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박용관,김태원,장영,김진호,강정원,천영욱,박유환,정춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Multiple myeloma is a disease caused by neoplastic plasma cells that synthesize abnormal amouts of immunoglobulin or immunoglobulin fragments. Light chain myeloma are regarded as a separate category characterized by a more malignant clinical course. Light chain myelomas are said to grow fastest of all and are associated with more osteolytic lesions, more hypercalcemia, and a higher incidence of renal failure and amyloidsis than either the IgG, IgA varienties The authors experienced a case of patients with λ-light chain myeloma. A 43-year-old male patient admitted to our hospital with the chief complaint of both rib and lower back pain. The radiologic findings showed multiple pathologic fracture in ribs. osteolytic lesions in 2nd, 3rd cervical spineimmuture plasma cells. Serum electrophoresis showed normal finding. Urine electrophoresis evealed an M-spike. Urine immunoelectrophoress demonstrated λ-monoclonal protein. With the cycle of melphalan, prednisone and α-interferon chemotherapy improved of pain was observed. So we reported the case with brief review of previous literature.
조은택,박용관,김진호,강정원,천영욱,전익섭,박유환,전춘해 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1
Malignant histiocytosis, originally described in 1939 as histiocytic medullary reticulosis by Scott and Robb-Smith, is a rare histiocytic proliferative disorder that often shows an acute onset and used to progress to death within a few months. This disorder characterized clinically by fever, generalized weakness, lymphadenopathy and hepatosplenomegaly, and shows a variable range of pancytopenia. Extranodal involvement is common, with an incidence ranging from 50% to as high as 90%, skin involves8ment was noted in 10% to 15%. Typical skin lesions were mainly founded in extremity. i.e. erythematous papule and nodule occasionally become to necrosis and ulceration. We experienced one case of malignant histiocytosis in a 46-years-old female. The major clinical findings are fever, malaise, hepatosplenomegaly and erythematous skin lesion. In the laboratory study, pancytopenia is noted on the peripheral blood. And also aggregation of many atypical histiocytes were shown on skin and bone marrow biopsy. So we reported one related case with malignant histiocytosis as well as reviewing literature .
국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포
이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5
Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)
Park, Kyung Sook,Kim, Yung Jin,Mok, Jee Won,Lee, Mi Hae 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-
한국인 383명의 Complement Componet 6(C6)의 유전적 다형을 등전점 전기영동과 immunoblotting으로 조사하였다. 5가지 allotypes, C6 A, C6 B, C6 B2, C6 M1, C6 M11이 나타났고, 이들의 대립유전인자 빈도는 C6^*A = 0.4399, C6^*B = 0.5144, C6^*B2 = 0.0392로 산출되어 이는 동아시아인과 비슷하였다. The phenotyping of the sixth complement component (C6) was performed on plasma or serum samples from 383 unrelated Korean, by IEF and immunoblotting using anti-human C6 serum. Three common allotypes, C6 A, C6 B and C6 B2 and two rare allotypes, C6 M1 and C6 M11 were observed. The allele frequencies of C6^*A, C6^*B and C6^*B2 were estimated to be 0.4399, 0.5144, 0.0392, respectively. These frequencies are similar to those of the Eastasian populations.
MALDI-TOF MS-based total serum protein fingerprinting for liver cancer diagnosis
Park, Han-Gyu,Jang, Kyoung-Soon,Park, Hae-Min,Song, Won-Suk,Jeong, Yoon-Yi,Ahn, Da-Hee,Kim, Seong-Min,Yang, Yung-Hun,Kim, Yun-Gon The Royal Society of Chemistry 2019 The Analyst Vol.144 No.7
<P>Serum is one of the most commonly used samples in many studies to identify protein biomarkers to diagnose cancer. Although conventional enzyme-linked immunosorbent assay (ELISA) or liquid chromatography-mass spectrometry (LC-MS)-based methods have been applied as clinical tools for diagnosing cancer, there have been troublesome problems, such as inferior multiplexing capabilities, high development costs and long turnaround times, which are inappropriate for high-throughput analytical platforms. Here, we developed a simple and robust cancer diagnostic method using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS)-based total serum protein fingerprinting. First, serum samples were simply diluted with distilled water and subsequently spotted onto a MALDI plate without prior chromatographic purification or separation. The sample preparation method was enough to collect reproducible total serum protein fingerprints and would be highly advantageous for high-throughput assay. Each of the integrated main spectrum profiles (MSPs), which are representative of liver cancer patients (<I>n</I> = 40) or healthy controls (<I>n</I> = 80), was automatically generated by the MALDI Biotyper 3 software. The reliability of the integrated MSPs was successfully evaluated in comparison with a blind test set (<I>n</I> = 31), which consisted of 13 liver cancer patients and 18 healthy controls. Additionally, our partial least squares discriminant analysis (PLS-DA) demonstrated a statistically significant difference in MALDI-TOF MS-based total serum protein fingerprints between liver cancer patients and healthy controls. Taken together, this work suggests that this method may be an effective high-throughput platform technology for various cancer diagnoses and disease evaluations.</P>
박경숙,김영진,백상기,안광숙,이미혜 한국유전학회 1992 Genes & Genomics Vol.14 No.1
In a series of genetic studies of the Korean population, the carbonic anhydrase polymorphism was investigated from unrelated 1,100 Korean individuals. The allele frequencies of carbonic anhydrase I and II (CA I and CA II) were analyzed from the red blood cell by the method of starch gel electrophoresis (Hopkinson et al., 1974). The electrophoretic phenotypes of CA I was monomorphic and two electrophoretic phenotypes, CA II 1-1 and CA II 1-2, were observed as the products of the different combinations of two alleles, CA II*1 and CA II*2 at autosomal loci. Based on the investigation of 1,100 samples, the following gene frequencies were obtained; frequencies of CA II*1 and CA II*2 were 0.999 and 0.001, respectively, and the CA I*1 was only allele found in Korean population.
Park, Min Jung,Lee, Min Young,Choi, Jung Hae,Cho, Hyun Kook,Choi, Yung Hyun,Yang, Ung Suk,Cheong, JaeHun BLACKWELL 2007 FEBS JOURNAL Vol.274 No.5
<P>Adipocyte differentiation is an ordered multistep process requiring the sequential activation of several groups of adipogenic transcription factors, including CCAAT/enhancer‐binding protein‐α and peroxisome proliferator‐activated receptor‐γ, and coactivators. Here we show that replication factor C 140, which was known to act as a coactivator for CCAAT/enhancer‐binding protein‐α in our previous study, was phosphorylated on the proliferating cell nuclear antigen‐bindng domain during the adipocyte differentiation process. Calmodulin‐dependent protein kinase II was responsible for phosphorylating replication factor C 140 in the process of adipocyte differentiation. Ser518 of replication factor C 140 was identified as a major target of calmodulin‐dependent protein kinase II phosphorylation <I>in vitro</I>. Calmodulin‐dependent protein kinase II inhibitor attenuated phosphorylation of replication factor C 140 by differentiation inducers and blocked replication factor C 140‐derived transcriptional activation. Taken together, these findings demonstrate that calmodulin‐dependent protein kinase II signaling leads the cooperative transactivation of CCAAT/enhancer‐binding protein‐α and replication factor C 140 through an increase in replication factor C 140 phosphorylation, and subsequently enhances the transcriptional activation of target genes involved in adipocyte differentiation.</P>