Factors Associated with Indeterminate and False Negative Results of QuantiFERON-TB Gold In-Tube Test in Active Tuberculosis

( Ki Won Cho ),( Eun Ha Cho ),( Soo Hoon Kwon ),( Sang Hyuk Im ),( In Sohn ),( Sook Hee Song ),( Hyeok Kim ),( Su Hyun Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.5

Background: The sensitivities and specificities of interferon-gamma release assays (IGRAs) vary among different population studies, and the data on the routine use of IGRAs are limited. The aim of this study was to evaluate the role of QuantiFERON-TB Gold In-Tube (QFT-GIT) test in the diagnosis of active tuberculosis. Methods: We conducted a prospective study, enrolling 77 patients with suspected pulmonary tuberculosis (TB), at a secondary care teaching hospital in Seoul. Results: In total, 12 (15.6%) patients showed indeterminate results due to positive control failure on the QFT-GIT test. Indeterminate results were significantly associated with the elderly, history of the intensive care unit stay, lymphocytopenia, especially low CD4 count, increased C-reactive protein and decreased protein levels. Of the 77 patients, 44 (57.1%) were diagnosed with active pulmonary tuberculosis, and the percentage of false negative results of the QFT-GIT was 36.4% (vs. 31.8% with TST). In the TB group with >65 years old (n=12), the proportions of the indeterminate (33.3% vs. 3.1%) and the false negative results (58.3% vs. 25.0%) of the QFT-GIT were significantly higher than in the younger TB group (n=32). Conclusion: Indeterminate and false negative results of QFT-GIT test were not infrequent in tuberculosis, especially in the elderly. Care should be considered for the interpretation with the elderly, immunocompromised, chronic and severely diseased patients.

Factors Associated with Indeterminate and False Negative Results of QuantiFERON-TB Gold In-Tube Test in Active Tuberculosis

Cho, Ki-Won,Cho, Eun-Ha,Kwon, Soo-Hoon,Im, Sang-Hyuk,Sohn, In,Song, Sook-Hee,Kim, Hye-Ok,Kim, Su-Hyun The Korean Academy of Tuberculosis and Respiratory 2012 Tuberculosis and Respiratory Diseases Vol.72 No.5

Background: The sensitivities and specificities of interferon-gamma release assays (IGRAs) vary among different population studies, and the data on the routine use of IGRAs are limited. The aim of this study was to evaluate the role of QuantiFERON-TB Gold In-Tube (QFT-GIT) test in the diagnosis of active tuberculosis. Methods: We conducted a prospective study, enrolling 77 patients with suspected pulmonary tuberculosis (TB), at a secondary care teaching hospital in Seoul. Results: In total, 12 (15.6%) patients showed indeterminate results due to positive control failure on the QFT-GIT test. Indeterminate results were significantly associated with the elderly, history of the intensive care unit stay, lymphocytopenia, especially low CD4 count, increased C-reactive protein and decreased protein levels. Of the 77 patients, 44 (57.1%) were diagnosed with active pulmonary tuberculosis, and the percentage of false negative results of the QFT-GIT was 36.4% (vs. 31.8% with TST). In the TB group with >65 years old (n=12), the proportions of the indeterminate (33.3% vs. 3.1%) and the false negative results (58.3% vs. 25.0%) of the QFT-GIT were significantly higher than in the younger TB group (n=32). Conclusion: Indeterminate and false negative results of QFT-GIT test were not infrequent in tuberculosis, especially in the elderly. Care should be considered for the interpretation with the elderly, immunocompromised, chronic and severely diseased patients.

