40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

신원방우황청심원의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-

Abstract-In order to investigate the phamacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH), effects of Wonbang Woohwangchungsimwon Pill (SCH) and NSCH were compared using various experimental models. In rat aorta, NSCH and SCH made the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6 M) regardless to endothelium containing or denuded rings of the rat aorta. Furthermore, the presence of the inhibitors of NO synthase and guanylate cyclase did not aftect significantly the relaxing effects of NSCH and SCH, NSCH and SCH inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs). NSCH and SCH decreased significantly heart rate. These, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In guinea-pig papillary muscle, these had no effects on parameters of action potential such as action potential amplitude (APA). V_max and resting membrane potential (RMP) at low doses, whereas inhibited the cardiac contractility at high doses. Furthermore, these had a significant inhibitory effects on palpitation of the heart in normotensive rats and SHRs. These results suggest that NSCH and SCH have weak cardiovascular effects, and that there is no significant differences between cardiovascular effects of two preparations.

신원방우황청심원액의 심혈관계에 관한 약효

조태순,이선미,김낙두,허인회,안형수,권광일,박석기,심상호,신대희,박대규 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

In order to investigate the pharmacological properties of New Wonbang Woohwangchungsimwon Liquid (NSCL), effects of Wonbang Woohwangchungsimwon Liquid (SCL) and NSCL were compared. In isolated rat aorta, NSCL and SCL showed the relaxation of blood vessels in maximum contractile response to phenylephrine (10^-6M) regardless to intact endothelium or denuded rings of the rat aorta. Furthermore, the presences of the inhibitor of NO synthase and guanylate cyclase did not affect the relaxing effect of NSCL and SCL. NSCL and SCL inhibited the vascular contractions induced by acetylcholine, prostaglandin endoperoxide or peroxide in a dose-dependent manner. In conscious spontaneously hypertensive rats (SHRs), NSCL and SCL significantly decreased heart rate. NSCL and SCL, at high doses, had a negative inotropic effect that was a decrease of left ventricular developed pressure and (-dp/dt)/(+dp/dt) in the isolated perfused rat hearts, and also decreased the contractile force and heart rate in the isolated rat right atria. In excised guinea-pig papillary muscle, NSCL and SCL had no effects on parameters of action potential such as resting membrane potential, action potential amplitude, APD_90 and V_max at low doses, whereas inhibited the cardiac contractility at high doses. These results suggested that NSCL and SCL have weak cardiovascular effects with relaxation of blood vessels and decrease of heart rate, and that this effect is no significant differences between cardiovascular effects of two preparations.

구강에 발생한 편평상피암종의 MMP-2, MMP-9, TIMP-1, TIMP-2 발현과 EGFR 및 E-cadherin 발현의 상호연관성

조성재,권창석,김용환,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Matrix metalloproteinases(MMPs) are involved in the degradation of extracellular matrix, which is related to infiltrative growth and metastasis of tumor. Positive correlation between MMPs expression and clinico-pathologic parameters were reported, and MMPs expressions were regulated by tissue inhibitor of metalloproteinases(TIMPs) or cell adhesion molecules such as E-cadherin and epidermal growth factor receptor EGFR). The aim of this study is to evaluate the relationship between MMP-2, MMP-9 expressions and clinico-pathologic factors such as clinical stage. recurrence. histologic grade and invasion pattern, and between MMP-2 and MMP-9 Expressions and TIMP-1, TIMP-2, and E-cadherin expressions. Methods and Material : The materials were 55 cases of squamous cell carcinoma of the oral cavity, and immunohisdtochemical studies for MMP-2, MMP-9, TIMP-1, TIMP-2, E-cadherin and EGFR were performed. Clinico-pathologic factors such as clinical stage, recurrence, histologic grade and invasion pattern were recorded through microscopic examination and clinical record review. Statistical analyses between MMP-2, MMP-9 expressions and clinico-pathologic factors, TIMP-1, TIMP-2 expressions and EGFR and E-cadherin expressions were done. Results : 1. MMP-2 and MMP-9 expressions were noted in 30(54.5%) and 22(40.0%) of 55 cases, respectively. TIMP-1 and TIMP-2 expressions were observed in 21(38.2%) and 33(60.0%), and E-cadherin and EGFR expressions were found in 35(63.6%) and 26(47.3%) of 55 cases, respectively. 2. MMP-2 expression rate was slightly higher in cases without recurrence, and TIMP-2 expression rate was slightly higher in cases showing more infiltrative growth pattern. However, there were no significant differences of MMP-2, MMP-9, TIMP-1, and TIMP-2 expression rates according to other clinico-pathologic parameters were noted. 3. The expression rate of EGFR was higher in cases with well differentiation (p=0.0047), but no positive relationship between the expression rate of E-cadherin and histologic grade was found. There were no significant differences of the expression rates of E-cadherin and EGFR according to other clinico-pathologic parameters. 4. Cases with positive reaction for MMP-9 showed an increasing tendency of negative reaction for TIMP-1. However, signigicant relationships between MMP-2, MMP-9 expressions and TIMP-1, TIMP-2 expressions were not noted. 5. The expression rate of MMP-2 was higher in cases with positive reaction for Ecadherin and EGFR with no statistical significance. The expression rate of MMP-9 was significantly higher in cases with positive reaction for E-cadherin(p=0.0221), but there was no significant relationship between MMP-9 and EGFR expression. Conclusion : These results suggest that MMP-2, MMP-9, TIMP-1 and TIMP-2 expressions are involved in the development of oral squamos cell carcinomas, but MMP-2, MMP-9, TIMP-1, and TIMP-2 expressions might not seem to be a sueful prognostic factors because there were no significant relationship between clinicopathologic parameters, EGFR expression showed positive correlation with low histologic grace, so EGFR expression could be regarded as a good prognostic factor. In the progression of squamous cell carcinoma of oral cavity, MMP-9 and E-cadherin might be involved with positive correlation, but there were no significant correlations between MMP-2, MMP-9 and TIMP-1, TIMP-2 and EGFR expressions rate. Further study for other factors such as cytokines or growth factors except TIMP-1, TIMP-2 and EGFR will be needed.

