Could cluster of risk factors predict clinical outcome in patients with acute myocardial infarction?

( Sang Mi Park ),( Hong Nyun Kim ),( Se Yong Jang ),( Myung Hwan Bae ),( Dong Heon Yang ),( Hun Sik Park ),( Yongkeun Cho ),( Shung Chull Chae ),( Jang Hoon Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Purpose: Conventional risk factors are differently contributed to short-term prognosis of acute myocardial infarction (AMI); hypertension and diabetes increase adverse outcome, whereas hyperlipidemia, smoking, and obesity paradoxically decrease adverse outcome of post-MI patients. The aim of this study is to assess whether cluster of conventional risk factors, PARADOCS (Pressure of ARtery Abnormality, Diabetes, Obesity, Cholesterol, Smoking) score, would improve the ability to predict major adverse cardiac events (MACEs) in patients with AMI. Methods: Between November 2005 and July 2011, 24,020 patients (17,232 men; mean age=63.0±12.8) with AMI were analyzed from Korean AMI registry. PARADOCS score was calculated as follows; [number of non-paradoxical risk factors (NRF) -number of paradoxical risk factors (PRF)]+3 in which non-paradoxical risk factors are hypertension and diabetes, and paradoxical risk factors are the rest. The 1-year MACEs were defined as death and non-fatal MI. Results: NRF including hypertension and diabetes were present in 49.6% and 27.0%, whereas PRF including hyperlipidemia, smoking, and obesity were present in 12.3%, 43.0%, and 34.6%, respectively. During the follow-up, 1,409 (5.9%) MACEs occurred. PARADOCS score was significantly higher in patients with 1-year MACEs (3.38±1.03 versus 2.81±1.08, p<0.001). In Cox proportional hazards model, PARADOCS score was an independent predictor of 1-year MACEs (hazards ratio 1.26, 95% confidence interval 1.18-1.34; p<0.001) after adjusting for confounding variables. Patients were categorized into 3 groups according to the PARADOCS score; PARADOCSLOW (0-1, n=2,446), PARADOCSMID (2-3, n=14,594), and PARADOCSHIGH (4-5, n= 6,980). Kaplan-Meier survival curve showed that there were significant differences in the 1-year MACEs among three groups including 3.5% in PARADOCSLOW, 8.5% in PARADOCSMID, and 16.4% in PARADOCSHIGH, respectively (long-rank p<0.001). Conclusions: In post-MI patients, conventional risk factors are differently associated with short-term prognosis, and score of these risk factors, PARADOCS score, can provide useful prognostic information to clinicians.

New polymorphic microsatellite markers in the Korean mi-iuy croaker, $Miichthys$ $miiuy$, and their application to the genetic characterization of wild and farmed populations

An, Hye-Suck,Kim, Eun-Mi,Lee, Jang-Wook,Kim, Dae-Jung,Kim, Yi-Cheong The Korean Society for Integrative Biology 2012 Animal cells and systems Vol.16 No.1

Eighteen new polymorphic microsatellite markers were developed for the Korean mi-iuy croaker ($Miichthys$ $miiuy$, Perciformes, Sciaenidae), and allelic variability was compared between a wild population in Mokpo, Korea, and a hatchery population in Tongyeong, Korea. All loci were amplified readily and demonstrated allelic variability, with the number of alleles ranging from 5 to 37 in the wild population, and from 4 to 12 in the farmed population. The average observed and expected heterozygosities were estimated, respectively, to be 0.74 and 0.78 in the hatchery population samples, and 0.79 and 0.86 in the wild samples. These results indicate lower genetic variability in the hatchery population compared with the wild population, and significant genetic differentiation between the wild population and the hatchery samples ($F_{ST}$=0.058, P<0.001). These microsatellite loci may be valuable for future population genetic studies, monitoring changes in the genetic variation within stocks in a commercial breeding program, conservation genetics, and molecular assisted selective breeding of the mi-iuy croaker in the future.