부모와 교사간의 연계교육 및 유아-교사간의 상호작용의 질에 따른 유아의 적응에 대한 연구

손인숙,송진숙 한국영유아보육학회 2004 한국영유아보육학 Vol.0 No.39

본 연구는 유아의 변수인 유아의 성별, 연령, 이전의 교육경험유무와 교사의 변수인 교사의 연령과 교사경력 등의 변수, 부모와 교사간의 연계교육과 유아와 교사간의 상호작용의 질에 따른 유아 적응의 차이를 알아보기 위하여 실시되었다. 본 연구의 대상은 전라북도 익산시와 전주시 그리고 군산시 소재 11곳의 유치원에 재원중인 아이를 둔 부모 612명과 교사 37명을 대상으로 실시하였다. 본 연구결과는 첫째, 유아의 적응에 있어 전반적으로 여아보다 남아가 유치원 적응을 잘하고 있는 것으로 나타났고, 이전 교육경험 유무에서는 전반적으로 이전 교육경험이 없는 유아보다 교육 경험이 있는 유아가 잘 적응하는 것으로 나타났다. 둘째, 교사의 특성에 따른 유아의 적응의 대한 결과는 교사가 30세 이하이고, 교사경력이 10년 이하일 때 유아가 안정성 측면에서 적응을 잘 하는 것으로 나타났다. 셋째, 부모와 교사간의 연계교육이 잘 수행될수록 유아의 적응이 잘 되는 것으로 나타났다. 넷째, 교사와 유아간의 상호작용의 질에 따라서는 교사-유아간의 상호작용의 질이 높을수록 유치원에서 유아의 적응이 잘 이루어지는 것으로 나타났다. The purpose of this study was to 1) investigate the differences between teacher and child's relationship, parent-teacher's partnership. 3) and its related variables - age of child, gender of child, educational experience of teacher, and so on - in kindergarten. Subjects were 612 parents and 37 teachers in Iksan, Junju, and Gunsan. The mean, percentile, t-test, and one-way ANOVA, were used. The results were as follows: First, there were significant difference among age of child, gender of child, and prior experience and child's adjustment in kindergarten. Second, there was significant difference between educational experience of teacher, age of teacher and child's adjustment in kindergarten. Third, there was significant difference between parent-teacher partnership and child's adjustment in kindergarten. Fourth, there was significant difference between child-teacher relationship and child's adjustment in kindergarten.

한국의 조기난소부전 환자에서 Inhibin 유전자의 변이 분석

김영진,손인숙,이지영,김수녕 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

The clinical models for studying ovary-determining genes may be premature ovarian failure(POF). POF is a condition causing amenorrhea, hypoestrogenism, and elevated gonadotropins in women under 40 years old. The prevalence of POF among reproductive women is 1%. POF is a highly heterogenous condition, but its etiology remains unknown in approximately two-thirds of cases. Many causes of POF were reported, including Turner syndrome, genetic disease, iatrogenic agents such as chemotherapy or radiotherapy, infection and autoimmune disease. FSH receptor, LH receptor, inhibin, GDF-9(growth differentiation factor), BMP-15(bone morphogenetic protein), DIAPH2(diaphanous gene) and XPNPEP2(X-prolyl aminopeptidase) genes were proposed as a possible candidate gene, but only mutations of FSH receptor, LH receptor, inhibin genes were reported in women with POF. The present study was performed to investigate whether the mutation of inhibin gene is observed in Korean patient with premature ovarian failure and whether mutation of these genes is a likely cause of POF. Eighty-six women with premature ovarian failure were studied and thirty-six normal women were enrolled as control. Mutation screening of these genes were established by denaturing HPLC and were confirmed by automatic sequencing. No mutation of inhibin gene was identified in Korean women with POF. In conclusion, premature ovarian failure was not likely caused by mutations of inhibin gene.

폐경 환자에게 호르몬치료 시 뇨중 N-Telopeptide의 유용성

이성기,윤병일,손인숙,김수녕,최영숙 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-

Objective: We evaluated the bone resorption rate in perimenopausal and postmenopausal women and determined whether urinary N-telopeptide of typeⅠ collagen(NTx), a marker of bone resorption, could predict the risk of osteoporosis and the bone turnover following hormone replacement therapy(HRT). Material and Methods: Twenty-eight women received HRT for climacteric symptoms, menopause, osteopenia, osteoporosis, or surgical removal of the ovaries. Serum FSH, LH, estradiol, and NTx were checked for baseline study. After 8 weeks HRT, NTx was rechecked. Result: NTx correlated positively with FSH, but negatively with estradiol. The level of NTx increased during first 5-years after menopause and then gradually decreased. After 8 weeks of HRT, average level of NTx was decreased to 56% of the baseline level. Conclusion: Bone resorption in menopause is closely related hypoestrogenemia. Examination of NTx levels may predict the risk of osteoporosis and the bone turnover after HRT.

난소암에서 CA125의 임상적 의의

윤병일,김수녕,손인숙,유연웅,최원석 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

The concentration of the tumor marker CA125 in serum from patients with ovarian tumor was measured to define the usefulness of them in differentiating malignant ovarian tumor from benign ovarian mass. In the study of 105 patients with gynecologic neoplasm, of whom 38 were myoma uteri, 42 benign ovarian tumor, and 25 ovarian cancer, the level of serum CA125 were measured. CA125 was greater than 35 U/ml in 2.6% of myoma uteri, in 2.4% of benign ovarian tumors and 68.0% of ovarian cancers. Using a cut-off level of 35 U/ml, the results can be characterized by a 68.0% of sensitivity and 97.5% of specificity in detecting an ovarian cancer. Among 25 patients with ovarian cancer, 11 of 14 (78.6%) patients with serous cystadenocarcinoma, 4 of 6 (66.7%) patients with mucinous cystadenocarcinoma and 2 of 5 (40.0%) patients with endometrioid carcinoma had CA125 values greater than 35 U/ml. In relation to a higher tumor stage, there was an increasing incidence of elevated levels of CA125. As a result, it is likely that the measurement of CA125 is useful for early diagnosis of ovarian cancer.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

