Comparison of trophic factors changes in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

Yan, Bing Chun,Park, Joon Ha,Kim, Sung Koo,Choi, Jung Hoon,Lee, Choong Hyun,Yoo, Ki-Yeon,Kwon, Young-Geun,Kim, Young-Myeong,Kim, Jong-Dai,Won, Moo-Ho Kluwer Academic/Plenum Publishers 2012 Cellular and molecular neurobiology Vol.32 No.8

<P>In the present study, we investigated neuronal death/damage in the gerbil hippocampal CA1 region (CA1) and compared changes in some trophic factors, such as brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and vascular endothelial growth factor (VEGF), in the CA1 between the adult and young gerbils after 5 min of transient cerebral ischemia. Most of pyramidal neurons (89%) were damaged 4 days after ischemia-reperfusion (I-R) in the adult; however, in the young, about 59% of pyramidal neurons were damaged 7 days after I-R. The immunoreactivity and levels of BDNF and VEGF, not GDNF, in the CA1 of the normal young were lower than those in the normal adult. Four days after I-R in the adult group, the immunoreactivity and levels of BDNF and VEGF were distinctively decreased, and the immunoreactivity and level of GDNF were increased. However, in the young group, all of their immunoreactivities and levels were much higher than those in the normal young group. From 7 days after I-R, all the immunoreactivities and levels were apparently decreased compared to those of the normal adult and young. In brief, we confirmed our recent finding: more delayed and less neuronal death occurred in the young following I-R, and we newly found that the immunoreactivities of trophic factors, such as BDNF, GDNF, and VEGF, in the stratum pyramidale of the CA1 in the young gerbil were much higher than those in the adult gerbil 4 days after transient cerebral ischemia.</P>

철계 소결부품의 사출성형에 관한 연구

김영홍,권영순,김환태,김충식 울산대학교 1994 공학연구논문집 Vol.25 No.2

P가 첨가된 미세한 Fe 분말을 사용하여 Fe 및 Fe-Mo-Ni계에 대해 금속사출 성형방법에 의한 소결부품의 제조 가능성에 대해 조사한 결과, 바닝더로 사용한 Methylcellulos의 부피분율이 11vol%, 용매인 뭉의 양이 12wt%일때 우수한 성형성 및 소결특성을 보였다. 사출성형 조건은 다이의 예열온도가 110℃, 다이내의 유지시간이 3분일때 우수한 성형성을 보였으며, 650℃의 온도에서 1시간 유지하였을때 바인더는 완전히 제거되었다. Fe계 사출성형체의 소결시 얻어진 소결밀도는 이론밀도의 90%였으며, 활성제인 P가 소량 첨가됨으로써 소결성이 개선되어 95%정도의 소결밀도를 나타내었다. Using fine powders, the possiblity for the Metal Injection Moulding of the Fe and Fe-Mo-Ni steel with addition phosphours was investigated. The experimental results were obtained as follow; 1. The relative good molding and sintering behavior were obtained by using the binder constituted of 11 vol% methylcellulose and 12w% water solvent. 2. The preheated mould temperature and residence time were 110℃ and 240 sec for the optimal moulding condition. The binder could be fully removed by debinding at 650℃ for 1 hour. 3. The injection moulded Fe-parts could be obtained the relative sintered density about 90%. By addition of the small amount of phosphorus the more densification and then the relative sintered density could be obtained about 95%.

부산, 울산, 경남지역 직업병감시체계에서 나타난 수지진동증후근의 역학적 특성

최영희,유철인,이지호,이충렬,이헌,김영욱,채창호,고상백,김은아,이유진,김양호 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.3

