제3형 개방성 경골 골절의 수술적 치료

송경진,신성진,황병연,박명식 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목 적: 저자들은 제3형 개방성 경골 골절로 수술적 치료를 시행한 환자의 결과를 분석하여 이에 대한 치료 지침을 제시하고자 한다. 대상 및 방법: 최근 7년간 본원에서 치료한 환자 42례를 대상으로 하였으며 연령 분포는 15세에서 76세로 남자가 35례, 여자가 7례였으며, 골절의 분류는 Ⅲa형 14례, Ⅲb형 20례, Ⅲc형 8례였다. 최종 기능적 평가는 Tucker의 분류법을 사용하였다. 결 과: 골 유합 기간은 Ⅲa이 9.2개월, Ⅲb형11.0개월, Ⅲc형이 13.8개월이었고 치료 기간 중 회전 피판 이식술과 유리 피판 이식을 시행하였으며 Ⅲc형에서는 골 연장술을 시행하였다. 기능적 평가로는 Ⅲc형로 갈수록 불량하였다 결 론: 비활성 조직의 충분한 제거, 노출 골편의 조기 피복 후 Ⅲa형에서는 골수강내 금속정을 이용한 견고한 내고정으로 좋은 결과를 얻을 수 있고 Ⅲb와, Ⅲc형에서는 외고정 기구를 사용하여 견고한 고정력을 얻을 수 있을 것으로 사료된다. Purpose: The purpose of this study was to analyze the functional outcome and propose the guidelines in the surgical treatment of open type Ⅲ tibial fracture. Materials and Methods: We have analyzed the treatment results of 44 cases; age was ranged from 15 to 76 years, and there were 35 males and 7 females. The type of fracture according to the classification by Gustilo revealed typeⅢa 14 cases, type Ⅲb 20 cases and type Ⅲc in 8 cases. We analyzed functional outcome according to the classification of functional result by Tucker. Results: The average union time of type Ⅲa was 9.2 months, Ⅲb 11.0 months, and Ⅲc was 13.8 months. The rotational flap and free flap were done during treatment and bone lengthening especially in type Ⅲc. Functional results were poor especially in type Ⅲc. Conclusion: Debridgement of devitalized tissue, early soft tissue coverage and sufficient stability using intramedullary nails will be necessary in type Ⅲa fracture. Rigid external fixation, early soft tissue coverage by rotational muscle flap and free flap reduced infection rate with satisfactory functional outcome especially in type Ⅲb and Ⅲc fractures.

전압제어 GIC를 이용한 대역 및 고역통과 필터의 특성 비교

송명석,노경호,김왕식,박종연 강원대학교 정보통신연구소 2004 정보통신논문지 Vol.8 No.-

In this paper, we have presented comparative characteristics of band-pass filter and high-pass filter using VCGIC(Voltage Controlled Genenalized Impedance Converter), which are the non-linearized VCR(Voltage Controlled Resistance) and the linearized VCR. We concluded that the linearized VCGIC circuit has the wide dynamic range and the improved linearity.

카드뮴투여가 흰쥐 고환의 조직변화와 단백질변화에 미치는 영향

최송표,김수일,조근자,양은진,김선,박경란,이영호,김원식 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

This study was done to investigate histochemical and protein changes in the rat testis I WAT and 3 WAT with 4 mg/kg of cadmium, IP, single injection. A control group and 2 experimental groups were studied. Testes were processed routinely for H&E stain and agarose gel electrophoresis. The results were as follows ; 1. In the histochemical studies, death of all the spermatogenic cells and Sertoli cells in the seminiferous tubules, and decreased ground substance, decreased fibroblasts and interstitial cells and increased inflammatory cells in the interstitial tissues were found in the cadmium treated groups, and the degree of necrotic changes was more severe in the 3 WAT group. 2. In the biochemical studies, two kinds of proteins, 25 kDa and 45 kDa, were disappeared and one kind of protein, 100 kDa, was decreased after Cd treatment. 25 kDa and 45 kDa proteins were suggested as actin which consist the spermatogenic cells, but what's the protein 100 kDa is unclear. According to the above results, it is considered that there would be irreversible changes in seminiferous convoluted tubules and also in the interstitial tissues after cadmium treatment, and detecting amino acid sequences of these proteins would help understanding the mechanism of necrosis in the testis tissue after cadmium administration.

