Astromicin sulfate의 약동학 및 안전성 평가

정숙인,김연숙,오원섭,복혜숙,김명민,최경업,김연화,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.3

목적 : Astromicin은 aminoglycoside계 항생제와 유사한 화학구조와 특성을 지니고, 기존의 aminoglycoside와 유사하거나 향상된 임상효과 및 부작용을 지닌 것으로 알려져 있다. 저자들은 astromicin의 약동학적 특성을 분석하고, astromicin 투여 환자를 대상으로 한국인에서 그 임상적 및 세균학적 효과와 안전성을 평가하고자 하였다. 대상 및 방법 : 약동학적 지표는 정상성인 남자를 대상으로 astromicin 200㎎을 30분간 정주한 후 24시간까지 혈장 및 뇨 검체를 수집하여 one-compartment open model에 따라 분석하였다. 중증으 세균감염이 있는 18세 이상의 환자를 대상으로 병용 또는 단독 투여한 후 임상적 효과와 세균학적 효과를 판정하였고, 치료전과 후의 순음청력검사와 혈청 크레아티닌으로 이독성과 신독성을 평가하였다. 결과 : 정상 성인 남자 12명을 대상으로 약동학적 지표를 평가하였고, 최고혈장농도는 투여 종료시점(C_(0))에서 16.87±1.68㎍/mL였으며, 반감기는 1.86±0.43 시간 이었고, AUC_(0-12h)은 38.12±10.57㎍ㆍhr/mL, Vd는 0.18±0.02L/㎏, CL은 5.25±2.07L/hr였다. 이러한 약동학적 지표는 다른 aminoglycoside와 유사한 결과를 보였다. 59명의 환자를 대상으로 시행한 임상적 효과 분석에서는 단독요법을 시행한 50명 중 임상적 치유율 94%, 세균학적 치유율 100%를 보였고, 순음청력검사를 시행한 48례의 환자중 의미있는 청력감소 소견은 관찰되지 않았으며, 신독성 또한 전혀 나타나지 않았다. 결론 : Astromicin의 약동학적 지표는 다른 aminoglycoside의 약동학적 지표와 비슷한 양상을 보이므로 향후 astromicin의 약물농도 감시에 있어서 다른 aminoglycoside의 치료적 약물 농도 감시 방법과 유사한 방법을 적용할 수 있으리라 기대된다. 또한 임상적 치유율이 우수하면서 신독성이나 이독성이 적어 세균 감염 환자의 치료에 있어서 단독 또는 병합 요법으로 비교적 안전하게 사용할 수 있으리라 생각된다. Astromicin(Fortimicin®) has some characteristics in common with other aminioglycoside antibiotics, although it has a unique chemical structure, which is different from them. This study was performed to elucidate the pharmacokinetic (PK) parameters of astromicin following single-dose intravenous infusion of 200 mg and to evaluate clinical efficacy and safety of astromicin in Korean populations. PK parameters of astromicin were determined in 12 healthy volunteers (65.5±5.2㎏). The plasma and urine samples were collected up to 24hrs. PK variables were calculated by fitting individual concentration-time curves to a one-compartment open model. Plasma level at the end of infusion was 16.87?1.68 ㎍/mL and declined to 1.05±0.35 (㎍/mL 8hr later. The half-life was 1.86±0.43 hr. Apparent volume of distribution was 0.18±0.02 L/㎏g, and total body clearance was 5.25±2.07 L/hr. These values were similar to those of other aminioglycosides. Clinical efficacy and safety were eviuated in 59 patients with moderate to severe bacterial infections who needed parenteral antibiotics. Among 50 patients who recieved astromicin monotherapy, 49 (98%) had favorable clinical reponse and 28 (100%) had favorable bacteriological response. Serial audiograms revealed no change in all of 48 patients. No nephrotoxicity was observed in all patients. Conclusively, our data suggest that therapeutic drug monitoring of astromicin can be conducted in a similar fashion as other aminioglycosides and astromicin is a useful and safe antibiotic in the treatment of severe bacterial infections.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

아동의 손톱중 질소 함량과 영양상태에 관한 연구

권선옥,박선미,장순영,전혜숙,정원혜,최혜옥 효성여자대학교 가정대학 학도호국단 1984 家政大論集 Vol.3 No.-

We estimated fingernail nitrogen content from children in a city, a farm village, a mountain village and a fishing village. Therefore, the result is as follow. In summer, nail nitrogen content was estimated 130.79±15.39mg/g in a city, 123.86±24.93mg/g in a farm village, 96.16±17.04mg/g in fishing village, 91.96±6.76mg/g in a mountain village. In winter was estimated 137.43ㄷ69.06mg/g in a city, 131.70±8.49mg/g in a farm village, 124.75±16.34mg/g in a fishing village, 115.81±6.36mg/g in a mountain village. According to this analysis, the nail nitrogen content lowered by turns a city, a farm village, a fishing village, a mountain village. The nitrogen contents of nails obtained in winter were found to be higher than those obtained in summer.