Floristic study of Jang-do (Isl.) in Korea

Son, Hyun-Deok,Gwon, Soon-Gyo,Jang, Jeong-Won,Sun, Eun-Mi,Kim, Byeol-Ah,Im, Hyoung-Tak The National Institute of Biological Resources 2013 Journal of species research Vol.2 No.2

We investigated the flora of Jang-do (Isl.), an island of the Heuksan archipelago, located in Heuksan-myeon, Shinan-gun, Jeollanam-do and discussed the remarkable plants found there. Thirteen-field trips (total 27 days) were completed from May of 2004 to May of 2013. As a result, we identified the distribution of 423 taxa in Jang-do (Isl.), comprising 104 families, 285 genera, 335 species, 78 varieties and 10 forms. There are a total of 95 taxa of floristic regional indicator plants. The floristic regional indicators are as follows; four taxa of level V such as Impatiens furcillata, four taxa of level IV such as Hosta yingeri, 14 taxa of level III such as Ophioglossum vulgatum, 5 taxa of level II, and 58 taxa of level I. In addition 10 red data plants, 2 vulnerable species (VU) including Calanthe striata for. sieboldii, and 4 least concern species (LC) like Ardisia crenata, 2 not evaluated species (NE) such as Hosta yingeri, were found in the investigated area. An unrecorded species, Fragaria (Rosaceae), was found in a forest of Jang-do (Isl.) for the first time in Korea.

농촌 자활사업참여자의 음주 문제 개입프로그램 개발: 동기강화상담의 적용

이종례(Jong Rea Lee),장수미(Soo Mi Jang),허성희(Seong Hui Heo) 한국지역사회복지학회 2022 한국지역사회복지학 Vol.- No.83

본 연구의 목적은 동기강화상담(Motivational Interviewing: MI) 모델을 적용하여 농촌 자활사업참여자의 음주 문제 개입프로그램을 개발하는 것이다. 개입연구(Intervention Research: IR)의 절차에 따라 문헌고찰, 실무자 인터뷰를 시행한 후 농촌 자활사업참여자의 음주문제 양상을 파악하고, 동기강화상담의 원리와 전략에 기반하여 1차 프로그램을 구성하였다. 전문가 자문을 통해 수정 보완 후 2차 프로그램을 도출하였고, 음주 문제를 가진 농촌 자활사업참여자를 실험집단(n=10)과 통제집단(n=10)으로 무작위 배치한 후, 실험집단에 동기강화상담 기반 음주 문제 개입프로그램을 실시하였다. 사전‧사후‧추후 조사를 통해 개입프로그램의 효과성을 평가한 결과, 실험집단의 음주 지식, 단주 자기효능감, 변화 동기, 음주 문제, 자활 성과의 사전‧사후 점수에서 유의미한 변화가 발생하였고, 음주 문제를 제외한 모든 변인에서 사전‧추후 점수의 유의미한 변화가 나타났다. 음주 문제의 경우 사전‧추후, 사후‧추후 모두 유의미한 변화가 발생하지 않아 효과성이 유지되지 않음을 확인하였다. 이후 현장 실험 결과에 대한 피드백을 반영하여 최종(3차) 프로그램을 개발하였다. 결론에서는 주요 연구 결과를 바탕으로 논의하고, 자활 현장을 중심으로 사회복지 실천 및 정책에의 함의를 제시하였다. The purpose of this study is to develop an intervention program for the drinking problem of participants in rural self-sufficiency center by applying the Motivational Interviewing(MI) model. According to the stages of Intervention Research(IR), the aspects of drinking problems of rural self-sufficiency participants was identified through literature review and interviews with practitioners, and the 1st program was constructed based on the principles and strategies of MI. After revising with experts advice, a 2nd program was derived, and rural self-sufficiency participants with drinking problems into an experimental group(n=10) and a control group(n=10) by random assignment, MI was conducted only in the experimental group. As a result of the program, significant changes occurred in the pre and post scores of the experimental group’s drinking knowledge, abstinence self-efficacy, change motive, drinking problem, and self-sufficiency outcomes, and significant changes in pre and 6 weeks later scores were found in all variables except for drinking problems. The drinking problem was not significant in pre and 6 weeks later, post and 6 weeks later, it could be seen that the effectiveness was not maintained. The 3rd(final) program was developed by evaluating the effectiveness of the programs, and reflecting feedbacks from field experiment. In conclusion, the implications for social welfare practices and policies were presented, focusing on the field of self-sufficiency.