허혈성심질환 환자에 있어 혈액 응고상태의 비교

이미경,송경은,이원길,김재식,박의현,전재은 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

연구배경: 최근에 지혈응고 및 섬유소 용해기능의 손상이 허혈성 심질환의 병인론에 중요한 역할을 한다고 알려져 왔다. 이에 저자들은 허혈성심질환군과 정상대조군에서 PT, aPTT, 섬유소원, α2-antiplasimin, tPA, PAI-I, AT Ⅲ, protein C, XL-FDP를 측정하여, 이들이 허혈성심질환의 발병에 미치는 영향 및 중요성에 연구하고, 혈전용해제 투여전과 투여후의 결과를 비교 분석하여 이들의 검사지표로서의 임상적인 유용성에 관하여 알아보고자 하였다. 방법: 39예의 정상대조군과 급성 심근경색 및 협심증으로 진단된 40예의 환자군에서 platelet-poor-plasma를 얻어 PT, aPTT, 섬유소원은 ELECTRA 1000C(Medical laboratory automation, Inc., USA)를 이용하여 측정하였고, α2-antiplasmin는 색소법으로 SPECT-ROLYSER α2-antiplasmin(Biopool AB, Canada)kit를, tPA와 PAI-1은 면역효소법으로, Protein C는 응고법으로 Bioclot?? Protein C(Biopool AB, Canada) kit를 사용하여 측정하였다. XL-FDP는 라텍스응집법으로 DIMERTESTR Ⅱ Latex Kit(AGEN Biomedical Limited, Australia)를 이용하여 측정하였다. 결과: 환자군과 정상대조군의 비교에서 에서 PT, aPTT, 섬유소원, PAI-1 및 ATⅢ는 두 군간에 통계학적으로 유의한 차의를 나타내었고 환자군에서는 62.5%에 해당하는 25예에서 증가된 소견을 보여 주었다. 환자군에서 혈전용해제 투여전과 투여후의 결과비교에서 PT와 섬유소원에서 유의한 차이가 있었으며, α2-antiplasmin, PAI-1 및 protein C는 유의하지는 않았지만 감소하는 경향을 나타내었다. 혈전용해제 투여후 1 시간결과를 대조군과 비교해 볼 때 PT와 tPA는 유의하게 증가하였고 섬유소원과 ATⅢ는 의의있게 감소하였다. 7일째 결과는 모든 지수에서 정상대조군과 유의한 차이가 없었다. 결론: PT, 섬유소원의 검사가 허혈성 심질환의 진단과 경과관찰에 도움을 줄 수 있으며, tPA, PAI-1, ATⅢ등과 같이 관찰함으로서 진단뿐만 아니라 예후와 재발위험성에 대한 예측 등 임상적으로 중요한 검사지표로서의 가능성을 나타냄을 알 수 있었다. Background: Many studies have shown that thrombus formation has important role in the pathogenesis of ischemic heart disease(IHD) and impaired fibrinolysis is associated with an increased risk of myocardial infacrtion. Forty patients with IHD and 39 normal controls were studied about blood coagulation, fibrinolytic, inhibitory proteins to evaluate their usefulness in diagnosing, predicting prognosis and monitoring after thrombolytic therapy in IHD. Method: Platelet-poor-plasma were obtained from the 3.8% trisodium citrate treated blood and prothrombin time(PT), activated partial thromboplastin time(aPTT), firbrinogen, α2-antiplasmin, tPA,PAI-1, antithrombin Ⅲ(ATⅢ), protein C. crosslinked fibrin degradation products(XL-FDP) were measured by appropriate functional or immunological assays. Results: The IHD group showed significant increases in PT,aPTT, fibrinogen, PAI-I and XL-FDP and significant reduction in AT Ⅲ concentration. No significant changes were observed between myocardial infarction and angina pectoris subgroups in the IHD. After thrombolytic therapy, PT and fibrinogen showed significant changes. In comparsion with normal controls, post 1 hour results showed significant changes in PT, fibrinogen, tPA, ATⅢ but no significant changes in post 7 days results. Conclusion: Our findings suggest that measurements of PT and fibrinogen are helpful for diagnosis in patients with IHD. And combined with tPA, PAI-1 and AT Ⅲ, they may be useful test for monitoring after thrombolytic therapy, predicting prognosis and risk of recurrence in IHD patients.