목적: 국내에서도 국소진동에 의한 수지진동증후군이 다수 있을 것으로 추정하나 최근에 이에 대한 보고가 적어 부·울·경 직업병감시체계를 통하여 수지진동증후군에 대한 환례를 수집하여 이의 역학적 특성을 밝히고자 본 연구를 실시하였다. 방법: 2001년 44월부터 2002년 12월까지 부산, 울산, 경남지역에 있는 종합병원 9곳을 통하여 특수 건강진단과 산업의학과 외래를 방문한 근로자를 대상으로 진동폭로에 대한 설문조사를 실시하고 이들중에서 수지진동으로 인한 증상을 호소하는 근로자는 이학적 검사와 Stockholm workshop scale을 이용하여 수지진동증후군이 있는지 평가하였다. 결과: 남자 188명, 여자 4명 등 총 192례의 수진진동증후군이 의심되는 환례를 수집하였으며, 업종별로는 조선업에 종사하는 근로자들이 가장 많았다. 국소진동의 주된 폭로원은 그라인더가 가장 많았으며, 혈관장해로 인한 증상보다 감각신경성 장해로 인한 증상을 많이 호소하였다. 결론: 전국적으로 조선업종의 그라인더 사용자를 중심으로 많은 수의 수지진동증후군의 환자가 있을 것으로 추정되며, 이들에 대한 예방대책을 마련하기 위하여 전국규모의 정확한 유병률 조사 및 실태파악이 필요한 것으로 판단된다. Objects: The objectives of this study were to estimate the epidemiologic characteristics of hand-arm vibration syndrome (HAVS) due to occupational exposure of hand transmitted vibration and to identify the occupations and industries where such exposures arises, and the main sources of exposure. Methods: In April 2001 the Busan, Ulsan, and Kyung-Nam Province occupational disease surveillance system was established to measure the incidence and prevalence of work-relatd HAVS and other occipational diseases in these Korean provinces. Occupational physicians of nine hospitals in Busan, Ulsan, and Kyung-nam Province were involved in this project between April 2001 and November 2002. Physicians collected information through questionnaires and interviews. Information gathered included age, occupation, types of vibration tools used and presence of subkective symptoms such as vibration-induced white finger (VWF), numbness and tingling. Results: A total 192 cases were reported with 188 males and 4 females. The shipbuilding industry was the most common type of industry and grinders were the most common source of exposire. Symptoms of neurological disorder were more common than those of vascular disprder. Conclusions: The authors concluded that exposure to hand transmitted vibration is common and that HAVS is one of the most common occupational diseases in Korea. However, the range and extent of hand transmitted vibration and the overall prevalence of HAVS in Korea is still unknown. More extensive research on this syndrome in order to priorite necessary preventive measures is required.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

동해안 연안어항 해수중의 COD 및 중금속 함량에 관한 연구

김영철,주충열,신응배 漢陽大學校 環境工學硏究所 1999 環境科學論文集 Vol.20 No.-

동해 연안 일부어항의 해수에 대한 수질환경 자료로 DO, ?? 총질소, 총인 그리고 납, 카드뮴, 크롬, 비소 및 수은 등의 중금속을 측정·조사하였다. 측정결과, DO 5.1∼6.2㎎/l, ?? 0.9∼2.7㎎/l, 납 trace∼0.054㎎/l, 카드뮴 trace∼0.004㎎/l, 비소 trace∼0.002㎎/l, 그리고 수은 trace로 나타났다. 이러한 결과로부터 오염의 정도를 판단하기는 어려우나 환경부가 정한 해역의 수질환경기준과 비교하여 볼 때 중금속으로 인한 오염문제는 크게 우려할 수준이 아니나 일부어항의 ?? 용존산소, 총질소, 총인의 농도로 판단할 때 Ⅱ등급 또는 Ⅲ등급 수질로 나타났다. 이들 지역이 선박이 정착하거나 출입하는 어항임을 감안할 때 비교적 양호한 결과인 것으로 분석된다. The seawater was sampled from the East Coast and the contents of DO, ?? total nitrogen, total phosphates, and heavy metals(Pb, Cd, As, Hg) in the water were measured and analyzed. DO 5.1∼6.2㎎/l, ??0.9∼2.7㎎/l, total nitrogen<0.131㎎/l, total phosphate <0.019㎎/l, Pb <0.0542㎎/l, Cd<0.0038㎎/l, As<0.0016㎎/l, and Hg(trace) were detected by the analytical techniquies such as UV-visible spectrometry and atomic absorption spectrometry. The results shows that heavy metal contamination of the East Coast is equivalent to the detection limits of the first grade seawater. But, the amount of DO, ?? total nitrogen, total phosphates shown above indicates that the seawater in the East Coast is of second or third quality. In conclusion, the samples cannot be justified as the first quality. Considering that the sampling sites were seaports, the seawater in the East Coast is not seriously contaminated.

