Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

제주 성상 S/S MTr #1 행원 풍력단지 전압해석

김상준(Sang-Jun Kim),조민호(Min-Ho Cho),윤기갑(Gi-Gab Yoon),장상옥(Sang-Ok Jang),안정식(Jeong-Shik Ahn) 대한전기학회 2003 대한전기학회 학술대회 논문집 Vol.2003 No.11

호우로 인한 수공구조물의 홍수피해 영향

안상진,김진극,전계원,곽현구 충북대학교 건설기술연구소 2003 建設技術論文集 Vol.22 No.1

In this study, small water power dam established for water-power generation in rivers, it alnalyze about effect that get in innudated damage by storm. If construction is established in rivers, the flood discharge will not pass rivers harmoniously. By this cause, storage happens and backwater effect is happened to upper stream. Draw basin characteristics index using GIS method, and do link with HEC-HMS and calculated the flood discharge 14,659CMS to 19:00 August 7 in Yeongchun gaging station (No.108), storage effect of small water power dam is calculated by 1,940CMS and effect on the backwater analyzed water lever rise of 0.27m to Yeongchun 2 bridge(No.89+70).

고출력 CW Nd:YAG 레이저를 이용한 CSP 1N 박판재 절단시 공정변수의 절단표면특성에 미치는 영향

안동규,김민수,이상훈,유영태,박형준 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

The objective of this research work is to investigate the influence of process parameters, such as power of laser, travel speed of laser and material thickness, on roughness and striation of the cut surface for the case of cutting of CSP IN sheet using high power Nd:YAG laser with continuous wave (CW). In order to find the practical cutting region and the relationship between process parameters on the roughness and the striation, several laser cutting experiments are carried out. From the results of experiments, the allowable cutting region and an optimal cutting speed for each cutting condition have been obtained to improve the quality of the cut surface. In addition, it has been shown that the surface roughness is related to the number of striation and depth of valley of the cut surface.

무선 센서 네트워크에서 신뢰성 전송을 위한 동적 그룹화 메커니즘

안성은,차홍준,정영준 강원대학교 정보통신연구소 2008 정보통신논문지 Vol.12 No.-

In recent years, many applications in WSN have increasingly interested in data transfer reliability. In this paper, we propose a dynamic grouping transfer mechanism which maintains both reliability and energy efficiency in transmission from a source to a sink. The proposed scheme considers channel error of each node. Then it uses an end-to-end ACK transmission in a group and a hop-by-hop ACK transmission between groups. Consequently this mechanism minimize the cost of packet transfer along with enhancing the network lifetime and reliability.

기저질환이 없는 사람에서 발생한 Campylobacter fetus에 의한 재발성 심내막염 1예

전재범,정진원,김성혜,송문희,오형철,안성기,최상호,김남중,김양수,우준희,류지소 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

C. fetus 심내막염은 드물게 발생하는 질환으로 주로 면역능이 저하된 환자에서 발병하고 대동맥판을 침범하는 경우가 많으며 적절한 치료가 되지 않을 경우 치사율이 높다. 저자들은 기저질환이 없던 69세 남자에서 C. fetus 심내막염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 발열로 내원하여 시행한 혈액배양 검사상 C. fetus가 동정되었고 경식도 초음파 검사상 삼첨판에 증식증이 발견되어 심내막염 진단하에 ceftriaxone에 이어 meropenem으로 총 4주간 항생제를 투여받고 호전되었다가 한달 후 다시 재발하였고 판막부전 소견 진행하여 삼첨판 치환술을 시행받고 전신상태 호전되어 퇴원하였다. Campylobacter fetus is a rare cause of endocarditis. To date, only about 30 cases of C. fetus endocarditis have been reported mainly in the elderly with chronic underlying illnesses. Most cases showed tendency to involve aortic valve. This report describes a case of native tricuspid valve infective endocarditis in a 69-year-old man without any underlying disease. Despite adequate antibiotic therapy for 4-weeks, endocarditis recurred and leading to surgical valve replacement.

백금 담지 촉매를 이용한 페놀 수용액의 촉매습식산화

안상준,이동근 경상대학교 환경보전연구소 2000 環境保全硏究所報 Vol.8 No.-

The effects of catalysts type in catalytic wet air oxidation of phenol using Pt/Al₂O₃ catalysts was studied in a batch reactor. The powdered catalyst was higher than pellet type catalyst in the removal of phenol. The effect of oxygen pressure was marginal above 180psi in the catalytic wet oxidation of phenol using powdered catalyst at 130℃. In the case of powdered catalyst, reaction order was first as a function of initial concentration of oxidation rate, whereas pellet type catalyst was not. The removal of phenol was most effective at pH 11 in both of catalysts.

신호분리를 위한 Diplexer에 관한 연구

성정현,김성균,김상혁,김호섭,박준석,안달 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

본 논문에서는 신호의 분리와 합성이 가능한 Diplexer를 제작하였다. 저역 통과 여파기와 고역 통과 여파기의 특성을 정합하여 Diplexer로 구현함으로써 신호의 분리와 합성이 가능하다는 것을 시뮬레이션을 통해 확인하였다. 또한 신호의 분리와 합성의 가능성을 입증하기 위해 실제 마이크로스트립구조의 Diplexer를 제작, 측정한 결과 각각의 통과 대역폭 내에서 0.4dB, 0.8dB이내의 삽입손실과 -20dB의 반사손실이 됨을 실험결과를 통해 알수 있었고 또한, 인덕터의 구현 방법을 마이크로스트립으로 하여 주파수 특성과 재현성을 높였다.

연속 퍼콜레이션 모형의 감수율의 진폭비의 보편성

安駿浩,李相法 경북대학교 과학교육연구소 1994 科學敎育硏究誌 Vol.18 No.-

We study the universality-related problem of continuum percolations. We specifically consider the amplitude ratio of susceptibilities, R=C_-/C_+, which is supposed to be universal but found to be different from the lattice value. We discuss several possible sources of errors in estimating R by computer simulations and present simulation data for penetrable-concentric-shell model, with the finite size effect being carefully taken into account. Results from any finite-sized system were found to be significantly larger than the known lattice values: however, after taking extrapolations to the infinite-system-limit, we obtained R very close to the lattice values for both two and three dimensions. Based upon these, we conclude the strong universality between continuum and lattice percolation models for at least PCS model.

방전관용 전극개발 및 특성에 관한 연구

안성환,황동원,최준영,송시준,전용우,박원주,이광식 영남대학교 공업기술연구소 2001 工業技術硏究所論文集 Vol.29 No.1

This paper describes the development of sputtered tungsten electrode for discharge tube by making use of Sputtering method using plasma. The Xe discharge tube was designed and fabricated by using sputtered tungsten electrode, and the ICCD(Intensified Charged Coupled Device) and monochromator were used in order to observe the discharge image distribution and to measure the signal intensity. As a result, the emission light form the electrode was spreaded almost uniformly over a wide wavelength band, and the discharge image distribution and the signal intensity show quite a uniform distribution. The emission light from the Xe discharge tube was peaked at 488[nm] and 648[nm].