교육사회학의 연구 동향 분석

김경식,권민석,김병규,박형진,송승면,황정희 경북대학교 사범대학부속 중등교육연구소 2005 중등교육연구 Vol.53 No.3

한국, 일본, 미국, 영국의 교육사회학 학술지 논문을 주제별 내용분석을 통해 각각의 하위개념을 도출하고 개념의 유사성의 정도에 따라 다시 상위개념으로 분류하여 교육사회학의 주요 연구영역을 탐색하였다. 학술지에서 가장 많이 다루어진 영역은 교육과 평등/지위획득, 교육정책과 제도, 교육사회학의 성격/이론, 학교사회와 학업성취, 페미니스트(여성), 청소년 문제와 문화, 교사교육/교직사회, 공교육의 문제/교육개혁 등의 순으로 나타났다. 특히 교육정책과 제도 문제는 한국과 일본에서, 교육사회학의 발달과 정체성 문제는 영국에서, 학업성취 관련 내용은 미국에서 가장 많이 다루어졌다. The purpose of this study was to explore the research trend in sociology of education. To conduct the purpose of this study, the Korean Journal of Sociology of Education(KJSE), the Journal of Educational Sociology(JES), Sociology of Education(SOE), and Bitish Journal of Sociology of Education(BJSE)'s articles were analyzed. The findings of this study were as follows: First, though the major categories(major domains) of research areas were a few differences among nations, they were education & equality, educational policy, sociology of education theory, school society & academic achievement, feminism, adolescent problem & culture, teacher education, school crisis & education reform, course education, sociology of curriculum, and etc. Second, the most frequent research area was the educational policy & system problems in Korea and Japan; the development and identity of sociology of education in Britain; The school society & academic achievement in U.S.A.

골격성 Ⅱ급 부정교합자의 악교정 수술 후 설골의 위치와 상기도 변화에 관한 연구

배진성,김경호,박형식,허종기,박광호 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

OSAS(obstructive sleep apnea syndrome) is becoming more and more of importance nowadays. Therefore the study concerning OSAS is very important. Most of the studies which have been reported were comparison of upper airway size and change of skeletal class Ⅰ group and skeletal class Ⅲ group respectively. But, most of the showing OSAS have pharyngeal narrowing combined with more or less distinct maxillary and mandibular deficiency. Therefore the aim of this study is to see posterior airway space and hyoid bone position in patients affected by class Ⅱ malocclusion and treated with orthognathic surgery. we measured the lines between selected upper air way landmarks on lateral cephalometric x-ray films of skeletal class Ⅱ 30 persons who had not been operated yet, were within 2 weeks after operation, were 6 months after operation. And we compared them respectively and analyzed them with pairing t-test, pearson correlation coefficient and multiple regression analysis. The results were as follows. First of all, skeletal class Ⅱ group was increased in all the level of PAS, especially PAS(MK) and PAS related to hyoid bone(H-phW, H-PhW(Me-H)) was significantly decreased within 6 months after operation but that was larger than preoperation. And then the PAS was increased after mandibular advancement surgery. While there was no significant correlation between PAS and surgical methods, there was statistical significance between PAS and a number of surgical movement. At last, the hyoid bone was advanced within 2 weeks after operation but relapsed within the follow up period. In the end of the study, it was turned out that PAS was always wider without distinction of the region after the operation and that there was significant correlation between the moving volume of hard tissues and the changing quantity of PAS( ; how much PAS was changed according to the moving degree of hard tissues). After this, to be based on the study, I consider that OSAS demands further study and that it is necessary to do more practical applications to the patients.

공개매수 대상기업과 피합병기업간 주주부 변화차이에 관한 실증연구

조경식,이송근 대구대학교 경제경영연구소 2005 경제경영연구 Vol.3 No.1

본 연구는 우리나라 상장기업들을 대상으로 인수유형 중 공개매수(Tender Offer) 대상기업과 피합병기업들이 증권거래소에 공시(제의) 전·후에 초과수익률(Abonrmal Return)의 변화차이를 시장모형(Market Model)을 사용하여 분석하고, 이 두 인수방법 간 초과수익률의 평균차이를 t-test를 통하여 비교분석하였다. 분석의 결과 일부 분석기간을 제외하고는 거의 대부분의 분석기간에서, 공개매수 대상기업이 평균적으로 피합병기업보다 더 높은 초과수익률을 얻는 것으로 나타났고, 특히 일부 분석기간[(+)1, (-1,+1), (-10,+1)]에서는 통계적 유의성이 있는 것으로 나타났다. 이 같은 결과는 우리나라 인수합병(M&A)시장에서도 Berkovitch & Khanna(1991) 등의 주장을 지지하는 것을 확인하였다. This study empirically examined the mean difference of abnormal return(AR) between tender offers and mergers surrounding the announcement date in Korea Stock Exchange(KSE). The empirically results are as follows. Tender offer's shareholder wealth, on average, almost revealed higher than Target merger's shareholder wealth, especially revealed statistically significant AAR(+1, t-value: 2.85), CAR(-1,+1, t-value: 2.11), and CAR (-10,+1, t-value: 1.93). The finding that tender offer's AR gained higher than merger's AR in target firm is consistent with the Berkovitch & Khanna(1991)'s insistence in Korea Capital Markets.