粉末洗濟에 대한 生分解度와 重金屬에 대한 硏究

김영철,김종섭,유찬주,주충열 漢陽大學校 環境工學硏究所 1997 環境科學論文集 Vol.18 No.-

현재 국내에서 시판중인 의류용 세탁 분말세제 6종을 대상으로 미생물에 의해 분해될 수 있는 정도를 파악하기 위한 생분해도(Biodegradability)를 측정하고 동시에 인체에도 직접적인 영향을 미치는 중금속(Pb,Cd,As 및 Hg)를 분석하였다. 분석결과 전제품이 KS 기준에 모두 적합하였으나 석유계 계면활성제인 AOS 또는 LAS가 다량 포함 되어있는 제품에서는 상대적으로 생분해도가 낮다는 것을 알 수 있으며 중금속 함유량은 제품 6종 모두 화장품 원료기준에 훨씬 못미치는 우수한 제품인 것을 알 수 있었다. As the subject of study of six kinds of laundry powder detergents for clothing that come into the domestic market at present, the biodegradabilities to understand the extent of microorganisms decomposition were measured and the heavy metals(Pb, Cd, As and Hg) to have a direct effect on human body were analyzed. Analysis results show that though they all suit KS(Korean Industrial Standards) well, powder detergents containing plenty of petroleum surface active agents have the lower biodegradability than the others and Heavy metal contents are that all of them are very good at the cosmetic material standards.

관상동맥색전증에 의한 급성심근경색증 4예

김민근,주혜원,강경필,최병돈,박민석,변영섭,고충원,이건주,김병옥 인제대학교 2006 仁濟醫學 Vol.27 No.-

Acute myocardial infarction(AMI) due to coronary embolism can occur in patients with normal coronary artery. Coronary embolism is believed to be a cause of acute myocardial infarction when emergent coronary angiography shows perfectly normal coronary trees, except for the finding of coronary artery occlusion. In this report, we describe four patients with AMI due to coronary embolism who were successfully treated using a thrombus aspiration device and anticoagulation, and those patients had intracardial thrombus arising from the left atrium due to chronic atrial fibrillation and valvular heart disease. Patients with chronic or paroxysmal atrial fibrillation can present with AMI due to coronary embolism, and thrombus aspiration with percutaneous aspiration device is a feasible treatment option for these patients along with anticoagulation the rapy.

배열형 전력 MOSFET의 설계 및 제작

김진형,최연익,정상구,박찬광,김충기,성만영 亞洲大學校 1987 論文集 Vol.10 No.-

In this paper, the design of the array type power MOSFETs is discussed in terms of on-resistance, breakdown voltage, placement of FLRs(field limiting ring) and threshold voltage. Also, 9-cell(square-on square grid) VDMOSs are fabricated to confirm the feasibility of the design method. Existence of optimum p-well spacing for minimum on-resistance, which is anticipated by the theoretical results is confirmed by the experiment of the fabricated power MOSFETs. Breakdown voltage of power MOSFET is upgraded by using two FLR's and their optimum placement is determined from the experimental results of the diodes with FLRs. The threshold voltage is controlled by the ion implantation within the design specification. Experimental results are in good agreement with the design specification. Experimental results are in good agreement with the design values. Characteristics of the fabricated power MOSFETs are 190Ω in on-resistance, 270V in breakdown voltage and 2.9V in thershold voltage.

