A comparison of fixation methods using three-dimensional finite element analysis following anterior segmental osteotomy

Kyoung In Yun,Min-Kyu Park,Myung-Kyun Park,Je Uk Park 대한구강악안면외과학회 2012 대한구강악안면외과학회지 Vol.38 No.6

Objectives: This study sought to evaluate fixation methods and determine the best method for the postoperative stabilization of maxillary osteotomy. For our analysis we performed a three-dimensional finite element analysis of stress distribution on the plate, screw, and surrounding bone, as well as displacement onto the plate. Materials and Methods: We generated a model using synthetic skull scan data; an initital surface model was changed to a solid model using software. Modified anterior segmental osteotomy (using Park’s method) was made using the program, and four different types of fixation methods were used. An anterior load of 100 N was applied on the palatal surface of two central incisors. Results: The Type 1 (L-shaped) fixation method gave stresses of 187.8 MPa at the plate, 45.8 MPa at the screw, and 15.4 MPa at the bone around the plate. The Type 2 (I-shaped) fixation method gave stresses of 186.6 MPa at the plate, 75.7 MPa at the screw, and 13.8 MPa at the bone around the plate. The Type 3 (inverted L-shaped) fixation method gave stresses of 28.6 MPa at the plate, 29.9 MPa at the screw, and 15.3 MPa at the bone around the plate. The Type 4 (I-shaped) fixation method gave stresses of 34.8 MPa at the plate, 36.9 MPa at the screw, and 14.9 MPa at the bone around the plate. The deflection of the plates for the four fixation methods was 0.014 mm, 0.022 mm, 0.017 mm, and 0.018 mm, respectively. Conclusion: The Type 3 (inverted L-shaped) fixation method offers more stability than the other fixation methods. We therefore recommend this method for the postoperative stabilization of maxillary osteotomy.

RAW264.7 세포에서 interferon-r 및 LPS에 의해 유도되는 NO생성에 미치는 TALT-35의 영향

박종일,박경석,김종석,박지훈,윤은진,송경섭,서강식,김훈,윤완희,박승길,임규,황병두 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

TALP-35 purified from human term placenta is known to increase microtubule polymerization and stabilize the polymerized microtubule. To examine the effect of TALP-35 on immune system this study was performed. MTT assay was performed to investigate the effect of TALP-35 on the proliferation of RAW264.7 cells. TALP-35 dose dependently suppress the proliferation of RAW264.7 cells at high concentration (above 1 μM) in unstimulated cells, in case of 10 μM TALP-35 treated cells the suppression was 25% but in stimulated cells it was only 15%. Cosedimentation assay was carried out to investigate whether TALP-35 can bind to tubulin of RAW264.7, monocyte/macrophage lineage of mouse, and polymerize it. TALP-35 polymerize the tubulin of RAW264.7 cells and sedimented in dose-dependent manner. To investigate the effect of TALP-35 on the expression of iNOS protein western blotting was performed. The expression level of iNOS was decreased dose dependently in high concentration of TALP-35 treatment. To examine the activity of iNOS, secreted NO was determined by method based on Griess reaction. Interferon-γ and LPS-stimulated production of NO from RAW264.7 cells was decreased dose dependently above 0.1 μM concentration of TALP-35 and 50% is decreased at 10μM of it. This study shows TALP-35 can control cytokine induced-iNOS expression therefore it might control inflammatory diseases.

