서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

용접공에서 혈중 중금속 농도와 혈장중 Malondialdehyde, α-tocopherol 및 적혈구내 Superoxide Dismutase 활성도에 관한 연구

이원진,장성훈,황천현,천병철,김해준 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

We investigated the association between the oxidative stress and the concentration of heavy metals in blood among welders. The study subjects were male manual CO₂welders(N=127) exposed to several heavy metals. The age distribution was from 20 to 63(GM=33.7) and the geometric mean(GM) of work duration was 4.2 years. We analyze the level of blood lead, cadmium, manganese and chromium which was related with the oxidative stress in the animal studies. Blood selenuim, plasma malondialdehyde(MDA), plasma α-tocopherol and erythrocyte superoxide dismutase(SOD) were analyzed as biological markers of the oxidative stress. The results of univariate analysis showed that the plasma MDA was significantly correlated with α-tocopherol(r=0.327) and blood selenium(r=0.313) concentration. But we could not find out any relationship between the erythrocyte SOD activities and those metal concentrations. Neither smoking nor alcohol consumption was related to the level of heavy metals and the oxidative stress biomarkers. As the results of multiple regression analysis with stepwise selection method, 1) the change of MDA level were dependent with the level of α-tocopherol and blood selenium concentration(R²=19.7), 2) the plasma α-tocopherol level was dependant with MDA and blood chromium concentration(R²=15.6), 3) in case of erythrocyte SOD activity, only the duration of work was significantly selected.

급성심근경색증의 조기진단에 있어서 Myoglobin의 진단적 의의

이정헌,김종근,정병천,서강석,박정배,조용근,류재근,전재은,채성철,박의현 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: Exact and early diagnosis of acute myocardial infarction (AMI) is essential for the subsequent routine management of this frequent cardiovascular disease. Currently, AMI has been diagnosed using the combination of the history, electrocardiogram(ECG), and biochemical markers of myocardial necrosis. At present, many biochemical markers are used to diagnose AMI. In this study, the predictive values of serum myoglobin and creatine kinase-MB(CK-MB) were compared in the emergency department. Methods: Fifty-four consecutive patients who presented within 12 hours from onset of chest pain of presumed cardiac origin were enrolled into the study. Patients with trauma or renal failure were excluded. The serial serum myoglobin and CK-MB levels were obtained prospectively at admission and 2, 4, 6, 12, 24 and 48 hours after admission. We compare the levels of serum myoglobin and CK-MB within 2, 4, 6, 8, 10, 12, 24, and 48 hours after symptom onset respectively. And we compare the sensitivity, specificity, positive predictive value, and negative predictive value of myoglobin and CK-MB. Results: using World Health Organization criteria, 28 AMI patients were identified. Mean time from symptom onset to presentation was 4.1±1.3 hours. The predictive values of serum myoglobin were better than those of CK-MB within 6 hours after symptom onset. But, 6 hours after symptom onset, the predictive values of CK-MB were better than those of serum myoglobin. The false positive cases of serum myoglobin were 3-one was lung cancer with pleural effusion and the others were unstable angina. The false positive cases of CK-MB were 6-one case was viral myocarditis and the ohters were unstable angina. Conclusion: To compare the serum myoglobin and CK-MB in the diagnosis of AMI, serum myoglobin had better predictive values than CK-MB within 6 hours after symptom onset and useful in the early diagnosis of AMI. But, 6 hours after symptom onset, CK-MB had better predictive values than serum myoglobin and useful in following up.

사람唾液 Superoxide Dismutase의 精製 및 性狀

이봉재,이병래,전현우,양종대,이근배 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1

The purification and some properties of superoxide dismutase(O_(2-)-O_(2-) oxidoreductase, ECI. 15.1.1) of human saliva have been studied. Human saliva was collected from medical students, male and female together with smoking male students. The activity of superoxide dismutase was measured by the method of McCord and Fridovich. The superoxide dismutase was purified by ammonium sulfate precifitation, DEAE-cellulose and sephadex C-100 column chromatography. The results are summerized as follows : 1. Human saliva contain measurable amounts of superoxide dismutase. 2. The activities of superoxide dismutase. were 0.72U/㎖ in male and 0.73U/㎖ in female saliva. The activity of this enzyme was 0.81U/㎖ in smoker. Accodingly, there was no recognizabIe differences in the enzyme activity between smoker and non-smoker. 4. The human salivary superoxide dismutase was purified approximately 90 folds, and the molecular weight of the purified enzyme was estimated to be approximately 32,000 by gel filtretion. 4. Purified salivary superoxide dismutase has contained 1.83 atoms of copper and 2.00 atoms of zinc per molecule and was strikingly similar to the superoxide dismutase previonsly isolated from other cukaryotes by other investigatury. 5. The ultraviolet absorption spectrum of purified salivan- superoxide dismutase was 268㎚ which was similar to the value previously seen with the cytosolic enzyme of eukaryotes.

