평수기 한강하구 염하수로 인근의 낙조 우세 및 조석 평균 흐름의 정량적 분석

윤병일,우승범 한국해양환경·에너지학회 2012 한국해양환경·에너지학회 학술대회논문집 Vol.2012 No.5

백서에서 셀레늄 함유 온천수 음용이 혈중 Leptin과 IGF-1에 미치는 영향

윤병일,김수진,조혁진,하유신,홍성후,이지열,황태곤,김세웅 대한남성과학회 2010 The World Journal of Men's Health Vol.28 No.2

Purpose: There have been reports that a higher serum level of selenium is related to a lower incidence of prostate cancer. Serum leptin and IGF-1 are factors related to metabolic syndromes which are also known to be related to prostate cancer, and the higher their levels, the higher the possibility of prostate carcinogenesis. Thus, we measured the serum levels of leptin and IGF-1 in rats that were given selenium-rich hot spring water to drink in an attempt to elucidate the role of selenium on prostate cancer prevention. Materials and Methods: A total of twelve white SD rats was included in the study, and they were further divided into a control group (Group 1, n=6) induced to drink normal saline, and those rats that drank selenium-rich hot spring water for 4 weeks (Group 2, n=6). The hot spring water that we used was from the Kum-jin region of Korea, which contains a rich supply of the minerals selenium, vanadium, calcium and magnesium. The concentration of selenium in the hot spring water was 480 μg/l. The two groups were each given 50 ml/day of normal saline or selenium-rich hot spring water. After the period of the experiment, we drew blood samples from both groups and measured their serum leptin and IGF-1 levels using ELISA. Results: The serum leptin level (pg/ml) was 964.04±127.77 in Group 1, and 531.92±151.04 in Group 2, allowing us to confirm that it was significantly less in those that drank the selenium-rich hot spring water (p<0.05). Also, the serum IGF-1 levels (pg/ml) were 1,247.72±53.85 and 933.03±113.69 in Groups 1 and 2, respectively, which again, illustrated the significantly lower level in those rats that were given selenium-rich hot spring water (p<0.05). Conclusions: Significantly decreased serum levels of leptin and IGF-1 were observed in rats that drank selenium-rich hot spring water. A study of the long-term effect of selenium-rich hot spring water on prostate cancer is necessary; if it is indeed proven to have long-term effects, we believe it will become valuable in clinical practice.

전립선특이항원치 4.0ng/ml 이상인 환자에서 전립선용적과 나이에 따른 전립선암의 발견율

윤병일,김수진,조혁진,홍성후,손동완,이지열,황태곤,김세웅 대한남성과학회 2010 The World Journal of Men's Health Vol.28 No.1

Purpose: We retrospectively investigated the changes of prostate cancer detection rate according to patients prostate volume, age with prostate-specific antigen (PSA) levels of above 4.0ng/ml. Material and Methods: Data were collected from 663 patients who underwent 10 core prostate biopsy for elevated PSA above 4.0ng/ml. The biopsy-proven cancer patient group was compared to the non-cancer patient group according to age, PSA, prostate volume and PSAD. Prostate cancer detection rate was calculated according to prostate volume (less than 40 vs 40 or more 40ml) and age (less than 60, 60-69, 70-79, 80 or more years old). Also we compared prostate cancer detection rate according to PSA levels (4-10 vs 10-20ng/ml). Results: Among the 663 patients who underwent prostate biopsy, prostate cancer was detected in 134 patients (20.2%). There were no stastically difference in mean age, mean prostate volume, and mean PSAD except mean PSA (13.9 vs 11.9ng/ml) between cancer and non-cancer groups. The cancer detection rate in small prostate was significantly higher than large prostate (23.5% vs 16.0%). The cancer detection rate was significantly increased with age: from 14.5% for below 60 year-old patients to 30.3% for the 80 or more year-old patients. There was no significant difference in cancer detection rate between the two PSA groups (19.0 vs 20.5%). Conclusion: Prostate cancer detection rate was higher in old patients and patients with small prostate volume. The older age group and the patients with small prostate volume was considered as the important factors to decide whether biopsy of prostate is needed.

