Comparative occurrence of ischemic stroke with the rhythm versus rate control strategy in a national prospective cohort of atrial fibrillation

( Jae Guk Kim ),( Young Soo Lee ),( Ki-woon Kang ),( Eue-keun Choi ),( Myung-jin Cha ),( Jung-myung Lee ),( Jin-bae Kim ),( Junbeom Park ),( Jin-kyu Park ),( Tae-hoon Kim ),( Jae-sun Uhm ),( Jaemin Sh 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1

Background/Aims: Comparative occurrence of ischemic stroke for rhythm versus rate control strategy in patients with non-valvular atrial fibrillation (NVAF) is still inconclusive. The purpose of this study was to investigate whether the rhythm control strategy is associated with a lower risk of ischemic stroke compared to the rate control strategy in NVAF patients. Methods: The CODE-AF registry prospectively enrolled 6,280 consecutive patients who were treated for NVAF at 10 tertiary referral centers in South Korea. Of these, 2,513 NVAF patients (age, 67 ± 10 years; male, 61.8%) were clinically followed up for over 1-year and divided into rate and rhythm control groups. Results: Those treated with the rhythm control strategy were younger and had less proportions of underlying disease compared to those treated with the rate control strategy. After the propensity matching analysis, those treated with the rhythm control strategy had similar baseline characteristics including the CHA₂DS₂-VASC score compared to those treated with the rate control strategy. The rate of oral anticoagulation, all bleeding, and hospitalization were also similarly between the two groups. The incidence rate of ischemic stroke in the rhythm control group was significantly lower than in the rate control group (0.7 vs. 6.9 per 1,000 person-years, p = 0.011). Conclusions: The rhythm control strategy demonstrated a beneficial effect to lower the risk of ischemic stroke during a 1-year follow-up compared to the rate control strategy.

Polaron Hopping in the K_(2)O · B_(2)O_(3) · V_(2)O_(5) Glasses

차유정,강재필,홍성덕,김복수,김영훈,서용문,송승기 명지대학교 자연과학연구소 2005 자연과학논문집 Vol.24 No.-

K_(2)O · B_(2)O_(3) · V_(2)O_(5) 계 유리의 조성비에 따른 밀도, 굴절율, 전이온도, 천이금속이온비율 등과 직류 전기 성질을 100~450K 온도영역에서 연구하였다. 실험결과를 비정질 반도체에 관한 전기전도에 대한 이론 모델을 이용하여 분석하였다. 고온 영역에서는 직류전도도의 온도 의존성을 Mott의 포논-도움껑충뛰기 전도모델로 분석할 수 있었다. 활성화에너지는 0.28~0.33 eV로 시료내 V_(2)O_(5) 의 양이 증가할수록 감소하는 경향을 보인다. 저온 영역에서 직류 전기전도도는 Mott의 가변거리 껑충뛰기(variable-range hopping)전기전도도와 잘 일치하며, N(E_(F))값은 국지화 상태에서와 같다. The dc conductivity of K_(2)O-B_(2)O_(3)-V_(2)O_(5) glasses has been investigated in the temperature range 100~450K and physical parameters such as density, refractive indices, glass transition temperature and fraction of reduced transition-metal ion, were observed for various compositions. The experimental results are analyzed with reference to theoretical models proposed for electrical conduction in amorphous semiconductors. The analysis shows that at high temperature region the temperature dependence of the dc conductivity is consistent with Mott's model of phonon-assisted hopping of small polarons. The values of activation energy are 0.28~0.33 eV and decrease with increasing V_(2)O_(5) content in the sample. The lowtemperature dc conductivity data can be well fitted to Mott's variable-range hopping conductivity and the values of N(E_(F)) are also reasonable for localized states.

흰쥐에서 paraquat독성에 미치는 tumor necrosis factor-α의 영향

차종희,박정수,양성훈,박재윤,이병래 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background : The toxicity of paraquat is due to the oxygen-derived radicals formed by the reaction of oxygen with bipyridylium radical cations. Tumor necrosis factor (TNF)-α induces the synthesis of mitochondrial manganese superoxide dismutase (Mn-SOD) and other protective proteins in a variety of tumor cells and these protein contribute to a protect tumor cells from free radical injury. In this study, the effects of TNF-α on paraquat-induced toxicity were investigated in rats. Methods : Experimental animal used was Sprague-Dawley male rat, body weight 150-200g. The paraquat toxicity was determined by survival rate. The SOD, catalse, and glutathione peroxidase(GSHPx) activity were spectrophtomerically determined by Crapo method, Aebi method and Flohe method, respectively. Results : The survival rate of paraquat-intoxicated rats was decreased by subctaneous injection of TNF-α. However, the survival rate of paraquat injected rats were increased by pretreatment of TNF-α, comparing to saline pretreatment. The liver SOD activity was increased significantly by TNF-α treatment, but kidney and lung enzyme was unaltered in TNF-α treated-rats, comparing to normal control rats. The increment of liver SOD activity by TNF-α treatment was dose- and time-dependant SOD activity of kidney and lung of rats were not changed by TNF-α injection. The activities of catalase and glutathione peroxidase and contents of thiobarbituric acid reactive substance(TBARS) in liver were not changed by TNF-α treatment. Conclusion : From these result, TNF-α potentiate paraquat toxicity in rats but TNF-α pretreatment reduce paraquat induced toxicity. Protective effect may be resulted from the increased liver SOD activities by TNF-α.

