전신성 건선환자의 광선치료 후의 임상적 특성에 대한 고찰

이충휘,조은정 한국전문물리치료학회 1996 한국전문물리치료학회지 Vol.3 No.1

데이터 마이닝을 이용한 산업재해 예측모델에 관한 연구

이관형,정호근,박정선 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.4

목적 : 우리나라 전체 산업재해의 발생패턴과 추이를 파악하구 미래시점에 발생할 수 있는 산업재해자수를 예측 개발하여 장단기 산업보건 예방정책을 수립하는데 기여하고자 한다. 방법 : 예측모형에 사용된 자료는 1986년 1월부터 1999년 7월 까지 발생된 월별 누적 재해자수이며, 이 자료로부터 테이터 마이닝 기법을 사용하여 미래시점의 산업재해자 예측모델을 개발하였다. 결과 : 163개월 분의 산업재해 발생자료로부터 미래시점의 산업재해자수를 예측한 결과, Robust한 예측모형은 Winter∼method multiplicative in exponential smoothing로 예측력이 95%을 보였다. 산업재해 시도표를 탐색하면 전체적으로 산업재해자는 감소추세를 보이며, 순환주기를 1년으로 보면 2월과 9월이 가장 낮고, 6, 7, 10, 11월에 재해가 가장 많이 발생됨을 알 수 있었다. 월 평균 재해자 발생규모는 8,709명이다(95% CI;8277명, 9140명), 개발된 예측모형으로부터 1999년 8월 이후의 산업재해 발생자 규모를 보면, 1999년 12월과 2000년 1/4분기에 급격히 감소추세를 보이다가 2/4분기 시점을 정점으로 다시 재해자수가 증가할 것으로 예측된다. 결론 : 개발된 윈터스 모형을 이용한 미래시점의 산업재해 월별 발생 예측치는 (Table 3)과 같다. 예측치를 보면 1999년 긴월에서 2000년 1월, 2월에 급격히 감소추세에서 2000년도 2/4분기에 다시 서서히 증가하고 있다. 그리고 과거시점과 미래시점의 월별 산업재해 발생 실측치와 예측치 시도표는 Fig. 12와 같다. 또한 1998년에는 전반적인 발생추이 경향이 무너졌는데, 이는 한국 경제의 크나 큰 사건인 1997년 10월에 발표한 IMF에 의한 산업전반의 침체가 개입된 것으로 판단되며, 1999년에는 경기침체에서 벗어나 경제가 활성화 국면이 된다면 10월, 11월에는 이전보다 다소 재해자가 증가할 것으로 예상된다. 그리고 시간이 지남에 따라 추가적으로 발생된 월별 산업재해자수를 개발된 모델에 투입시키면서 검증과 평가를 통해모델을 정립할 계획이다. Objectives : This study is to see the transition and pattern of the industrial i울ureal worker, and to develop the prediction model. Methods : The data of the study are based on the samples from data-warehouse of Occupational Safety & Health Research Institute and are summed monthly from Jan 1986 to Dec 1999. This study data used data mart and Meta data from DW in KOSHA. The prediction model of the injured worker in Industry is designed by using a winters time series method after data preparing (i. e. sample, explore, modify) from DW. Results : Thls predicted model obtained Winters-method multiplicative in exponential smoothing among applied all models, after the tlme series (total 163 months). It showed that the prediction power was 95.5 %. Conclusions : In the process of exploring the data, totally the rate of industrial injureal workers reduced, and in the yearly circulation, in February and September the number is the lowest but in June, July, October and November the higher. The number of monthly average injureal workers is 8709 (95 % confidence interval 8277, 9140). From the developed prediction model, since Aug 1999 the industrial injureal worker reduced rapidly in Dec 1999 and first period of 2000. But In second period of 2000 the number of the injured workers is increasing. To conclude, as the total economic situation is becoming better in 2000 than In 1999, its is supposed that the injured workers will increase more than the predictive injured workers because of the increase of production rate and labor force.

최대 등척성 수축시 표면근전도에서 근 수축 개시점 결정을 위한 기법들의 신뢰도

정이정,조상현,이정훈,이상헌 한국전문물리치료학회 2003 한국전문물리치료학회지 Vol.10 No.1

The purpose of this study was to compare the relative accuracy of a range of computer-based analysis with respect to EMG onset determined visually by an experienced examiner. Ten healthy students (6 male, 4 female) were recruited and three times randomly selected trials of isometric contraction of wrist flexion and extension were evaluated using four technique. These methods were compared which varied in terms of EMG processing, threshold value and the number of samples for which the mean must exceed the defined threshold, and beyond 7% of maximum amplitude. To identify determination of onset time, ICCs(Intraclass Correlation Coefficients) was used and inter-rater and intra-rater reliability ranged good in visually derived onset values. The results of this study present that in wrist flexion and extension, the reliability of the inter and intra-examiner muscle contraction onset times through visual analysis showed beyond .971 with ICCs. The reliability of the muscle contraction onset time decision through visual reading, tested with computer analysis, showed a relationship of all the selected analysis methods with ICCs .859 and .871. The objective computer-based analysis comparing with visual reading at the same time is the effective and qualitative data analysis method, considering the specificity of each study method.

