경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

안료-수지-용제간의 상호작용이 TiO_2 안료의 분산에 미치는 영향

이근대,홍성수,박진환,안병현 釜慶大學校 2000 釜慶大學校 論文集 Vol.5 No.-

The effect of pigment-resin-solvent interaction on dispersion of pigment has been studied. The solubility parameter of TiO_2 pigment, determined in terms of suspension behavior of pigment in various solvents, was 10.27 (cal/cc)^1/2(δ_d = 8.23, δ_p = 3.45, δ_h = 5.10). The solubility parameter of Acryloid B-44, determined using rheological parameters of resin solution in different solvent, was 9.4 (cal/cc)^1/2. The solvent showing weaker interaction with pigment increased the adsorption of resin on to the pigment, resulting in higher dispersibility and higher storage stability of dispersion.

디지털 영상인식 방법을 통한 자세평가 및 운동가동범위 측정시스템 개발

문영진,이순호,백진호,이종각,이건범 한국운동역학회 2004 한국운동역학회지 Vol.14 No.3

Y. J. MOON, S. H. LEE, J. H. BACK, J. K, LEE, K. B. LEE. The development of posture evaluation and Range of Motion(ROM) system by using digital vision analysis method. Korean Journal of Sport Biomechanics, Vol. 14, No. 3, pp. 49-65, 2004. The purpose of this study is development of posture evaluation and Range of Motion(ROM) system by using digital vision analysis method. The results of this study are as follows. First, Scoliosis evaluation through this research measurement system represent 3mm error in 7 cervical point and deepest lumbar point, 0.7mm error in other point. This mean this research measurement system have a reliability for scoliosis evaluation. Second, for spine line evaluation on high fat subject, we need reconstrection spine line after mesurement for fat thickness in 7 cervical point and deepest lumbar point. Third, In pedioscope error test, it present 0.01848cm in X axis and 0.01757cm in Y axis. This results mean pedioscope have a reliability foot evaluation. Forth, Posture evaluation and Range of Motion measurement system by using digital vision analysis method can fast measure in range of motion and foot evaluation and posture. therefore we can expect this system application in young people posture clinic center and hospital and so on.

코로나 플라즈마 처리에 의한 HDPE 표면의 개질에 관한 연구

최진숙,전종탁,정봉규,이근대,문명준,이종무 釜慶大學校 2001 釜慶大學校 論文集 Vol.6 No.-

We are able to generate the stable plasma in open air and nitrogen using a corona plasma treatment system(CPTS) with a high voltage. This was applied to treat the surface of rather non-polar HDPE(High Density Polyethylene) intended for the improvement of adhesion of over-coated layers such as coatings, printing inks. The surface tension of HDPE was significantly improved by the CPTS. The characteristics of surface layer were evaluated by means of contact angle measurement, ATR-FT/IR spectroscopy, and it was found that functional groups were introduced into the surface layer of the HDPE. The use of nitrogen was increased the surface tension of the HDPE from 33.8 mJ/m^2 to 66.56 mJ/m^2, and highly effective method of HDPE surface modification could be realized.

사람 혈청 알부민에 대한 단세포군 항체의 제조와 특성 연구

태건식,안혜진 호서대학교 반도체제조장비국산화연구센터 2000 학술대회 자료집 Vol.2000 No.1

Serum albumin은 혈청 단백질 중 50-60%를 차지한다. 알부민은 순환계 내에서 삼투압을 유지시켜 세포내외의 체액을 유지 및 지용성 물질의 이동에 관여한다. 신사구체와 기저막의 투과성이 증가하거나 세뇨관의 흡수감소 등으로 단백질의 요배설량이 하루에 150mmg 이상되는 단백뇨는 신장내의 병변이 있음을 나타내는 중요한 지표이다. 이러한 단백뇨는 크게 사구체성 단백뇨, 세뇨관성 단백뇨, 혼합성 단백뇨로 나눌수 있는데 이중 사구체 기저막의 손상으로 발생되는 사구체성 단백뇨는 알부민과 같은 고분자량의 단백질이 소변 내로 배설되는 현상이다. 일반적으로 알부민이 정상치 이상으로 소변을 통하여 배설되는 것을 'microalbuminuria'라고 하며 당뇨병으로 인한 신장병변을 예견하는데 중요한 지표로 알려져 있다. Microalbuminuria는 방사 면역확산법, 방사성 면역측정법, 면역혼탁측정법, 비탁측정법, 효소결합면역측정법(ELISA) 등으로 겸출할 수 있으나 최근에는 안전하면서도 민감도가 높고 측정이 용이한 방법인 ELISA를 이용한 면역분석방법이 많이 사용되고 있다. 면역특이성이 떨어지는 다세포군 항체를 사용한 방법의 문제점을 극복하기 위해서 세포융합기술을 이용한 단세포군항체를 생산하는 세포주를 개발하였고 그 특성을 규명하였다. 따라서 본 연구에서 세포융합기술을 도입하여 개발된 인간혈청 알부민에 대한 단세포군항체는 glycohemoglobin에 대한 단세포군항체와 더불어 당뇨병의 진행 정도를 진단할 수 있는 키트의 원료로 사용될 수 있다.

