food intake following 9 days of udenafil and/or leptin treatment in control- and HF-fed mice.Results: Udenafil suppressed hypothalamic TLR4 mRNA expression dose-dependently. The changes were associated with decreased PDE5, NF-κB, and Myd88 expression. Udenafil treatment for 9 days reduced body weight and caloric intake in HF-fed mice. This may have been associated with the suppression of NPY expression that was elevated by HF feeding. POMC expression was not affected by udenafil. However, udenafil did not augment the effects of leptin on the reduction of body weight and caloric intake in HF-fed mice. Conclusions: These results suggested that udenafil reduced body weight by suppressing hypothalamic TLR4 mRNA expression in HF-fed mice and the combination effect of udenafil and leptin was additive rather than synergistic.

SNS 피로증후군의 선행요인에 관한 연구: 베블런의 유한계급론 관점

류성열,김경규 한국지식정보기술학회 2017 한국지식정보기술학회 논문지 Vol.12 No.3

In hyper-connected communication environment, users of social networking services (SNSs) often consume highly conspicuous SNSs in order to advertise their SNSs, thereby achieving greater social status. SNSs users have a willingness to pay a higher time and effort for making social relationships and then engage in conspicuous consumption of SNSs by overpaying for conspicuous social relationships. These overpayment for conspicuous consumption of SNSs may cause SNSs fatigue. As SNSs have rapidly grown, there has been little attempts to examine why individuals continue to overuse SNSs even though they have felt regret on using it. Using Veblen’s conspicuous consumption theory as the overarching theory, this study regards both conspicuous consumption tendency and competitiveness as antecedents of conspicuous SNSs consumption. This study also regards conspicuous SNSs consumption as an determinant SNSs fatigue. The data used in this study were collected from 342 individuals through online surveys. The results show that conspicuous consumption tendency has significant impacts on conspicuous SNSs consumption. Competitiveness also significantly influenced conspicuous SNSs consumption. Then, conspicuous SNSs consumption was a significant predictor of SNSs fatigue. The contribution for research is that it develops and tests a integrative model of understanding conspicuous SNSs use by employing Veblen’s conspicuous consumption theory.

소셜커머스의 유희성 및 보완성이 지속적 사용의도에 미치는 영향에 관한 연구

류성열,박상철,곽수환 한국지식정보기술학회 2014 한국지식정보기술학회 논문지 Vol.9 No.6

As social commerce has rapidly grown, a number of studies have been conducted to investigate into an individual’s intention to use social commerce. Considering the benefits related to the social commerce, there still remain opportunities for identifying some key variables that may help explain the continuous usage intention in social commerce. In particular, there has been little empirical work in this area to understand why people continuously use the social commerce. In this study, drawing on the main variables such as hedonic need fulfillment of social commerce and complementarities of social commerce, we develop and test a model of an individual's continuous usage intention in social commerce. Our model posits that both hedonic need fulfillment and complementarities of social commerce affect continuous intention by mediating both expected confirmation and satisfaction. Survey data collected from social commerce consumers were used to test the model by using PLS (partial least squares) analysis. According to our results, hedonic need fulfillment and complementarities of social commerce affected both expected confirmation and satisfaction, respectively. We also found that expected confirmation has a positive effect on satisfaction, which leads to the individuals’’ continuous usage intention. Based on our empirical findings, the implications for both research and practice are discussed.

IT아웃소싱에서 고객기업의 서비스기업에 대한 의존성과 전환비용에 관한 연구

류성열,이민혜 한국지식정보기술학회 2013 한국지식정보기술학회 논문지 Vol.8 No.2

A strategic decision to discontinue an existing IT outsourcing contract could incur substantial switching costs whenterminating the relationship with an IT service vendor and securing an alternative. The purpose of this research is toinvestigate the impact of a client's dependence on a vendor, uncertainty, and a client's vendor management capability on IToutsourcing switching costs in IT outsourcing context. A total of 210 data collected from field survey were analyzed forthis study. The results indicate that both a client's dependence on a vendor and uncertainty positively influence IToutsourcing switching costs, but a client's vendor management capability negatively influences IT outsourcing switching costs. And the results indicate that a client's vendor management capability has moderating effect on the relationship between aclient's dependence on a vendor and IT outsourcing switching costs.

담도암의 방사선 치료

柳星烈 대한의학협회 1994 대한의학협회지 Vol.37 No.4

加速器를 利用한 癌治療技術 現況

柳星烈 대한방사선방어학회 1986 방사선방어학회지 Vol.11 No.1

재사용 정보 관리 도구의 설계 및 구현

류성열,정민영 崇實大學校 大學院 1993 崇實大學校 大學院 論文集 Vol.11 No.-

한글 워드프로세싱 시스템의 표준화 설계

류성열 崇實大學校 1986 論文集 Vol.16 No.-

본 논문은 지금까지 연구되고 실용화되고 있는 한글 워드 프로세싱 시스템의 설계 이론과 이용 방법을 집대성하여, 분산 처리 시스템 하에서 단말기로 이용되는 마이크로 컴퓨터를 효율적으로 이용할 수 있도록 한글 워드 프로세싱 시스템의 표준화 방안을 제시하고자 한다. 본 연구에서는 Text Editor와 Formatter를 원칙적으로 구분 설계하되 소량의 문서처리에도 적합하도록 Edit 기능에 Formater 기능을 추가시키고, 특히 기종 별로 다양하게 사용하고 있는 Function Key의 종류와 역할을 분석, 표준 Function을 정의하고 이를 기종에 관련없이 사용할 수 있도록 Menu Driven 방식을 채택하였으며, 마이크로 컴퓨터의 처리 능력의 향상에 따른 대량 문서 처리를 위한 Formatter 기능을 정의하고 설계하고자 하였다.