국내외 ‘영아’ 관련 연구물의 최근 동향 분석 : 2000년~2013년 발간 논문을 대상으로

이승연,권수현,권연정,김언경,나영이,유주연,최정아 이화여자대학교 교육과학연구소 2015 교육과학연구 Vol.46 No.3

The purpose of this study was to examine research trends in infant research published from 2000 to 2013, in order to understand overall aspects in research topics, methods, and subjects in infant research and to suggest directions for future infant research. A total of 2916 journal articles and theses/dissertations, both domestic and foreign, were selected for the analysis. The findings of this study were as follows: First, for the 14 year period, 737 domestic articles, 634 domestic theses/ dissertations, 1242 foreign articles, and 303 foreign dissertations on infant research were published, and there was a steady increase in the number of articles and theses/dissertations over the years. Second, in terms of research topics, different patterns were found between the domestic ones and the foreign ones; the topic of “education and teachers” in the domestic ones and “development” in the foreign ones occurred most frequently. Third, in terms of research methods, the domestic ones employed “survey” the most, and the foreign ones employed “experiment” the most among quantitative research methods; when analyzing the relation between methods and topics, the foreign ones showed clear matches between topics and research methods, while the domestic ones preferred “survey” regardless of the topics. Fourth, in terms of subjects/participants, “infants” were the most researched in both the domestic ones and the foreign ones, followed by “parent” and “teachers.” Among the infants, the domestic ones focused on 25~36-month olds the most, while the foreign ones focused most on 0~12-month olds. In addition, in all types of infant research, there were more single subject studies than multiple subject ones.

임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

대학생들의 다이어트 식습관 실태 조사

김연정,문진아,왕수경 대전대학교 기초과학연구소 2010 自然科學 Vol.21 No.-

대전대학교 교양과목으로 개설된 ‘식생활과 다이어트’ 교과목을 수강하는 남녀 학생 151 명을 대상으로 다이어트 경힘과 함께 그들의 식습관을 알아온 결과는 다음과 같다 조사대상자는 남학생 81 명과 여학생 70명으로 총 151 명이었다. 남학생들의‘식생활과 다이어트’ 수강동기는 식생활 전반에 대해 공부하고 싶다는 응답이 여학생들은 특히 다이어트에 관심이 있어서 라고 응답한 학생이 가장 높아 유의적 차이를 보였다 여학생 중 51 .4%, 남학생 중54.3%는 다이어트에 대한 경험이 있었으며, 다이어트 해 본 시기는 남학생은 대학교 때 여학생은 고등학교 때가 가장 높게 나타나 유의적 차이를 보였다. 다이어트 정보는 남학생과 여학생 모두 인터넷과 경험 있는 친구 나 선배를 통해서가 가장 높게 나타났다. 남녀 학생의 평균 운동 시간은 유의적 차이를 보여 남학생은 주 1 - 3시간 운동하는 학생이 가장 많았고 여학생들의 주 1 시간미만 운동하는 학생이 많았다. 식생활 태도에 대한 조사에서 아침 식사를 하지 않는 학생이 남녀 각각 19.6%. 18.6%로 나타났다. 남학생이 여학생보다 과식하는 경향을 보였으며 간식을 먹는 횟수는 여학생이 많았다. 조사대상자 자신의 식생활의 개선점으로 남녀 학생이 각각 56 .4%와 47.0%가 불규칙한 식사로 답하였다. 이상의 결과로 남녀 학생들이 다이어트에 대한 관심도가 높았고 식습관에 문제가 있어 “식생활과 다이어트”과목을 수강함으로써 식습관과 다이어트 과목을 통한 영양교육이 효과가 있을 것으로 본다. In th is study, 151 students(male were 81 and female were 70enrolled in ‘' Food and Diet course were asked about their diet experiences and food habits . In the question asking the reasons for taking this‘' Food and Diet'class , most male subjects answered they enrolled 'to learn about overall knowledge’, whereas female students answered ' special interest in diet’' led to taking th is class. 67 .1 %of women and 64.2% of men said they put effort to maintain weight. Also , 51 .4%of female and 54.3% of male have experience of diet. The period of diet was most frequent in University for men (33 .3%) and in high school for women (47.1 %). Diet information was gathered from internet of from friends with previous experiences for both genders . It showed students gain little through reading nutrition related books , percentage was low for men and women (3 .7%. 1.4%, respectively). For diet methods. 40% of the subjects in total said they do diet through exercise. Female subjects showed that they've tried many different methods such as yoga and diet therapy . 53 .1 % of male and55.7% of female answered the diet was effective and lost weight. In the questionnaire about the dietary life and habits. percentage of the subjects who do not eat breakfast was 19.6% for men and 18.6% for women. The frequency of excessive eating and taking snacks was higher in men and it showed statistically meaningful result. From above results , we can conclude that the interest in diet was high in both gender and they both have problems regarding eating habits. 80 by taking ‘' Food and Diet’' class , it is predicted that this course will have educational effect on students 'eating habits and their diet.

