관상동맥 누공에 의한 급성 심근 경색 1예

서유승,최재웅,송창섭,조용범,양진수,박준섭,정인수 대한내과학회 2003 대한내과학회지 Vol.65 No.2

관상동맥 동정맥루 기형은 매우 드문 질환으로 치료가 불필요한 경우가 대부분이나 coronary steal 현상으로 인해 증상이 발생하거나 합병증이 발생한 환자에 대해선 치료를 요한다. 최근에는 시술에 적합한 누공을 가진 선택된 환자군을 대상으로 카테터를 이용한 중재적 시술이 시행되어 수술적 치료와 유사한 결과를 얻고 있다. 저자들은 젊은 남자에서 관상동맥 동정맥루 기형과 동반된 급성 심근 경색증을 진단하여 비 수술적 방법인 카테타 코일 색전술로 성공적 치료 후 증상 및 심근 재관류에 호전을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. We report a case of coronary fistula between the left anterior descending and main pulmonary artery complicating acute non-Q wave myocardial infarction. A 27-year-old man visited emergency department because of severe chest pain lasting two hours. The electrocardiogram showed ST segment elevation in precordial leads V3~6. Cardiac enzymes were as follows;CK-MB:36.44 IU/L T-T:0.489 ng/mL, CPK:542 IU/L, and LDH:475 IU/L. The thallium-201 dipyridamole stress perfusion scan showed perfusion defect and reversed redistribution in the anteroseptal wall. The coronary angiogram revealed coronary artery fistula between the proximal left anterior descending artery and main pulmonary artery without significant stenoses of coronary arteries. The result of ergonovine test was negative. After micro-coil embolization to the coronary fistula, symptoms were improved. Follow-up thallium-201 scan showed normalized blood flow in the left anteroseptal wall.

이기종간의 상호운용성을 지원하는 이동 에이전트 시스템

이명준,박양수,유양우,문남두,김진홍,안건태 울산대학교 2000 공학연구논문집 Vol.31 No.1

현재 대부분의 이동 에이전트 시스템들은 그들 자신의 구조를 가지며 서로 다른 방법으로 구현되어 있다. 이러한 에이전트 시스템들은 서로 다른 인터페이스를 제공하고 있어서 이기종의 에이전트 시스템에서 새성된 에이전트들은 상호 이동하여 작업을 수행할 수 없다. 이러한 문제를 해결하기 위하여 이동 에이전트 시스템간의 상호운용성 지원이 중요한 과제로 다루어지고 있다. OMG(Object Management Group)는 이질적인 에이전트 시스템간의 상호운용성을 증진시킬 목적으로 MAF(Mobile Agent Facilities)명세를 제안하였다. MAF명세는 MADAgentsystem과 MAFFinder 두개의 인터페이스로 구성되어 있으며 에니전트 관리, 코드의 이동성, 명명 규칙에 관한 기능을 제공한다. 본 논문에선는 OMG의 MAF 명세를 만족하는 SMART 이동 에이전트 시스템의 설계와 이의 구현에 대하여 설명한다 SMART 이동 에이전트 시스템의 구성은 에이전트를 실행시키는 환경을 제공하는 플레이스(place), 에이전트의 라이프사이클과 플레이스를 감시하는 모니터(monitor) 그리고 에니전트에게 시스템의 자원을 할당하는 자원관리자(resource manager)로 이루어져 있다. Most current mobile agent systems adopted their own architectures, being implemented in various ways. Since those agent systems provide different interfaces, agents created in one mobile agent system could not move to other agent systems to perform their tasks. To solve this problem, interoperability becomes one of the important issues on mobile agent systems. The OMG(Object Management Group) proposed the MAF(MAF(Mobile Agent Facilities) specification for the interoperability among heterogeneous mobile agent systems. the MAF specification contains MAF Agent System and MAFFinder interfaces, and defines agent management, code mobility and naming rules. In this paper, we describe the design and implementaion of the SMART mobile agent system which satisfies the OMG MAF specification. The SMART system consists of Places that provide execution environments for agents, Monitor that monitors life-cycle of agents and places, and Resource Manager that allocates resources of system for agent.

