알레르기성 비염 환자에서 절지동물성 특이항원의 양성율 및 항원간 일치율

황규윤,남해선,박준수,권준택,백병준,김장묵,오천환,조성란 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

The current study was designed to evaluate the positive rates of arthropod allergens by Korean inhalant panel of MAST-CLA in patients with allergic rhinitis. One hundred sixty patients, diagnosed to allergic rhinitis in an Out Patient Center of Soonchunhyang University Chunan Hopsital during Aug 1998 to July 2000, were studied. 1. The overall positive rate among 35 specific allergens was 59.4% (95 patients). 2. The arthropod related allergen accounted for 82.1% (78 patients) of the positive rate. 3. Each positive rate of Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dp), house dust (Hd), and cockroach mix (Cm) was 45.0% (72 patients), 43.1% (69 patients), 28.1% (45 patients), and 8.8% (14 patients), respectively. 4.Significant agreement between arthropod allergens was observer (P < 0.05). 5. The obseved agreement between Df and Dp was 95.6%, showing most significant Kappa index (Kappa = 0.911, P < 0.001). There results suggested that although MAST-CLA is a useful measure of identifying specific allergens, the specificity of two mite allergen relatively low, implying because of common allergen between mites in Korean panel of MAST-CLA. Our data also supported that arthropod is the major cause of allergen in patients with allergic rhinitis, however, the MAST-CLA should be modified in order to exclude common allergen of mite and to include more specific mite allergen.

국내 건설 프로젝트의 하도급체계에서 대금불공정 거래에 대한 연구

황윤재,이창훈,윤준선,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study is to investigate Unfair Practice and Unfair-Bidding Practice of Sub-Contract System in domestic Construction Project. Even though the Sub-Contractors are very important positioned in Construction Project, Sub-Contractors have not been given fair services in Construction project. Firstly, This study investigates the Sub-contract system. Unfair Practice and bidding Practice. And then the investigated documents are rearranged for searching why Unfair-Practices spreaded in Korea and why unfair-bidding Practices were followed. The results include Unfair institutions. Law and Contractors' oppressions which should be corrected. Rearranged documents are suggested to Contractors. Sub-contractors and government for improving Fair Sub-contracts system in domestic Construction industry.

순천향대학 천안병원에 내원한 알레르기환자의 특성

황규윤,남해선,,안현철,박준수 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

This study was designed to evaluate gencral features related to allergy of allergic patients living in northern and western Chungchungnamdo, visited to an allergic unit in Soonchunhyang University Chunan Hospital during August 1998 to July 2000. Three hundred allergic patients were enrolled. Among them, 87.7% were outpatients and were analysed for the study. Demographic variables as well as resident living conditions and immunologic results were assessed. Overall IgE, house dust, Dermatophagoides farinae (Df), and Dermatophagoides pteronyssinus (Dp) antibody were assessed using MAST-CLA in 263 outpatients. Relations between allergens and age, sex, and living conditions were evaluated by chi-square tests. Mean age was 21.0 ± 17.3 year-old and male accounted for 59.3% in total subjects. Among them, 52.0% lived in an apartment and 65.3% were from urban area near Chunan and Asan city. Admission rate of allergic patients was 12.3%. The positive rates of total IgE, house dust, Df, and Dp were in 55.1%. 19.0%, 30.0%, and 29.3% in outpatients, respectively. No significant relations between allergens and sex. living home, and region were observed (P>0.05). Adolescents showed significantly higher positive rate of total IgE (P=0.02). Our data suggested that residential environment may not be a significant factor of main causative allergens in northern and western Chungchungnamdo. However more controlled study should be required to elucidate the relations between living environments and major causative allergens in this area.

