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손인숙 ( In Sook Sohn ),유달영 ( Dal Yeong Yoo ),장동욱 ( Dong Wook Jang ),차윤정 ( Yun Jeong Cha ),김수녕 ( Soo Nyung Kim ),이지영 ( Ji Young Lee ),윤병일 ( Byung Il Yun ),정소정 ( So Chung Chung ),박기현 ( Ki Hyun Park ),이병석 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.8
목적: 조기난소부전은 난소발달기전을 이해하는 임상적 모델로, 조기난소부전의 유전적 원인을 밝힘으로써 난소분화 및 난포 형성과정에 관련된 유전자를 알 수 있다. 조기난소부전은 40세 이전에 무월경과 성선자극호르몬이 증가되는 임상증후군으로 빈도는 약 1% 정도이다. 아직 조기난소부전의 기전은 밝혀지지 않았고, 터너 증후군, 자가면역질환, 항암제 치료, 방사선 치료 및 감염 등이 원인으로 알려져 있다. 많은 유전자가 조기난소부전의 후보 유전자로 제기되었고, Objective: Premature ovarian failure (POF) is a highly heterogenous condition, and its etiology remains unknown in approximately two-thirds of cases. POF can be caused by Turner syndrome, genetic disease, iatrogenic agents such as chemotherapy and radioth
손인숙 ( In Sook Sohn ),김수녕 ( Soo Nyung Kim ),이지영 ( Ji Young Lee ),이선주 ( Sun Joo Lee ),권한성 ( Han Sung Kwon ),김영진 ( Young Jin Kim ),우남식 ( Nam Sik Woo ),최영숙 ( Young Sook Choi ),이홍기 ( Hong Ghi Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.11
Essential thrombocythemia (ET) is a chronic myeloproliferative disease characterized by a markedly elevated platelet count in the peripheral blood due to excessive proliferation of bone marrow megakaryocytes. When the disease affects women during pregnancy, an adverse obstetric outcome is possible: miscarriages, intrauterine growth restriction, preterm delivery, intrauterine fetal death, preeclampsia. Maternal complications, both thrombotic and hemorrhagic, were reported relatively infrequently. Various treatments as acetylsalicylic acid, hydroxyurea, anagrelide, heparin, interferon-alpha and plateletpheresis have been proposed to improve the pregnancy. Our case was a 38 years old multiparous women at 37 weeks of gestation with preeclampsia, intrauterine growth restriction. Under the impression of oligohydramnios and fetal distress, an emergency cesarean section was performed under epidural anesthesia. During cesarean section, sudden cardiac arrest with unknown cause was developed, and successful resuscitation was done. After cesarean section, patient continued to elevate platelet count. So bone marrow aspiration and biopsy were performed and showed essential thrombocythemia. We report a case of essential thrombocythemia diagnosed during pregnancy with brief review of the literature.
손인숙 ( In Sook Sohn ),김지연 ( Ji Yeon Kim ),권한성 ( Han Sung Kwon ),이선주 ( Sun Ju Lee ),이지영 ( Ji Young Lee ),김수녕 ( Soo Nyung Kim ),최원혁 ( Won Hyeok Choe ),우남식 ( Nam Sik Woo ),한혜승 ( Hye Seung Han ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12
Acute fatty liver of pregnancy is a rare but usually fatal complication of the last trimester of pregnancy. The primary therapy is early delivery and supportive care. We report two cases of favorable outcomes in acute fatty liver of pregnancy. First case was a nulliparous twin pregnant woman at 33 weeks of gestation with jaundice, abdominal pain, and diarrhea. Because the acute fatty liver of pregnancy was diagnosed by typical laboratory findings, an emergency cesarean section was performed. Then, she showed the symptoms of acute renal failure, and the laboratory findings of disseminated intravascular coagulation. Second case was a nulliparous women at 37 weeks of gestation with malaise, upper abdominal pain, and elevated transaminase level. Under the impression of the acute fatty liver of pregnancy and fetal distress, an emergency cesarean section was performed under both epidural and general anesthesia. Liver biopsy was performed and showed microvesicular fatty infiltration of hepatocyte. In spite of the literature`s dismal prognosis, our cases seemed to be favorable maternal and perinatal outcomes because of early recognition and immediate termination of pregnancy with intensive and supportive care
한국인 여성에서 다낭성난소증후군의 발생 위험도와 Catechol-O-Methyltransferase 유전자 다형성과의 관련성에 관한 연구