만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구

차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

Prednisolone과 Prednisone의 임상약동학적 평가

신재국,윤영란,차인준,이경훈,장인진,신상구,박찬웅 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

유도선수들의 스포츠자신감 수준이 귀인형태에 미치는 영향

홍재표,차정훈,전승훈 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

The present study was designed to examine the effect of sport-confidence on attributional perceptions across male and female fencers. Judo athletes reported their sport-confidence, attribution perceptions on Sport-Confidence Inventory. CDSⅡ(Causal Dimension Scale Ⅱ) According to the previous research findings related to the theme of the study, it was hypothesized that the independent variables of trait sport-confidence. state sport-confidence influence the dependent variable of attributional perceptions. and the relationships between the two kinds of variables were examined using two-way ANCOVA. The implications of the study are as follows : Firstly. Trait sport-confidence and state sport-confidence of judo athletes significantly affected the locus of contorl dimension. Secondly. Trait sport-confidence and state sport-confidence of judo athletes significantly affected the stability dimension. Thirdly, Trait sport-confidence and state sport-confidence of judo athletes significantly affected the contro lability dimension.

어린이에서 함치성 낭과 연관된 매복 소구치와 대구치의 치료

신차욱,김영재,김정욱,장기택,이상훈,김종철,한세현 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

치아 매복은 어린이 환자 진료시에 자주 관찰되는 맹출 장애이다. 어린 환자에서 매복된 치아가 존재하는 경우,함치성 낭과 연관이 있을 가능성이 높다. 함치성 낭은 제3대구치를 제외하고는 상악 견치,하악 소구치 부위에서 가장 호발하며,점진적인 증식으로 악골이 팽윤되어 안모를 변화시키며,주위 악골의 파괴와 치근의 흡수를 야기하거나 침범된 치아의 변위를 유발할 수 있으므로,조기 진단과 적절한 치료가 무엇보다도 중요하다. 함치성 낭과 연관된 치아가 과잉치나 지치라면,치아의 발거를 포함한 완전한 낭종 적출술이 적절한 치료라 할 수 있지만,그렇지 않은 경우에는 환자의 심리적,정선적 외상을 예방하기 위해 원인 치아의 보존이 고려되어야 할 것이다. 이뿐만 아니라,치아의 변위 정도,골 파괴 정도,치근의 성숙도,주위 치아와의 관계,환자의 교합과 구강 악안면 영역의 성장 양상 등도 같이 고려되어야 할 것으로 생각된다. 본 증례에서는 위와 같은 사항들을 고려하여,함치성 낭과 연관된 매복 소구치와 대구치블 낭종 적출술 후 공간 유지,외과적 수술과 교정적 견인,외과작 발거 후 교정적 배열 등의 방법을 통해 양호한 치료 결과를 얻었기에 보고하는 바이다. Tooth impaction is a frequently observed eruption anomaly in pediatric dental practice. Young patients with impacted or unerupted teeth have more prediction for dentigerous cyst formation. Dentigerous cyst presents radiographic features. unilocular or multilocular radioluscency. Cysts occur most frequently in the premolar region except third molar. Dentigerous cysts can grow to a considerable size, and large cysts may be associated with a painless expansion of the bone in the involved area. Extensive lesions may result in facial asymmetry, osseous destruction, root resorption of proximal teeth and displacement of associated tooth. The nature of the causative tooth influences the type of surgical treatrnent required for the dentigerous cyst. If the cyst is associated with a supernumerary or wisdom tooth. complete enucleation of the cyst along with extraction of tooth may be the first treatment choice. Otherwise. preservation of the associated teeth should be considered to prevent a young patient from psychological and mental trauma because of the loss of tooth. We should consider the degree of tooth displacement. osseous destruction and growth pattern of oromaxillofacial area when planning treatment. Thus a proper and logical treatment planning can help a proper growth and development of oromaxillofacial area and can save the patient from a psychological and mental trauma. This report describes 4 cases of the management of impacted premolars and molars associated with dentigerous cysts in children.

