서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

Caffeine이 지구성 운동 수행능력에 미치는 영향과 억제성 아미노산에 의하여 활성화되는 이온통로의 조절작용

김은경,김영표,천병옥,이계영,김연정,임백빈,조영욱,김창주,김성수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

To investigate the effect and mechanism of caffeine on endurance exercise, two experiments were performed. First, to test caffeine effect on aerobic exercise, 200-300g Sprague-Dawley rats were used and three groups, control group, low caffeine injection group and high caffeine injection group, were divided. Blood smpling by heart puncture were done at rest, after 30 min treadmill exercise, and after maximal exercise. Blood glucose, free fatty acid concentration were detected and following results were obtained. Glucose concentration showed significant difference between groups(p=0.0305) and also significant changes were exhibited between time(p=0.0004). Free fatty acid concentration had no difference between groups. but had significance between times(p=0.00065). Exercise endurance performance time showed significant difference(p=0.02350 in high caffeine injection group compared to control group. In this experiments, endurance exercise capacity was increased by caffeine injection. Therefore, second experiment was performed to investigate the effect of caffeine on ion current induced inhibitory amino acid neurotransmitter. GABA and glycine. Single periaqueductal gray neuron was acutely dissociated and nystatin perforated patch clamp was performed under voltage clamping condition. Caffeine evoked outward current in PAG neuron dose dependent manner. 1mM of caffeine application had no response. but 3mM caffeine evoked about 32.5±8.539pA outward ion current and 10mM caffeine evoked about 215.46±19.4pA outward current. 10^-2mM GABA activated Cl￣current and recorded by inward current. Caffeine inhibited GABA activated Cl￣ current concentration dependent manner. 10^-2mM of caffeine had no effect on 1-^-2mM of GABA response. but 10^-1mM caffeine inhibited GABA activated Cl￣ current about 5.74±2.13%, 1mM caffeine inhibited about 17.25±2.70%, 10mM caffeine inhibited GABA response about 45.31±7.71%. 10^-1mM of glycine activated Cl￣ current and also recorded by inward current. Caffeine inhibited glycine activated Cl￣ current concentration dependent manner. 10^-2mM caffeine decreased glycine activated Cl￣ current about 4.61±1.650%, 10^-1mM caffeine decreased about 6.49±2.24%, 1mM caffeine decreased about 26.82±4.27%, and 10mM caffeine decreased glycine response about 94.47±1.39%. These results suggest that caffeine inhibite inhibitory amino acid, GABA and glycine, this response causes excitation of CNS and this seems to be the basic mechanism of increasing effect to aerobic exercise performance by caffeine.

분편 인플루엔자백신(split influenza vaccine)의 임상효과 및 면역원성에 관한 연구

우흥정,김동림,정희진,천병철,이주연,안정배,김지희,박찬,신영규,김우주,김민자,박승철 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