이지영,차윤정,허성은,권한성,이선주,손인숙,김수녕,성연아,정혜원,Lee, Ji Young,Cha, Yun Jeong,Hur, Seung Eun,Kwon, Han Sung,Lee, Sun-Joo,Sohn, In Sook,Kim, Soo Nyung,Seung, Yon A,Chung, Hye Won 대한생식의학회 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.2
연구목적 : 한국인 여성에서 에스트로겐의 대사 및 불활성화와 관련된 COMT 유전자 다형성과 다낭성 난소증후군의 발생 위험도의 관련성을 알아보고자 하였다. 연구방법 : 연구대상자는 2003년 ESHRE의 진단기준을 만족하는 다낭성 난소증후군 여성 136명과 연령이 비슷하며 규칙적인 생리를 하는 여성 84명의 대조군을 대상으로 하였다. 연구대상자들의 genomic DNA는 혈액에서 추출하였으며, PCR 및 RFLP를 이용하여 유전자 다형성을 조사하였다. 결과 : COMT를 코딩하는 유전자의 exon4에서 $G{\rightarrow}A$로의 다형성을 조사한 결과 오히려 저활성 유전자형인 $COMT^{LL}$ 군에서 통계적으로 유의하게 다낭성 난소증후군의 발생 위험도가 낮아지는 것으로 나타났다(OR 0.241(CI 0.114~0.508)). 결론 : 이상의 결과로 볼 때 저활성 유전자형인 $COMT^{LL}$ 다형성 군에서 한국인 다낭성 난소증후군 발생이 감소하였으며, 에스트로겐 의존형 질환이 증가함에도 혈중 에스트라디올의 농도가 높지 않은 것은 다낭성 난소증후군 환자에서 $COMT^{HH}$ 다형성군이 증가되어 있는 것과 관련된 것으로 사료된다. Objective: To investigate whether polymorphism of Catechol-O-methyltransferase(COMT) gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women. Methods: One hundred and thirty-six PCOS patients and eighty four controls were enrolled. Blood samples were collected from the patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited as control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype. Results: In women with $COMT^{LL}$ genotype, there was decreased PCOS risk and this difference was statistically significant (OR 0.24, 95% CI 0.11~0.51). Conclusion: The results suggest that the $COMT^{LL}$ genetic polymorphism might be associated with PCOS risk in Korean women.
이소영 ( So-young Lee ),오수영 ( Soo-young Oh ),손인숙 ( In-sook Sohn ) 한국모자보건학회 2021 한국모자보건학회지 Vol.25 No.1
This study aimed to review the definitions of reproductive health rights, investigate reproductive health status, and suggest policy strategies to promote reproductive health in Korea. Current laws, the Constitution of the World Health Organization, works from Guttmacher-Lancet Commission on Sexual and Reproductive Health and Rights, the Program of Action of the International Conference on Population Development, the Nairobi Statement on ICPD25, and the Convention on the Elimination of all Forms of Discrimination Against Women were reviewed to define reproductive health right s. The reproductive health status focusing on high-risk pregnancy was analyzed. Definitions of reproductive health rights include the right of every person to have lifetime access to the information, resources, services, and support needed to achieve bodily integrity, privacy and personal autonomy regarding their reproductive health. Most indices of reproductive health in Korea analyzed here are and would remain negative. Reproductive health should be approached from the perspectives of rights. We should continuously monitor the indicators of reproductive health and policies corresponding to low fertility rates in Korea should focus on improving women’s reproductive health. This suggests support for obstetrics and gynecology check-ups and treatments before pregnancy and postpartum care, the provision of education on the importance of prepregnancy health care for men and women and comprehensive information and counseling services. It is also necessary to establish a delivery infrastructure for safe pregnancy and childbirth and unify governmental ministries related to pregnancy and childbirth.
이원욱(Won Wook Lee),이성기(Sung Ki Lee),손인숙(In Sook Sohn),김수녕(Soo Nyung Kim) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
Castlemans disease is a relatively rare disease of differential diagnostic interest in patients with lymphadenopathy. The etilogy and pathogenesis are still not elucidated. One case of Castlemsns disease of the pelvis is reported. Tumoral lesion was located in the lymph nodes of the right broad ligament. Histologically, the lymph nodes demonstrated the the hyaline-vascular type of Castleman's disease which had a favorable prognosis. This unusal presentation made Castlemans disease difficult to diagnose preoperatively. We describe a patient with Castleman disease of hyaline-vascular type localized to the pelvic cavity.