칠레산 Propolis의 Flavonoid

이연아,이민원 중앙대학교 약학연구소 1996 약학 논총 Vol.10 No.-

Propolis is a natural resinous substance produced by honey bees and used by them to strengthen their nest and was known to have significant biological effect including antibacterial, anti-fungal, anti-inflammatory and anti-oxidant activity. Form the EtOH extract of Chilean propolis, two flavonoid compounds were isolated by chromatographic separation. The structure of these compounds was elucidated as pinocembrin and chrisin by physico-chemical and spectral evidences.

Chlorhexidine과 fluoride 성분의 varnish가 타액 내 mutans streptococci 수에 미치는 효과

서정아,김재곤,백병주,양연미,이용희,김상훈 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

본 연구의 목적은 chlorhexidine(Cervitec)과 fluoride(Fluor-protector) 성분을 각각 포함한 varnish를 치아에 적용하였을 때 타액내의 mutans streptococci의 수의 감소에 미치는 효과를 알아보기 위한 것이다. 전북대학교 치과대학생 40명을 대상으로 하여 mutans streptococci 균종 수를 평가하였으며, 이들을 무작위로 네 군으로 나누어 다음과 같이 varnish를 적용하였다; A) varnish를 적용하지 않은 군(n=10), B) chlorhexidine varnish 적용군(n=10), C) fluoride varnish 적용군(n=10), D) chlorhexidine과 fluoride varnish를 모두 적용한 군(n=10), Mutans streptococci 수 측정에는 Orion diagnostica 사의 Dentocult SM을 사용하였다. Varnish를 적용하지 않은 상태에서 1차로 Mutans streptococci 수를 측정한 후 각각의 varnish를 적용하였으며, varnish 적용 12주 후 다시 측정하여 기록하였다. 모든 실험군(group B, C, D)에서 12주 후에 측정한 Mutans streptococci 수가 감소한 개체가 증가한 개체보다 많았으나 통계적으로 유의한 차이는 보이지 않았다(p>0.05). 실험에 사용된 어떠한 varnish도 적용 12주 후에 타액 내 mutans streptococci 수에 통계적으로 유의할 만한 변화를 주지는 못하는 것으로 나타났다(p>0.05). The objective of the present prospective trial was to compare the efficacy of chlorhexidine(Cervitec), Fluoride(Fluorprotector) and combination of chlorhexdine and fluoride varnishes in decreasing the level of salivary mutans streptococci. Forty healthy students of school of dentistry, Chonbuk national university were investigated to evaluate mutans streptococci(MS) counts and randomized into four groups to treat with the experimental varnishes: A) untreated group(n=10), B) chlorhexidine group(n=10), C) fluoride group(n=10), D) chlorhexidine and fluoride group(n=10). Dentocult SM^(�)(Orion Diagnostica) strip method was used for measurement of the level of mutans streptococci in saliva. Stimulated saliva were collected at baseline for mutans streptococci counts evaluation(ms1), 12 weeks later the completion of each varnish treatment, mutans streptococci counts were re-evaluated. In varnish group with chlorhexidine, fluoride and combination of chlorhexidine and fluoride, the level of mutans streptococci was lower after 12 weeks than at baseline, but there were no significant differences in saliva(p>0.05), when compared with baseline. After 12 weeks, a remarkable reduction was still found in the subjects with high level of mutans streptococci at baseline, but not different in the low and moderate level of mutans streptococci(p>0.05).

