정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

남성화를 보이는 여성에서 발견된 난소의 Steroid Cell Tumor 1예

조인호,정대훈,박영미,서영진,손영실,정철회,강영미,정수전,김영남,이경복,성문수,김기태 인제대학교 2006 仁濟醫學 Vol.27 No.-

Steroid cell tumor is a rare ovarian sex cord-stromal tumor which accounts for 0.1% of all ovarian tumors. Until now, only 4 cases have been reported in domestic literatures. Steroid cell tumor often secrets testosterone and presents virilization in adult women or precocious puberty in children. Treatment is often performed by surgical removal, adjuvant chemotherapy and radiation, but completely accepted treatment was not existed. We experienced a case of steroid cell tumor, which was manifested by typical virilization in a 43-year old patient, who was previously performed hysterectomy and unilateral oophorectomy. So, we present with a brief review of the literatures.

아르곤 이온빔 보조증착 방법으로 제작된 TiN 박막의 특성

손영호,김인수,홍영호 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(A)

TiN thin films were deposited on to mirror-like polished stainless steel by ion beam assisted deposition (IBAD) method. The deposition characteristics of TiN films were invested by various analysis method - Color Test, XRD, AES and Scratch Tester. The SEM analysis showed that the morphologies of TiN films were changed with smooth surface as according to the increasing of the ion arrival ratios. From the AES analysis, TiN films were confirmed only the composition of Ti and N. The ratios of the composition N/Ti were increased as according to the increasing of ion energy per atom. The TiN thin films have a strong preferred orientation of (lll) crystallographic plane. The color of films is golden yellow above 600 eV/A. The adhesion of films were decreased as according to the increasing of ion energy per atom, but the values of adhesion were excellent as the above 18 N and the maximum value was 38 N at l of the ratio of the composition N/Ti.

이온빔 보조증착 방법으로 제작된 Al 박막의 특성

손영호,김인수,황도원 경운대학교 산업기술연구소 1999 産業技術硏究論文誌 Vol.2 No.1

Al thin films were fabricated by using vacuum evaporation method and ion beam assisted deposition method. The effects of ion impact on Al thin films were characterized by the surface roughness and the SEM morphology. Al thin films fabricated by vacuum evaporation method were increasing surface roughness as increasing substrate temperature. Al thin films fabricated by ion beam assisted deposition method were decreasing hillock profiles and increasing density as increasing ion arrival ratio comparing to the Al thin films fabricated by vacuum evaporation method.

가열처리에 의한 단감의 이화학적 특성

손규목,김광호,성태수,김종현,신동주,정지영,배영일 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.2

단감의 기능성 소재 및 기호성이 우수한 부원료로서의 이용 가능성을 확인하기 위하여 단감새옥를 전처리별 즉, 열처리 온도 (25℃, 75℃ 및 95℃) 에서 NaCl (0, 1, 3%) 농도별로 침적 (1, 5분) 하여 동결건조한 시료구를 대상으로 탄닌, 비타민 C, 색도 및 조직감 등을 분석한 결과는 다음과 같다. 탄닌 성분은 열처리 온도, NaCl 농도 및 침적시간이 증가할수록 탄닌함량이 감소하는 경향을 나타내었으며, 특히, 대조구 (420 mg%) 에 비해 95℃에서 1% 및 3% NaCl 농도에 5분간 침적시 각각 228 및 198 mg%로 감소하였다. 비타민 C 함량은 대조구 (122.4 mg%)에 비해 95℃에서 3% NaCl 농도에 5분간 침적시 75.8 mg% 로 감소하였고, 색도는 열처리 온도, NaCl 농도 및 침적시간이 증가할수록 L(명도) 및 b(황색)값이 뚜렷하게 증가한 반면, a(적색도) 값은 감소하였고, ??E 값은 증가하여 처리조건이 가중될수록 색의 변화가 진행됨을 알 수 있었다. 단감껍질과 전처리한 시료 (95℃, 1% NaCl, 5 분)의 flavonol 함량은 껍질에 myricetin(2.0 ㎍/g), quercetin (34. 5 ㎍/g) 및 kaemferol (1.1 ㎍/g) 성분이 검출되었고, 전처리한 시료는 myricetin (9.5 ㎍/g), quercetin (5.5 ㎍/g)이 검출되었다. 조직감은 대조구에 비해 전처리 (95℃, 1% NaCl, 5분) 한 시료에서 부서짐성, 응집성, 점성 및 씹힘성이 우수하였다. 관능검사는 95℃에서 1% NaCl에 5분 및 3% NaCl 농도에 1부간 침지한 시료가 좋은 평가를 받았다. Sweet persimmon were tested in order to identify their use as secondary material which is excellent in function and taste as food. Samples were soaked for 1 and 5 min with NaCl concentration (0, 1 and 3%) at a certain heating temperature (25, 75 and 9r℃), and then tannin, vitamin C, flavonol, color intensity, sensory test and textural properties were analyzed. The results of the analyses were as follows. Tannins were decreased as heating temperature, NaCl concentration and soaking time were increased, especially, that the control was 420 mg% but decreased 228 and 198 mg% at 95℃ (1 and 3% NaCl concentration) for 5 min, soaked in each. Vitamin C content also decreased more in higher temperature and NaCl concentration than control (122.4 mg%). Color intensity showed higher value in L and b than in heating temperature, NaCl concentration and soaked time longer remarkably, but a value decreased. The peel of sweet persimmons was analyzed myricetin (2.0 ㎍/g), quercetin (34.5 ㎍/g) and kaemperaol (1.1 ㎍/g), but in pre-treatment sample ( 95℃, 1% NaCl concentration and 5 min, soaked ) was showed higher myricetin (9.5 ㎍/g) and quercetin (5.5 ㎍/g). Textural properties were good in pre-treatment sample ( 95℃, 1% NaCl concentration and 5 min, soaked) such as brittleness, cohesiveness, gumminess and chewiness. In sensory analysis, the pre-treatment samples (95℃, 1% NaCl concentration and 5 min, soaked and 95℃, 3% NaCl concentration and 1 min, soaked) were showed higher point than others.

