정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

임신 종결 후 발생한 자궁 동정맥 누공에서 자궁동맥색전술로 치료한 1예

김종민,이해혁,김태희,남계현,심일구,이권해,김형문,이임순,장종호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Arteriovenous fistula of uterus is rarely reported disease. This vascular malformation is very dangerous condition because Dilatation & curettage can cause massive uterine bleeding without accurate diagnosis. The diagnosis is made by angiography, gray scale ultrasonography, color and duplex doppler ultrasonography, computed tomography, and magnetic resonance imaging is helpful. Especially color and duplex doppler ultrasonography is allows convincing detection and diagnosis of arteriovenous fistula. Recently transcatheter uterine artery embolization is treatment of choice. We have experienced a case of arteriovenous fistula of uterus. Which is presented with a brief review of literature.

하악골 골수염이 동반된 전신적 골화석증

이종호,정중재,정종철,서구종 大韓顎顔面成形再建外科學會 1992 Maxillofacial Plastic Reconstructive Surgery Vol.14 No.4

Osteopetrosis is a rare skeletal disease of unknown etiology. Osteomyelitic changes in the jaw bones are frequently seen in this disease, especially in the mandible and may follow upon tooth extractioin. A case is reported of a 31-year-old male who was seen because of intraorally exposed bony spicule and chronic dull pain. Radiographic and haematological investigations led to the diagnosis of osteopertrosis with osteomyelitis. The striking radiologic findings were pathologic mandibular fracture and generalized skeletal thickening. The present case could be grouped under the benign form, type II osteopetrosis. With the conservative and minimally invasive modes of treatment including administration of penicillin G sodium, curettage and closed reduction, we could successfully manage the osteomyelitis and pathologic fracture associated osteopetrosis.

범용 크랭크 프레스에 의한 정밀진단 특성에 관한 연구

이종구,오환섭 경희대학교 산학협력기술연구원 1996 산학협력기술연구논문집 Vol.2 No.-

This study was performed the characteristics of Fine-blanking by conventional crank press, such as maximum blanking force, burnish, dish-shape, hardness. etc. in fine-blanking die by the experimental method. Two types of aluminum such as annealed and unannealed materials were used for the experiment. In order to get a hydrostatic pressure effect, the clearance was set to 0.5% of the thickness of strip, and the counter punch and blankholder with vee-ring was set-up. While this experiment was carrying out, the average blanking velocity was constant. As a result of this study, we got a good surface roughness and a glassy shear plane(burnish) of the sheet over 90% thickness, the excellent accuracy of dimensions, the good squareness and the reduction of dish-shape could be obtained, Also the additional results obtained were such that the hardness of burnish was increased and the maximum blanking force was reduced.

팥바구미 저항성 녹두의 작물학적 특성

이구환,정승근,박상일,송범헌,조용구,김홍식 忠北大學校 農業科學硏究所 2002 農業科學硏究 Vol.19 No.-

디지탈 制御 可變 能動濾波器 構成에 관한 硏究

李鍾憲,田龜濟,金斗泳 동아대학교 공과대학 부설 한국자원개발연구소 1981 硏究報告 Vol.5 No.2

Digital Controlled Variable Conductance(DCVC) whose conductance is varied by binary input is constructed with IC analog switch and Digital Controlled variable Duty-ratio Generator(DCVDG). Applying this DCVC to the wave active filter, digital controlled variable active filter is constructed. Experimental results of 5th Chebyshev LPF and 4th Butterworth BPF are agreed well with theoretical ones.

유한요소법을 이용한 정밀전단 변형부의 응력해석

이종구,오환섭 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.6

The goal of this study is to analyse the stress and the strain occurring within the work piece at the fine-blanking process and hence to assume the size, direction and a distribution chart of the shearing stress as the penetration of the punch is being increased trough the application of the FEM. For this analysis we introduced the piece-wise linear method in the non linear structural analysis program for large deformation sheet metal forming and we defined it as the problem of the non linear contact. Therefore, we modeled the above problems as quadratic-nodded axi-symmetrical elements for the characteristics of the work piece. From the result of this analysis, it was found that the shearing stress is a great deal occurred on the surface of the work piece during the beginning process of the punch penetration and it's effect is expected to influence importantly for th formation of burnish because the deeper is the penetration of the punch in the narrow clearance zone, the greater is the degree of the strain stress.