조선대학병원에서 경험한 삼일열 말라리아의 임상적 고찰

서영선,김양수,김태균,박유환,홍순표,정춘해 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

In the five years since 1993 Malaria has made a ceaseless attack on the native Koreans as an indigenously formed disease in addition to the imported one. This study was aimed at clinical symptoms and signs of Malaria which had occurred indigenously in Cheon-Nam. 18 cases were reviewed retrospectively in this study which was composed of 17 men and 1 woman. They were admitted to Chosun Hospital because of the indigenous Malaria in 1998. Fever and chill , the most frequent symptoms in early stages made a 100% occurrence followed by general myalgia(89%) and headache(83%). Physical examination of those admitted showed the splenomegaly most frequently in 61% of the patients. It took four to ten days to visit the hospital since the symptoms first occurred in the patients. Gametocytes among the Malarial life cycle were observed most commonly (91.3%) in the occurrence of the disease and the prestages of the life cycle as well. The hematologic abnormalities observed was Anemia(89%), Thrombocytopenia(61%), and Neutropenia(50%) in the order named. On the third hospital day since giving the standard Malarial drugs parasitemia decreased remarkably (1540/㎕ : Mean parasitic concentration) and 28th day of treatment no parasitemia were found. In conclusion the patients suffering from malaria in Cheon-Nam had been in an armistice area and the symptoms were so relatively mild that the responses to treatment were good and relapses occurred. But, it requires further epidemiologic survey and more concern about the indigenous Malaria.

Paraquat 투여 백서에서 Cyclophosphamide와 Dexamethasone의 치료 효과

신정철,신양수,유병전,임현성,정태흥,박찬국,오금탁,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

Paraquat (N,N'-dimethy 1-4,4'bipyrydinium : Gramoxone^(R), a widely used herbicide, is extremely toxic to all green plants and many eukaryotic organisms. In human, paraquat intoxication leads to multiple organ failure, it preferentially damages the lung, kidney and liver and may result in death. The participation of superoxide in initiating tissue damage by administration of paraquat is well known in which one electron reduction of paraquat leads to the formation of radical species which react with molecular oxygen to give superoxide. This process initiates immunological changes with the activation of neutrophilic leukocytes, which is related to further production of superoxide. In this experiment, therapeutic effects of cyclophosphamide and dexamethasone on blood cell count, malondialdehyde as a indicator of lipid peroxidation, and antioxidant enzymes levels in the lung, liver and kidney of paraquat intoxicated rats were inbestigated. The WBC count were significantly decreased by combined treatment of cyclophosphamide and dexamethasone in paraquat intoxicated rats at 3 and 5 days but RBC count were not changed. The contents of malondialdehyde were significantly decreased in the lung and Kidney by combined treatment at 10 days after paraquat intoxication. The catalase acitvities were markedly increased in the lung and liver of rats at 10 days after paraquat intoxication, and superoxide dismutase activities showed minimal changes in the lung, liver and kidney of rats by combined treatment. These results suggest that paraquat induced tissue damage in rats can be redeced by combined administration of cyclophosphamide and dexamethasone.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

분만 후 심한 저혈당이 동반된 림프구성 뇌하수체염 1예의 경과 관찰

손장명,고승현,안유배,주강,이정록,양성은,송기호,손호영,전정수 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.3

저자들은 출산 후 발생한 심한 저혈당을 주소로 내원한 31세 여자 환자에서 뇌 자기공명영상검사에서 뇌하수체종괴가 관찰되고 복합 뇌하수체 기능검사 결과전반적인 뇌하수체 기능저하증의 소견을 보여 림프구성 뇌하수체염을 진단하고, 호르몬 보충요법만으로 경과를 관찰하여 호전된 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Lymphocytic hypophysitis, an inflammatory disease of the pituitary gland that is often associated with pregnancy, is caused by autoimmune destruction of the pituitary gland evidenced by diffuse inflammatory cell infiltration of the pituitary gland and some kinds of detectable autoantibodies. We report a case of lymphocytic hypophysitis in a 31-year-old woman presenting with severe hypoglycemia and hyponatremia after delivery. Hormonal study revealed panhypopituitarism and magnetic resonance imaging with enhancement showed the bulging contour of the right side pituitary gland with an ill-defined mass-like lesion and nodular thickening of the stalk The patient's symptoms and biochemical data improved greatly with replacement of L-thyroxine and glucocorticoid. Partial recovery of panhypopituitarism was also seen. The follow-up tests revealed dramatic resolution of the pituitary lesion (J Kor SOC Endocrinol 1 8 : 3 25 -33 1, 2003).