스트레칭운동에서 온열요법이 요부의 유연성에 미치는 영향

황윤태,유경태,이미영,박래준 대구대학교 특수교육재활과학연구소 2007 再活科學硏究 Vol.25 No.1

스트레칭(stretching)은 최근 신체 각 부위를 적절하게 움직이게 하여 긴장과 피로를 풀어주어 신체 발달을 꾀하고 유연성을 향상시키는데 좋은 운동방법으로 평가되고 있다. 온열요법(heating therapy)은 신체부분에 국소적으로 열을 가하여 혈액의 순환을 증가시켜서 손상의 빠른 회복을 기대하여 물리치료학에서 현재 많이 이용되는 방법으로 관절 경직의 완화, 동통 완화, 그리고 근 경련의 감소에 효과적이다. 본 연구에서는 20대에서 40대 사이의 신경학적 제한이 없는 정상인을 대상으로, 스트레칭 운동을 시행할 때 혼합되는 온열요법이 요부의 유연성 개선에 미치는 효과를 알아보고자 하였다. 20대에서 40대 20명(남10, 여10명)을 10명씩 두 집단으로 나누어 한 집단은 8 동작의 스트레칭 시행하는 스트레칭 집단으로 하고, 다른 한 집단은 온습포(hot pack)와 8 동작의 스트레칭을 혼합하는 열-스트레칭 혼합 집단으로 하였다. 각 집단은 주 4회 6주간 실시되었으며, 유연성 검사를 위해 체간 굴곡(trunk flexion), 체간 신전(trunk extension), 그리고 요부의 유연성을 나타내는 Schober-test를 측정하였다. 두 그룹간의 차이를 연구하여 요부의 유연성 개선에 미치는 효과를 검증하였으며, 나아가 본 연구는 요부 안정화 프로그램의 중요성과 산업체 근로자와 장시간 같은 자세로 작업을 하는 장애자들에게서 흔히 발생하는 요부의 통증에 접근하기 위해 고안되었다. The purpose of this study is to verify the difference of effect between group and period in order to find out effect on lumbar flexibility of treatment modality(stretching, heat - stretching) and period. The subject was chosen from the mild physically normal person who range from 20 to 40 years old without any neurological problem. Among these subjects, 20 persons(10 male, 10 female) were selected to two different groups. These were classified as stretching and heat- stretching groups. In stretching group, 8 different kind of stretching exercises were performed. In heat-stretching group, hot pack and stretching were performed together with 8 different stretching exercises. For the measurement of flexibility, trunk flexion test, trunk extension test and Schober-test were used. Pre-test was performed before treatment test, post-test was performed after 6 week of treatment test. As a result of this test, the following fact was shown 1) In trunk flexion and trunk extension test, effect between groups did not occur but effect of treatment period showed significance statistically. In addition, interactive effect between treatment period and each group showed the biggest difference in heat and stretching group. 2) In Schober-test, effect of treatment period showed significance statistically, effect between group and interactive effect did not occur.

흰쥐에서 방광경부 부분폐쇄의 제거가 방광근의 수축력에 미치는 영향

김준철,윤재영,황태곤,박용현,김광명 大韓泌尿器科學會 1997 Korean Journal of Urology Vol.38 No.12

韓國人에서 HumFIBRA/FGA와 D21S11 遺傳座의 對立遺傳子 頻度와 遺傳的 變異의 分析

김윤신,황적준,이혜린,구태완,한길로,김성민,이혜승 大韓法醫學會 1998 대한법의학회지 Vol.22 No.1

Allele-and genotype frequencies of the two short tandem repeat (STR) loci, HumFGA and D21S11, were determined in Korean population(n=196). DNA typing was accomplished by applying fluorescence-labeled PCR products and a differently labeled sequenced allelic ladders, followed by automated analysis using ABI 377 automatic sequencer and GeneScan 2.02 software. Prior to typing, allelic ladder of each locus was constructed with a combination of all alleles occuring from the population sample. A total of 15 alleles and 48 genotypes with the heterozygosity of 0.854 for HumFGA, and 12 alleles and 33 genotypes with the heterozygosity of 0.787 for D21S11 are observed in a population of 196 genetically unrelated individuals. No deviations from Hardy-Weinberg equilibrium were observed(p=0.753 for HumFGA, p=0.262 for D21S11). The data presented here (power of discrimination and average power of exclusion) show that both STR Loci, HumFGA and D21S11, are very informative for individualization from criminal evidences, and are also useful for parentage testing.