Hall 소자를 이용한 승강기용 로프의 평가

이종오,윤운하,손영호,김정우,이종규 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

홀 소자를 이용한 누설자속 측정으로 승강기용 와이어 로프의 결함 검출에 대한 연구를 수행하였다. 소선파단, 마모, 내부 소선파단 형태의 인공결함을 제작하여 시험편에 영구자석으로 자장을 걸어 결함에서 누설되는 누설자속을 홀 센서를 사용하여 검출하였다. 로프의 소선은 0.5, 0.8mm 두 종류로 시험결과 단선모델 시험에서 0.4mm, 내부의 소선 파단의 경우 1mm 정도 깊이를 가진 인공결함까지 검출이 가능하여 1개의 소선 파단도 검출할 수 있는 것으로 보인다. 마모모델에서 결함의 폭이 작은 경우 검출이 불가능하였으나, 폭이 4mm이상인 경우 자극이 결함을 통과할 때 자속의 변화에 의해 깊이가 0.2mm 정도의 작은 결함도 구별이 가능하였다. 따라서 Hall 센서에 의한 누설자속 측정이 wire rope의 결함 검출에 좋은 도구가 된다고 본다. Defect detection of wire rope for an elevator was investigated through the measurement of magnetic flux leakage. The types of defect usually found in wire rope categorized such as inner and outer wire breakage and wear. The specimens that has artificial defects were magnetized via permanent magnet, and measurement of magnetic flux leakage on the defects was performed with Hall sensor. In wire broken model, a defect smaller than 0.4mm and 1mm in depth on outer and inner wire rope, respectively, could be detected well. In wear model, smaller defect could not be detected clearly, however, appearance of changing of total magnetic flux during magnetic pole of the sensor passing through a defect 0.2mm in depth at 4mm or above width could make possible to detect it. From the results, the measurement via Hall sensor might be useful tool for defect detection of wire rope.

Fine-Blanking시 전단 단계별 변형 거동에 관한 연구

이종구,박원규 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.4

One characteristic of Fine-Blanking is that the size and the direction of stress and strain are very complex in the plastic flow according to the condition of blanking. Especially, they are affected by the clearance of punch and die, by the force of blanking holder and by the force of counter punch. The purpose of this research is to know the deformation behavior in shear zone more clearly, based on Green & Cauch's large deformation theory. The deformation behavior and cracks were investigated in each step of shear, according to punch penetration increase, the use V-indenter ring the hardness of materials. This research found that the transforming behavior was the same as pure discretion, and the cracks could be prevented when hardness is low.

청각장애아동의 조음특성에 관한 연구

이종구 龍仁大學校 1991 용인대학교 논문집 Vol.7 No.-

This study is about the articulation of the hearing loss and deaf children. Especially, it is related to the several hearing types in audiogram and articulation. 1.Summary A.Subject o S special primary school 170 students B.Periods o 1990, July, 1 ~ July, 20 C.Instruments 1) Articulation test Cards ; 68 2) Individual audiogram 3) Cassette recorder 4) The list of individual's articulation D.Procedure The surveyer showed clients the articulation cards including Korean phoneme. The surveyer recorded the articulation conditions of hearing loss and deaf children by recorder. According to results, the surveyer decided the scores. ; Two points (excellent level), One point (moderate, similar level), Zero point (never pronounced) E.Results 1) Single vowels easily can pronounced than dipthongs 2) The peongem([g], [d], [b], [s], [z]) can more good pronounced than kyongem(['g], ['d], ['b], ['s], ['z]) and keokem([gh], [dh], [bh], [zh], [hh]) 2.Proposal A.Speech therapy prospects 1) It is more effect that the speech Therapist to teach the dipthongs after single vowels. 2) It is necessary that the speech Therapist must to teach not only hearing loss but also hearing type in audiogram. 3) It is more effect that ther are used cued speech and etc, in difficulty phonems. B.Special education prospects 1) The speech therapist are to be placed in special schools 2) Separation of primary schools from secondary schools is necessary. 3) Specialists' committee is necessary for the placement of proper class.