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서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)
김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1
Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.
항암성 생약제로 부터 항암성분의 추출 및 항암활성 측정
이영기,신석우,염곤 단국대학교 신소재기술연구소 1993 신소재 Vol.3 No.-
암치료에 많이 사용되는 생약제 16종을 대상으로 항암활성을 규명하고자 in vitro에서 세포 독성능을 측정하여 다음과 같은 결과를 얻었다. HEP 2 cell에 대해 세포 독성능을 높게보인 생약제는 하고초>고삼>화누>선복화 순이었고, HeLa cell에 대해 세포독성능을 높게 보인 생약제는 선복화>아출>포공영>화누>구맥>하고초>고삼>오공>금은화>천문동 순 이었다. RAW 71 cell에 대해 세포독성능을 높게 보인 생약제는 구맥>화누>고삼>호모초>천문동 순 이었고, VERO E6 cell에 대해 세포 독성능을 높게 보인 생약제는 선복화>하고초 순 이었다. 또한 Herbal drug 처리에 의한 HEP 2와 HeLa 세포의 세포 독성능과 Staphylococcus aureus의 항균력간의 관계를 알아본 결과 HEP 2 cell은 약 43%, HeLa cell은 약 71%가 일치하였다. We tested the cytotoxic ability on the tumor cell line by 16 kinds of herbal drugs of which contains the alkaloids and flavoids which shows high antitumoral activity. This has been done on the condition of in vitro. the conclusion are as follows. 1. The herbal drugs which have shown the strong cytotoxic activity to HEP 2 cell are as follows. Prunella vulgaris has the strongest activity, followed by Sophorra angustifolia>Trichoosanthes kirilowii>Inula brontannaca. 2. The herbal drugs which have shown the strong cytotoxic activity to HeLa cell are as follows. Inula britannica has the strongest activity, followed by Curcuma zedoooaria>Tarazacum platycarpum>Trichosanthes kirilowii>Dianthus sinesis>Prunella vulgaris>Sophra angustifolia>Scolopendra subspinpes>Lonicera Japonica>Asparagus cochinensis. 3. the herbal drugs which have shown the strong cytotoxic activity to RAs 71 cell are as follows. Dianthus sinesis has the strongest activity, followed by Trichosanthes kirilowii>Sophra angustifolia>Corispermum stauntoni>Asparagus cochinensis 4. The herbal drugs which have shown the strong cytotoxic activity to VERO E6 cell are as follows. Inula britannica has the strongest activity, followd by Prunella vulgaris. 5. After the treatment with herbal drugs, the relationshipbetween the cytotoxic activity to HEP 2 and HeLa cell, the antimicrobial activity of Staphylococcus aureus was found. these two activites show the similarity of about 43% in HEP 2 cell and 71% in HeLa cell.
이우선,조금배,장순석 조선대학교 에너지.자원신기술연구소 1999 에너지·자원신기술연구소 논문지 Vol.21 No.1
We have been fabricated the high voltage TFT(HVTFT) having output voltage of l00V. The hysteresis curves occurred in the HVTFT. Hysteresis charactristics measured in the range of drain voltage of l00V, gate voltage of 100V. Drain current Id showed negative current characteristic a t high gate voltage. We found that the according to the forward voltage Vg increase, the drain current Id decreased. And the reverse voltage Vg decreased exponentially with the drain current Id. The hysteresis region occurred mare larger at high voltage. According to the Vd increase, Id (on/off) ratio decreased exponentially.
腸內棲息菌에 對한 硏究 : 變形菌(Proteus)에 關한 硏究
石鐘聲,金漢壽,張友鉉,李承薰 現代醫學社 1969 現代醫學 Vol.10 No.2
The proteus group are known to be widely distributed in nature and also constitute one of the important micro-flora, of human intestines. The identification of the Proteus and further differentiation into 5 species are made chiefly by their biochemical activities, which are conventionally studied with the cultures grown at 37℃. Since it is known that the metabolic activities of bacteria are influenced by the physicochemical natures of environment, it is conceivable that results of bacterial identification and differentiation based on their biochemical reactions might be different when the culture conditions differ. Thus, 100 strains of the proteus isolated from various clinical specimens were grown aerobically at 37℃ and 22℃ and the patterns of their 1, biochemical activities under the different cultural conditions were studied. The results might be summarized as follows: 1) By the biochemical activities with the cultures grown at 37℃, 100 proteus strains were differentiated into 4 species; P. rettgeri 4, P. vulgaris 14, P. mirabilis 36, and P. morganii 46. 2) If the differentiation into the species was made by the biochemical activities with the cultures grown at 22℃, the 100 strains might be classified into, P. rettgeri 41, P. vulgaris 20, P. mirabilis 34, and P. morganii 5. 3) Regardless the difference of the culture temperatures, 47 strains among the 100 strains were identified into the same species of proteus; P. rettgeri 2, P. vulgaris 7, P. mirabilis 33, and P. morganii 5. 4) Biochemically the proteus strains appeared to be more active at 37℃ than at 22℃. 5) The distribution of the 100 strains among the clinical specimens were stool or recta swat 68, pus or discharge 14, urine 10 and miscelleneous specimen 8.
비호지킨 림프종환자에서 proMACE-cytaBOM 복합항암화학요법의 유효성에 대한 제 2상 임상시험
김성우,안명주,박석규,이영렬,정태준,최일영,김인순 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1
Aggressive non-Hodgkin's lymphoma by REAL classification is a heterogenous group of disease. With recent advances in combination chemotherapy, the long-term survival is improved to 40-65%. We investigated twenty-one aggressive non-Hodgkin's lymphoma patients treated with pro-MACE-cytaBOM (prednisone, adriamycin, cyclophosphamide, etoposide, cytosine arabinoside, bleomycin, vincristine and methotrexated) to determine the efficacy and toxicites. There were seven patients older than 60 years. Histologic types by REAL classification were as follows : diffuse large B cell (12/21), peripheral T cell (6/21), anaplastic large cell (2/21) and angiocentric T cell (1/21). Most of patients were classified in Stage Ⅱ-Ⅳ (20/21). According to IPI (international prognostic index) score, seven patients were included in low risk, five were low-intermediate risk, three were high-intermediated risk and six were high risk group. seventeen complete responses (85%) and two partial responses (10%) were achieved. The overall response rate was 95%. The mena disease free survival was 30 months, the mean overall survival was 29 months (range:21-36), and the median overall survival was not reached. WHO grade Ⅲ/Ⅳ neutropenia or thrombocytopenia was observed in 16.7% and 2.8%, respectively. There was no treatment-related death. These results suggest that proMACE-cytaBOM combination chemotherapy is very effective and has low toxicity in the treatment of aggressive non-Hodgkin's lymphoma even treated in elderly patients.