목적 : 아단위 인플루엔자 백신 접종 후 백신의 인플루엔자 예방효과, 인플루엔자 방어 항체형성, 인플루엔자 백신의 안전성을 조사하고자 하였다. 방법 : 총 571명을 대상으로 인플루엔자 백신 접종을 하였고, 이들 접종자에서 인플루엔자 양질환의 이환을 조사하여 인플루엔자 백신의 인플루엔자예방효과를 알아보았고, 백신의 접종 전 및 접종 4주 후 혈청에서 혈구응집억제물(Hemagglutination Inhibition : HAI) 항체 검사를 실시하여 백신의 방어항체생성을 조사하였고, 백신의 안전성을 알아보기 위해 백신접종 후 1주일 이내의 부작용을 조사하였다. 결과 :백신 접종군과 백신 비접종군에서 인플루엔자 양 질환의 이환을 조사한 결과 접종군 28.35%, 비접종군 35.88%으로 나왔으며, p 값이 0.001로 통계적으로 접종군에서 유의하게 낮았고, 인플루엔자 양 질환의 예방 효과는 20.97%를 보였다. 백신의 방어항체 형성의 평가를 위해 유럽의 인플루엔자 백신 허가 기준을 조사하였는데 B/Guangdong/5/94균주의 백신접종 후 항체가 40이상의 비율을 제외한 다른 기준은 모두 만족 시켰다. 부작용은 전체 조사자 521명중 149명(29%)으로 주로 접종 부위의 국소 부작용을 호소했고, 전신 부작용은 2% 내외였으며 특별히 심각한 부작용은 발견되지 않았다. 결론 : 분편 인플루엔자 백신은 인플루엔자양질환의 예방과 방어항체생성에 효과 있으며 안전한 것으로 사료된다. Background : The safety and effectiveness of influenza vaccine are well known in developed country. The influenza vaccination has been recommended as one of the tentative immunization schedule for indicated persons since 1997 in Korea. But there are still no available data about them, even though nearly 5 million doses of influenza vaccine were used in 1997-1998 season. So it is immediately needed to investigate the safety. efficacy and immunogenicity of influenza vaccine among Korean. Methods : We studied the clinical efficacy of influenza vaccine by monitoring Occurrence of influenza-like illness in influenza risk group(vaccination ; 300, non-vaccination; 215) from December in 1997 to March in 1998. We used the split quadrivalent influenza vaccine containing 15 microgram of hemagglutinin of A/Beijing/262/95(HlNl), A/Wuhan/359/95(H3N2), B/Mie/1/93 and B/Guangdong/5/94. Hemagglutination inhibition(HA1) antibody titers were determined before immunization and 1 months after vaccination And we evaluated adverse effect of influenza vaccination at 7 days after vaccination. Results : Influenza vaccination was associated with si@icant reductions in influenza-like spptoms(vaccination group; 28.35%, non-vaccination group, 35.88%, p=0.001). The preventive effect of influenza-like i3lne.s among influenza risk goup was 20.97%. And immunogenicity of influenza A and B exceeded all of the European licensure criteria for immunogenicity except postvaccination proportion of titers 240 of B/Guangdong/5/94 strain. And the adverse effects were mainly local injection site problem and no serious adverse effect was noted. Conclusion : Split influenza vaccine is safe, inmunogenic and eff'tive in influenza risk group in Korea.

동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예

신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3

Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.

Medicinal Chemistry : EVALUATION OF CADMIUM-INDUCED NEPHROTOXICITY USING URINARY METABOLOMIC PROFILES IN SPRAGUE-DAWLEY MALE RATS

( Yu Kyung Lee ),( Eun Young Park ),( Shi Won Kim ),( Ji Yeon Son ),( Tae Hyung Kim ),( Won Gu Kang ),( Tae Chun Jeong ),( Kyu Bong Kim ),( Seung Jun Kwack ),( Jae Won Lee ),( Suh Mann Kim ),( Byung M 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-

The aim of this study was to investigate urinary metabolomics profiles associated with cadmium (Cd)-induced nephrotoxicity and their potential mechanisms. Metabolomic profiles were measured by high-resolution 1H-nuclear magnetic resonance (NMR) spectroscopy in the urine of rats after oral exposure to CdCl2 (1, 5, or 25 mg/kg) for 6 wk. The spectral data were further analyzed by a multivariate analysis to identify specific urinary metabolites. Urinary excretion levels of protein biomarkers were also measured and CdCl2 accumulated dose-dependently in the kidney. High-dose (25 mg/kg) CdCl2 exposure significantly increased serum blood urea nitrogen (BUN), but serum creatinine (sCr) levels were unchanged. High-dose CdCl2 (25 mg/kg) exposure also significantly elevated protein-based urinary biomarkers including osteopontin, monocyte chemoattractant protein-1 (MCP-1), kidney injury molecules-1 (Kim-1), and selenium-bingding protein 1 (SBP1) in rat urine. Under these conditions, six urinary metabolites (citarate, serine, 3-hydroxyisovalerate, 4-hydroxyphentllactate, dimethylamine, and betaine) were involved in mitochondrial energy metabolism. In addition, a few number of amino acids such as glycine, glutamate, tyrosine, proline, or phentlalanine and carbohydrate (glucose) were altered in urine afrer CdCl2 exposure. In particular, the metabolites involved in the glutathione biosynthesis pathway, including cysteine, serine, methionine, and glutamate, were markedly decreased compared to the control. Thus, these metabolites are potential biomarkers for detection of Cd-induced nephrotoxicity. Our results further indicate that redox metabolomics pathways may be associated with Cd-mediated chronic kidney injury. These findings provide a biochemical pathway for better understanding of cellulat mechanism underlying Cd-induced renal injury in hunmans.