Effect of Ionizing Radiation on Rat Tissue: Proteomic and Biochemical Analysis

Park*, Eui‐,Chul,Yoon, Jong‐,Bok,Seong*, Jin‐,Sil,Choi, Kyoung‐,Soo,Kong, Eung‐,Sik,Kim, Yun‐,Jeong,Park, Young‐,Mee,Park, Eun‐,Mi Taylor Francis 2006 Preparative biochemistry & biotechnology Vol.36 No.1

<P>Reactive oxygen species (ROS), generated by ionizing radiation, has been implicated in its effect on living tissues. We confirmed the changes in the oxidative stress markers upon irradiation. We characterized the changes in the proteome profile in rat liver after administering irradiation, and the affected proteins were identified by MALDI-TOF-MS and ESI-MS/MS. The identified proteins represent diverse sets of proteins participating in the cellular metabolism. Our results demonstrated that proteomics analysis is a useful method for characterization of a global proteome change caused by ionizing radiation to unravel the molecular mechanisms involved in the cellular responses to ionizing radiation.</P>

월악산국립공원의 곤충다양성에 관한 연구 - 노린재목, 딱정벌레목, 나비목 -

박성준(Seong-Joon Park),전용락(Yong-Lak Jeon),홍의정(Eui-Jung Hong),윤주창(Ju-Chang Yun),박서경(Seo-Kyoung Park),김병진(Byung-Jin Kim) 국립공원연구원 2010 국립공원연구지 Vol.1 No.4

본 연구는 2007년부터 2009년까지 3년 동안 월악산 모니터링 조사 지점과 동일지구에 대해 정기적인 주 간조사를 통해 주간곤충류(노린재목, 딱정벌레목, 나비목)의 종목록을 확보 하여, 월악산국립공원의 생태계에 자연적 혹은 인위적으로 변화된 내용을 측정하여 곤충자원의 체계적인 관리를 위한 자료를 제공하고자 실시되었다. 본 조 사기간 동안 채집 확인된 주간곤충류는 65과 404종(노린재목 21과 86종, 딱정벌레목 38과 244종, 나비목 6과 74종) 이 조사되었다. 따라서 문헌조사를 포함한 결과 월악산국립공원에 서식하는 것으로 확인된 주간곤충류는 멸종위기야 생동물 2종, 고유종 6종, 국외반출승인대상종 10종과 특정종 50종을 포함하여 총 72과 609종(딱정벌레목 44과 368 종, 노린재목 22과 126종, 나비목 6과 115종)으로 나타났다. 아울러 조사지점별 분석결과 S3에서 종다양성이 가장 높게 나타났으며, S10은 다른 조사지점과 다르게 종다양성이 현저하게 떨어지는 것으로 나타났다. 각 조사기간별 우점종으로는 2007년과 2009년도에 넉점박이송장벌레, 2008년도에는 더듬이긴노린재로 나타났다. This study were conducted for three years from 2007 to 2009 and at the same points as monitoring surveys, through regular surveys insects (Hemiptera, Coleoptera, Lepidoptera) to obtain the list, to measure and assess  Woraksan National Park ecosystem’s natural or artificial change, to provide data for systematic management of the contents of insects. As a result of all the collections were examined, 404 species of 65 family under 3 order were identified. Therefore, the species composition of insect over each result from Woraksan National Park’s was a total of 3 orders,  72 families, 609 species including 2 Endangered species, 6 Endermic species, 10 Management of exotic species and 50 Designated species; 368 species of family Coleoptera which is the highest, 126 species of family Hemiptera and 115 species of family Lepidoptera. Site 3 had the highest indices diversity. In contrast, Site 10 indices diversity, different  from the other survey points, were significantly low. In each survey period, dominant species included Nicrophorus quadripunctatus in 2007 and 2009. In 2008, dominant species was Pachygrontha antennata.

월악산국립공원의 곤충다양성에 관한 연구 : 노린재목, 딱정벌레목, 나비목

박성준(Seong-Joon Park),전용락(Yong-Lak Jeon),홍의정(Eui-Jung Hong),윤주창(Ju-Chang Yun),박서경(Seo-Kyoung Park),김병진(Byung-Jin Kim) 국립공원연구원 2010 국립공원연구지 Vol.1 No.3