열대열 말라리아 치료 후 발병한 삼일열 말라리아 1예

이건화,김태형,박노진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Endemic malaria in the northen parts of the Republic of Korea is caused by P. vivax. And imported malaria cases in Korea from south Asia, Indian subcontinents are usually caused by P. falciparum species. We report a case P. vivax malaria after successful treatment of P falciparum malaria with a review of literatures. Co-infection of P. vivax and P. falciparum, which relapsed only with P. vivax, after successful treatment of P. falciparum malaria was considered. A 38-year old Bangladeshi woman who had lived in Korea visited our hospital due to fever and headache. Eight months ago, she was admitted to a hospital in Calcutta in India because of P. falciparum malaria. She was treated successfully with mefloquine and doxycycline. In this time she was presented with features of malaria with every-other day fever. Awaiting the species identification, we empirically prescribed mefloquine and doxycycline. But the peripheral blood smear showed erythrocytic schizogony, trophozoite and gametocytes typical of P. vivax. So she was finally treated with hydroxychloroquine and primaquine. The patients was well during outpatient follow up period.

Panipenem을 포함한 Carbapenem 계열 항생제의 몇 가지 임상균주에 대한 시험관내 항균력

이동건,김명신,강진한,전혜선,최수미,위성헌,김상일,최정현,유진홍,신완식,강문원 대한감염학회 2003 감염과 화학요법 Vol.35 No.2

목적 : Panipenem은 일본에서 개발된 카바페넴계 항생제로 그람양성균, 그람음성균, 혐기균에 이르기까지 광범위한 항균력을 나타낸다고 보고되고 있지만 국내에서 분리되는 균주에 대한 감수성 검사결과는 아직 없다. 본 연구에서는 임상에서 분리된 E. coli, K. pneumoniae, P. aeruginosa, S. pneumoniae 균주를 대상으로 carbapenem 계열 및 몇 가지 항생제와 감수성을 비교하고, 특히 P. aeruginosa의 경우 carbapenem의 효과를 Muller-Hinton agar (MHA)가 반감시킬 수 있는 특성을 고려하여 감수성에 변화가 있는지 확인하고자 하였다. 방법 : 2002년 3월부터 6월까지 가톨릭대학교 성모병원, 강남성모병원, 성가병원, 성모자애병원, 성빈센트병원에서 분리된 임상균주 E. coli, K. pneumoniae, P. aeruginosa, S. pneumoniae를 대상으로 하였다. 항생제 감수성 검사는 NCCLS 기준에 따랐고 P. aeruginosa의 경우 MHA 이외에 minimal agar Davis (MAD)를 추가로 사용하였다. 감수성 결과 해석시 panipenem은 imipenem과 같은 기준을 적용하였다. 결과 : E. coli, K. pneumoniae, P. aeruginosa는 각각 100균주였고, S. penumoniae는 134균주였다(PSSP 41, PNSP 93균주). E. coli, K. pneumoniae는 모든 균주가 imipenem, meropenem, panipenem에 대해 감수성을 보였다. P. aeruginosa의 경우 imipenem, meropenem, panipenem, ceftazidime의 MIC_(90)은 각각 16, 8, 32, 64㎍/mL이었다. MHA와 MAD 배지를 이용하여 P. aeruginosa에 대한 항생제 감수성을 비교해 본 결과 imipenem, panipenem의 MIC_(90)가 각각 16, 32㎍/mL에서 8㎍/mL로 감소하였고, imipenem에 비해 panipenem이 더 많이 감소하였다. S. pneumoniae의 경우 PSSP는 imipenem, meropenem, panipenem에 대해 모두 내성이 없었고 PNSP는 imipenem, meropenem, panipenem에 대한 MIC_(90)가 각각 1, 2, 0.25㎍/mL이었다. 결론 : 결론적으로 panipenem은 E. coli, K. pneumoniae에 대해 기존의 카바페넴계 항생제와 유사한 우수한 항균력을 보였다. P. aeruginosa의 경우 ceftazidime, imipenem과 비슷한 항균력을 보였고 아미노산 함량이 적은 배지를 사용함에 따라 MIC가 낮아졌으며 imipenem보다 더 많은 영향을 받았다. S. pneumoniae의 경우 특히 PNSP에서 기존의 카바페넴계 항생제보다 우수한 항균력을 보였다. Panipenem은 주요 그람음성균 및 폐렴연쇄구균 감염에 유용할 것으로 기대된다. Background : Panipenern (PAPM) is a new carbapenern which has an enhanced broad spectrum against both gram-positive and negative organisms. The aim of study was to compare the activities of PAPM with those of imipenern (IMPM), meropenern (MRPM) against several clinical isolates in Korea. Methods : We tested the in vitro antimicrobial activities of PAPM, IMPM, and MRPM against total 300 clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa and 134 Streptococcus pneumoniae collected from 5 different university hospitals. Using NCCLS guidelines, MICs of PAPM, IMPM, MRPM, and/or ceftazidime were determined. Results : All isolates of E. coli and K. pneumoniae were susceptible to PAPM, IMPM and MRPM. MIG_(90) of PAPM, IMPM, and MRPM against P. aeruginosa were 32, 16, and 8 ㎍/mL, respectively. Comparing Mueller-Hinton agar (MHA) and minimal agar Davis (MAD), the MIG_(go) of PAPM and IMPM were reduced from 16 and 32 ㎍/mL to 8 and 8 ㎍/mL, respectively. PAPM was more influenced by MAD than IMPM. All isolates of penicillin susceptible S. pneumoniae showed 0% of resistance to the carbapenems tested. MIC_(90) of PAPM, IMPM and PRPM against penicillin non-susceptible S. pneumoniae were 0.25, 1 and 2 ㎍/mL, respectively. Conclusion : Panipenern could be one of the potentially useful drugs for the treatment of infections caused by E. coli, K. pneumoniae, and S. pneumoniae. We also showed that PAPM had good anti-pseudomonal activity when examined in MAD, the amino acid-limited media. Therefore, it could be useful for the treatment of infections caused by P. aeruginosa.