대상 포진 반흔 부위에 발생한 대상 편평 태선 1예

김지숙,김명화,최혜영,명기범 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.2

Many cutaneous reactions have been known to occur within resolved herpes zoster lesions. These include granuloma annulare, pseudolymphoma, lymphoma, granulomatous vasculitis, lichen planus and other dermatoses. The pathogenesis of these reactions remains unclear and it has been proposed that they may represent isotopic response. A dermatomal distribution in lichen planus is very rare. We report here a case of zosteriform lichen planus that was developed on the site previously affected by herpes zoster. (Korean J Dermatol 2004;42(2):217~219)

유비쿼터스 시스템을 활용한 도서관에 대한 현황 사례연구

박혜숙 한양대학교 2011 韓國 生活 科學 硏究 Vol.31 No.2

Ubiquitous computing technology has great impact on service and function of modern library. With the development of this technology, new trend would bring forth much change to roles and function of current library. In this study, we tried to find out the definition of ubiquitous computing, space characteristics and development stage of ubiquitous computing library. After that, we analyzed current condition of university library which used ubiquitous computing technology based on our research. Domestic journal, professional database, all internet searches on ubiquitous technology and domestic university library were used for this study. Research objects are 6 libraries: Yonsei University Library, Kyoungwon University Library, Myounggi University Library, Sulkyoung University Library, Jeonju University Library, Sunkyunkwan University Library. the result of this study as follows; firstly, almost of university libraries furnished ubiquitous computing technology system for convenience. Moreover, ubiquitous libraries were basically composed of private carrels, group study room, presentation room and other various forms of spaces for effective learning and meeting spaces. This presence of these facilities stands for some truth that ubiquitous library should exist not only just for effective alternative for materials sorting but also for appropriate communication space. From now on, ubiquitous libraries should try to arouse the people to the importance of ubiquitous computing system and make settle as a cultural center of local community.

幼弱白鼠 肝細胞內 DNA, RNA 및 PAS 陽性物質에 미치는 Chlorambucil과 Ginseng Saponin의 相互作用에 關한 組織化學的 硏究

閔惠淑,全容赫,羅福瑛 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

The effects of interaction between chlorambucil and crude ginseng extract (ginseng saponin) had teen investigated on liver cell of 90 experimental weanling albino rats from 22 healthy primiparous mother rats by means of histochemical detection as RNA, DNA and PAS positive materials 1. Severe regressive changes of the liver tissue, especially on the portal area, induced by intraperitoneal administration of single dose of chlorambucil rated 0.2㎎/0.1㏄ per 20㎎ of body weight had been protected or recovered from the degeneration by following administration of single dose of the crude ginseng extract rated 1.0㎎/0.1㏄ per 20㎎ of the body weight of young. 2. An abrupt declination of PAS positive material in hepatocyte due to use of chlorambucil was contrasted with a gradual inclination of it induced by use of crude ginseng extract, and the effect of the latter appears to be contributed for recovering the lower PAS reaction into that of the normal on the former hepatic cellular change. 3. A declination of stain property or RNA to Azure B was resulted from the use of chlorambucil, while that of DNA was not affected until 24 hours and later it was increased by 36 hours after the administration. 4. A slight decrease of the staining in both the DNA and RNA was recovered the property by 48 hours after the administration of crude ginseng extract. 5. On concomitant administration of both the chlorambucil and crude ginseng extract the staining property of the RNA to Azure B was shown a decrease in the initial stage, and was recovered in that of the normal immediately thereafter without influencing that for DNA.

꽃새우 乾製品의 맛成分 : 1. 유리아미노酸의 變化 1. Changes of Free Amino Acids in Trachypenaeus curvirostris During Sun Drying

李惠淑,金奉玉,成洛珠,鄭承鏞 진주여자전문대학 1981 論文集 Vol.3 No.-

Changes of free amino acids a s taste compounds during sun drying of shrimp Trachypenaeus curvirostris, were analyzed by amino acid autoanalyzer. Glycine, arginine, proline and alanine were dominant amino acids in fresh extracts, having 44.8%( 6109.9㎎%, on dry base), 21.9% (2989.3㎎%), 10.4% (1418.3㎎%)and 5.9% (805.1㎎%) of the total amino acids, respect-ively. Free amino acids were not changed in composition during sun drying of shrimp. Glycine, arginine, proline and alanine were dominant in both fresh extracts and dried products. In dried extracts,.such amino acids as glycine, arginine, proline and alanine were 44.7% (4162.3㎎%, on dry base), 24.1% (2244.61119 %), 11.7% (1090.l㎎%)and 5.3% (495.8㎎%) of the total amino acids, respectively. It is believed that glycicne, arginine, proline and alanine may play an important role as taste compounds in sun dried shrimp.

