정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Trioctylamine에 의한 유기산의 추출

강안수,이병철,이한섭,안형환,이영주,류운형 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

For elucidation of various parameter's effect on the reactive extraction of organic acidstrioctylamine(TOA)-diluents system, the association model, equilibrium constants and extraction factors(loading) were investigated . The organic acids rosed were propionic. succinic, masonic, and benzoic acid. Extractant was tertiary amine, TOA and diluents were butylaeohol, hexane, and benzene. It was concluded that the loading of monobasic acid of propionic acid were higher than that of dibasic acids of oxalic, and malonic acid with extranctant TOA. In the extraction of monobasic acid the extraction factor was not affected by the initial concentration of extractant amine, but in the extraction of dibasic acids the extraction factor was getting better with decreasing the initial concentration of amine. There was a strong effect of diluents upon the extractien factor, and the order of these factor was as shown below: xylene<Benzene<butylalcohol<choloroform<methylisobutylketone.

도시지역 한방의료이용자의 질병양상 조사연구

강영우,조태현,김병하,남철현,조남춘,안창수,이재홍 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

To provide the basic data for improving of curative measures in oriental medicine and for developing of health education and preventive program after understanding of classification of diseases in oriental medicine users, questionnaire interview was carried out with city dwellers, over 20 years old, selected randomly in big cities from 2nd Oct. to 11th Nov. 1995. The results were summarried as follows: 1. In the general characteristics of subjects, the highest portion of each part was 61.2% of female, 25.5% of thirties, 28.5% of high school graduate, 63.3% of middle class and 11.8% of lower class in economic status. 31.9% was housewife, 73.5% was merried and 55.1%, 38.1% came from big or small cities each. 2. By 21 classification of diseases, 19.7% was blood disorders, 17.6% was pregnancy & delivery complications and 15.2% was endorine & nutritional disorders. 3. As for age 22.6% of endocrine & nutritional disorders in twenties, 20.8%, 28.1%, 27.8% of blood & defence mechanism disorders in thirties, forties, sixties each and 24.9% of pregnancy & delivery complications in fifties were the higher than the other groups. 4. By educational level, 47.8%, 30.5% of blood & defence mechanism disorders in uneducated and middle school graduate were the higher than the other groups. 5. As for occupation, 20.8%, 32.9% of blood & defence mechanism disorders in housewives and sales each, were the higher than the other groups. 6. By economic status, 20.2% of blood & defence mechanism disorders in middle and high class, were the higher than the other groups. 7. By marital status, 21.3% of endocrine & nutritional disorders in singles, 22.0%, 25.7% of blood disorders in having partners, were the higher than the other groups. 8. As for living areas, 18.2% of pregnancy & delivery complications in big city dwellers, 21.3% of endocrine & nutritional disorders in town dwellers were the higher than the other groups. The distribution of diseases in oriental medicine users wes very different by chracteristics according the results. So It's important and essential project to improve curative technics and to develop.

자궁내막증의 임상적 고찰

강길전,유병대,원철,이기환 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Objective : Between 1991 and 1993 data were collected to evaluate risk factors for endometriosis. Design : A case-control study was conducted on 54 cases with laparotomically confirmed pelvic endometriosis consecutively admitted to CNUH. The control group consisted of 60 women admitted to hospital for benigh gynecologic disease. Results : No relation emerged with marital status, age at marriage, marital life, level of education, socio-economic status, age at menarche, menstrual regularity, number of spontaneous abortion, duration after last delivery, height and weight. But compared to control group, longer menstrual period, larger menstrual amount, severe menstrual pain, less number of parity, and less number of induced abortion signifcantly increased risk of endometriosis Conclusions : This study showed that frequent menstrual cycles and long period of menstruation with frequent and large amount of retrograde menstrual flow increased the risk of endometriosis.