유방 절제술 후 조기 운동프로그램의 치료 효과

이규완,이충휘,조상현,박정미 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.1

The purposes of this study were to investigate the therapeutic effects of an early exercise program after mastectomy and to provide the early exercise program protocol for patients who had undergone mastectomy. The subjects were seventy women who were diagnosed with breast cancer. They were randomly assigned either to a experimental group (n=35) that received early postoperative exercise program or to a control group (n=35) that received only education by nurses. Data were obtained for each patient from goniometric measurements of shoulder flexion, abduction, external rotation, 10 elements of functional performance, and subjective pain evaluation using visual analogue scale (VAS). All variables were measured preoperatively, three days postoperatively, and one month postoperatively. Data were compared by groups using independent t-test and Mann-Whitey U test for parametric or non-parametric data, respectively. There were no significant differences between the groups for all variables preoperatively and at three days postoperatively. But there were significant differences at one month postoperatively. The experimental group showed a statisti-cally significant increases in shoulder flexion, abduction, and external rotation and in the pain VAS at one month Postoperatively (p〈,05). Also, at one month prostoperatively, the experimental group had less difficulty with three elements of functional performance-doing up a 'back' zippered article of clothing, reaching the ipsilateral scaula, and contralateral scapula with the fingers on the operated side- than the control group (p〈.05). The results of this study suggest that after mastectomy, the early exercise program conducted by a well-trained physical therapist can make a significant contribution to the return of more normal shoulder function and activities of daily living and to an increased quality of life.

등속성 운동 시 근전도 주파수 분석에서 얻은 피로지수의 특성

권오윤,이충휘,조상현,이영희,원종임,박정미 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.3

In rehabilitation programs involving muscle re-education and endurance exercise, it is necessary to confirm when fatigue occurs. It is also necessary to quantify fatigue, to confirm whether the muscle has been exercised sufficiently. In general, as fatigue occurs, the force-generating ability of the muscle is reduced. If the median frequency (MDF) obtained from electromyograrn (EMG) power spectrum is correlated highly with work, then the timing and degree of fatigue may be confirmed. This study examined the relationship between work and MDF obtained from the EMG power spectrum during repetitive isokinetic exercise. Surface EMG signals were collected from biceps brachii and vastus lateralis of 52 normal subjects (26 males, 26 females) at 120˚/sec and 60˚/sec while performing an isokinetic exercise. The exercise was finished at 25% of peak work. MDF data was obtained using a moving fast Fourier transformation (FPT), and random noise was removed using the inverse FPT, then a new MDF data was obtained from the main signal. There was a high correlation between work and MDF during repetitive isokinetic exercise in the biceps brachii and vastus lateralis of males and the biceps Brachii of temales (r=.50∼.77). However, there was a low correlation between work and MDF in the vastus lateralis of females (r=.06∼.19).

테니스 주(tennis elbow)에 대한 레이저치료와 관절가동화기법의 효과: 메타분석

문미향,남경모,정이정 한국전문물리치료학회 2003 한국전문물리치료학회지 Vol.10 No.3

한국인 제2형 당뇨병 환자의 골격근에서 인슐린 신호전달체계의 결함

최준혁,이관우,김효정,이동훈,이종우,김정은,엄현채,김경미,최성이,정윤석,김현만 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.5