본 연구는 2007년부터 2009년까지 3년 동안 월악산 모니터링 조사 지점과 동일지구에 대해 정기적인 주간조사를 통해 주간곤충류(노린재목, 딱정벌레목, 나비목)의 종목록을 확보 하여, 월악산국립공원의 생태계에 자연적 혹은 인위적으로 변화된 내용을 측정하여 곤충자원의 체계적인 관리를 위한 자료를 제공하고자 실시되었다. 본 조사기간 동안 채집 확인된 주간곤충류는 65과 404종(노린재목 21과 86종, 딱정벌레목 38과 244종, 나비목 6과 74종)이 조사되었다. 따라서 문헌조사를 포함한 결과 월악산국립공원에 서식하는 것으로 확인된 주간곤충류는 멸종위기야생동물 2종, 고유종 6종, 국외반출승인대상종 10종과 특정종 50종을 포함하여 총 72과 609종(딱정벌레목 44과 368종, 노린재목 22과 126종, 나비목 6과 115종)으로 나타났다. 아울러 조사지점별 분석결과 S3에서 종다양성이 가장 높게 나타났으며, S10은 다른 조사지점과 다르게 종다양성이 현저하게 떨어지는 것으로 나타났다. 각 조사기간별우점종으로는 2007년과 2009년도에 넉점박이송장벌레, 2008년도에는 더듬이긴노린재로 나타났다. This study were conducted for three years from 2007 to 2009 and at the same points as monitoring surveys, through regular surveys insects (Hemiptera, Coleoptera, Lepidoptera) to obtain the list, to measure and assess Woraksan National Park ecosystem’s natural or artificial change, to provide data for systematic management of the contents of insects. As a result of all the collections were examined, 404 species of 65 family under 3 order were identified. Therefore, the species composition of insect over each result from Woraksan National Park’s was a total of 3 orders, 72 families, 609 species including 2 Endangered species, 6 Endermic species, 10 Management of exotic species and 50 Designated species; 368 species of family Coleoptera which is the highest, 126 species of family Hemiptera and 115 species of family Lepidoptera. Site 3 had the highest indices diversity. In contrast, Site 10 indices diversity, different from the other survey points, were significantly low. In each survey period, dominant species included Nicrophorus quadripunctatus in 2007 and 2009. In 2008, dominant species was Pachygrontha antennata.

발열로 인해 발현된 부루가다 증후군 1례

박혜연,김종훈,박경일,황철웅,김태년,남궁준,도준형,이원로,이성윤 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

Brugada syndrome is characterized by right bundle branch block morphology and ST segment elevation in the right precordial leads and a propensity to develop ventricular arrhythmias. Mutations in a cardiac sodium channel gene have been linked to this syndrome, and the ionic mechanisms responsible for the electrocardiographic phenotype are temperature-dependent. This case report describes a patient in whom a typical Brugada ECG pattern developed during fever and returned normal ECG after fever was subsided.

Apolipoprotein E 다형성에 따른 사업장 근로자의 혈중 지질농도, 영양소 섭취 및 건강관련 생활습관

박유경,조상운,강지연,백윤미,성숙희,최태인 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.5

The purpose of this study was to investigate the association among nutrient intakes and health-related lifestyles with cardiovascular disease risk assessed by blood lipid profile according to Apolipoprotein E genotypes. Middle-aged industrial male workers who had completed their annual medical examination were recruited and data of 675 subjects who finished the nutrient survey were used in the analysis. Anthropometric parameters, dietary assessment (FFQ), health-related lifestyles and blood profiles were used for statistical analyses. Apo E genotype groups were classified into the following three genotypes: Apo E2 group (including E2/E2, E2/E3, E2/E4), Apo E3 group (including E3/E3), Apo E4 group (including E3/E4, E4/E4). The frequency of Apo E2, E3, and E4 allele were 13.3%, 75.0% and 11.7% respectively. There were no significant differences in the anthropometric parameters depending on different Apo E genotypes. Also, no significant differences in the nutrient intakes were found according to the genotype groups. The nutrient intakes of all subjects were similar to or higher than the level of KDRIs (Dietary Reference Intakes For Koreans) except for intakes of calcium (67.44% of KDRIs), vitamin A (73.83% of KDRIs) and vitamin B2 (78.02% of KDRIs). Also, there were no significant differences of health-related lifestyles according to Apo E genotype groups. As for the lipid profiles, Apo E4 group had significantly higher total and LDL-cholesterol concentrations than the Apo E2 group (p < 0.05). We confirmed that plasma total and LDL-cholesterol concentrations were greatly influenced by Apo E genotypes. However, nutrient intakes and health-related lifestyles were not associated with Apo E genotypes.