당뇨병 백서의 부신 Glomerulosa세포에서 Angiotensin Ⅱ자극후 인지질분해효소 활성의 변화

성연아 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.1

연구배경: 당뇨병에서 흔히 고칼륨혈증과 대사성 산혈증을 초래 하는 저aldosterone혈증의 원인은 확실히 밝혀져 있지 않으나 혈중의 renin농도와 ACTH, K^+ 자극에 대한aldosterone의 분비는 다양하였으나 angiotensin Ⅱ(A Ⅱ)자극에 대한 aldosterone의 분비는 공통적으로 감소 되어 있다고 보고되었다. 그러나 이러한 AⅡ 자극 aldosterone분비 감소의 기전은 확실히 밝혀져 있지 않다. 본 연구는 당뇨병을 유발시킨 백서에서 생체와 시험 관내 aldosterone분비의 변화양상을 관찰하고 AⅡ 자 극 aldosterone 분비의 감소가 세포막 신호전달계의 이 상에 의해 나타나는지 밝히기 위해 AⅡ 작용의 세포막 신호 전달계중 세포내칼슘증가와 PKC활성화에 중요한 PLC 및 PLD의 활성의 변화를 관찰하여 당뇨병에서 AⅡ 자극 aldosterone분비변화의 기전을 AⅡ의 신호 전달계중 인지질분해효소 활성화를 중심으로 밝히고 이러한 변호가 인슐린 치료에 의해 교정되는지 규명하고자 하였다. 방 법: Sprague-Dawley 백서를 정상대조군, streptozotocin으로 당뇨병을 유발시킨 군, 당뇨병 유발후 인슐린으로 혈당조절을 한 세군으로 분류하고 실험시작 2주후 회 생시켜 혈중 renin과 aldosterone을 측정하였다. 부신 glomerulosa세포를 분리한 후 시험관내에서 ACTH와 K^+ 자극 aldosterone 분비 반응의 변화 및 AⅡ 자극 aldosterone 분비 반응을 측정하였다. AⅡ 자극후 PLC 및 PLD의 활성을 반영하는 IP_3, PA,PEt, DAG를 측정하였다. 결 과: 1)당뇨병백서의 혈장 renin활성도와 aldsoterone 농도는 정상 대조군 및 인슐린으로 혈당을 조절한 군과 유 의한 차이가 없었다(p<0.05). 2)당뇨병백서의 부신 glomerulosa세포의 기저상태, K^+, ACTH자극 aldosterone 분비는 정상대조군과 차이가 없었으나(p>0.05), AⅡ자극 aldosterone의 분비가 정상대조군과 유의한 차이가 없었다.(p>0.05). 3) AⅡ자극에의한 IP_3와 PA, PET, DAG의 생성은 세균간에 유의한 차이가 없었다.(p>0.05). 결 론: 당뇨병백신에서 부신 glomerulosa세포의 AⅡ자극 aldosterone분비가 감소되며 이러한 AⅡ자극 알도스테론 분비 변화는 인슐린의 치료에 의해 교정되고 PLC와 PLD 활성화후 산물의 생성이 정상군과 차이가 없는 것으로 보아 phospholipase의 활성화이후의 신호 전달체계의 결함에 의할 것으로 생각되었다. Objectives : Diabetic patients develop hypoaldosteronism which frequently caused hyperkalemia and metabolic acidosis and diabetic hypoaldosteronism is associated with selective unresponsiveness of aldosterone to angiotensin Ⅱ(AⅡ), but mechanism of defect in AⅡ stimulated aldosterone response still remain unclear. To elucidate the mechanism of defect in AⅡ stimulated aldosterone response and whether the defect was corrected by insulin treatment. author evaluated the responses of aldosterone production to AⅡ, K^+ and ACTH. I also evaluated the products of phospholipase C(PLC) and phospholipase D(PLD) activation important for increase of intracellular calcium and protein kinase C activation after AⅡ activation in adrenal glomerulosa cells prepared from streptozotocin induced diabetic rats. Methods : Two weeks after induction of diabetes by streptozotocin, rats were sacrificed by decapitation. The aldosterone production to AⅡ, K^+ and ACTH was measured by RIA. Inositol triphosphate(IP_3) and diacylglycerol(DAG) generated by activation of PLC and phosphatidic acid(PA), phosphatidylethanol(PEt) and DAG generated by activation of PLD were measured by anion exchange column and thin layer chromatography. Results : 1) Plasma renin activity and aldosterone level were not different among control rats, untreated and insulin treated diabetic rats. 2) basal, ACTH and K^+-stimulated aldosterone production were similar in cells from the three groups(p>0.05), but AⅡ stimulated aldosterone production was significantly decreased in cells from untreated diabetic rats compared with control and insulin treated diabetic rats(p<0.05). 3) AⅡ-induced IP_3, PA, PEt and DAG generation was similar among the three groups(p>0.05). Conclusion : These results suggested that decreased AⅡ-stimulated aldosterone response was present in glomerulosa cells from strepzptocin induced diabetic rats and reversed by insulin treatments. The main defect of altered AⅡ response of zona glomerulosa might be located in the step distal to the activation of phospholipase.

