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Guinea Pig 에 있어 Asorbic Acid 지속성 캅셀제제의 생체이용률에 관한 연구
안형수,박재길,한창훈 한국약제학회 1985 Journal of Pharmaceutical Investigation Vol.15 No.1
Bioavailability studies in guinea pigs and dissolution tests of sustained release capsules of ascorbic acid were investigated comparing with those of solution. The results were as follows; 1. In the dissolution test, sustained release capsules released 90% of ascorbic acid after 12 hours, and ascorbic acid in the chewable tablet was dissolved. completely within 10 minutes. 2. In the determination of total ascorbic acid concentration in serum, the area under the curve between 0 and 24 hours (AUC 0∼24h) and the maximum serum concentration (C_(max)) did not show any significant difference between solution and sustained release capsule. The time to the maximum concentration (T_(max)) and the time over 50㎍/㎖ cocentration showed significant difference. 3. The time reached to maximum excretion rate (T_(max)) in sustained release capsule was longer than that of solution.
안형수,황인숙 동덕여자대학교 종합약학연구소 2001 동덕약학연구지 Vol.5 No.-
Antiasthmatic effects of clenbuterol transdermal preparation were evaluated in guinea pig. In vitro organ bath experiments, pD2 value of clenbuterol on the isolated trachea dilation effects in ginea pig was 8.0. The trachea dilation effects of clenbuterol showed tachyphylaxis and epithelum dependent trachea dilation. These results suggested that chronic use of clenbuterol may induce tolerance and the effect of bronchodilation of clenbuterol would be reduced in severe asthmatic patients who have impaired epithelium cell of bronchi. In vivo experiment, clenbuterol transdermal patch preparation (5 Cm2) recovered histamine-induced reduction of tidal volume and minute volume during carbon dioxide inhalation until 72 hours later. This result was simliar to the effect of clenbuterol 10㎎/㎏ oral administration after 3 hours. The maximum effect of clenbuterol transdermal preparation in the increase of respiratory volume resulted at 6 hours later. Clenbuterol transdermal preparation significantly inhibited the capsaicin-induced cough in guinea pig until 48 hours later. These results suggested that bronchdilatory effects of clenbuterol transdermal preparation would be continued more than 48 hours, while the skin irritation was mild.