두 종류의 고리화 리간드가 배위된 이리듐 착물의 합성과 그 발광 특성 연구

朴貴蓮,河潤卿 弘益大學校 科學技術硏究所 2005 科學技術硏究論文集 Vol.16 No.-

The new types of iridium complexes with two kinds of (CˆN) ligands were designed and synthesized to improve the luminescence efficiency by avoiding triplet-triplet (T-T) annihilation. Ir(ppy)_(2)(piq) and Ir(ppy)_(2)(piq-F) were designed and prepared, where ppy, piq and piq-F represent 2-phenylpyridine, 1-(phenyl)isoquinoline and 1-(4'-fluorophenyl)isoquinoline, respectively. These heteroleptic complexes are expected to have a high luminescence efficiency by the intramolecular energy transfer from the energy absorbing ligand (ppy) to the luminescent ligand (piq derivatives), leading to a decrease on quenching or energy deactivation. Luminescent characteristics of the heteroleptic Ir complexes were inviestigated photophysically and compared with homoleptic Ir complexes, Ir(ppy)_(3), Ir(piq)_(3), and Ir(piq-F)_(3).

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.

腦囊尾蟲症의 化學的療法에 관한 臨床的 硏究

朴昌潤,朱炅煥,林漢鍾 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

The purpose of this study was to evaluate the therapeutic effect of praziquantel (Embay8440, Biltricide®) on human cerebral cysticercosis. The praziquantel is a broad spectrum anthelmintic agent and has a high activity against cestodes and trematodes. Before and after the treatment with oral administration of the praziquantel the changes in structure of Cysticercus cellulosae biopsied in subcutaneous tissue were studied by scanning and transmission electron microscope, and cerebral cysticercosis by computerized tomographic scanning. The results were as follows : 1. The findings of the observations on subcutaneous Cysticercus biopsied after treatment were compared with those of before treatment. At the early stage of the treatment, small vacuoles were scattered along the basement layer in the tegumental syncytium of the scolex and neck regions. In the scanning electron microscopic observation, marked surface changes were present in the neck region with many bleb-like structures formed by the bursting of the large vacuoles in the tegumental syncytium. In the specimens biopsied at 2 or 5 weeks after treatment, the degenerations and necrosis of the tegumental syncytium were seen in all part of cysticercus. 2. The scanning electron microscopic findings of Cysticercus cellulosae obtained from the 4th ventricle of the cerebral cysticercosis patients by the surgical operation were identical with those of subcutaneous tissues. 3. In 12 cases of cerebral cysticercosis treated with prziquantel in dosage of 3×25 ㎎/㎏ for 3 or 4 consecutive days, there were no cessations of the convulsive seizures during the 6 months follow up. Among them 9 cases were given again with the same doses of the drug for 4 or 7 days. In 7 of 9 cases, no more convulsive seizure was experienced over one or two years after the second treatment. At the same time the lesions of the brain C.T. scanning were disappeared, decreased in size or calcified. In the other 3 cerebral cysticercosis cases, the complete cure was also obtained after the oral medication of praziquantel with the doses of 3×25 ㎎/㎏ for 7 consecutive days. 4. In the treatment of cerebral cysticercosis with praziquantel, it was found that the combined oral medication of dexamethasone during the course of treatment was effective on preventing and minimizing the side effects.