직렬 리액터를 이용한 계통연계형 태양광 발전 시스템

金大均,鄭春炳,全基英,李丞煥,吳鳳煥,李勳九,金容珠,韓慶熙 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

Since the residential load is an AC load and the output of solar cell is a DC power, the photovoltaic system needs the DC/AC converter to utilize solar cell. In case of driving to interact with utility line, in order to operate at unity power factor, converter must provide the sinusoidal wave current and voltage with same phase of utility line. Since output of solar cell is greatly fluctuated by insolation, it is necessary that the operation of solar cell output in the range of the vicinity of maximum power point. In this paper, DC/AC converter is three phase PWM converter with smoothing reactor. And then, feedforward control used to obtain a superior characteristic for current control and digital PLL circuit used to detect the phase of utility line.

건식법에 의한 폐PCBs와 자동차 폐촉매로부터 동시 귀금속 농축 회수 공정개발

김병수,이재천,서승필 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.6

In the world large amount of used printed circuit boards (PCBs) and spent autocatalysts which contain precious metals have been emitted. However, processes which can recover the precious metals simultaneously from them have not been developed yet. In this study a new process for recovering the precious metals contained in the used PCBs and spent autocatalyst by a pyrometallurgical process simultaneously was developed. The distinguish of that is to use copper, tin, and iron contained in the used PCBs as collector metals of the precious metals contained in the used PCBs and spent autocatalysts. Advantages of the process suggested are simply and economic compared with the previous processes which could recover the precious metals from the used PCBs and spent autocatalysts, respectively. Using the suggested process the precious metals such as Au, Pd, and Pt contained in the used PCBs and spent autocatalyst could be recovered up to 95 % in Cu alloy phase.

텔레비전 브라운관 생산업체 남자 근거리 검사작업자에서 시력, 눈물분비기능의 변화

김성아,천병렬,김상우,정상재,이광자 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 장기간의 근거리검사작업이 굴절력 및 눈물분비량의 감소를 초래하는지를 관찰하고자 3년간추적 연구를 시행하였다. 방법 : 구미소재 일개 TV브라운관 제조공작의 미세한 이상여부를 확인하는 검사작업에 종사하는 남자 근로자 396명 중 정시안, 눈물분비기능이 정상, 40세 미만이며 3년간 추적가능했던 65명을 대상으로 하였다. 시력, 색신 검사 외에 자동굴절력검사, 누액분비검사, 안증상, 근무기간, 실제 검사작업을 수행하는 시간, 일상생활중 TV시청 및 VDT사용시간,작업환경에 대한 불편감, 안경착용여부 등에 대한 설문조사를 시행하였다. 이중 누액분비검사는 쉬르머 I검사로써 1996년과 1998년에만 실시되었으며, 시력및 누액분비기능의 변화가 안증상과 관련이 있는지를 보기 위한 설문조사는 1999년에 시행되었다. 결과 : 32개월간의 구면굴절력의 변화량은 좌우안모두 0.18D(diopter)였으며, 년간 변화량은 0.068D/yr로서 근시화되는 방향으로 진행하였다 20개월간의 눈물의 변화량은 좌안이 6.57 mm/s min, 우안이 6.40 mm/5 min만큼 감소하였다. 30세 이하 연령군과 2년 미만 근무군에서 0.5 D 이상 감소한 빈도가 높았으나 유의한 차이는 없었으며, 조명, 소음,공기에 대한 주관적인 상태와 작업시간외 영상화면사용시간에 따른 차이도 없었다 안불편감의 호소율은 52.3 %이었고 굴절력의 변화, 나안시력의 변화, 눈물분비변화량에 따른 차이는 없었다. 연령, 근무기간과도 관계가 없었고, 조명, 공기, 소음에 대한주관적인 상태에 따른 차이도 없었으나 작업시간외영상화면사용시간이 4시간 이상에서 4시간 미만에 비해 유의하게 높았다. 구면굴절력, 나안시력 및 눈물분비 변화량, 20개월 후의 눈물분비상태, 나이,근무기간, 불량한 조명, 일상생활중 VDT 혹은 TV시청을 독립변수로 하고 안불편감여부를 종속변수로하여 로지스틱 회귀분석을 실시하였다. 유의한 변수는 작업시간외 영상화면의 사용시간으로 4시간 이상인 군이 4시간 미만인 군이 비해 비차비가 10.5(95% 신뢰구간 1. S~73.9)이었다. 결론 : 근거리 검사작업자에서 굴절력 및 눈물분비의 저하가 관찰되었으며, 그 방향은 근시화 및 건성안의 진행방향이었으나, 눈물분비의 저하는 유의한 정도는 아니었고, 근거리검사작업으로 인한 부가적인 근시화의 영향은 관찰되지 않았다. 근거리작업자의 안건강관리측면에서 시력뿐만 아니라, 눈물분비기능, 눈물층의 상태 등을 포함한 안건강프로그램이 필요하다. Objectives : The aim of this field-based longitudinal study was to investigate the effects of near-work on lacrimation and visual function, particularly refractive power. Methods : Our study tracked sixty five male workers for about three years by means of ophthalmologic examinations and questionnaires, to collect data including eye symptoms and subjective work environmental factors. Ophthalmic examinations included visual acuity, Shirmer I test, and autorefractometry. In the first year, the inclusion criteria were ages less than 40 years, no history of ophthalmic diseases, emmetropia (-1.0 ≤spherical refractive power〈 1.0) and normal lacrimation. Results : Over a period of 32 months, spherical equivalents were decreased as much as 0.18D (diopter) for LE(left eye) and 0.18D for RE (right eye). Lacrimation by Shirmer's I test during 20 months were decreased as much as 6.57 mm/5min for LE, and 6.40 mm/5min for RE. Although more myopic-changed workers demonstrated young age (〈30 years) and short work duration (〈2 years), there was no significance to this correlation. Additionally, subjective work environmental factors such as poor illumination, noise, uncomfortable air and daily use of VDT and/or TV were shown to have no significant effect. However, as for eye discomfort, which was reconstructed from several dry eye symptoms, the daily use of VBT and/or TV was a significant variable. According to a logistic regression analysis concerning the effects of refractive power, lacrimation, work duration, poor illumination, and daily use of VDT and/or TV on eye discomfort, only daily use of VDT and/or TV greater than 4 hours displayed OR of 10.5. Conclusions : Myopic changes due to near work were not observed, however lacrimal function was changed in workers. These results suggest that we should consider various factors such as lacrimation, tear film and refraction as well as visual acuity in order to establish an eye care program among near-work performing employees.