한양대학교 (안산 캠퍼스) 주변 담수호의 수질분석

김용건,원호식,경진범,김동국,홍태기 漢陽大學校 環境科學硏究所 2000 環境科學論文集 Vol.21 No.-

본 연구의 목적은 한양대학교(안산캠퍼스) 주변 호수들의 수질과 물의 오염 상태를 조사하기 위해서이다. 수질은 물의 온도, pH 화학적 산소 요구량(CODMn), 총 질소(T-N), 총 인(T-P), 부유물질(SS), 그리고 중금속(Zn, Cd, Pb, Cu, As, Cr(VI), Hg)을 측정했다. 호수들의 수질등급은 환경처에 의해 평가된 등급V보다 더 낮았다. 한양대학교(안산캠퍼스) 주변의 모든 저수지들은 생활폐수, 그리고 산업폐수의 유입으로 이미 심각하게 오염되어 있다. 그러나 중금속의 오염은 관찰되지 않았다. 만약 폐수의 처리가 확립되지 않는다면 한양대학교 주변 저수지들의 수질은 더욱악화될것으로 사료된다. The objective of this study was to investigate the water quality and status of water pollution in the lakes around Hanyang University (Ansan campus). Water quality was determined by monitoring water temperature, pH, chemical oxygen demand(CODMn), total nitrogen (T-N), total Phosphorus (T-P), suspended solids (SS), heavy metals (Zn, Cd, Pb, Cu, As, Cr(VI) and Hg). The level of water quality of lakes was lower than the level V estimated by the Enviroment Ministry. All of the reserviors around Hanyang University (Ansan campus) had been already seriously polluted by inflow of wastewater from residents, animal husbandries and industries. However, heavy metal pollution was not observed. It is recommended to establish plans for water quality improvement for the reserviors around Hanyang University before it gets worse.

가로쓰기 한글의 글자꼴과 글줄이 인지속도에 미치는 영향

이병근,이진호,심효섭 東西大學校 1997 동서논문집 Vol.3 No.1

This study investigated the effect of character form and the Numbers of characters per line on Readability of Hangul characters and words horizontal printing. The results were as follows. In canceling tests. (1) the speeds of character canceling were faster in the order of elongated form condensed form and original form conditions, and (2) the speeds of word canceling were in the order of elongated, original and condensed form conditions. But in a reading task, (3) the order of the Readability were [40>35>30] in number of characters per line condition and [original>elongated>condensed] in character form conditions. The above indicates that original form with 40 characters per line is the best combination for horzontal Haugul printing.