Mycobacterium intracellulare에 의한 요추부 척추염 1예

장은영,김미영,김정욱,송은희,백관미,정용필,성흥섭,김미나,김양수,우준희,이상호 대한감염학회 2007 감염과 화학요법 Vol.39 No.3

비결핵성 미코박테리아에 의한 척추염에 대한 증례 보고가 국내에서는 아직 없었다. 저자들은 기저질환이 없는 환자에서 M. intracellulare에 의한 척추염을 rpoB 유전자에 대한 PCR-RFLP 방법을 통해 진단하였고 수술적 치료와 3제 병합 항균 요법으로 성공적인 임상 경과를 보인 1예를 경험하였기에 보고하는 바이다. We report a case of vertebral osteomyelitis due to Mycobacterium intracellulare in a 60-year-old man without predisposing conditions. He was successfully treated with surgical excision of the inflamed tissue and combined antimycobacterial therapy consisting of clarithromycin, ethambutol, and rifampin. In this case, polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) based on the rpo B gene of cultured isolates allowed rapid identification of M. intracellulare. Although very rare, nontuberculous mycobacteria (NTM) should be suspected as a causative pathogen of vertebral osteomyelitis. To the best of our knowledge, this is the first case of vertebral osteomyelitis caused by NTM reported in the Korean literature.

防風類의 比較檢討

김미경,김미정,김은영,류건영,이은미,장원희,황선희 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

김영랑의 시 「모란이 피기까지는」의 음상적 특징 분석

장보미(Jang, Bo?mi) 한국시학회 2013 한국시학연구 Vol.- No.37

김영랑의 시는 음악성을 함유한다. 음악이 소리를 전제하고, 그 소리들이 의미의 전개를 야기하듯이 시어는 그것이 함유하고 있는 음성적 효과를 통해 시어의 의미 전개에 영향을 미친다. 그러나 지금까지 김영랑 시의 리듬은 대체로 시의 형식 측면에서 연구되었다. 시의 음악성을 밝히기 위해 시어의 길고 짧음과 같음, 반복 및 일정한 휴지가 제시되었는데, 시의 다채로운 면모를 밝히기에는 제한적인 것이었다. 소리와 의미의 기표로서 시어를 분석하는 과정은 낭독을 통한 청각적 효과와 의미의 환기, 재발화를 통한 의미의 확산이 실질적으로 시의 가치를 확인하는 의미 있는 활동이 될 것이다. 본 연구는 형식과 의미의 결합으로서의 시어의 소리 결합과 그것의 리듬 체계를 언술함으로써 시의 가치를 탐구하려 한다. 본 글은 현대시의 리듬을 규명하기 위한 지표로서 음상적 특징을 시 분석에 활용한다. 음상(音相)은 소리의 차이로 말미암은 어감의 차이를 의미하는 것으로 시의 각 분절과 구조, 주제의 성격을 가늠하는 단서가 된다. 한 편의 시를 장악하는 음상의 특성을 파악함으로써 화자의 감정과 호흡의 짜임과 함께 시의 리듬을 발견할 수 있다. 따라서 이 글에서 시의 음성적 특징, 음상 분석은 하나의 발화로서의 시를 이해하기 위한 기초 단위의 분석이 된다. 이러한 논지를 뒷받침하는 예로 본문에서는 ?모란이 피기까지는?을 분석한다. 각각 공명음과 장애음의 계열로 구성된 두 개의 동심원은 시의 분절마다 다른 배합으로, 이미지와 감각으로서의 분위기를 형성한다. 이 시에서는 공명음을 기본 단위로 하여 장애음의 빈도가 증가할수록 화자의 호흡과 긴장의 정도가 달라진다. 두 개의 동심원으로 표현된 음성적 자질들의 배합이 주제 표현을 위한 의미 형성을 돕는 것이다. 시적 언어의 형식으로서 음성적 자질들은 의미 자질을 내포한다. 소리를 전제한 시어는 청각적 요건뿐만이 아니라 주제를 구현하기 위한 위치와 의미 자질을 전제한다. 이 점에서 시를 지배하는 의미의 최소 단위로서의 음상적 특징을 분석하는 것이 흐름으로서의 시의 리듬을 밝히는 실마리라 본다. The purpose of this study is to show that a rhythm is combination of meaning and form in Kim yeong-rang’s poem. When we consider the process of poetic diction"s vocalization, sound feature is the key to determine rhythm that controls over poem’s meaning and tone. The previous discussions noted a foot for sense of stability while reciting a poem. That means harmonious auditory characteristic makes a poetic beauty, but the balance of sound is not everything in poem’s musicality. Sounds, basic elements of a subject in a poem, are designated in their own places not separating form and meaning. Especially, the harmony of sound is not the only way to create poetic esthetic in the modern poetry. Thus, previous theories have a limitation that cannot be to analyze the whole structure of a poem. Till the peonies bloom produces a rhythm through the placement of sonorant and obstruent. Sonorant makes a soft sound with positive vowel harmony. In contrast, Obstruent produces grave sound with passive vowel harmony. Poetic languages obtain sound images depending on sound characters. Similarly, every sound image is connected with other senses and meaning structure. For that reason, the poetic narrator’s dictions express his emotion. In Till the peonies bloom, both sonorant and obstruent comprising its structures interact each other. In last line, two sounds are mixed and combined with their sound images for realize main topic. In this poem, two different sounds make the narrator’s breath. Arrangement of sonorant shows the mellow stream, and that of obstruents display fast breathe. The gradual flow of aspiration is based on a lot of nasal and liquid sound in poetic diction. In contrast, rough curve is based on aspirated consonant, tense consonant which are belonged to obstruents. Two sound streams control the poem’s mood depending on sound frequency. Among these curves, first line and last line have a similar syntax. The Last one expands a meaning of first by removing the boundary of seasonal circulation, beauty and sadness. Poetic narrator gets a maturation of consciousness trough that meaning expansion. An echo symptom is originated in rhythm of verse. Not a simple repetition but producing difference, makes for the second articulation according to comprehension of poetic symbol. A result of this thesis is the new condition of rhythm. The two concentric circles create an aesthetic value depending on fusion of content and form. Sonorant"s circle and obstruent’s circle make upsurge of sentiment and tension of breathing in this poem. Rhythm is not a perfect means of analyzing musical form in the poem. In process of poetic creation, sound image, sense, progression of meaning, and topic determinate placement of phonemes. So, rhythm is not an accent or a beat. Therefore, sound qualification which reflects meaning and structure is the new way of analyzing rhythm. That is the main thrust of this study.