민간 산후조리원 공공성 제고를 위한 산후조리서비스 체계 고찰 및 개선 방안

김희선 ( Hee-Sun Kim ),이재희 ( Jae Hee Lee ),이정림 ( Jeong Rim Lee ),엄지원 ( Ji-Won Eom ),구자연 ( Ja Yeun Koo ),박병록 ( Byoung Lok Park ),박현수 ( Hyun Soo Park ),손인숙 ( In Sook Sohn ) 한국모자보건학회 2021 한국모자보건학회지 Vol.25 No.3

The study aimed to review the current postpartum care service system and suggest measures of improvement for the public reinforcement of the private-postpartum care center (PCC). We conducted a review of literature, including an internet search, and we analyzed the in-depth interviews using questionnaires answered by workers from the 6 private-PCCs operated in Goyang city. Using these data, we derived possible measures which could improve the publicity of private-PCCs. It was found that the 11 nationwide public-PCCs had serious operating deficits, and its utilization by the vulnerable was insufficient. In areas where private-PCCs are concentrated, we can propose the following policies to strengthen publicity, rather than establishing another public-PCC. First, it is important to provide support for private-PCCs to apply cost reductions for vulnerable groups, similar to the maternal and newborn medical care of public- PCCs. Second, publicity would be strengthened by reorganizing the pregnancy and childbirth education program, while also offering additional services for mothers with stillbirths and abortions. For the integrated management of postpartum care services, this should be shifted towards reinforcing the publicity of private-PCCs, rather than operating a public-PCC in relative ly concentrated private-PCC areas. Through these policies, it is expected that financial and administrative waste will be reduced, and an integrated management system for postpartum care services will be established.

Mg₂SiO₄ : La, Ho 열형광선량계에서 활성제 농도가 글로우 커브에 미치는 영향 La, Ho TLD on Activation Concentration

김영국,손인호,채건식,노경석,오재근,이은숙 경남대학교 신소재연구소 1996 論文集 Vol.6 No.-

본 연구에서는 Mg₂SiO₄에 활성화 물질로 La, Ho를 첨가하여 열형광체를 제작하였고 불순물의 농도를 1wt.% ∼5 wt.%까지 변화시키면서 열평광강도의 glow curve를 측정하였다. 도한 열형광체의 glow curve를 peak shape법으로 분석해서 TL특성에 대한 포획 매개변수와 활성화 에너지, 발광차수, 선량의존성등을 조사하였으며, 그 물리적 특성을 조사하고 선량계로서 타당성과 실용성을 확인하였다. The Mg₂SiO₄: La, Ho thermoluminescent phospher has been prepared by sintring Mg₂SiO₄after doping the transition elements La and Ho. The heating rate is 10℃/sec at this thermoluminescent phospher are heated. The maximum peaks are found in the measured Mg₂SiO₄: La and Ho. TL glow curve at 229℃ and 345 C when the 1 wt.%-5 wt.%. The glow curve of TLD increased TL intensity and temperature of peak appears to the high temperature when the heating rate is l0℃/sec-25℃/sec. The activation energy of the main peak has been estimated by the peak shape method. The estimated activation energies are 1.77 eV. 1.52 eV respectively. The thermoluminescence process in Mg₂SiO₄: La and Ho are found to the 2nd order when the main peak of the glow curve is analyzed by peak shape method. The dose responses of Mg₂SiO₄: La and Ho TLD are linear up to intensity of X-ray.

갑상선기능저하증에 합병된 중증 전자간증과 심외막 삼출액으로 의한 심장탐폰을 동반한 임신 1예

구희주,최원석,이지영,손인숙,김수녕 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Hypothyroidism presenting during pregnancy is rare, probably due to the lower incidence of hypothyroidism during reproductive years. And hypothyroidism rarely complicates pregnancy because most hypothyroidism is accompanied by amenorrhea and anovulation. Risk of maternal complications of hypothyroidism including preeclampsia, placental abruption, anemia, postpartum hemorrhage, cardiac dysfunction are increased. Hypothyroidism accompanies pericardial effusion frequently. But the diagnosis of pericardial effusion is usually made incidentally by routine check-up because the patient rarely complains any symptoms of pericardial effusion. Moreover it is extremely rare that pericardial effusion makes the presenting sign of hypothyroidism. We experienced a case of preeclampsia with pericardial effusion in hypothyroid parturient that needed pericardial window operation with emergency cesarean section. So we present this case with a brief review.