製絲時(韓國,中國産고치)의 界面活性劑(Monopol LX, Emulon DO#113) 處理가 製絲成績에 미치는 影響

최진섭,裵啓宣,鄭元福,金東建 東亞大學校生命資源科學大學附設 農業資源硏究所 1992 農業生命資援硏究 Vol.1 No.1

본 實驗은 界面活性劑인 Monopol LX와 Emulon DO #113을 0.04%, 0.07%, 0.1%로 稀釋하여 煮菌時의 低溫渗透部 단독 處理區와 低溫渗透部 및 繰絲湯의 동시 處理區로 하여 中國産고치와 韓國産고치의 繰絲成績 및 絲質을 調査 分析한 結果는 다음과 같다. 1. 解舒率은 韓國産, 中國産 모두 無處理區에 비해 Monopol LX 와 Emulon DO #113을 處理時에 增加하였으며 0.1% 濃度에서 그 경향이 높았다. 2. 解舒絲長은 解舒率과 같은 傾向으로 無處理區보다 Monpol LX와 Emulon DO #113 處理區에서 전반적으로 길어졌는데 특히 中國産고치에서 Monopol LX 0.1% 處理時 高度의 有意差를 보였다. 3. 菌絲長은 處理別로 다소의 增感은 있었으나 無處理區와 거의 비슷한 傾向을 나타내었다. 4. 菌絲量은 Monopol LX와 Emulon DO #113약제 처리시에 감소하는 경향을 나타내었다. 5. 生絲量比率은 無處理區에 비해 減少하는 경향을 나타내었다. 6. 副蠶絲量은 界面活性劑 處理의 結果 그 양이 減少되었으며 특히 韓國産 누에고치에서 0.07%, 0.1%의 Emulon do#113 渗透部 및 繰絲湯 處理區에서 5%의 有意差를 보였다. 7. 解舒率이 높을수록 無處理區에서는 强力은 負의 相關을 解舒絲長, 繭絲長, 繭絲量, 生絲量比率, 伸度등에서는 正의 상관을 나타내었고, Monopol LX 0.1% 處理區는 副蠶絲量에서, 그리고 Emulon Do#113 0.1% 處理區에서는 副蠶絲量, 繭絲織度, 伸度 등에서 負의 相關을 나타내었다. 8. 한국산 고치에 비해 중국산 고치는 고치의 크기가 작고, 解舒率, 解舒絲長, 繭絲長, 繭絲量, 生絲量比率, 伸度등의 成績이 떨어졌으며, 副蠶絲量이 많은 편이었다. This experiment was carried out to investigate the reeling silk results and silk quality of Korean cocoon and Chinese cocoon which were experimented on the following condition that Monopol LX & Emulon DO #113(penetrating agents) were 0.04%, 0.07%, 0.1% under only low temperature osmose treatment and simultaneous treatment of low temperature osomose & reeling bath in cocoon cooking, and the results obtained were as follows; 1. The percentage of reliability increased in the treatment of Monopol LX, Emulon DO #113 as compared with control in both Korean cocoon & Chinese cocoon exhibited a high tendency in 0.1% concentration to the extent to show a significant difference. 2. The nonbreaking length of a bave was totally longer in the treatment of Monopol LX, Emulon DO #113 than control as in the percentage of rawsilk, especially, showed a highly significance in the treatment of Monopol LX 0.1% of Chinese cocoon. 3. The length of a bave showed almost similar tendency to control with more or less increase and decrease according to the treatments. 4. Decreasing tendency was revealed in treating Monopol LX and Emulon DO #113 on the terms of the bave weight. 5. On the terms of the percentage of rawsilk, decreasing tendency was appeared in treating plots as compared with control. 6. The weight of byproduct was decreased by treating the penetrating agents especially on Korean cocoon, the statistically significant differences of 5% were revealed in treating the osomose and reeling both of Emulon DO #113 concentrated with 0.07% and 0.1%. 7. Negative correlation in tenacity was appeared in control as increasing the percentage of rawsilk, and positive correlation in the nonbreaking length, length of a bave weight, percentage of reliability, and elongation was convinced and also negative correlation was revealed in weight of byproduct treated with Monopol LX(0.1%) and in weight of by product, size of bave, and elongation treated with Emulon DO #113(0.1%), 8. The percentage of rawsilk, nonbreaking length of a bave, percentage of reliability, weight of a bave, size of a bave and elongation of Chinese cocoon were all lower than those of Korean cocoon, and on the hand, the weight of byproduct was more.