체제 순응과 이미지의 여성들

장영미(Jang Young - Mi) 돈암어문학회 2006 돈암어문학 Vol.- No.19

The paper is a feminism study mainly dealing about Kwon Jung Seang's ‘Mong-Sil On Ni’. Kwon's ‘Mong-Sil On Ni’ outwardly seems to be a story about a woman undergoing war. But this is just a small part of it. Actually if we look at it more extensively, we can find out that it is viewing the Modern and Contemporary history of Korea. Shortly, by viewing the Korean War we can find out the life and the living and surviving ways of the people in those days. Like the war has separated the left and the right wing, inside of ourselves are also dividing man/woman, adult/children, and black/white in dichotomy logic. The fact that the dichotomy logic is caught sight of us can be said as a necessity for a meaningful discussion in this society of diversity. With these sense, the authority in Kwon's ‘Mong-Sil On Ni’, which men exercises on women in patriarchy society, can be said as violence. Also women's appearance seems to be created by men's sense of sight than the own identification of women.

아버지-어머니의 양육스트레스 감소, 공감능력 증진 및 가족기능 개선에 미치는 부모놀이치료의 효과

승진주 ( Jin Ju Seung ),장미경 ( Mi Kyun Jang ) 대한아동복지학회 2011 아동복지연구 Vol.9 No.1

본 연구는 Guerney(1964)가 개발하고 국내에서 장미경(1998)이 변형하여 실시한 부모놀이치료(Filial Therapy)를 유아기 자녀를 둔 아버지-어머니를 대상으로 실시하고 부모놀이치료가 양육스트레스 감소, 자녀에 대한 부모의 공감능력 증진 및 가족기능 개선에 미치는 효과가 있는지 알아보고자 하였다. 본 연구는 단일집단 사전사후설계로 이루어졌으며, 실험집단은 유아기 자녀를 둔 부부5쌍으로 충남 천안시에 소재하고 있는 대학 부설 아동가족상담센터에서 1주일에 1회씩 모두 8주에 걸쳐 총 8회의 집단 모임이 이루어졌다. 프로그램의 결과를 분석하기 SPSS Ver 10.0 을 이용해 t검증을 실시하였고 질적 분석을 위해 프로그램 진행과정을 녹화한 CD자료를 반복해서 보면서 Spradley(1980)가 제안한 주제별 약호화와 주제별 파일화, 주요 사례추출, 분류체계 분석, 성분분석, 원인연쇄 분석의 방법을 사용하였다. 영역분석을 통해 가장 중요하게 추출된 주제들을 선정하여 진술하였다. 연구결과, 첫째, 아버지-어머니를 대상으로 한 부모놀이치료 프로그램에의 참여가 양육스트레스를 감소시켰으며, 하위변인으로 부모영역인 우울감, 역할제한, 배우자 관계, 사회적 고립, 건강도 긍정적으로 변화시켰다. 또한 다른 하위변인인 아동영역에서도 자녀의 주의산만성, 요구성, 수용성, 부모강화도 긍정적으로 변화시켰다. 둘째, 자녀에 대한 부모의 공감능력이 증진되었다. 셋째, 가족기능 개선에도 긍정적인 영향을 미치는 것으로 나타났으며 하위변인으로 가족 응집성과 가족 적응성을 개선시켰다. The purpose of this study is to verify the effect of Finial Therapy, which was developed by Guerney (1964) and revised by Jang, Mi-kyung (1998), on decrease of parenting stress of fathers and mothers and improvement of empathy and family function. In line with the purpose and assumptions of Finial Therapy, this study conducted Finial Therapy on parents who have infants and examined the effectiveness of the Filial Therapy program. This study used the One-Group Pre-test-Post-test Design. The study subjects were five parents who have infants. They met once a week for eight weeks and they had eight meetings at a Child and Family Counseling Center located in Chung-Nam Province. To analyze the results, this study used SPSS Ver. 10.0 and conducted T-test. For qualitative analysis, this study used coding and classifications suggested by Spradley (1980), major case sampling, classification system analysis, component analysis, and cause chain analysis to analyze the progress of the parents after it was observed and recorded. The study results are summarized as follows. 