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Penicillin, Chymotrypsin 및 Oradezon等의 건초막내 朱入이 腱癒着에 미치는 影響에 關한 實驗的 硏究
金興基,李弘鍵 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1
Functional restoration of surgically repaired tendons, particularly in the hand, have frequently been unsatisfactory because of the formation of peritendinous adhesions which impede smooth gliding motion of the tendon. Numerous materials and drugs have been used to lessen the formation of peritendinous adhesions without interfering tendon healing. Author have made an experimental study with penicillin, chymotrypsin and oradexon infiltrated along the repaired tendon of adult rabbits and observed the nature and extent of peritendinous adhesion. Forty rabbits were divided into four groups, each comprised 10 rabbits. In group I, tendon and tendon sheath were cut and closed after author's modification of Bunnell's tendon suture of divided flexor digitorum longus as control, and penicillin infiltrated in group Ⅱ, chymotrypsin in group Ⅲ, oradexon in group Ⅳ, respectively after the same method of repair. The results obtained are as follows: 1. In all the groups, the healing of the cut tendon were established in the dual mechanisms; The one is the proliferation of the fibrovascular tissue from the tendon sheath and the other is the regeneration of tenocytes of the tendon itself. 2. The evidence of the adhesion between tendon and tendon sheath was displayed from the postoperative 2 weeks in all groups and continued to display to the postoperative 6 weeks in the group of suture only and the penicillin injected group, but disappeared at the postoperative 6 weeks in the chymotrypsin injected group and at the postoperative 4 weeks in the oradexon injected group. The effect in the prevention of the adhesion was most remarkable in the oradexon injected group and was the next in the penicillin injected group. 3. The regeneration by the tenocytes of the cut tendon were noticed from the postoperative 4 weeks in the group of suture only and the penicillin injected group, while the regeneration were noticed from the postoperative 3 weeks in the oradexon injected group and the chymotrypsin injected group, so that chymotrypsin and oradexon were seemed to be favorable in the regeneration of the tenocytes.
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Oradexon의 건초막내 주입이 건유착에 미치는 영향에 관한 실험적 연구
김흥기,이홍건 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.1
Surgical repair of tendon lacerations in the hand is frequently unsatisfactory because of the formation of peritendinous adhesions which impede smooth glidng motion of the tendon. Numerous materials and drugs have been used to limit the formation of peritendinous adhesions without interfering of tendon healing and sliding. Author's experimental study is focused on the effects of infiltration of the oradexon into the tendon sheath upon the peritendinous adhesion in the adult rabbits. Twenty rabbits were divided, into two groups, each group comprised 10 rabbits. In group 1, oradexon was infiltrated into the tendon sheath after Bunnell suture of divided flexor digitorum longus, and in group 2, oradexon was not infiltrated into the tendon sheath after Bunnell suture. The results obtained are as follows: 1. Inflammatory reactions at the suture line were no great difference between the two experimental groups during the first week and were disappeared in the oradexon treated group more faster than in the nontreated group from the second week. 2. In the oradexon treated group, arrangement of fibroblast was much more irregular than in the nontreated group. 3. In the oradexon treated group, peritendinous covering was much more thinner than in the nontreated group.
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