연구배경: 제2형 당뇨병에서 나타나는 인슐린 저항성은 간, 지방, 근육 같은 말초조직에서 인슐린의 작용이 떨어지는 것을 말한다. 제2형 당뇨병의 발생기전에 인슐린 저항성과 인슐린 분비능 저하가 같이 관여함은 잘 알려진 사실이다. 인슐린의 세포내에서의 저항성을 규명하기 위한 인슐린의 세포내 신호전달체계에 대한 연구가 활발히 진행되고 있으며 몇몇 연구에서 인슐린 저항성을 가진 골격근육에서 IRS와 관련된 PI3-kinase의 활성감소와 Akt kinase의 활성감소를 보고하고 있으나 아직까지 명확하게 그 기작이 설명되어지지 않고 있다. 본 연구에서는 정상성인, 제2형 당뇨병 환자를 대상으로 경구당부하검사 및 인슐린 클램프검사를 시행하고 인슐린 클램프 검사시 대상인의 근육을 채취하여 인슐린 신호전달 체계(IR-β, IRS, Akt(PKB, Rac) kinase, GSK-3)를 연구하였다. 방법: 연구대상자는 한국인으로서 경구당부하검사상 정상인 및 당뇨병 환자 각각 11명, 9명을 대상으로 하였으며, 정상인은 건강인으로 과거력상 당대사에 영향을 줄 질환이 없고, 현재 당대사에 영향을 줄 약물 복용 및 다른 소견이 없는 경구당부하검사상 정성 내당능을 보이는 대상자로 하였다. 당뇨병환자는 모두 제2형 당뇨병 환자로 이환기간이 만 5년 이내인 경우로 하고, 인슐린으로 치료하는 대상자는 제외하도록 하였다. 대상자의 연령, 체질량지수, 체지방량, 공복시 총콜레스테롤, 중성지방, 고밀도지단백 콜레스테롤 및 HbA1c, 인슐린, C-peptide를 측정하였고, "HOMA model"을 이용하여 베타세포의 기능와 인슐린저항성 정도를 평가하였다. 정상혈당클램프 검사(euhlycemic hyperinsulinemic clamp test)를 시행하고 인슐린 투입 전과 인슐린 투입 30분후, 두차례에 걸쳐 대퇴부 근육생검을 실시한후 western 법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 측정하였다. 결과: 정상인 11명과 당뇨병 환자 9명을 대상으로 하였으며 대상자의 평균 연령, 평균 체질량지수, 체지방량, 허리/엉덩이 둘레의 비(waist hip ratio; WHR)는 두 군간에 차이가 없었다. 평균 공복혈당은 정상군 98.0±0.3㎎/dL, 당뇨병군 208.1±16.5㎎/dL(p<0.05), HbA1c는 정상군 5.4±0.5%, 당뇨병군 9.2±0.6%(p<0.05)였다. "HOMA model"을 이용한 베타세포의 기능과 인슐린저항성은 정상군 56.4±8.5%, 1.4±0.2, 당뇨병군 72.2±52.3%(p<0.01), 10.2±6.3(p<0.01)였으며 정상혈당클램프 검사상 포도당 이용률은 정상군 8.2±0.6㎎/㎏/min, 당뇨병군 3.7±1.1㎎/㎏/min(p<0.01)로 정상군과 당뇨병군간에 유의한 차이를 나타내었다. Western blot법으로 IR-β, IRS, Akt kinase, GSK-3의 인산화량을 인슐린 투입전과 인슐린 투입 30분후 측정하였을 때 IR-β에서는 정상군이 103.9±2.3에서 241.3±18.6, 당뇨군이 108.9±2.2에서 198.7±6.3으로 증가하였다(p=NS). 이는 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 통계적인 차이가 없었다. IRS에서는 정상군이 111.6±7.3에서 295.6±17.2, 당뇨군이 114.5±6.1에서 222.0±23.2로 증가하였으며(p<0.05), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 24% 감소하였다. Akt kinase에서는 103.4±6.0에서 416.8±29.5로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 43% 감소하였다. GSK-3에서는 정상군이 107.7±6.7에서 595.7±28.1, 당뇨군이 104.3±4.8에서 443.3±12.9로 증가하였으며(p<0.01), 인슐린 투입후 당뇨병군이 정상군과 비교하여 인산화량의 증가정도가 약 25% 감소하였다. 결론: 제2형 당뇨병 환자에서 정상인과 비교하여 인슐린 자극후 IR-β는 인산화량의 증가정도가 큰 차이가 없었으나, IRS, Akt kinase, GSK-3에서는 인산화량의 증가 정도가 감소되는 것으로 보아 상위 인슐린 신호전단체계부터 결함이 있는 것으로 생각된다. Background: The glucose uptake rate is the limiting step in glucose utilization and storage. The failure of insulin to stimulate glucose uptake in muscle appears to be a primary defect of insulin resistance. This study was undertaken to examine the effect of physiological hyperinsulinemia on the phosphorylation of the insulin receptor (IR-β), insulin receptor substrate (IRS), Akt kinase and GSK-3 in isolated skeletal muscle, in people with type 2 diabetes(n=9) and control subjects(n=11). Methods: 75g OGTT and euglycemic hyperinsulinemic clamp test were done. And vastus lateralis muscle was obtained before and 30 min into the euglycemic clamp. Western blots were performed for tyrosine phosphroylation of insulin receptor substrate (IRS) and phosphorylation of the insulin receptor(IR-β), Akt and GSK-3. Result: There were no statistical differences in the mean age, BMI and body fat between the control subjects and diabetic patients. The fasting blood sugar and HbA_1c in controls and diabetic patients were 98.0±0.3 and 208.1±16.5ng/dl, and 5.4±0.5 and 9.2±0.6%, and 1.4±0.2 in the control subjects, and 72.2±52.3%(p<0.01) and 10.2±6.3(p<0.01) in the diabetic patients, respectively. The insulin resistance from the euglycemic hyperinsulinemic clamp test were 8.2±0.6㎎/㎏/min and 3.7±1.1ng/㎏/min in the control subjects and in the diabetic patients, respectively(p<0.01). Compared with the normal controls, insulin-stimulated IR phosphorylation was no different to that in the diabetic patients. However, insulin-stimulated IRS phosphorylation, insulin-stimulated Akt phosphorylation and insulin-stimulated GSK-3 phosphorylation were reduced in the diabetic patients compared with the normal controls by 24, 43 and 25%, respectively(p<0.05). Conclusion: In Korean type 2 diabetic patients, the insulin resistance may be due to the impairment of the upstream insulin signal molecular network. Further studies will focus on determining whether these signaling defects are the cause of the development of insulin resistance, or secondary to the altered metabolic state, associated with type 2 diabetes mellitus (J Kor Soc Endocrinol 17:685∼697, 2002).