소생 불가능한 환자에 대한 간호 행위를 찾기 위한 탐색적 연구

김달숙,이혜경 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.1

This study was advanced with a view to identify the most desired nursing behaviors of patient's family for almost dying, through this, and to explorate appropriate nursing action intervend in patients almost dying. The 26 family members whose patients were cancers were interviewed at Chung-Nam national University Hospital, Dae-Jeon Eul Ji Hospital, and Dae Jeon Sun Hospital with questionaire which included 52 nursing behaviors items each having 10 grade scale and classified with psychosocial, environmental psychosocial, physical aspects and is generated through in depth literature review from April 15 to May15. he results were analyzed by basic descriptive statistics and were as follows: 1. The ten most desired nursing behaviors by family members were the nurse 'do not abandon patient', keep comfortable positon and change position frequently', `eliminate urine and feces as usual', have humorous talks to the patient frequently' `keep the patient out of suffering (cough, nausea, vomiting)', try to keep the patient to eat his favorite foods, `keep the patient rest appropriately', `ventilate the room and keep the patient inspire fresh air', try for the patient to meet the medical personnel when she or he want', keep the environment out of noise', 2. The ten least desired nursing behaviors were the nurse `act religious rituals with the patient', 'crywith the patien when the cry', `talk to the patient honestly when he keep him informed of his lab data and his condition', `administrate sedatives to the patient to keep him sleep', `try for the patient to take part in a sort of nursing action as much', 'encourage the patient I his grief', 'allow the patient to cry when he want to cry' 'keep and assist the patient his mouth cleaning', 'give the pain medications as often as possible as ordered by doctor', 3. Nursing behaviors of psychological aspects for almost dying patient showed the least quanti-

발레 동작의 운동학적 분석 : 그랑 바뜨망 디벨로빼와 아띠튜드 크로아즈 데리에르를 중심으로 -

이혜숙 한국운동역학회 1997 한국운동역학회지 Vol.7 No.1

This study was performed for the purpose of ①trying scientific analysis of dance movement, ②increasing the ability of dancer's to perform high level ballet movement, and ③getting some basic information to perform the ballet movement safely and effectively. Four subjects perforemd "Grand Battment Developpe", "Attitude Croise Deirerr", and "Demi Plie" consecutively, and their performance were filmed by three video cameras. The film was digitized for 20 joints and calculated 3D real coordinates by the DLT method. Followings are the results of analyzing the data. 1. The movement size of the "Grand Battement Developpe". o.The maximum height of toe were 173.1 - 189.6cm, 104.3- 118.5% for her own height. o.The angle between thigh(supporting leg) and pelvis was 144 - 165degree and the angle between trunk and vertical line was 6 -24 degree. 2. The position of segments when "Grand Battment Developpe" o.The angle of knee(supporting leg) was 170-175degree. o.The angle of knee(gesture leg) was 162-175degree. o.The angle of ankle(gesture leg) was 158-170degree. 3. The body balance during battement developpe and attitude croise derierre. o.The displacement of toe(supporting leg) was 12.7-25.0cm for left-right and 6.3-22.6cm for front-back. o.The displacement of body C.O.G was 3.4-10.7cm for left-right and 6.5-13.3cm for front-back. 4. The position of gesture leg during "Attitude Croise Derierre". o.the maximal height difference between hip joint and knee joint were -5.5 - -10.0cm for under direction between hip joint and toe were -10.8 - -22.0cm for under direction and 7.5 - 17.2cm for upper direction.

都市主婦의 結婚 適應度에 關한 硏究

金惠貞,李蓮淑,任春淑,鄭明姬,曺鏞旬,黃智暎 효성여자대학교 가정대학 학도호국단 1984 家政大論集 Vol.3 No.-

We measured general marital adjustment of the housewives who ilve in Daegu. We analysed marital affectional expression, cohesion, consensus and satisfaction and also analysed marital adjustment according to the level of education or length or marriage. The results are as follows; 1. The level of general marital adjustment of the urban housewives was medium. 2. According to factor analysis, the level of marital affectional expression was medium, the level of marital satisfaction and consensus was high, and the level of cohesion was low. 3. The more educated, the higher the degree of marital adjustment in general. 4. The marital adjustment was lowest in housewives whose length of marriage was 9-11 years. The second lowest were 3-5 years and 21-23 years. The highest was 15-17 years.