액체식품의 건조시 방향물질의 보존 제1보 : 평판건조시 방향물질의 보존

강안수,이병철 明知大學校 産業技術硏究所 1993 産業技術硏究所論文集 Vol.12 No.-

The aroma retention in the drying of light foods. which is an important factor fur determining the quality of products, was analysed by a theoretical model and was investigated through experiments. Model liquid foods were made of aqueous solutions of sugar, sucrose and maltodextrine, to which fixed ratios of benzaldehyde were added. It was assumed that aroma component and water in drying material were transported by molecular diffusion. The system was treated as a pseudo-binary system when the transport of volatiles is considered and as a binary system of water and sugar when the transport of water is considered. Approximate solutions of the diffusion equation were obtained for the case of fast drying and fur the case of slow drying. In solving the diffusion equation, the shrinkage of the specimen was in proportion to the amount of water evaporated in the slow drying case and that the specimen behaved as a semi-infinite body in the fast drying case. The experimental results showed that the aroma retention was high when the initial concentration of sugar was high. The higher the molecular weight of sugar and aroma components, the lower the diffusion coefficients of aroma in sugar solution, so that the aroma retention was high. And when the concentration of aroma components was below 1.000ppm. it's concentration had no influence on the aroma retention.

신경회로망을 이용한 송전선로 고장판별에 관한 연구

강승호,이병길,김철환 成均館大學校 科學技術硏究所 2000 論文集 Vol.51 No.1

High impedance fault(HIF) is defined as the fault that cannot be detected or removed by conventional overcurrent relays(OCRs). When HIF occurs in residential areas, energized high voltage conductor results in fire hazards and causes damages in electrical equipments or personal threat. This paper proposes the fault classification of not only LIFs but also HIFs using artificial neural networks. In this paper, classification of faults in transmission line is performed using the instantaneous 3-phase currents. Test results show that the neural networks were able to classify the faults including HIF accurately in transmission lines within a half cycle.

신경회로망을 이용한 송전선로 고장거리 추정에 관한 연구

강승호,이병길,김철환 成均館大學校 科學技術硏究所 2000 論文集 Vol.51 No.1

When faults occur in transmission lines, protective relays need to operate fast and accurately to protect transmission lines and electrical equipments and to supply power with good quality. To advance the reliability of power network, the accurate fault detection and fault distance estimation must be implemented. This paper proposes the fault distance estimation method using artificial neural networks. In this paper, fault distance estimation is performed using fundamental component of 3-phase voltages and currents. To evaluate the performance of the technique using artificial neural network, the propriety of fault distance estimation is verified using EMTP(Electromagnetic Transient Program).

CFD를 이용한 광촉매 정수장치모듈의 최적구조 국문제목

강한용,최병철,김종호 한국공업화학회 2004 응용화학 Vol.8 No.1

The flow fields inside the photo-catalytic module for water treatment system were studied. The fluid flow inside the module was visualized mainly by CFD (computer fluid dynamics) analysis, and the numerical analysis was authorized by PIV(particle image velocimetry) measurement. The flow patterns in the module for 3 types of innards and 6 kinds of flow rate were analyzed by CFD. Model 1 had better performance below 0.1 L/s of the flow rate, and model 2 over 0.2 L/s of the flow rate with the homogeneous flow field innards of photo-catalytic module.

재발성 일과성 허혈 발작을 주소로 내원한 비-안와-대뇌 모균증 1예

강우열,이주헌,성영희,최일수,송홍기,이병철 대한노인병학회 2002 대한노인병학회지 Vol.6 No.3

난황 단백질의 효소분해 특성

강병철 東義大學校産業技術開發硏究所 2003 産業技術硏究誌 Vol.17 No.-

Ths performance of enymatic hydrolysis on egg yolk protein was investigated in this study. Ethanol concentration in egg yolk protein was changed from 10 to 40 % (wt/wt). As ethanol concentration was increased, the recovery yield of total solid and protein in enzymatic hydrolysate was also increased. We also investigated the effect of ethanol concentration on the performance of ultrafiltration. As the concentration of ethanol in yolk protein was increased, the recovery yield of product was increased. The recovery yield and the purity of sialic acid did not correlate with the types of modules and the size of MWCO. The effect of pH and temperature was also investigated using immobilized supports, Celite R640, Duolite A568 and Silicagel 60. The optimum operation condition of enzymatic hydrolysis were obtained at pH 5.0 and 30℃.