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Immunohistochemical Study on β1- and β2-Adrenergic Receptors in Rat Vestibular Nuclei
안성기,Roza Khalmuratova,허동구,김호엽,박현우,주연희,강흥수 대한평형의학회 2012 Research in Vestibular Science Vol.11 No.2
Background and Objectives: The aim of this study was to examine the localizations of β1- and β2-adrenergic receptors (ARs) in rat vestibular nuclei by immunohistochemical staining procedure. Materials and Methods: Twelve male Sprague-Dawley rats were used in this study. Primary antibodies for the β1- and β2-ARs were used. The sections were treated with a biotinylated goat anti-rabbit antibody. The sections were then incubated in avidin-biotin-peroxidase reagent and processed with immunoperoxidase using 3.3’-diaminobenzidine tetrahydrochloride. Results: β1-AR and β2-AR immunopositive neurons were found to be distributed throughout the four major vestibular nuclei. Both receptors were primarily detected in neuronal somata and their proximal dendrites. β1-AR and β2-AR were moderately expressed in the superior vestibular nucleus, lateral vestibular nucleus, medial vestibular nucleus,and spinal vestibular nucleus. Conclusion: The present study demonstrates, for the first time, that β1-AR and β2-AR receptors are localized in rat vestibular nuclei. Furthermore, this study may provide additional speculation into the role of ARs during vestibular signal processing. Further studies are needed to clarify the roles played by β1-ARs and β2-ARs through physiologic and functional studies. Background and Objectives: The aim of this study was to examine the localizations of β1- and β2-adrenergic receptors (ARs) in rat vestibular nuclei by immunohistochemical staining procedure. Materials and Methods: Twelve male Sprague-Dawley rats were used in this study. Primary antibodies for the β1- and β2-ARs were used. The sections were treated with a biotinylated goat anti-rabbit antibody. The sections were then incubated in avidin-biotin-peroxidase reagent and processed with immunoperoxidase using 3.3’-diaminobenzidine tetrahydrochloride. Results: β1-AR and β2-AR immunopositive neurons were found to be distributed throughout the four major vestibular nuclei. Both receptors were primarily detected in neuronal somata and their proximal dendrites. β1-AR and β2-AR were moderately expressed in the superior vestibular nucleus, lateral vestibular nucleus, medial vestibular nucleus,and spinal vestibular nucleus. Conclusion: The present study demonstrates, for the first time, that β1-AR and β2-AR receptors are localized in rat vestibular nuclei. Furthermore, this study may provide additional speculation into the role of ARs during vestibular signal processing. Further studies are needed to clarify the roles played by β1-ARs and β2-ARs through physiologic and functional studies.
전정신경염 환자에서 Beck Anxiety Inventory 설문지를 이용한 불안감의 평가
안성기,김진용,권오진,조수연,허동구,전시영,김대우 대한평형의학회 2010 Research in Vestibular Science Vol.9 No.2
Background and Objectives The intimate relationship of vertigo and anxiety has been previously recognized. Anxiety may have an important influence on recovery of symptoms in vestibular neuritis (VN). The aim of study was to evaluate subjective anxiety of the pre-VN, at the time of onset of VN, and just after vestibular rehabilitation therapy (VRT) using Beck Anxiety Inventory (BAI)questionnaire, respectively. Materials and Methods Twenty-eight patients with VN were asked to complete the BAI and dizziness handicap inventory (DHI). Each of the BAI and DHI was scored. We also evaluated the relationship between the DHI and BAI scores. Results The VN patients at the time of attack had significantly more anxiety with vertigo and related symptoms (p<0.05). In most patients, anxiety level decreased following VRT. Conclusion These findings indicate that almost every VN patients can recovery from anxiety as vertigo regressed. However, the emotional support as well as physical and/or functional rehabilitation may be required to provide a more rapid and complete return to normal daily lives for these patients.
근간대와 간질발작을 동반한 조발형 가족성 알쯔하이머병 환자 1예
안성기,이재홍 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1
Early-onset familial Alzheimer's disease (EOFAD) is rare and autosomal-dominantly inherited disease by mutations in one of the following three known causative genes:amyloid precursor protein (APP) gene, presenilin-1 (PS1) and presenilin-2(PS2) genes. EOFAD tends to present clinically at a younger age (40-60 years) and myoclonus is recognized as a prominent and early clinical feature, particularly in chromosome 14-linked pedigrees with mutations in the PS1 gene, when myoclonus may be accompanied by seizures. We present a 44-year old man who developed progressive dementia and accompanied by myoclonus and recurrent seizure. His father and uncle had early-onset dementia at the fifth decade. He was pathologically confirmed as Alzheimer's disease. He had apolipoprotein E (ApoE) epsilon 3 allele and PS-1 mutation was not found.
안성기 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.10
Interplay between migraine and balance disorder morbidities has been a topic of interest for many years. Migrainous vertigo (MV) is acknowledged as a common cause of episodic vertigo. Like migraine itself, MV is diagnosed on the basis of clinical information as there are no specific biological makers. A preliminary classification proposed two separate diagnostic categories: definite and probable MV. For treatment of MV, it is suggested that drugs used for migraine may be effective. However, current treatment recommendations are generally based on expert opinion rather than ran-domized or controlled trials. Therefore, large prospective, multi-center studies are necessary to better define criteria and optimal treatment.