Montessori와 Piaget의 인지개념에 관한 비교 고찰

손영수 진주여자전문대학 1995 論文集 Vol.18 No.-

The purpose of this study is to analyze both similarity and difference in the concept of cognition between two approaches of Montessori and Piaget by comparing the basic theory of Montessori. This study is summarized as follows. Firstly, this study was carried out by comparing 'sensitive period' of Montessori with 'optimal period' of piaget. Both Montessori and Piaget were influenced by biology, so that they insisted that there is a certain development period in the process of human development which is different from each human being. Secondly, this study Was performed by comparing the concept of Montessori's 'normalization' with one of piage's 'assimilation·accomodation·equilibrium'. Their similarity is that they emphasized the active and spontaneous action of children, insisting that their intellectiual development is accomplished by interaction between innate factors and external environment. But Piaget emphasized the social relation of children in the process of the intellectual development, while Montessori neglected the social human relations. Thirdly, it was to compare 'sensory education' of Montessori with 'sensory-motor period' of Piaget with respect to their concept. Then, their similarity is that they used the method of clinique for observing children, and that they emphasized the early sensory experience of the children, considering 'sense' as the starting point to be composed of their sense and intellect in the future.

생쥐에서 過排卵誘導時 姙馬性腺刺戟홀몬의 投與用量이 體外受精 및 胚子의 成長에 미치는 영향

손영수 梨花女子大學校 韓國生活科學硏究院 1991 韓國生活科學硏究院 論叢 Vol.48 No.-

A common feature of many in vitro fertilization and embryo transfer(IVF & ET) programs is the stimulation of ovarian follicular development by the administration of exogenous gonadotropins, which routinely results in the recovery of multiple oocytes. However, less favorable consequences of excessive gonadotropin stimulation have been demonstrated in both animal models and human IVF & ET. The effects of increasing the level of ovarian stimulation on preimplantation embryonic development were assessed using mouse in vitro fertilization system. When F1 hybrid(C57BL×CBA) mice received a single injection of 3IU, 5IU or 10IU PMSG, there was no significant difference in the total number of eggs ovulated. Increasing the does of PMSG from 3IU to 5IU resulted in significant reduction in the frequency of development to the embryo over 2-cell stage. However, there was no significant reduction by increasing the does of PMSG from 3IU to 10IU. And no reduction in the frequency of development to the blastocyst or hatching blastocyst was observed when the does of PMSG was increased from 3IU to 5IU or 10IU. The result suggest that lower does of PMSG(3IU) be favorable to superovulation of mouse to lessen the adverse effect to the oocytes superovulated.

그림을 통한 유아의 지능분석 방법에 관한 연구

손영수 진주여자전문대학 1993 論文集 Vol.16 No.-

A study on the Analytical Method the Infants' Intelligence through Their Paintings. This study, as a method of infants' intelligence analysis, aimed to review features and problems of the analysis focused on the infants' paintings. In this study, figure paintings were analyzed mainly, were given scores in each part of the paintings by analysis criteria, and were added up scores. This study suggests appliable method in the field through converting this total scores into Intelligence Quotient, reviews reliability and Validity of this study, and relations to other studies of Intelligence analysis methods. From a viewpoint of Intelligence Analysis, we raise some problems and the need of other methodological studies.

능력검정에 의한 우량 종봉 선발에 관한 연구

손영익,차용호,최광수 慶北大學校農業科學技術硏究所 2001 慶北大農學誌 Vol.19 No.-

The study was conducted to establish the method of performance test of honeybee queens under Korean environment. Colony performances of apis mellifera were tested based on wintering ability, colony population and honey yield in Sangju, Korea from November, 1999 ∼2000 season were averaged 22.6±2.6kg and 20.1±2.6kg, respectively, showing the decrease of 2.5 ±0.7kg. During 2000∼2001 winter season, the colony weight before wintering was 22.6±2.3kg and was decreased by 2.3± 0.6kg. The number of combs well covered with bees was 13.1± 4.6 as measured on the 22nd of May. 2000 and 16.0± 3.8 on the 21st of May. 2001, respectively. The rate of supering colonies were 50% and 98.5% in 2000 and 2001, respectively. The amount of honey production was 12.7± 8.6kg per colony in 2000, 14.2± 7.6kg per colony with unselected queens and 23.5± 4.9kg per colony with seleceted-tested queens in 2001, which were harvested two times during main nectar flow season of black locust, Robinia peseudoacasia.

所謂 「假性小兒코레라」에 關한 臨床的 觀察

孫永俊,金洙煥,李東近 대한소아과학회 1970 小兒科 Vol.13 No.6