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바터 팽대부에 발생한 선암과 대세포 신경내분비암의 충돌종양 1예
주강,김태효,김차영,이상수,김홍준,김현진,정운태,이옥재 대한소화기내시경학회 2011 Clinical Endoscopy Vol.42 No.2
Most tumors affecting Vater’s ampulla are adenocarcinomas, but a neuroendocrine carcinoma in the ampulla of Vater is extremely rare. The coexistence of these two tumors has been reported in only a few cases. Here, we report a rare case of a collision tumor of the ampulla of Vater with an adenocarcinoma and a large cell neuroendocrine carcinoma. 바터 팽대부에 발생하는 악성 종양은 대부분 선암(adenocarcinoma)이며 다른 조직학적 형태의 암 발생은 극히 드물다. 특히 선암과 신경내분비암이 동시에 발생하는 복합종양은 매우 드문 것으로 알려져 있다. 저자들은 최근 상복부불쾌감과 황달을 주소로 내원한 60세 여자에서 바터 팽대부암 의심 하에 유문보존 췌십이지장절제술 후 조직학적으로 선암과 대세포 신경내분비암이 병발한 바터팽대부의 충돌종양을 진단하였다. 복합종양 중 대세포 신경내분비암이 췌장 주위 지방조직으로의 침윤 및 림프절 전이가 있어 수술 후 보조항암요법을 받았던 예를 경험하여 문헌고찰과 함께 보고한다.
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Cell Cycle에서 ^3H-thymidine 標識指數와 分裂指數가 일치하지 않는 原因
朱剛 慶北大學校 醫科大學 1978 慶北醫大誌 Vol.19 No.2
cycle에서 標識指數와 分裂指數가 일치하지 않는 원인을 알고저 Shaver種白色 Leghorn 수평아리를 오전 오후 실험군으로 나누어 3가지 方法에 의해서 검토한 결과 다음과 같은 성적을 얻었다. 1. 分裂指數와 標識指數는 一致하지 않았다. 2. 世代時間(generation time)도 理論的 방법에 따라 實測値와 많은 차이가 있었으나 本人의 方法이 가장 實測値에 가까웠다. 3. 標識指數와 分裂指數가 一致하지 않는 原因의 한가지 說明으로서 圖 4에 提示된바와 같은 model를 설정하였다. The rate of cell prolferation and cell specialization are influenced by a wide variety factors in the microenvironment of the cell pepulation. the development of definitions of kinetic parameters related to cell proliferation, and the collection of quantitative data to estimate a few of the parameters, has facilitated the development and use of simplified ideal proliferative systems or models. Some of the methods to estimate compartive rate of cell proliferation in the renewing populations of the gstrointestinal tract, have used the ratio of the number of cells in DNA synthesis(S) or mitosis(MI), to the duaration of DNA synthesis (TG) or mitosis (TM), and have noted limitations of the estimate. The cell cycle duraration has also been approximated by observing the time between successive waves of labeled mitoses after administration of tritiated thymidine. In the present analysis tritiated thymidine autoradiography has been applied to the esophageal epithelial cell pouplation in two groups of male chicks, and then, comparative rates of cell proliferation were determined by observing the appearance of successive waves of labeled mitoses. In addition, the theoretical models were compared to experimental data, in an attempt to gain further insight into nature of the differences between theable llring indeses and mitotic indeces. Theoretically all the cells which undergo DNA duplication should divide so that lagelling indeces is in proportion to mitotic indeces ineach cell population. The result of many studies, however, tend not to be this theory. It seemed that all the and M. pahse, cells which completed DNA duplication do not necessarily enter the mitotic phase directly. The auther, therefore propsed another GO which tentatively between S pahse and M pahse, celled GO_2 and accordingly traditional GO is called GO.
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Cortisone의 鷄胎器官成長에 미치는 影響에 對하여
朱剛 慶北大學校 醫科大學 1967 慶北醫大誌 Vol.8 No.1
This study is to observe the effects of cortisone on the weight gains of body and various organs of chick embryo, out of which growth and relative growth formula has been derived. On the 8th and the 12th days of incubation, 0.5㎎ and 2.0㎎ of cortisone were injected into the chorioallantoic membrane of each incubated egg of two groups. Between the 12th and 18th of Incubation days, a daily total of 10 treated eggs was broken for weighing the body weights of chicks embryos and six organs-brain, eye ball, heart, lung, liver, and kidney. The effects of doses and difference of injection times on growth were analyzed by the Repeated Two Way Layout Method, and the determination of the significance in the levels of difference was made by the Turkey's Method. The formulas applied to analyzing the changes in growth are: y=a+bt+ct^2, coefficient of relative growth (α) by y=bxα. y= growth quantity of organs; t= specific date of incubation period, x= body weight; a,b,c=constants. The results are summarized as follows: (1) When injected with cortisone acetate, the chick embryos were observed with remarkable growth inhibition(p<0.01). (2) The growth inhibition appeared to be much stronger with the group of 2.0㎎ dosage than that of 0.5㎎ dosage. No noticeable differences were observed on the liver of the 8th day group, and on the kidneys of the 12th day group. (3) Generally, the growth inhibition was found stronger on the 8th day group than on the 12th (p<0.01), but in brain and eye balls, no inhibitory difference depending on the injection days was observed. Lungs were unique in that the growth inhibition appeared in the 12th day group (p<0.01). (4) Growth rate: In the 8th day group, the growth rate was observed to be increased in body weight, lungs, liver, and kidneys throughout the two injected groups- 0.5㎎ and 2.0㎎: brain and heart, however, showed the increase only in 2.0㎎ injected group. The growth rate was observed decreased in eye balls of two injected groups; the decrease of brain and heart were in 0.5㎎ injected groups. In the 12th day group, the increase in growth rate was shown in the followings: body weight, eye balls and lungs of 0.5㎎ injected group, body weight, eye balls and kidneys of 2.0㎎ injected group, the other organs except the increased ones showed decrease in all injected groups. (5) Specific Growth Rate: (a) In the 8th day group: 1) increase was observed only in lungs, 2) decrease was in all organs except lungs. (b) In the 12th day group: 1) increase eye balls of 2.0㎎ injected group; kidneys of 2.0㎎ group. 2) decrease was in the other organs except the above mentioned. (6) The Growth Gradient: The growth centers appeared as follows: (a) In the 8th day group: lungs of all two injected groups, on the 18th day of incubation; liver of 2.0㎎ injected group, on the 15th; kidneys of 0.5㎎ injected group, 17th day of incubation; the others all appeared on the 12th day. (b) In the 12th day group: brain, heart and liver of 0.5㎎ injected group had the growth centers on the 12th incubation day, and the others had them on the 18th incubation day. (7) The Coefficient of Relative Growth: The coefficient of relative growth was observed as follows: (a) In the 8th day group: the liver of two injected group, and kidneys of 0.5㎎ injected group were of positive allometry; the others showed negative. (b) In the 12th day group: liver of two injected groups and heart and kidneys of 2.0㎎ injected group were positive, while the others were negative.
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