소아에서 알레르기 증상과 알레르겐 특이항체와의 관련성

박준수,안현철,남해선,황규윤 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

To evulate usefulness of application of MAST-CLA to identify allergens in children, authors conducted MAST-CLA allergen-specific IgE assay and collected allergy related symptoms in 88 pediatric allegic patients diagnosed at Soonchunhyand University Chunan Hospital during October 1998 through January 2000. The mean (SD) age of study subjects was 8.8(3.2) years. The frequent allergic symptoms were rhinorrhea (40.9%), nasal stuffiness(38.6%), cough(36.4%), sneezing(35.2%), and itching sensation(28.4%) in order. Among them, 56.8% revealed at least more than one allergen specific IgE by MAST-CLA. The three most frequent specific allergens were Dermatophagoides farinae(52.3%) Dermatophagies pteronyssinus(51.1%), and house dust(35.2%). The positive rate of allergen specific IgE was increased by increasing age(P<0.001). Among the symptoms the sneezing showed most high positive rate of allergen specific IgE(80.7%) and total IgE(80.7%). In multivariate analysis, significant odds ratios remained(adjusted OR-4.66, P=0.004). In conclusion, our data suggest that allergic symptoms are associated with allergen-specific IgE using MAST-CLA assay, which is an useful measure for identification of causative allergens in pediatric allergen patients.

알레르기 환자에서 MAST-CLA 검사의 의의

남해선,황규윤,,백병준,정윤영,오천환,조성란,박준수 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

To evaluate usefulness of application of MAST-CLA to indetify allergens, authors conducted MAST-CLA allergen-specific IgE assay and collected allergy related symptoms in 118 allergic patients diagnosed at Soonchunhyang University Chunan Hospital during October 1998 through January 2000. The results were as followings; 1. The mean (SD) age was 23.1 (±12.17) years old and teenagers accounted for 33.1% of patients. 2. The frequent allergic symptoms were sneezing (59.3%), rhinorrhea (53.4%), nasal stiffness (44.1%), itching sensation (24.6%), cough or sputum (16.1%), and eye symptom (8.5%) in order. 3. Among these subjects, 62.7% of patients revealed at least more than one specific allergen and 70.3% showed elevated total IgE levels by MAST-CLA. The three most frequent specific allergens were Dermatophagoides farinae (47.5%), Dermatophagoides pteronyssinus (45.8%), and house dust (30.5%). 4. While age was not significantly related to positive of both specific allergens and total IgE (P>0.05), sneezing and nasal stiffness were significantly associated with positive of specific allergen and total IgE, respectively (both P<0.05). 5. Total IgE increased with the number of specific allergens, but both specific allergen and total IgE were not significantly related to increases of allergic symptoms (P>0.05). In conclusion, our data suggest that MAST-CLA allergen-specific IgE assay is useful measure for identification of causative allergens in allergic patients, however, it is recommended that more specific allergic antigens should be determined and replaced or added to Korean inhalent panel of MAST-CLA.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

알레르기성 소인이 없는 정상인에서 특이 알레르겐항체 양성율

남해선,안현철,박준수,황규윤,박춘식 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

This study was designed to evaluate prevalence of allergen-specific antibodies in healthy adults. During Mar. ~ Aug. 2001, 1,925 subjects visited for medical check-up, were inquired to fill out a standardized questionnaire. Among them, 200 subjects who had no current and past allergic disorders were randomly selected for rhe current study and examined for allergen-specific antibodies using Korean inhalant panel of MAST-CLA allergen-specific IgE assay. Among them, 170 persons (85.0%) did not have any positive allergen-specific antibody. Each positive rate of 35 allergen specific antibodies was usually less than 3%, except Cockroach Mix (3.5%), Dermatophagoides farinae(8.5%), Dermatophagoides pteronyssinus(6.0%). Among 30 positive subjects, 19(63.3%) showed one or two allergen-specific antibodies. Although atopic subjects in non-allergic population were not common, few of them showed allergen-specific antibodies in Korean inhalant panel of MAST-CLA. Our results suggested that the standardized questionnaire and MAST-CLA could be an useful tool of a screening test for allergy, showing high specificity and sensitivity.