檢査資料의 活用을 통한 集團指導 活動事例의 效果評價

朴敬玉,李永植,宋在鴻 全北大學校 學生生活硏究所 1992 學生生活硏究 Vol.19 No.-

This study was attempted to introduce the group guidance activity, in which the guide has provided the freshmen with their results of psychological tests and has encouraged to improve their self-understanding, and to examine the effectiveness of that activity. In this study, investigators have highlighted the historical background of the group guidance activity through using the results of psychological tests, and have given and outline of the practice of present activity, including 1) the understanding of human behavior and the functions of psychological testing in the base of the information-processing approach ; 2) the main points in interpreting the results of psychological tests and the implications of individual test for self-understanding ; 3) the general strategies for identifying the problems of individuals and coping with them ; and 4) the introduction to the purpose and activities of the Student Guidance and Counseling Center at Chonbuk National University and the guide to use the Center. And then they have examined the direct and/or indirect effectiveness of that activity. This study has suggested several recommandations for the future activity as follows : 1. It is necessary to examine earnestly the purpose and contents of psychological tests used in the group guidance, so that students may search the self-understanding actively. 2. It is necessary to make an effort in helping the students identify the practical problems, specific to psychological adjustment such as interpersonal relationships, adademic performance, career development, and so on, and cope with them. 3. It is necessary to evaluated continuously the effectiveness of the group guidance activity through using the result of psychological tests, and it is followed by formulating a plan which may result in the improvement of that activity in future.

미만성 경화 아형 갑상선 유두암 1예

최정민,이송주,김부경,최영식,박요한,김정훈,허방 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

The diffuse sclerosing variant (DSV) is a rare malignant tumour that accounts for 0.7-5.3% of all papillary thyroid cancers. DSV tends to occur at a younger age and has a higher incidence of cervical lymph node metastases, compared with papillary thyroid carcinoma. A 62-year-old female patient diagnosed thyroid nodule with diffuse and mild increased 18F-deoxy-glucose (FDG) on FDG positron emission tomography (PET)-computed tomogram (CT) scan. The ultrasound images showed typical findings of DSV such as diffusely enlarged thyroid lobes and diffusely scattered microcalcification. We performed this patient ultrasonography guided fine needle aspiration and cytologic analysis revealed papillary carcinoma. Total thyroidectomy with central compartment node dissection and lateral lymph node dissection was performed and finally diagnosed DVS. The authors report this case with literature review.

석이로부터 분리한 페놀성 화합물의 phospholipase A_2 저해활성

김진우,송경식,유익동,장현욱,유승현,배강규,민태진 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

호알카리성 진균 Cephalosporium sp. RYM-202가 생산하는 alkaline xylanase (CX-III)의 작용에 의해 xylan 기질로부터 생성되는 주요 가수분해 산물은 xylobiose와 중합도가 4 이상인 xylooligosaccharides이었다. 이 효소는 xylobiose에 대한 분해능을 가지고 있지 않지만 xylotriose로부터는 xylobiose를, xylotetraose로부터는 xylobiose와 xylotriose를 주산물로 형성하였다. 이러한 결과들은 CX-III가 transglycosidase 활성을 소유하는 전형적인 endo-type xylanase임을 보여준다. N-bromosuccinimide에 의한 CX-III의 화학적 변화 실험 결과 효소 1분자 당 2개의 tryptophan 잔기가 활성에 관여하는 것으로 나타났다. 그러나 iodoacetamide 및 diethylpyrocarbonate에 의한 효소활성의 저해효과는 나타나지 않음으로써 이 효소의 활성부위에 cysteine과 histidine 잔기가 필수적이지 않음이 확인되었다. The hydrolysis products formed from birchwood xylan by the action of an alkaline xylanase (CX-III) from alkalophilic Cephalosporium sp. RYM-202 were xylobiose and xylooligosaccharides polymerized with more than 4 sugar molecules. This enzyme was not active on xylobiose but readily attacked xylotriose accumulating xylobiose as a major product. The predominant end-products from xylotetraose by CX-III were xylobiose and xylotriose. These results indicate that the enzyme is typically endo-type xylanase possessing transglycosidase activity. Chemaical modification of CX-III with N-bromosuccinimide revealed that two tryptophan residues per molecule of CX-III were essential for its catalytic activity on xylan. On the other hand, iodoacetamide and diethylpyrocarbonate did not influence the activity of the enzyme, suggesting that cysteine and histidine residues are not involved in the active site of this alkaline xylanase.