1) Filial Therapy significantly reduced parents` parenting stress. It also positively changed sub-variables of parent domain such as depression, role restriction, spouse relationship, social isolation, and health. In addition, sub-variables of child such as distraction, needs, acceptability, and parent reconciliation were also changed positively by the program. 2) Filial Therapy significantly improved parents` empathy forwards their children. 3) Finial Therapy had a significant effect on the improvement of family function. It also had a significant effect on sub-variables such as family cohesiveness and adaptability.

국가 음악과 교육과정에 기초한 초·중등학교 음악예술프로그램 적용

석문주,권덕원,최은식,최미영,김명숙,박장미,손미현,정지혜 이화여자대학교 사범대학 교육과학연구소 2011 교육과학연구 Vol.42 No.2

In order to increase opportunities for students to enjoy the musical arts, it is necessary to develop musical arts programs that are based on students’ interests and the national (or provincial) curriculum, that can be systematically and effectively supported by teachers. In this regard, the purpose of this study was to develop those musical arts, carry out the programs in one elementary school and one middle school from October to December 2011, and analyze each implementation. For the analysis, lesson videos, students’ worksheets, in-depth interviews with students, teachers, and teaching artists, and lesson plans were collected. The conclusions and implications are as follows: 1) the role and meaning of musical arts programs based on national curriculum were more highlighted; 2) students could have great depth of aesthetic experience by the means of direct contact with professional musicians and concrete musical experience; 3) the role of music mediators and its importance was magnified; 4) there was a positive change in the musical preferences and attitudes of students with regard to the musical artsprograms. 본 연구는 학생들의 음악 예술 향수기회 확대를 위해 학생들의 흥미와 국가 교육과 정을 중심으로 하는 ‘현장성’, 교사들의 음악 교육을 효과적으로 지원할 수 있는 ‘체계성’, 그리고 음악 예술 전문가들과 학교 사이에 꾸준히 실행될 수 있는 ‘지속성’을 갖춘 음악예술프로그램을 2010년 10월부터 12월까지 초등학교와 중학교에 적용하고 그 결과를 분석하고자 하는데 목적이 있다. 본 연구는 수업 동영상, 학생 활동지, 학생과 교사 심층인터뷰, 강사 인터뷰, 수업안 자료를 수집하여 분석하였다. 본 연구의 결론은 첫째, 국가 교육과정을 반영한 음악 예술프로그램의 역할과 의미가 더욱 확장되었다. 둘째, 음악가들과의 직접적인 만남과 구체적인 예술적 체험을 통하여 학생들은 이전과 비교될 수 없는 ‘깊이 있는 미적 경험’을 하게 되었다. 셋째, 음악메디에이터의 역할이 부각되었다. 넷째, 음악예술프로그램을 통하여 학생들에게 음악에 대한 삶의 변화가 있었다.