Intervention Effects of Nedaplatin and Cisplatin on Proliferation and Apoptosis of Human Tumour Cells in Vitro

Su, Xiang-Yu,Yin, Hai-Tao,Li, Su-Yi,Huang, Xin-En,Tan, Hua-Yang,Dai, Hong-Yu,Shi, Fang-Fang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: To study synergistic effects of nedaplatin and cisplatin on three human carcinoma cell lines (esophageal carcinoma cell line Eca-109, ovarian carcinoma Skov-3 and cervical carcinoma Hela). Methods: Inhibition effects were evaluated by MTT assay and cell apoptosis was detected by flow cytometry. In addition, changes of Ki-67, Bax and Bcl-2 at mRNA and protein levels were quantified by RT-PCR and Western blotting. Results: Growth inhibition in each cell lines was dose-dependent after exposure to nedaplatin or cisplatin alone. The interaction of the two drugs was synergistic at higher concentrations according to the median-effect principle. The inhibition rates with nedaplatin, cisplatin and combined treatment were $41.9{\pm}4.1%$, $47.4{\pm}2.9%$, $52.5{\pm}0.9%$(Eca-109), $39.0{\pm}1.26%$, $45.0{\pm}1.45%$, $56.2{\pm}1.44%$ (Skov-3) and $44.8{\pm}2.11%$, $46.9{\pm}0.99%$, $56.6{\pm}1.83%$ (Hela) respectively, with increase in apoptosis. Compared with the nedaplatin or cisplatin alone treatment group, the combinative treatment group's Ki-67 and bcl-2 mRNA (protein) expression was decreased while that of Bax mRNA (protein) was increased. Conclusion: Compared to the effects of nedaplatin or cisplatin alone at high concentrations, combination of nedaplatin and cisplatin at low concentrations proved to be much more effective for inhibition of proliferation and the induction of apoptosis in the Eca-109, Skov-3 and Hela cell lines.

Components Variation on Processing of Salvia miltiorrhiza and Antler-shaped Ganoderma lucidum

Yu Su Shin(신유수),Chang Yeol Yang(양창열),Su Ji Choi(최수지),Kyung Hwan Bang(방경환),Jang Uk Kim(김장욱),Kyung Suk Han(한경숙) 한국약용작물학회 2021 한국약용작물학회 학술대회논문집 Vol.2021 No.1

Corellation coefficient of biological activity and chemical constituents on processing of Hericium erinaceus and antler-shaped Ganoderma lucidum

Yu Su Shin,Chang Yeol Yang,Byeong Ju Lee,Su Ji Choi 한국버섯학회 2022 버섯 Vol.26 No.2

A Comparison of Developmental Trajectories of Prepulse Inhibition between Male and Female Rats

Yang Yang,Yun'ai Su,Chunmei Guo,Yu Feng,Jitao Li,Tianmei Si 대한정신약물학회 2010 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.8 No.3

Objective: Various studies have demonstrated that childhood and adolescence are critical periods of brain development characterized by both dramatic changes and sexual dimorphism in anatomy, physiology and cognition. Prepulse inhibition (PPI) is an operational model of sensorimotor gating process, but data concerning the interactions of sex and normal ontogeny of PPI is of a particular paucity. Methods: We led a longitudinal study to compare the PPI between male and female Sprague-Dawley rats during postnatal day 23 to 43. Results: We found that the PPI of both male and female rats increased during this period. We also found that the PPI of male and female rats had different developmental trajectories when the prepulse intensity was 20 dB [A] above background, a result similar with a previous study done in humans. Conclusion: The finding confirms the face validity of PPI as a model of information processing across species and supports its utilization for investigation of potential aetiological factors implicated in mental disorders.