중등 과학교사 양성 교육과정과 교수내용지식 연구 동향의 탐색

조희형,조영신,권석민,박대식,강영진,김희경,고영자 이화여자대학교 교과교육연구소 2006 교과교육학연구 Vol.10 No.2

과학교사의 양성을 위한 교육과정 또는 그 프로그램의 주된 목적은 바람직한 과학교사가 지녀야 할 전문적 자질을 함양시키는 데에 있다. 그러나 우리나라의 과학교사 양성을 위한 프로그램 또는 사범대학 과학교육학 계열 교육과정에는 과학교사 교육의 본성과 그의 자질에 관한 연구의 결과가 충분히 반영되어 있지 않다. 이 연구는 자질기반 과학교사 양성 교육과정의 개발 틀, 교직의 전문성과 전문성발달기준, 우리나라의 과학교사 양성 교육과정 및 프로그램에 관한 문헌을 조사·분석한 다음, 그 결과로부터 우리나라의 과학교사 양성을 위한 교육과정의 개발 방향을 도출하고 그 모형을 탐색할 목적에서 수행하였다. 이 연구에서는 과학교사 양성 교육과정을 그 과목이나 지식기반 영역에 따라 교수내용알기(PCKg), 교수구성단위(TPCs), 내용표상화(CoRe)와 교수전문경험자료(PaP-eRs), 그리고 교수상황지식(PCxK)을 단위로 이용하여 구성할 것을 강조하였다. 또한 과학교사의 전문적 자질의 함양에 목적을 둔 교육과정 또는 그 프로그램의 과학교육 및 과학과 관련된 과목으로 일반과학, 심화과학, 일반과학교육학(과학교육론, 과학 교수-학습 포함), 과학 교육과정 및 평가, 과학교육 시설과 자원, 과학교육 실습, 과학교육 연구를 제안하였다. The subjects and their contents comprising the curricula for secondary science teacher education should be selected/organized to assist pre-service teachers to gain understandings of knowledge ba ses and to help them acquire professional teaching competences. However, the nature of science teacher education has not been reflected on the Korean science teacher education programs. The research was performed to review the literature on teachers' competencies including PCK(pedagogical content knowledge), teaching as profession, curricula or programs for secondary science teacher education, and, based on the results, to suggest curricular subjects and their contents for secondary science teacher education in Korea. The research emphasizes that the subjects and their contents for secondary science teacher education should be developed by the use of PCKg(pedagogical content knowing), TPCs(teacher professional constructions), CoRe(content representation) and PaP-eRs(pedagogical and professional-experience repertoires) as constitutive units, depending on the subject areas or contents. Also suggested in this research are the knowledge bases assumed to be necessary for the development of secondary science teachers' professional qualities, which include general sciences, enrichment sciences, general science education, science education curricula and evaluation, facilities and resources for science education, teaching practices, research in science education.

L929 및 CV1 세포를 사용한 한천중층법에서 치과용 합금의 독성 비교

조욱희,윤일,최석규,김형일 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2

Biocompatability of pure gold, Au alloy, pure titanium, Ti alloy, Ni-Cr alloy, Co-Cr alloy and pure copper was assessed through the agar overlay test using L929 and CV1 cells. Pure gold, pure titanium and Ti alloy had none to mild cytotoxicity, Ni-Cr, Co-Cr and gold alloy had mild to moderate cytotoxicity and pure copper had severe cytotoxicity. Generally, L929 cells were more sensitive to toxic substances than CV1 cells. The application of human gingival fibroblast to the agar overlay method seemed not to be proper.