단일기관의 방사선과와 비뇨기과에서 시행한 경직장 초음파유도하 전립선생검 후 임상적 및 병리적 결과에 대한 고찰

윤병일,김수진,조혁진,홍성후,손동완,이지열,황태곤,김세웅 대한남성과학회 2010 The World Journal of Men's Health Vol.28 No.1

Purpose: Many centers rely on radiologists to detect prostate cancer by transrectal ultrasound guided prostate biopsy. In this study we evaluated transrectal ultrasound guided prostate biopsy by radiologist or urologist, and compared prostate cancer detection rate, pathologic results and pain scrore. Material and Methods: In all, 259 consecutive patients had transrectal ultrasound guided prostate biopsy by one radiologist (group 1) and one urologist (group 2). The indication for prostate biopsies were a raised or rising prostate specific antigen (PSA) level or abnormal digital rectal examination (DRE). All data were collected prospectively. Results: Both group showed comparable demographic data in age, PSA, prostate volume. But pain score showed higher in urologist group (p<0.05). Prostate cancer was detected in 73 patients (28.1%). Radiologist detected prostate cancer in 38 patients (29.2%) and urologist detected prostate cancer in 35 patients (27.1%) (p=0.70). Both groups showed comparable cancer detection rates in PSA of <4, 4-10 and >10 ng/ml. Both groups had similar Gleason score (6.8±0.7 vs 6.7±0.8) and number of cancer cores (3.0±1.7 vs 3.9±2.3). Group 1 showed significantly low visual analogue pain scale compared with Group 2 (2.9±1.9 vs 4.0±2.1)(p<0.05). Conclusion: Transrectal ultrasound guided prostate biopsy showed equally reliable datas whether performed by radiologist or urologist. The urologist can effectively perform transrectal ultrasound guided prostate biopsy like radiologist in detecting prostate cancer. Also we recommend to perform anesthesia to relieve pain before prostate biopsy and furthermore future studies with more patients with more datas are needed.

한국인에서 전립선 생검의 기준으로 전립선특이항원 절단치 2.5 ng/ml가 적절한가?

윤병일,조혁진,홍성후,손동완,이지열,황태곤,김세웅,김수진 대한남성과학회 2009 The World Journal of Men's Health Vol.27 No.3

Purpose: Currently many clinicians have recommendsprostate biopsy when the level of prostate specific antigen (PSA) is higher than 4.0 ng/ml. However, recently the prostate cancer detection rates werereported to be about 20% at PSA level 2.5 to 4.0 ng/ml. Therefore, an increasing amount of hospitals have recommends lowering the PSA cut off level to 2.5 ng/ml. We retrospectively evaluated the prostate cancer detection rate and pathologic characteristics of patients with PSA level of 2.5 to 4.0 ng/ml and we compared this with the patients who had PSA level in the range of 4.1 to 10.0 ng/ml. Material and Methods: We analyzed the data of 515 patients who received prostate biopsy in the range of PSA level 2.5 to 10 ng/ml. The clinical characteristics, cancer detection rate and pathologic findings of the biopsy were compared between the PSA 2.5-4.0 ng/ml group and PSA 4.1-10.0 ng/ml group. Results: Cancer detection rates in patients who underwent biopsy were 18.1% and 22.4% at PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. Mean Gleason scores were found 6.4±0.5 and 6.6±0.7 and high grade cancers with Gleason score 7 or more were found in 50% and 58.4% of patients with cancer with PSA 2.5 to 4.0 and 4.1 to 10.0 ng/ml, respectively. There were no significant difference between the 2 groups in cancer detection rates and pathologic findings on biopsy including mean Gleason score and high grade cancers with Gleason score 7 or more between two groups. Conclusion: There were no significant difference in cancer detection rates and pathologic findings between PSA 2.5-4 ng/ml group and PSA 4.1-10 ng/ml group. These results suggest that a lower PSA cutoff should be considered as an indication for prostate biopsy in the Korean population.