Estradiol에 의한 흰쥐-자궁의 수축 기능과 Polyamine 대사의 변동에 관한 연구

이명아,고재홍,이영재,신경호,전보권,천연숙 고려대학교 의과대학 1995 고려대 의대 잡지 Vol.32 No.3

The polyamines have been postulated to be essential in most processes associated with both hypertrophy and hyperplasia. The effects of estrogen on uterine contractility vary with animal species, and most reports have shown that in vitro contractility of rat uterus is decreased after estrogen treatment, but estrogen increases polyamine contents in castrated rat uterus. This study was carried out to investigate whether the regulation of polyamine metabolism may be instrumental in the contractile response of castrated nonpregnant uterus of female SD rats to electrical field stimulation (40 V, 100 μsec : EFS). Estradiol (E2) increased uterine contents of putrescine (PT), spermidine (SPD), and spermine (SPM). These E2 effects were inhibited by tamoxifen or DFMO, but E2-incuced increase of uterine SPM content was enhanced by aminoguanidine. E2 decreased the amplitude of force developed in the rhythmic spontaneous contraction of rat uterus, but it exaggerated the increase of uterine contraction force in response to EFS. The E2-dependent exaggeration was inhibited by tamoxifen, DFMO, or indomethacin, but was significantly enhanced by aminoguanidine. The synergism between E2 and aminoguanidine on uterine contractility was little affected by indomethacin. These results suggest that E2-dependent increase of uterine contractility may be ascribed partly to increase of uterus polyamines.

선천성 결손치에 관한 임상적 연구

정해경,양연미,김재곤,백병주,정진우,김하나,김미아 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