탈진적 수영운동과 Selenium투여가 혈액 내 지질과산화물과 항산화효소 활성도에 미치는 영향

조형숙,김문희 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.4

This study investigates the blood MDA(malondialdehyde), SOD(superoxide dismutase), CAT(catalase) and GPX(glutathione peroxidase) activity in response to acute exhaustive swimming and selenium administration in rats. The animals in this study were chosen fourty-eight rats (Sprague -Dawley, male, 10 weeks, 300g), they were separated selenium group and placebo group. Selenium (sodium selenite, 2ppm/300g) solved in distilled water 1.0ml was administrated to them using by zoned needle at before 10 minutes swimming. The blood sampling time of two groups were three times (rest, after 30min swimming, exhaustion), 6ml blood were collected by abdominal aorta after the ethyl ether inhalation. The blood samples were centrifuged 3,000rpm for serum CAT, plasma SOD, plasma GPX and blood MDA activities analyzing. The statistical method was used by 2-way ANOVA. In summary, selenium, as a component of GPX, as a lipid soluble free radical scavenger serve and biological antioxidant defense system. selenium supplementation and acute exhaustive swimming within blood in rats enzyme activities (SOD,CAT,GPX) increase but MDA decrease. Also, our findings indicate that selenium have a positive effects to prevent the exercise induced increase in oxidative stress. Acute exhaustive swimming the improved of the body's defense capacities against free radical generation, likely as a result of adaptable increase in activities of antioxidant enzyme system.

용융염산화 반응기에서 기체체류량 및 기-액 흐름특성

조용준,양희철,은희철,유재형,김준형 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.5

용융염산화는 혼성폐기물과 유해폐기물을 효과적으로 산화 및 분해할 수 있는 소각대체기술중 하나이다. 본 연구에서는 직경이 0.079 m이고 높이가 0.653 m인 용융염산화 반응기에서 기체체류량 및 기-액 흐름특성에 대한 연구를 수행하였다. 액상으로 용융탄산나트륨을 기상으로 건조된 공기를 사용하였으며 기체유속(0.05-0.22 m/s)과 용융염온도(870-970℃) 변화가 기체체류량 및 기-액 흐름특성에 미치는 영향을 규명하였다. 기체체류량은 용융염 온도가 상승함에 따라 증가하였는데, 이는 용융염 온도의 증가로 인해 용융된 탄산나트륨의 점도와 표면장력이 감소하였기 때문이다. 실험에서 얻어진 기체체류량 데이터를 drift-flux 모델에 적용하여 용융염반응기 내의 흐름특성을 규명할 수 있었으며, 이를 통해 흐름영역에 따른 기체체류량을 정확하게 예측할 수 있었다. Molten salt oxidation is one of the most promising alternatives to incineration that can be used to efficiently destroy the organic components of mixed wastes and hazardous wastes. In this study, the gas holdup and gas-liquid flow characteristics are investigated in the molten salt oxidation reactor (0.076 m D×0.653 m H.). Effects of input air velocity (0.05-0.22m/s ) and molten salt temperature (870-970℃) on the gas holdup and flow characteristics have been studied. Molten carbonate as the liquid phase and air as the gas phase have been used in this study. The gas holdup increases with increasing molten salt temperature due to the decrease of viscosity and surface tension of molten carbonate. The experimentally obtained gas holdups in the molten salt reactor have been well described and characterized by means of drift-flux model. The gas holdups with variation of the flow regime have been well predicted.

반복 용체화처리에 의해 조직제어된 Ti-6Al-4V 합금의 인장성질

조형준,임영호,이준희 동아대학교 공과대학 부설 한국자원개발연구소 1994 硏究報告 Vol.18 No.2

The purpose of the present study is to improve the tensile properties of the beta-quenched with little strain due to processing, only by heat treatment. Control of volume fraction, morphology and distribution of alpha is of great importance in achieving desired mechanical properties with a good combination of strength and elongation. Accordingly, a cyclic solution treatment has been proposed to obtain bimodal structures of equiaxed and acicular alphas. The microstructures of the specimens subjected to the Cyclic Ⅲ solution treatment consisted of nearly equiaxed and acicular alphas with the matrix of the tempered martensite. As a result, the tensile properties became almost equivalent to the specimens of the double solution treatment in the α+β region.

석탄회를 활용한 콘크리트의 성능에 관한 연구

조형근,양회진 호남대학교 산업기술연구소 1997 산업기술연구논문집 Vol.4 No.-

석탄화력발전과정이 부산물인 석탄회가 사용석탄량의 11∼57%로 생성됨에 따라 이의 처리비용 및 환경보전적 측면에서의 많은 문제점이 야기되고 있어 석탄회의 유효이용에 관한 연구가 절실하다. 따라서 본 연구에서는 석탄회를 콘크리트 혼화재로 재활용하기 위한 방안을 강구하고자 석탄회의 발생과정 및 종류, 물리적 및 화학적 특성, 재활용 현황등을 파악하고, 석탄회의 배합혼입률에 따른 콘크리트 재령별 압축강도 특성에 대한 실험연구를 수행하였다. During combustion of powdered coal in modern power plant, coal ash is produced by 11∼57% of resource coal. The coal ash requires a great deal of disposal expense and causes a number of probrems in environmental conservation. It is necessary that researches for utilization of fly ash are required as soon as possible. The goal of this study are to develop a methodology for the utilization of fly ash as a mineral admixture in concrete. This paper presents the performance of concrete using fly ash. Results of the experimental study indicates that fly ash concrete tend to reduce the early compressive strength up to 28 days, but improve the long term compressive strength.