경기만 한강하구 수로별 조석전파 특성 분석

윤병일,우승범,김민하 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6

복강경하 근치적 전립선적출술이 요실금 및 하부요로증상의 변화에 미치는 영향

윤병일,황태곤,김준철 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.2

Purpose: The definition of continence after radical prostatectomy has not been established. We examined the continence rate and changes in voiding and storage symptoms after laparoscopic radical prostatectomy(LRP). Materials and Methods: Fifty-seven patients were enrolled and followed for more than 12 months after a LRP. Postoperative evaluation of urinary incontinence was performed by interview, and was classified as completely dry, intermittent(occasional dribbling only), using only 1 pad/day, using more than 1 pad/day, and no control. Pre- and post-operative International Prostate Symptom Scores(IPSS) were compared(Total, each criterion, and quality of life, voiding, and storage symptom subscores). Results: Sixty seven percent of patients were completely dry and 17% of patients were classified as intermittent. Those using 1 pad/day, more than 1 pad/day, or no control accounted for 2%, 9%, and 5%, respectively. Pre- and post-operative total IPSS and quality of life scores were not different, but urgency and nocturia scores increased(p<0.05). The voiding subscore decreased and the storage subscore increased after LRP(p<0.05), suggesting aggravation of storage symptoms after LRP. Conclusions: We need to determine which definition of continence is most clinically useful. It is important to assess lower urinary tract symptoms, especially storage symptoms, as well as urinary incontinence after LRP. (Korean J Urol 2008;49:134-138) Purpose: The definition of continence after radical prostatectomy has not been established. We examined the continence rate and changes in voiding and storage symptoms after laparoscopic radical prostatectomy(LRP). Materials and Methods: Fifty-seven patients were enrolled and followed for more than 12 months after a LRP. Postoperative evaluation of urinary incontinence was performed by interview, and was classified as completely dry, intermittent(occasional dribbling only), using only 1 pad/day, using more than 1 pad/day, and no control. Pre- and post-operative International Prostate Symptom Scores(IPSS) were compared(Total, each criterion, and quality of life, voiding, and storage symptom subscores). Results: Sixty seven percent of patients were completely dry and 17% of patients were classified as intermittent. Those using 1 pad/day, more than 1 pad/day, or no control accounted for 2%, 9%, and 5%, respectively. Pre- and post-operative total IPSS and quality of life scores were not different, but urgency and nocturia scores increased(p<0.05). The voiding subscore decreased and the storage subscore increased after LRP(p<0.05), suggesting aggravation of storage symptoms after LRP. Conclusions: We need to determine which definition of continence is most clinically useful. It is important to assess lower urinary tract symptoms, especially storage symptoms, as well as urinary incontinence after LRP. (Korean J Urol 2008;49:134-138)

경기만 한강하구 창·낙조 특성 분석

윤병일,우승범,김민하 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6

“새 情報時代”의 참뜻을…

尹炳一 한국언론진흥재단 1983 신문과 방송 Vol.- No.146

급성 세균성 전립선염에서 만성 염증으로의 진행과 관련된 인자의 고찰

윤병일,조용현,김설,신태성,하유신,손동완 대한요로생식기감염학회 2011 Urogenital Tract Infection Vol.6 No.2

Purpose: We conducted a retrospective analysis of acute bacterial prostatitis (ABP) to evaluate the factors of progressing to chronic bacterial prostatitis (CBP) and inflammatory chronic pelvic pain syndrome (CPPS) from ABP. Materials and Methods: The clinical records of 480 cases compatible with a confirmed diagnosis of ABP from five urological centers between 2001 and 2010 were reviewed. We defined chronic infection (CI) as a progression to CBP and inflammatory CPPS after treatment of ABP in admission periods when followed-up at 3 months or more. Results were analyzed according to two groups: recovered without CI (group A, n=428) and developed to CI (group B, n=52). Results: Of the 480 ABP patients, 1.3% (6/480) progressed to CBP and 9.6% (46/480) progressed to inflammatory CPPS. The progression rate of CI was 10.9% (52/480). The factors that affected progress to CI were diabetes, prior manipulation, prostate volume, absence of cystostomy and urethral catheterization (p<0.05). Conclusions: The identification and characterization of influential factors may accelerate the development of preventive, diagnostic and therapeutic strategies for the treatment of CI from ABP.