폐결핵 초치료 환자들의 치료 결과에 영향을 주는 요인

김경순,조영하,전진호,조은희,은충기 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

Objectives : To figure out the factors related to the failure of primary pulmonary tuberculosis(Tb) treatment and to enhance the efficiency of the treatment. Methods and Materials : The subjects were 137 Tb patients composed of the two groups; 44 failure cases and 93 success cases who admitted in National Masan Tuberculosis Hospital during 2001. The failure means no improvement with the standard short term regimen of INH and RFP. Patients' informations were gathered through medical records and face-to-face interview survey, and, the data were analyzed with SPSS(ver 10.0). Results : Mean age of the subjects were 47.6 years. Most cases were diagnosed at clinics or hospitals at first, due to the symptoms. No difference in smoking and alcohol habits between the two groups. The cases who got the informations about the whole process of treatment, and following regular regimens were more in the success group. The proportion of multi-drug resistance to the regular primary Tb regimen was higher in the failure group 8 cases out of 25 detectable failure cases. 0 case among 46 successful cases. And the four regular regimen(INH, RFP, EMB, PZA) was popular type of the resistance. In chest X-ray, multiply involved lesion(≥ two lobes), atelectasis and pleurisy were more frequent in the failure group. Conclusion : The major factors that enhance the efficiency of Tb treatment were the informations and compliance. Enough explanation about the whole process would be essential during Tb treatment, and, in case of MDR-Tb, susceptible regimen and surgical therapy should be considered.

인터넷 비즈니스에서 효과적인 소비자 관계관리(Customer Relationship Management)를 위한 데이터 마이닝 기법의 응용에 대한 연구

김충영,장남식,김상욱 한국산학경영학회 2002 산학경영연구 Vol.15 No.-

본 연구에서는 고객 세분화를 위하여 고객프로필과 사이트 접속자료를 통합, 분석하는 분석적 CRM을 시도하였다. 실제 고객 데이터를 분석하여 고객의 특성과 기호, 방문행태 등을 이해할 수 있다면 이를 기반으로 고객 세분화(segmentation)가 가능할 것이다. 예를 들어 고객의 거주지, 재산정도, 교육수준, 연령 등 진적정보를 토대로 동일 사이트에 접속하는 고객의 공통점을 찾게 된다면 이들 고객에 접근할 수 있는 적절한 마케팅 미디어가 무엇인지, 어느 페이지에 홍보ㅜㄹ을 게재하는 것이 효과적일 것인가 등을 결정하는 데 도움을 줄 수 있을 것이다. 한편 웹 기반 마이닝의 핵심은 웹으로 부터의 자료를 어떻게 하면 효율적으로 수집할 것인가, 또한 이렇게 수집된 자료를 다양한(multiple) DB와 어떻게 통합하고 분석하여 필요한 정보를 추출할 것인가 일 것이다. 본 연구에서는 실제 인터넷 사업자의 사용자 그룹의 비율에 따라 구성된 패널을 활용하여 효율적인 자료수집 방안을 모색하였다. 패널 구성원에 대한 웹 데이터를 수집함으로써 신뢰성과 대표성을 확보하면서 분석대상 자료의 양을 적절한 수준으로 유지할 수 있었다. 또한 고객자료 분석에서는 OLAP과 데이터 마이님 기법(의사결정나무)을 동시에 사용하여 그 분석 결과를 비교함으로써 각 기법의 결과를 상호 확인하고 보완할 수 있었다. 이 결과는 데이터 마이닝 기법에 의해서 발견된 패턴을 분석 하고 확인하는 작업에서 OLAP이 유용하게 사용될 수 있다는 과거 연구의 주장을 확인하였다. In this study, an analytical CRM for customer segmentation is exercised by integrating and analyzing the customer profile data and the access data to a particular web site. We believe that effective customer segmentation will be possible with a basis of the understanding of customer characteristics as well as behavior on the web. One of the critical tasks in the web data-mining is concerned with both ?how to collect the data from the web in an efficient manner??and ?how to integrate the data(mostly in a variety of types) effectively for the analysis??This study proposes a panel approach as an efficient data collection method in the web. For the customer data analysis, OLAP and a tree-structured algorithm are applied in this study. The results of the analysis with both techniques are compared, confirming the previous work which the two techniques are inter-complementary.