포도 뿌리혹병 방제를 위한 길항균 선발

박광훈,김정희,차재순 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 2002 연구보고서 Vol.6 No.-

Previous study showed that crown gall disease is very severe on the tetraploid cultivars of grape. One of the promising control measures of the disease is biological control using a antagonist against pathogen, Agrobacterium vitis. Total 215 bacteria and 21 putative agrobacteria were isolated from galls of grapevine and a Korean wild grape, Vitis amurensis respectively. Antagonistic ability of the isolates was checked by growth inhibition test of pathogens, A. tumefaciens and A. vitis on agar and on tamato seedling by co-inoculation of the isolates and pathogen. Two selected antagonists, isolate 197 and Va 21 strongly suppressed gall formation of A. vitis K306 on grapevine when they were co-inoculated with pathogen K306. Both gall size and rate of gall formation were significantly lower on grapevines inoculated of 197-K306(9:1) or Va 21-K306(9:1) mixture than on them inoculated of just K306. Antagonistic ability of the two isolates was similar to F2/5, which is known as a strongest antagonist against A. vitis so far. Further field study for biological control of crown gall disease on grapevine by the two isolates is needed.

Agrobacterium radiobacter K84에 의한 장미 뿌리혹병의 생물적 방제

박광훈,차재순 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

최근 우리 나라의 여러 작물에서 뿌리혹병(根頭癌腫病, crown gall)의 발생이 증가하고 있음이 보고되고 있으며, 특히 중요한 화훼작물인 장미를 재배하는 시설하우스에서 뿌리혹병의 발생은 매우 심한 피해를 가져오고 있다. 그럼에도 불구하고 이 병에 대한 방제는 거의 이루어지지 않고 있는 실정이다. 본 연구에는 전 세계적으로 매우 성공적으로 뿌리혹병의 생물농약으로 개발된 Agrobacterium radiobacter K84의 장미 뿌리혹병 방제효과를 검정하여 국내에서 장미 뿌리혹병의 방제에 그 사용가능성을 확인하고자 하였다, 장미의 지상부에 인위적인 상처를 주고 병원균을 접종하기 전에 그리고 접종후 A. radiobacter K84 균주 현탁액의 살포는 뿌리혹병의 발병율과 혹의 크기를 크게 감소시켰다. K84균주를 처리한 장미에서 뿌리혹병의 발병율은 5.0 - 6.7%로서 병원균을 단독 접종한 대조구에서의 발병율 85% 비하여 크게 낮았다. K84 균주를 처리한 장미에서 형성된 혹의 크기와 생체중도 병원균만을 접종한 대조구 장미에 형성된 혹은 4-5%로서 K84균주의 처리에 의해 크게 감소하였다. 장미의 뿌리에 인위적인 상처를 주고 병원균의 접종 전 및 후에 K84 현탁액에 침지 처리한 처리에 의해서도 혹의 크기, 생체중, 그리고 병발생율이 크게 감소하였다. 전체적으로 K84균주 처리에 의한 지상부 혹의 생물적방제가는 92-94%이었고, 뿌리에서의 뿌리혹병 생물적방제가는 51-59%이었다. 이상의 결과는 A. radiobacter K84균주의 처리가 매우 효과적으로 장미 뿌리혹병을 방제할 수 있음을 보여주고 있다. Servere crown gall disease was occurred in green house cultivating rose in Jinchen, Chungbuk recently. Although it causes problem on rose cultivation, the growers do not have many choices of control measures for the disease now. A. radiobacter K84 has been known as a strong antagonist against A. tumefaciens, a pathogen causing crown gall disease and used as a biopesticide for crown gall in many countries since it had been introduced in 1972. We tested control ability of A. radiobacter K84 for the crown gall disease on rose. Spray of A. radiobacter K84 suspension on above ground of rose either before of after pathogen spray reduced size and fresh weight of galls significantly. Size and fresh weight of galls on roses inoculated with pathogen either before A. radiobacter K84 spray (pathogen-K84 treatment) or after A. radiobacter K84 spray (K84-pathogen treatment) were 4 to 5% of those of galls on roses inoculated pathogen only. Diseased rate of plants inoculated pathogen only was 85% whereas diseased rates of pathogen-K84 or K84-pathogen treatments were 6.7% and 5.0% respectively. Dipping of roots of rose in suspension of A. radiobacter K84 was also reduced size of galls and diseased rate significantly. These results indicate that A. radiobacter K84 is effective in the prevention of gall formation by A. tumefaciens and it can be used to control of crown gall disease of rose.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.