검색 엔진을 이용한 검색 서비스 설계 및 구현

전병태,김병철,이명선 高麗大學校附設 컴퓨터科學技術硏究所 1999 JOURNAL OF COMPUTER SCIENCE & ENGINEERING TECHNOLO Vol.2 No.-

최근 급격한 인터넷의 발전은 검색 서비스로 인해 주도되었다고 해도 과언이 아닐 것이다. 방대한 정보의 바다 인터넷을 통해 정보를 얻으려 해본 적이 있다면 어떤 검색엔진을 사용하여야 할지 어떤 검색어를 사용하여야 할지 한 번쯤은 고민 해 보았을 것이다. 이러한 이유로 많은 사람들이 메타 검색엔진이라는 것을 이용하게 된다. 그러나 이러한 메타 검색엔진도 자체내의 여러 가지 정보 처리로 인한 느린 결과 처리의 문제점이 있다. 본 논문에서는 인터넷의 정보검색을 하는 사용자의 특성을 고려한 정보 검색 서비스를 제공해 주는 시스템을 설계 구현하여 본다. It is needless to say that information search service leads explosive growth Internet. When you have a experience to get information what you search in Internet, puzzled about what kind of search engine and search keyword should select. Thus many people want to use Meta-search engine. But Meta-search engine has some problem. one of problem is that meta-search engine manages information which is obtained by several search engine. Thus meta-search engine has some severe performance degradation. In this paper we designed and implemented information search service system for the purpose of using internet to get information search result.

영양제로서 결정 NH₄H₂PO₄를 첨가한 피혁 공장 폐수의 생물학적 처리

전명순,임병란,최기덕,이수구 서울산업대학교 산업대학원 1993 大學院論文集 Vol.2 No.-

피혁 공장 폐수의 생물학적 처리에 있어서 유입 폐수의 급격한 부하변동, 독성물질의 유입 및 미생물의 성장에 필요한 각종 영양소의 불균형 등으로 인해 처리효율이 낮고 운전관리상 어려움이 많다. 따라서 본 연구에서는 피혁공장 폐수의 생물학적처리효율을 높이기 위하여 각종 영양제의 주입에 따른 처리효과에 관한 실험을 실시하여 적절한 영양제를 선정하고, 최적 주입량 등을 결정 하였다. 실험대상 폐수는 반월공단내의 피혁 공단 폐수로서 중화 및 응집참전 밥법으로 전처리 한 후 포기조에 유입되는 폐수를 대상으로 하였다. 영양제로는 회분식 실험에서 피혁폐수의 처리효율이 가장 우수한 것으로 나타난 결정 APM (ammonium phosphate monobasic, NH₄H₂PO₄)을 이용하였다. 연속식 활성 슬러지 공장에 있어서 폐수의 유량, 슬러지 반송율, 결정 APM 주입량 등을 변화시켜 그에 따른 처리효율에 미치는 영향을 실험 고찰하였으며, 생물 반응공학적인 반응해석을 통하여 설계에 필요한 반응상수 등을 구하였다. 연속식 활성슬러지법에서체류시간 12시간의 조건에서 영양제 미주입시 BOD 제거효율은 68%에 불과하였으나, 영양제로서 요소와 인산을 주입한 경우 73%로 증가하였으며 결정APM을 주입한 경우 90% 이상의 높은 처리율을 얻을 수 있었다. 결정 APM의 최적 주입량은 회분식 실험의 경우 300㎎/L이었으나, 연속식 실험의 경우 50㎎/L로 낮게 나타났는데, 이는 반송되는 슬러지내의 높은 인농도와 미량원소에 기인한다. 결정 APM을 50㎎/L 주입한 후 수리학적 체류시간을 6∼30 시간의 범위로 변화시켜 실험한 결과, BOD 제거효율은 체류시간 6시간에서는 67%에 불과하였으나, 12시간의 경우 93%, 30시간의 경우 98%이었다. 따라서 BOD제거효율 90%이상을 얻기 위해서는 수리학적 체류시간은 11시간 이상, F/M비는 0,65 ㎏ BOD/㎏ MLVSS·d 이하로 운전하여야 하는 것으로 나타났다. This study was performed to enhance the treatment efficiency of leather wastewater adding APM(ammonium phosphate monobasic, NH₄H₂PO₄) crystal as nutrient which contained the sufficient mineral components. The effect of APM crystal on biological treatment were studied and its optimum dosage and kinetic coefficients were determined. In the continuous activated sludge system for field wastewater of Banwol leather complex, BOD removal efficiency could be obtained over 90% with adding APM crystal, while it was 68% without nutrients and 73% with urea and phosphoric acid in the condition of HRT 12hr and SRT 3 days. The optimum dosage of APM crystal was 50㎎/L which was low compared with 300㎎/L in batch test due to recycling sludge contained high content of phosphate and mineral nutrients. In the condition of adding APM crystal 50㎎/L and hydraulic retention time in the range 6∼30hr, BOD removal efficiencies were 67% for HRT 6hr, 93% for 12hr and 98% for 30hr. In order to obtain over 90% of BOD removal efficiency, HRT should be maintained over 11 hr and F/M ratio within 0.65 ㎏ BOD/㎏ MLVSS·d.