여가스포츠 참여 직장인의 성격유형과 여가만족간의 관계

전병관,김홍석 慶熙大學校 社會體育硏究所 1998 體育科學論叢 Vol.- No.11

This study was aimed at defining on what relationship have between personality styles and leisure satisfaction of the workers. In order to accomplish such purpose, studying issues were established as indicated below. First, Dependent one among personality styles of workers participating in leisure sports was showed to the strong relationship at aesthetic leisure satisfaction. Second, Independent one among personality styles of workers participating in leisure sports was showed to the strong relationship at educational leisure satisfaction. Third, Dependent one among personality styles of workers participating in leisure sports was showed to the strong relationships at rest leisure satisfaction. Froth, Independent one among personality styles of workers participating in leisure sports was showen to the strong relationships at psychologial leisure satisfaction. Fifth, Dependent one among personality styles of workers participating in leisure sports was showed to the strong relationships at physical leisure satisfaction. Sixth, Independent one among personality styles of workers participating in leisure sports was showen to the strong relationship at social leisure satisfaction.

의사국가시험성적과의 상관관계로 살펴본 임상종합평가시험의 가치 : 2002년 연세대 원주의대 졸업생을 대상으로

김명수,김춘배,차병호,박기창,권상옥,신계철,이혜용,강성준,차봉석 한국보건의료인국가시험원 2004 보건의료교육평가 Vol.1 No.1

Korean Medical Licensing Examination(KMLE) 2002 focused on evaluation of the integrative medical knowledge such as primary clinical care or problem-solving competence. We analyzed the correlation among the year-wise student academic scores(grade score), trial examination scores and KMLE score by correlation analysis and multiple regression method. Four times of trial examination were taken in 2001, which were composed according to the principles of KMLE. Trial examination scores were significantly correlated with student grade scores (p(0.05). KMLE score also correlated with student grade score a nd trial examination score. The grade score at senior had higher correlation coefficient than the grade score at junior in correlation analysis. In multiple regressions, grade score at senior and mean score of trial examinatio n score were significant variants affecting KMLE score. Based on this result, regression formula such as [KMLE score] = 110.596+21.449^*[6th grade score of student] + 0.577^*[mean of trial examination score] was established (R2=0.764, p<0.001). Our results show that the trial examination is useful evaluation tool for final assessment of medical achievements. Also a trial examination is used as a reference data for student guidance and control in preparing for KMLE.