The congenital missing of teeth is common, which takes place since the proliferation and differentiation are not allowed in that tooth bud fail to start development. The purpose of this study is to research incidence rate, number, and missing part of congenital missing teeth, and to study whether a person who has missing teeth has other abnormality of teeth or not. For this study, 1,520 subjects(aged 2.9~17) who had visited pediatric dentist department of Chonbuk national university dental hospital within 2 years were examined with an panoramic radiograph ; exempting third molar missing state. The obtained results are as follows. 1. 8.88% among total subjects show missing teeth ; male 9.05%, female 8.64% 2. The most frequently missing permanent teeth were the mandibular second premolars(22.3%). The most frequently missing primary teeth are mandibular lateral incisors(50%). 3. 43.3% patients have one permanent missing tooth, 34.3% have two, and 10.4% have more than six, respectively. In primary teeth, 86.7% patients have one missing tooth, and 13.3% have two missing teeth. 4. 18 patients(13.3%) have missing teeth as well as hyperdontia, while some patients have microdont, ectopic eruption, and fusion teeth. 치아의 선천성 결손은 치배의 발육이 시작되지 못하여 치아의 증식, 분화가 일어나지 못함으로서 발생하는 흔한 치아의 발육 이상이다. 이 연구의 목적은 선천성 결손치의 발생률, 결손치의 수, 발생부위와 결손치 환자에게서 나타난 다른 치아이상의 발생여부를 조사하는 것이다. 본 연구는 2006년 7월부터 2008년 6월까지 전북대학교 소아치과에 내원하여 파노라마를 촬영한 1,520명의 환자(2.9~17세)를 대상으로 제 3 대구치를 제외한 선천성 결손치의 분포를 조사하여 다음과 같은 결과를 얻었다. 1. 전체 1,520명 중 총 8.88%에서 결손치가 관찰되었으며, 남자가 9.05%, 여자가 8.64%에서 결손치가 관찰되었다. 2. 총 350개의 영구 결손치 중 하악 제 2 소구치가 22.3%로 가장 발생률이 높았고, 하악 측절치, 상악 제 2 소구치, 하악 중절치, 상악 측절치 순이었다. 또한 총 18개의 유치 결손치 중 하악 유측절치가 가장 높은 발생률(50%)을 보였다. 3. 1개의 영구치 결손치를 가지는 환자는 43.3%, 2개는 34.3%, 3개는 6,7%, 4개는 1.5%, 5개는 3.7%, 6개 이상은 10.4%이었다. 또한 유치 결손치의 수는 1개는 86.7%, 2개는 13.3%이었다. 4. 결손치가 있는 환자 중 과잉치를 가지는 환자는 18명(13.3%)이 있었으며, 왜소치, 이소맹출, 융합치 등의 치아이상을 지닌 환자도 관찰되었다.

당뇨병에 기인한 허혈성 말초 혈관 질환에 대한 Cilostazol의 유효성 평가

김희진,성연아,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.1

Objectives : Diabetic peripheral neuropathies are one of the most frequent complications of diabetes, and multiple metabolic and vascular disturbances are involved in the pathogenetic mechanisms of diabetic neuropathies. Methods : Thirty patients with diabetic neuropathies from ischemic peripheral vascular disease were received cilostazol, an antithrombotic and vasodilating drug, 200mg a day in two divided doses for eight weeks at the Ewha Womans University Hospital. We analysed the eff-ects between before and efter treatment with cilostazol. Results : 1) Total 30 patients were studied : 21 patients wre female and 9 patients were male. Their mean age was 60.2±9.9 years, and mean duration of diabetes was 8.0±4.9years. As comp-lications, 47% of them had retinopathy and 30% of them nephropathy. 2) No significant difference was found in physical findings, metabolic control states, CBC, blood chemistry and lipid levels before and after cilostazol treatment. 3) The score of resting pain and numbness were significantly decreased, and cold sensation and claudication were decreased after cilostazol treatment. 4) The score of arterial pulsation and Doppler wave was decreased, and the ankle pressure index was increased from 1.04±0.07 to 1.08±0.13 after cilostazol treatment, but there was no statistical significance. 5) Adverse effects were noted in 20% of cilostazol treated patients, 3 cases of headache, 2 facial flush and palpitation and 1 rash and urticaria, respectively. 6) The assessment of overall improvement of the disease, including "markedly improved", "improved" and "slightly improved" amounted to 63%. The assessment of overall safety of the drug, including "safe" and "almost safe" amounted to 80%. The assessment of overall utility of the drug, including "very useful","useful" and "slightly useful" amounted to 63%.

Inoue Balloon을 이용한 PMV의 장·단기 결과 분석

진은선,이연아,전숙,김현숙,정승묵,박상선,최락경,임달수,홍석근,황흥곤 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.11