칠절봉 신갈나무(Quercus mongolica)림의 군락구조와 토양환경

이호준,배병호,전영문,정흥락,홍문표,김용옥,길지현 建國大學校基礎科學硏究所 1998 理學論集 Vol.23 No.-

칠절봉 신갈나무림의 군락구조와 토양환경과의 관계를 파악하기 위해 식물사회학적 조사와 토양 환경을 분석하였다. 조사지역의 신갈나무림은 신갈나무군락, 철쭉꽃하위군, 큰개별꽃하위군으로 구분되었으며, 철쭉꽃하위군과 큰개별꽃하위군에서의 방형구당 평균출현종수는 각각 30종(24∼46종), 43종(31∼52종) 이었다. 피복지수치에 의한 계층별 우점순위는 교목층에서 신갈나무(6750.0), 아교목층에서 당단풍(2364.0) 관목층에서 철쭉꽃(988.5), 초본층에서 쌀새(1040.5)가 가장 높게 나타났다. 신갈 나무림의 DBH 분포는 2∼10㎝ 범위의 소경목이 전체의 29.7%를 차지하였으며 전체적으로 정규분포를 나타내어 교란 후 재생과정에 있는 것으로 조사되었다. 또한 후계목의 발달로 인한 극상상태로의 천이가 가능할 것으로 조사되었다. 전반적인 토양환경은 두 하위군 간에 뚜렷한 차이가 없었으며, 큰개별꽃하위군이 철쭉꽃하위군에 비하여 다소 양호한 것으로 조사되었다. 환경구배분석에서 까치박달, 물푸레나무, 함박꽃나무 등은 습한 곳에 분포하고 철쭉꽃, 전나무, 국수나무 등은 건조한 곳에 분포하는 것으로 나타났다. A relationship between the community structure composition and soil environmental factors of the Quercus mongolica forest on Mt. Chiljelbong was investigated from June 1996 to August 1997. The Q. mongolica community was classified into two subcommunity of Rhododendron schlippenbachii and Pseudostellaria palibiniana. The 30(24-46) species per quadrat were appeared in R. schlippenbachii subcommunity and 43(31-52)species in P. palibiniana subcommunity. The dominant sequences on each stratum determined by the coverage index showed that Q. mongolica was the most dominant in tree-1 layer with 6750.0, Acer pseudo-sieboldianum in tree-2 layer with 2364.0, R. schlippenbachii in shrub layer with 988.5, and Melica onoei in herb layer with 1040.5 value. The value of diameter breast height(DBH) showed a normal distribution displaying a highest value in the range of 2∼10㎝(29.7%) in Q. mongolica forest and it was investigated being at restoration phase after disturbance. It also was investigated that the succession to climax state would be possible due to growth of successive tree. Overall, which the soil conditions make little difference between two subcommunities, P. palibiniana subcommunity was favorable than those of R. schlippenbachii subcommunity. It was shown that in an environmental gradient analysis, Carpinus cordata, Fraxinus rhynchophylla, and Magnolia sieboldii were distributed in a mesic area, but R. schlippenbachii, Abies holophylla, and Stepanandra incisa in a xeric area.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