A Novel BJT Structure Implemented Using CMOS Processes for High-Performance Analog Circuit Applications

Jung, Yi-Jung,Park, Byoung-Seok,Kwon, Hyuk-Min,Kwon, Sung-Kyu,Jang, Jae-Hyung,Kwak, Ho-Young,Chung, Yi-Sun,Lee, Jung-Hwan,Lee, Hi-Deok IEEE 2012 IEEE transactions on semiconductor manufacturing Vol.25 No.4

<P>In this paper, a novel bipolar junction transistor (BJT) structure is proposed for high matching characteristics and its performance is compared with a conventional BJT structure. Although the proposed BJT matching structure indicates a decrease of collector current density <TEX>$J_{C}$</TEX> and current gain <TEX>$\beta$</TEX> of about 5.36% and 1.02% compared with those of the conventional BJT structure, the matching characteristics of the collector current <TEX>$(A_{\rm IC})$</TEX> and the current gain <TEX>$(A_{\beta})$</TEX> for the proposed structure are improved by about 31% and 24%. The improved matching characteristic of the proposed structure is believed to be due to the reduced effect of the deep n-well or the reduced current path from emitter to collector.</P>

Seroepidemiological Survey of Zoonotic Diseases in Small Mammals with PCR Detection of Orientia tsutsugamushi in Chiggers, Gwangju, Korea

Jung Wook Park,Jae Keun Chung,Sun Hee Kim,Sun Ju Cho,Yi Deun Ha,So Hyang Jung,Hye Jung Park,Hyun Jae Song,Jung Yoon Lee,Dong Min Kim,Jah Pyus,Dong Ryong Ha,Eun Sun Kim,Jae Il Lee 대한기생충학열대의학회 2016 The Korean Journal of Parasitology Vol.54 No.3

Genetic Diversity Assessment and Phylogenetic Analysis of Peanut (Arachis hypogaea L.) in RDA Genebank Collection using SSRs

Yi, Jung-Yoon,Lee, Gi-An,Lee, Jeong-Ran,Lee, Myung-Chul,Kang, Man-Jung,Baek, Hyung-Jin,Kim, Chung-Kon The Plant Resources Society of Korea 2011 한국자원식물학회지 Vol.24 No.3

It is very crucial to evaluate the genetic diversity of peanut genetic resources for identification of peanut germplasm accessions and variety improvement. Cultivated peanut generally has two subspecies, hypogaea and fastigiata. In this study, we identified peanut into three plant types, virginia (var. hypogaea), spanish (var. vulgaris), and valencia (var. fastigiata). Former one belongs to ssp. hypogaea and latter two are involved in ssp. fastigiata. Twenty SSR markers were used to assess the genetic variation of three sets, hypogaea, vulgaris, and fastigiata, respectively. Out of variety-specific SSR primers tried in this study, ten pairs of SSR primers showed polymorphisms. Each accession could be identified by a specific set of polymorphic SSR primers, and allele number was evaluated among accessions, with an average of 6.7 in var. hypogaea and 5.4 in var. vulgaris and fastigiata. For evaluation of genetic diversity, gene diversity ranged from 0.336 to 0.844 and PIC (polymorphism information contents) ranged from 0.324 to 0.827 were investigated. Dendrograms based on genetic distances were constructed, which showed the existence of three different clusters. And these three different clusters might be associated with the genes involved in three plant types. The results also suggested that there were plentiful SSR polymorphisms among peanut germplasm accessions in RDA (Rural Development Administration, Korea) Genebank and SSRs might play an important role in evaluating peanut accessions and cultivar improvement.