코크스 제조 및 사용 공정에서의 코크스오븐 배출물질 연구

이종천,안규동,조광성,이병국 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.2

This study was performed to evaluate the coke oven emissions (COE) and polynuclear aromatic hydrocarbon levels in coke manu- facturing industry, secondary lead smelting industry and glass bottle manufacturing industry. 1. There were no significant difference between the means of personal samples and area samples by the types of industry(p>0.05). The levels of airborne total particulates of the secondary lead smelting industry was the highest(2.30㎎/㎥), and those of the coke manu- facturing industry and glass bottle manufacturing industry were 1.95 ㎎/㎥ and 1.37 ㎎/㎥. The concentration of COE was the highest in the glass bottle manufacturing industry(0.79 ㎎/㎥), and in order of 0.19㎎/㎥ in the coke manufacturing industry and 0.05 ㎎/㎥ in the secondary lead smelting industry. COE/total particulates(%) was highest in the glass bottle manufacturing industry(58.1%) and in order of 10.3% in the coke manufacturing industry and 3.1% in secondary lead smelting industry. There were significant differences in the total particle concentration and Coe by the types of industry(p<0.05) 2. The levels of airborne total particulates was the highest at the smelting process of secondary lead smelting industry(2.30±0.72 ㎎/㎥), and the lowest at the smelting process of glass bottle manufacturing industry (0.99±1.22㎎/㎥) Concentration of COE was the highest at the casting process of glass bottle manufacturing industry (1.09±1.15㎎/㎥), the lowest at the smelting process of secondary lead smelting industry(0.06±0,03 ㎎/㎥). The COE/total particulates(%) was the highest at the casting process of glass bottle manufacturing industry(65.9±20.5%), and the lowest at the smelting process of secondary lead smelting industry(3.1±2.7%). 3. There were positive correlations between level of The airborne total particulates and concentration of COE in COKE manufacturing industry and glass bottle manufacturing industry(p<0.05), but negative correlation in secondary lead smelting industry. 4. The numbers of case and rates that over the Threshold Limit Values(TLVs) were 24 (77.4%)cases in glass bottle manufacture, 14(23.7%) cases in the coke manufacturing industry and no one case in secondary lead smelting industry. Total numbers of case and rates that over TLVs were 38(35.5%) cases. 5. The limit of detection(LOD) for PAH was 10 ㎍/㎖) in standard sample. All PAH levels of the cokes manufacturing industry and the secondary lead smelting industry and the glass bottle manufacturing industry were trace or not to detect.

팔영산 삼림식생과 토양환경

이호준,김종홍,배병호,박문수,전영문,강재구,신정식 建國大學校基礎科學硏究所 1997 理學論集 Vol.22 No.-

전라남도 고흥군 소재 팔영산 (608.6 m) 일대의 삼림군락에 대한 색생조사를 1993년 10월부터 1995년 7월까지 실시하였다. 조사한 자료는 Z-M 방식에 의해 종조성표를 작성하였다. 이에 따라 삼림군락은 신갈나무군락, 졸참나무군락, 굴참나무군락, 서어나무군락, 소나무군락등 5 개 군락으로 분류되었다. 입지와 환경과의 유기적 관계를 조사하기 위해 토양을 분석한 결과, 신갈나무군락은 토양의 비옥도가 높은 산의 능선 부위에 집중 분포하였으며, 굴참나무군락과 소나무군락은 토양의 비옥도가 낮고 비교적 건조한 고도 400 m 이하 지역에 주로 군락을 형성하고 있었다. 또한 졸참나무군락은 고도 300 - 550 m 이내에서 부분적으로 나타났으며, 서어나무군락은 토양의 비옥도가 양호한 고도 300 - 550 m 사이의 골짜기 주변에 국지적으로 분포하였다. 팔영산 삼림식생의 특징은 상록활엽수림이 형성될 수 있는 지역이나 후박나무, 동백나무, 사스레피나무 등의 몇몇 종을 제외하고는 상록활엽수의 분포를 확인할 수 없었으며, 일부 식재림을 제외한 대부분의 지역이 낙엽활엽수와 소나무의 혼효림으로 구성되어 있었다. The phytosociological study forest vegetation on Mt. Palyoung (608.6 m) was investigated from October 1993 to July 1995 in Koheug-Gun, Cheonnam province. According to Z-M method, the floristic composition table of the forest vegetation was divided into five community as follows; Quercus mongolica community, Quercus serrata community, Quercus variabilis community, Pinus densiflora community, Carpinus laxiflora community. The soil was analyzed to investigated the soil conditions and soil fertility. As a result, the organic matters which showing soil fertility were found to be low Quercus variabilis and Pinus densiflora community at comparatively xerophic conditions, below 400 m altitude, while they were increased in Quercus mongolica community on mountain ridge, and that Quercus serrata community was appeared 300-550 m altitude around mountain stream to moderate soilfertility. The forest vegetation of Mt. Palyoung area unconfirmed capable of evergreen broad-leaved forest, but appeared to Machilus thunbergii, Camellia japonica and Eurya japonica species etc. On the other hand, surveyed site's vegetation was distributed mixed forest of deciduous leaved forest and Pinus desiflora, except for some afforestation.